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CSIR NET JUNE 2015 Question Paper + Answer Key
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PART A
Ans: 1
Explanation:
The
base
consist
of
4X4,
the
next layer would be 3X3 (as 0.5 has to be
step), next would be 2X2, 1X1,
Total=16+9+4+1=30
Ans: 4
Explanation: Explanation: Either B can lie or A
Ans: 3
Explanation: n=(360/theta)‐1, theta=60, n=5
Ans: 4
Explanation: Let the the third angle in the
traingle containing the x be y (seond angle
would be 180‐130=50
Fom the other triangle, 180‐y+50=130
==>y=100. If y=100, x=30.
Ans: 4
Explanation: The area would be maximum at
equator as the radius is maximum.
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Ans: 2
Explanation: Total distance=4+3=7, Speed =7,
Time=1
Ans: 4
Explanation: if m+n+mn = 118 then mn = 118
‐ (m+n). when 22 is substituted for m+n value
of mn
will
be
96.
96
can
be
written
as
16
x 6
that is value of m and n. hence 16 + 6 is 22. At
the same time 16 + 6 + (16*6) will be 118.
Ans: 1
Explanation: Let the price be x, after discount
it would be 0.9x. A loss of 90% incurred, so
final s.p=0.9*0.9x=0.81x
0.81x=729. Or x=900
Ans: 1
Explanation: X‐4 cannot be equal to x^2 ‐4^2,
it should be (x‐4)^2
Ans: 2
Explanation: We can select 11 players from 40
by 40 C 11 ways. We can choose 1 captain out
of 11 in 11 C 1 ways.Totally the number of
ways
11
C
1
x
40
C
11
=
11
x
40
C
11(11
C
1
=
11!/10! 1! = 11)
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Ans: 4
Explanation: The maximum diversity is
possible when all the bases occur in the same
proportion
Ans: 4
Explanation: Percentage increase in
2010=20/18*100:
Percentage increase in 2002=15/7*100:
Ans: 4
Explanation: 10000/3=3333
Ans: 2
Explanation: Hidden numbers are A: Eleven,
B: Nine, C: Eight, D: Ten. So according arrange
in ascending order C, B, D and A
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Ans: 4
Explanation: If we consider the southern
hemisphere, there is a ring near the South
Pole that has a circumference of one mile. So
what if we were standing at any point one
mile north
of
this
ring?
If we
walked
one
mile
south, we would be on the ring. Then one
mile east would bring us back to same point
on the ring (since it’s circumference is one
mile). One mile north from that point would
bring us back to the point were we started
from.
Ans: 2
Explanation: The answer most likely is option
2. Surface area changes by 5 % Volume of
sphere = 4/3 x pi x r^3 Since 7% is lost (10% of
70%), new volume is 0.93 x earlier volume So
the radii is also in the proportion r^3 = 0.93 x
R^3 (considering
r to
be
earlier
radius
and
R
new radius after loss of water) r = 0.976 R
Surface area = 4 x pi x r^2 So it will change by
a factor of (0.976)^2 = 0.952 So the change is
approx 5%
Ans: 1
Explanation: If the batch of 10 marbles we
moved from B to A contained k
black ones and 10 − k white ones, then A, at
the end, has k black marbles, and
B has 10 − (10 − k) = k white marbles. Thus the
two numbers are the same.
Ans: 1
Explanation: The distance between A and B
=pi R=3.14 R. As the speed is in ratio of 2:1
and hence
the
distance
covered
would
be
in
ratio of 2:1. i.e R from A and 2R from B
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Ans: 1
Explanation: aN when reversed is Na that is
sodium hence S. similarly eF = Fe = iron = I, gH
= Hg = mercurry and nS = tin hence T
Ans: 2
Explanation: mark a point O (center) on AB.
Join OC and OD. Hence OC, OD, OB will be
radius of circle = x. Let OP = y. Since OB is x OP
can be written as x ‐ 1. Apply pythorarus
theorem to triangle OCP. x^2 = 4+ (x‐1)^2. By
solvinf the equation x will be 2.5 which is the
radius of the circle.
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Ans: 3
Explanation: Long chain saturated fatty acids would be
responsible for decreasing the fluidity of the plasma
membrane. As
the
bacteria
would
be
shifted
from
lower
to higher temperature therefore, it would be requiring
long chain saturated fatty acids for its survival.
Ref: Chapter 4: Structure and Function of Plasma
membrane, Page 134, Cell and Molecular Biology by
Karp (6th Edition)
Ans: 1
Explanation: Sucrose is trans located via phloem in
plants
Ref: https://en.wikipedia.org/wiki/Phloem
Ans: 4
Explanation: Most transposans in bacteria are DNA and
Eukaryotes have both DNA and RNA
Ref : https://en.wikipedia.org/wiki/Transposable_element
http://www.slideshare.net/ambicaparthasarathi/transposa
ble-elements
Ans: 1
Explanation: LEAFY is a floral meristem identity gene
Ref: http://www.ncbi.nlm.nih.gov/books/NBK10122/
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Ans: 1
Explanation: The process is coupled to the hydrolysis of
16 equivalents of ATP and is accompanied by the co‐
formation of one molecule of H2
Ref : https://en.wikipedia.org/wiki/Nitrogen_fixation
Ans: 2
Explanation: Wavelengths beyond 700nm are
apparently
of
insufficient
energy
to
drive
any
part
of
photosynthesis. So a huge drop in efficiency has been
noticed at 700nm.It is a part of the emerson effect.
Ref : Book: Gupta and Gupta, Plant physiology 2005
Ans: 3
Explanation: Book: Gupta and Gupta, Plant physiology
2005
Ref :
http://chemwiki.ucdavis.edu/Biological_Chemistry/Protei
ns/Protein_Structure, Lehninger Principles of
Biochemistry, chapter 4
Ans: 2
Explanation: The S wave is the first negative deflection
after the R wave. It represents the late ventricular
depolarisation.
Ref: http://www.cardionetics.com/conduction-
system#lateventriculardepolarisation
Ans: 4
Explanation: The transport of chloride ions helps
control the movement of water in tissues, which is
necessary for the production of thin, freely flowing
mucus
Ref: http://ghr.nlm.nih.gov/gene/CFTR
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Ans: 2
Explanation: The 2'OH of th adenosine will attack the
5'splice site
Ref : https://en.wikipedia.org/wiki/Group_II_intron
Ans: 4
Ref :
http://chemwiki.ucdavis.edu/Biological_Chemistry/Metab
olism/Pyruvate_Dehydrogenase_Complex
Ans: 2
Explanation: Immunodeficient. Mutation in genes
required for site specific recombination results in
reduced or absence of mature T and B cells. Immature
cells are still present resulting in immune deficient state
Ref: https://en.wikipedia.org/
wiki/Severe_combined_immunodeficiency
Ans: 4
Explanation: Kcat is the turnover number calculated as
Kcat = Vmax/Et where, Vmax = max velocity; Et = total
enzyme concentration. In the question we should
convert the concentration terms to molarity. Vmax = 10
*10^‐3/400 = 0.25 * 10^‐4; Et = 20 * 10^‐6/200000 =
10^‐10. Kcat = 0.25 * 10^‐4/10^‐10 = 2.5 * 10^5/min
Ans: 4
Explanation: Beating of cilia is carried through nexin ‐
dyenin microtubule activity .All the other options are
related to microfilaments.
Ref: http://jcs.biologists.org/content/123/4/519.full.pdf
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Ans: 4
Explanation: All others would result in increased
concentration of Ca2+ except for DNA synthesis and
nuclear envelope breakdown which might occur due to
activation of a cAMP dependent kinase.
Ref : https://books.google.co.in/books?id=dmokq_M-
gm8C&pg=PA337&lpg=PA337&dq=g+protein+coupled+r
eceptors+%2B+sperm&source=bl&ots=hrQEV2_OHH&s
ig=BpgomZxHHAfS2ymOC4GW-
5D7trc&hl=en&sa=X&ei=aG2GVYrnAsKfugS3u4OQAg&
ved=0CEIQ6AEwBA#v=onepage&q=g%20protein%20co
upled%20receptors%20%2B%20sperm&f=false
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228701/
Ans: 1
Explanation: The pathway which plays an important
role in axis formation during morphallactic regenration
in Hydra would be beta catenin/Wnt pathway
Ref :
http://www.eecs.harvard.edu/~rad/courses/cs266/papers
/wolpert-chap13.pdf
Ans: 1
Explanation: immortality and contact inhibition.
transformed cells have loss of tumor suppressor activity
and activation of tumor suppressor genes
Ref:
http://library.med.utah.edu/WebPath/NEOHTML/NEOPL
105.html
Ans: 2
Explanation: The DNA sequence c has the highest
amount of GC content aomng the three and hence
would have maximum stability
Ans: 2
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Explanation: Polar and Kinetochore microtubules
present in the center of the cell are responsible for
determining the plane of formation of contractile ring
Ref : http://www.ncbi.nlm.nih.gov/books/NBK26831/
Ans: 2
Explanation: In triple response of seedlings when
exposed to ethylene, thickening and shortening of
hypocotyl with pronounced apical hook occurs.
Ref: https://en.wikipedia.org/wiki/Ethylene,
http://www.sccs.swarthmore.edu/users/08/wnekoba/Stud
ent5Handout.pdf
Ans: 1
Explanation: Inside cells, however, do not turn on the
Cdx2 gene, and express high levels of Oct4, Nanog, and
Sox2, These
genes
suppress
Cdx2
and
the
inside
cells
maintain pluripotency generate the ICM and eventually
the rest of the embryo proper
Ref : https://en.wikipedia.org/wiki/Inner_cell_mass
Ans: 3
Explanation: As the proof reading activity is carried out
at the 3; growing end and it done by 3'‐5'exonuclease activity
Ref : https://en.wikipedia.org/wiki/Proofreading_(biology)
Ans: 4
Explanation: Secondary oocyte is arrested at
Metaphase II of Meiosis II till the time sperm enters the
secondary oocyte which results in completion of 2nd
meiotic division of formation of ovum.
Ref : Chapter 14.3: Meiosis, Page 595, Cell and
Molecular Biology Karp (6th edition)
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Ans: 3
Ref :
https://books.google.co.in/books?id=KR1GlQs__9wC&p
g=PA257&lpg=PA257&dq=basal+metabolic+rate+would
+be+lower+during+prolonged+starvation,+sleep,+high+e
nvironmental+temperature&source=bl&ots=K2UYsT9slv
&sig=wedZnLXHhuhHVk1qIj8wKzX-
Au0&hl=en&sa=X&ei=rLiGVdCFIJeGuATMoY7wCg&ved
=0CB0Q6AEwAA#v=onepage&q=basal%20metabolic%
20rate%20would%20be%20lower%20during%20prolong
ed%20starvation%2C%20sleep%2C%20high%20enviro
nmental%20temperature&f=false
Ans: 1
Explanation: As there should be inverse relation
between r and T. So that can be justified only by option
1.
Option 2 denotes a direct relation between r and T
which is not possible. Option 3 and 4 are also not
possible since according to them if generation time is increasing then population growth constant should also
be increasing which is again not true.
Ref: https://en.wikipedia.org/wiki/Generation_time
http://vlab.amrita.edu/?sub=3&brch=65&sim=174&cnt=1
Ans: 3
Explanation: Steroid receptor requires a NLS signal and
the DNA binding domain is Zinc fingers
Ref :
https://en.wikipedia.org/wiki/Steroid_hormone_receptor
Ans: 3
Explanation: thigh muscles can have a thousand fibers
in each unit,
Ref: https://en.wikipedia.org/wiki/Motor_unit
Ans: 1
Explanation: The ordered tetrad is observed in N. Crasa
Ref : Griffith: Page 142
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Ans: 3
Explanation: rRNA and are used in reconstructing
phylogenies, due to the slow rates of evolution of this
region of the gene
Ref : https://en.wikipedia.org/wiki/16S_ribosomal_RNA,
http://eebweb.arizona.edu/blast/rna_lecture.pdf
Ans: 2
Explanation: Procollagen peptidase helps in the
processing of procollagen to collagen
Ref : http://www.medscape.com/viewarticle/423231_2,
https://en.wikipedia.org/wiki/Procollagen_peptidase
Ans: 2
Explanation: σ32 (RpoH) ‐ the heat shock sigma factor,
it is turned on when the bacteria are exposed to heat.
Ref : https://en.wikipedia.org/wiki/Sigma_factor
Ans: 1
Explanation: Semelparous organisms generally
reproduce only once in their lifetime producing many
offsprings at once. Cicada and Mayfly exhibit
semelparity along with bamboo which is a long lived
semelparous plant. Hence, option 1 would be correct.
Ref : Smith and Smith 2015, Elements of ecology, https://en.wikipedia.org/wiki/Semelparity_and_iteropa
rity
Ans: 1
Explanation: As only the elongation factors undergo for
conformational changes, ribosome do not undergo for
conformational changes during the GTP hydrolysis
Ref : http://www.ncbi.nlm.nih.gov/books/NBK26829/
Ans: 1
Explanation: Uv spectroscopy can be used to quantitate
proteins using Tyrosine and tryptophan content. rest of
the methods cannot be effectively used for quantitation
Ref : http://www.labome.com/method/Protein-
Quantitation.html
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Ans: 3
Explanation: As compared to normal population,
individuals of sub‐population within a metapopulation
are dynamic in nature which is determined by their
continuous immigration and emmigration.
Ref : Chapter 8: Properties of Population, Page 159,
Smith: Elements of Ecology (8th Edition)
Ans: 3
Explanation: The probability of having no dominant
phenotype=1/64 (tripple homozygous recessive)
Therefore the probability of having atleast one
dominant=1‐(1/64)=63/64
Ans: 3
Explanation: If high number of specialists would be
present then they would be dependent on a particular
type of food only. Similarly fewer number of functional
links would result in destabilization as high functional
diversity is required for stabilization. If an ecosystem is
having linear food web then the interdependence of
organisms on one other would be very strong while if
reticular food web is present then the interdependence
of organisms would be weak. Hence, linear food web
(food chain) would tend to decrease stability. While,
omnivores which are generalists would most likely be
increasing ecosystem stability since they can feed on
both plants and animals.
Ref : https://en.wikipedia.org/?title=Food_chain
Ans: 3
Explanation: T test is used in case of high variability
Ref : http://www.socialresearchmethods.net/kb/stat_t.php
Ans: 2
Explanation: Hybrid dysgenesis refers to the high rate of
mutation in germ line cells of Drosophila strains
resulting from a cross of males with autonomous P
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elements (P Strain/P cytotype) and females that lack P
elements (M Strain/M cytotype)
Ref: https://en.wikipedia.org/wiki/P_element
Ans: 4
Explanation: The protocol of DNA footprinting involves
one of the ends to be labelled so that after digestion
with DNaseI the distance from the end can be observed
by autoradiography. But of we incorporate label by nick
translation, this will allow the label to present across
the length of the DNA to be analyzed and we can not
accurately determined the length of the DNA fragments
Ref :
http://cshprotocols.cshlp.org/content/2013/5/pdb.prot074
328.short
Ans: 3
Explanation: As serum is outside the cell and hence
ELISA would be used
Ref :
http://labmed.ascpjournals.org/content/34/1/58.full.pdf
Ans: 1
Explanation: Noro virus and Rota virus both cause acute gastro intestinal illness. But Rota virus is more
associated with pediatric acute gastroenteritis. Where
ac Noro virus causes gastroenteritis in all age groups. It
is more contagious compared to Rota virus and is often
called as winter vomiting bug.
Ref : http://www.healthline.com/health/viral-
gastroenteritis#Overview1,
https://en.wikipedia.org/wiki/Norovirus
Ans: 3
Explanation: In the question taking path length as 1 cm.
A = ecl. The combined extinction coeff needs to be
considered whic is e = e trp * no. of trp + e tyr * no. of
tyr. In the question since both tyr and trp are 1 each. So
the combined molar extinction coeff is simply the sum
of both i.e 3000 + 1500 = 4500. Putting values in eqn,
0.90 = 4500 * c x 1; c = 0.90/4500 = 0.0002 M or 0.2 mM
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Ans: 1
Explanation: In punctuated equilibrium the species do
not evolve for a long period of time and would evolve
very rapidly for a short period of time.
Ref : https://en.wikipedia.org/wiki/Punctuated_equilibrium
Ans: 2
Explanation: The hearing capabilities of elephant is
superior compared to human beings. They use infra
sonics more frequently for hearing. they detect sounds
as low as 14 to 16 hz (human low range: 20 hz) and as
high as 12,000 hz (human high range: 20,000)
Ref: http://seaworld.org/animal-info/animal-
infobooks/elephants/senses/
Ans: 4
Explanation: As the mean remains same but the
variance decreases and hence this is an example of
stabilizing selection
Ref : https://en.wikipedia.org/wiki/Stabilizing_selection
Ans: 1
Explanation: Only Basidiomycotes have septate hyphae
which reproduce asexually by budding, conidia and
fragmentation.e.g. yeast. In zygomycetes, hyphae is
asepatate. It only forms septa where gametes are
formed or to wall off dead hyphae. Chytrids is also a
group of fungi which are asepatate and they reproduce
through zoospores. The Glomeromycota have generally
coenocytic (occasionally sparsely septate) mycelia and
reproduce asexually through blastic development of the
hyphal tip to produce spores called Glomerospores).
Ref: Sharma OP Textbook of fungi ,
https://books.google.co.in/books?id=4fcGAZBbZHAC&p
rintsec=frontcover&dq=op+sharma&hl=en&sa=X&ei=x5
OHVee8LI‐ jugS‐
6ZywCw&ved=0CB0Q6AEwAA#v=onepage&q=op%20sh
arma&f=false
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Ans: 1&4
Explanation: Bell‐shaped is a characteristics of
polygenic inheritance and almost all the polygenic inheritance is effected by environment
Ref:
http://highered.mheducation.com/sites/007246268x/stud
ent_view0/chapter7/index.html
Ans: 2
Explanation: Females have about 3/4 similarity with
their sisters, however, have only 1/2 similarities with
their daughters
Ans: 4
Ref : http://www.tutorvista.com/content/biology/biology-
iii/animal-kingdom/phylum-echinodermata.php
Ans: 2
Explanation: According to the question, glycolipids
would be facing the cytosolic side while sphingomyelin
would be facing the luminal side of Golgi. Now as the
vesicle would be budding from the Golgi, the luminal
portion of Golgi would be becoming the extracellular
portion of the plasma membrane while the cytoplasmic
portion would remain the cytoplasmic portion of plasma membrane. so, sphingomyelin would be facing the
extracellular side but for glycolipids to face the
extracellular side, we will be requiring flippase. So,
flippase along with membrane fusion between vesicle
and plasma membrane would be involved.
Ref : Chapter 8.3: The Endoplasmic Reticulum, Page
279, Cell and Molecular Biology by Karp (6th Edition)
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Ans: 3
Explanation: Telomeres are ends of linear
chromosomes. they are specific structures that protect
the inside relevant DNA region from getting digested by
nucleases and also prevent from chromsome fusions.
plasmids like pYAC system use this technology of having
telomeres at the ends to make the plasmid more stable.
Ref: http://www.els.net/WileyCDA/ElsArticle/refId-
a0000379.html
Ans: 1
Explanation:
The
surface
area
of
the
raft
is
35
nm2
which is equal to 3500 A2. Cholesterol to sphingolipid
ratio is 2:1. So if we have y residues of sphingolipid
there are 2y molecules of cholesterol. The equation will
be 2y * 40 +y * 60 =3500, this gives y = 25
(sphingolipids) and cholesterol as 50
Ans: 2
Explanation: Polymerization of microtubles is inhibited
by colcemid, which in turn would inhibit the transport
of secretory vesicles.
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Ref : Intracellular Trafficking of Proteins by Clifford J
Steer, https://en.wikipedia.org/wiki/Colcemid
Ans: 2
Explanation: PLA2 are commonly found in mammalian
tissues as well as insect and snake venom.[2]Venom
from both snakes and insects is largely composed of
melittin, which is a stimulant of PLA2. Due to the
increased presence
and
activity
of PLA2
resulting
from
a
snake or insect bite, arachidonic acid is released from
the phospholipid membrane disproportionately. As a
result, inflammation and pain occur at the site.
Ref: https://en.wikipedia.org/wiki/Phospholipase_A2
Ans: 4
Explanation: Once primase has created the RNA
primer, Pol α starts replication elongating the primer
with ~20 nucleotides.[18] Due to their high processivity,
Pol ε and Pol δ take over the leading and lagging strand
synthesis from Pol α respectively.
Ref: https://en.wikipedia.org/?title=DNA_polymerase
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Ans: 4
Explanation: Option A is correct as orthodox seeds are
long lived seeds. they can be successfully dried to
moisture contents as low as 5% without injury. Option C
and D are also correct as precocious germination is
defined as that kind of germination wherein the seed
germinates without undergoing all the four stages of
germination,
i.e.,
globular,
heart
shape,
torpedo
shape,
and cotyledonary stage. ABA is known to inhibit
precocious germination. Option B says that dormant
seeds would germinate upon rehydration. this is
incorrect. they might germinate or might not as
germination of seeds is dependent not only on water
but also on oxygen and temperature.
Ref: https://en.wikipedia.org/?title=Germination,
Copeland et al. Principles of seed science and
tecnhnology
Ans: 4
Explanation: oxidation of glucose involves glycolysis
during which 2 NADH are produced by the action of
glyceraldehyde ‐3‐ dehydrogenase, coversion of
pyruvate to acetyl coA by PDH complex produces 2
NADH, oxidation of acetyl coA by citric acid cycle
produces 6 NADH molecules and 2 FADH2 molecules.
These reduced co‐enzymes are oxidized back by
electron transfer chain.
Ref : Ref: Lehninger's Book of biochemistry Chapter no.
14, 16 and 19
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Ans:
Explanation:
Ans: 1
Explanation: It has been observed that 90% of N‐H‐‐‐O
bonds in proteins lie between 140 and 180°, and that
they are centred around 158°C. There fore graph b
seems more appropriate
Ref :
http://www.cryst.bbk.ac.uk/PPS2/projects/day/TDayDiss/
HBonds.html
Ans: 1
Explanation: P1 has genotype Oc I+ Z‐, this strain even
though the operator carries constitutive mutation
phenotype, will still not result in beta‐gal production as
the structural genes Z‐ is defective. Strain P2 phenotype
is O+ I‐ Z+, here repressor is defective, so this will result
in constitutive expression of beta‐gal as there is no
active repressor to block the operator region.
Merodiploid will be represented as Oc I+ Z‐/O+ I‐ Z+.
Here, Lac I is a trans acting factor, so in the merodiploid
strain, which has both I+ and I‐ copy, will essentially
behave as I+. However Operator is a cis‐acting factor so merodiploid Oc/O+ will behave as O+ as functional Z
gene is present on O+ chromosome. Therefore the
expression of beta‐gal will be inducible.
Ref:
http://dwb4.unl.edu/Chem/CHEM869N/CHEM869NLinks
/www.acsu.buffalo.edu/~jbarnard/LacOperonII.html
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Ans: 1
Explanation: breast cancer categorized as ER +ve are
more prone to distant reccurence and are associated
with dormancy. The main cause being Cells that are
chemo‐resistant get disseminated to lungs induce the
expression of Periostin (POSTN) in fibroblasts, which
reciprocally increases WNT signaling and promotes
tumor‐initiating potential and tumor outgrowth.
Similarly, lung micrometastases can also produce
tenascin C (TNC), an ECM protein, that facilitates
maintenance of tumor initiating potential by activating
WNT and Notch pathways in cancer cells.
Ref :
http://clincancerres.aacrjournals.org/content/19/23/6389.
full
Ans: 2
Explanation: Calculate Kcat for each of the protein as
Vmax/Protein concentration. Km is calculated from the
graph as substrate conc at which 1/2 Vmax is obtained.
this value for all the protein comes to be 1 uM. So the
Catalytic efficiency depends on Kcat alone.
Ref: For protein A: Kcat = 20/1 = 20; For protein B: Kcat
= 30/4 = 7.5; For protein C: Kcat = 12.5/2 = 6.25; So
catalytic effciency is in the order a>b>c
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Ans: 3
Explanation: Transcription termination in eukaryotes is
less understood but involves cleavage of the new
transcript followed by template‐independent addition
of adenines at its new 3' end, in a process called
polyadenylation. When the RNA is cleaved,
polyadenylation starts, catalysed by polyadenylate
polymerase. Polyadenylate polymerase builds the
poly(A) tail by adding adenosine monophosphate units
from adenosine triphosphate to the RNA, cleaving off
pyrophosphate
Ref :
https://en.wikipedia.org/wiki/Transcription_(genetics),
https://en.wikipedia.org/wiki/Polyadenylation
Ans: 3
Explanation: RNA editing through the addition and
deletion of uracil has been found in kinetoplasts from
the mitochondria of Trypanosoma bruce The
mechanism of the editosome involves an endonucleolytic cut at the mismatch point between the
guide RNA and the unedited transcript. The next step is
catalyzed by one of the enzymes in the complex, a
terminal U‐transferase, which adds Us from UTP at the
3’ end of the mRNA. Here U is found in the stretches
dispersed along the sequence, so deamination of C
resulting in U will also happen. Further trans splicing
follwed by demaination could result in sequences which
doesn't match genomic DNA.
Ref: https://en.wikipedia.org/wiki/RNA_editing,
https://en.wikipedia.org/wiki/Trans-splicing
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Ans: 1
Explanation: viral load will be increased in the test
group because of knockout of chemokine receptors. Plus due to further addition of proinflammatory
cytokines and HIV viral load will further increase. In the
control group, viral load will be comparitively less due
to presence of chemokine receptors.
Ans: 3
Explanation: Under such specific conditions in
microorganisms during stationary phase there is
presence of 100 S ribosome which do not have
translational activity but formation of such ribosomes
requires specific proteins
Ref : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-
2443.2009.01364.x/full
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Ans: 2
Explanation: TFIIH, have helicase and ATPase activities
and help create the transcription bubble, and TFIIH is
involved in nucleotide excision repair.
Ref:
https://en.wikipedia.org/wiki/Transcription_factor_II_H Ans: 3
Explanation: Since all the vulval precursor cells are
under the control of anchor cell. so if anchor cell is
removed then it would result in no vulva formation.
Also, signals from hypodermis would be inhibiting the
development of primary and secondary vulva. However,
these signals are overcomed by the signals from anchor
cell (LIN 3)
Ref:
https://books.google.co.in/books?id=WbO6BwAAQBAJ&pg=PA252&lpg=PA252&dq=a+constitutive+fate+from+h
ypodermis+inhibits+the+development+of+both+primary+
and+secondary+fates&source=bl&ots=9nIjfsSVMS&sig=
LtfnaLKk8lKs6YIeHuHpnTbQfw4&hl=en&sa=X&ei=P4O
GVczrN8emuQTcoo2YCg&ved=0CB0Q6AEwAA#v=one
page&q=a%20constitutive%20fate%20from%20hypoder
mis%20inhibits%20the%20development%20of%20both
%20primary%20and%20secondary%20fates&f=false
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Ans: 2
Explanation: Since
cohesion
is mutated,
therefore
sister
chromatid will not be joined together and hence
improper reduction division in meiosis will result into
low viability of tetrads
Ans: 4
Explanation: The frequency depends upon the order of
the genes. Most frequent Leu+ arg‐met‐ followed by
leu+ arg+
met
‐and
least
frequent
leu+arg+met+
Ref : Figure 8.15: Page 214. Pierce Benjamin
Ans: 3
Explanation: As B, C, and D are involved in the steps of
nitogen fixation
Ref : https://en.wikipedia.org/wiki/Nod_factor
Ans: 2
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Explanation: Wingless is expressed in the posterior
region of each segment or in the anterior portion of
each parasegment. If RNAi of wingless is present then it
will not allow wingless to be expressed because of
which the posterior compartment of each future
segment will get affected.
Ans: 2
Explanation: Connexons are gap junction proteins. Gap
junctions are a specialized intercellular connection
between a multitude of animal cell‐types.They directly
connect the cytoplasm of two cells, which allows
various molecules, ions and electrical impulses to
directly pass through a regulated gate between cells. So
when the inhibior P is added, gap junctions are not
properly formed, thus the protein P can not move
between the cells
Ref : https://en.wikipedia.org/wiki/Gap_junction,
https://en.wikipedia.org/wiki/Connexin
Ans: 1
Explanation: Till 4 cell stage, since the cells contain part
of the animal and vegetal axis, therefore, if isolated they
would be giving rise to the entire embryo. However, at
the 8 cell stage, since the blastomeres have been
formed as a result of equational division, thereby the
animal and vegetal exis gets divided. So these
blastomeres would not be able to give rise to the intact pluteus larvae.
Ref : http://www.ncbi.nlm.nih.gov/books/NBK9968/
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Ans: 1
Explanation: In picture 1. no cellular signalling is
involved , It depicts cellular migration via
polymerisation of actin filaments along the leading end
of the cell
Ref :
https://en.wikipedia.org/wiki/Cell_migration,
http://www.ncbi.nlm.nih.gov/books/NBK9961/
Ans: 4
Explanation: Pyruvate dehydrogenase is inhibited when
the following ratios are increased: NADH/NAD+ and
acetyl‐CoA/CoA.
Ref :
https://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_c
omplex,http://watcut.uwaterloo.ca/webnotes/Metabolism/pdhReg
ulation.html
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Ans: 3
Ref : https://en.wikipedia.org/wiki/Ingression_(biology)
Ans: 2
Explanation: The cells cannot enter the M phase
because of the inhibition of cdk 1 phosphorylation. At
this stage sister chromatids will be held together by
cohesins throught the length of the chromosome.
Ref:
https://books.google.co.in/books?id=a2YdBQAAQBAJ&p
g=PA212&lpg=PA212&dq=sister+chromatids+are+held+
together+by+condensins+and+attached+to+each+other
+only+at+the+centromere&source=bl&ots=-
wo82Yv1Cf&sig=3gzyO00T3j-
qQzgMBwr_561Wirw&hl=en&sa=X&ei=b5-
GVebSDJepuwTSk7ioBA&ved=0CFgQ6AEwCQ#v=one
page&q=sister%20chromatids%20are%20held%20toget
her%20by%20condensins%20and%20attached%20to%
20each%20other%20only%20at%20the%20centromere
&f=false
Ans:
Explanation:
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Ans: 1
Explanation: A is a protein, B is hapten and C isadjuvant.
Hence in first graph there is no anti A production. in the
second graph the adjuvant has enhanced the
immunogenicity of B (hapten) and there is increased
antbody production. In the third graph there is hapten protein conjugation plus enhanced immunogenicity
when administered with an adjuvant. Hence there in
production of more of anti B compared to anti A
Ref : https://en.wikipedia.org/?title=Hapten,
Ans: 4
Explanation: Phytochrome C is not the most prominent
photoreceptor of red light. In rice and Arabidopsis,
PHYTOCHROME C (PHYC) requires other phytochromes
for stability and function. option D is false, as Far red light is preceived by phy A. Statements A and C are true.
Ref : https://en.wikipedia.org/wiki/Cryptochrome,
http://www.pnas.org/content/111/28/10037
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Ans: 3
Explanation: As the parents have only one band
therefore F1 will have the allleles in trans. The
recombinants are 10 (5+5)/ Therefore distance =10cM
Ans: 2
Explanation: Nonreducing sugars are less likely to react
with other substances along the way.
Sucrose can be uploaded by either symplastic and apoplastic route
Route: mesophyll cells‐>phloem parenchyma‐
>companion‐>sieve
Transport is via pressure flow model
Ref:
https://books.google.co.in/books?id=e8BxM8FOTv8C&p
g=PA97&lpg=PA97&dq=sucrose+uploading&source=bl&
ots=j2J6PbgqhB&sig=xMDzs-d1-
feyiDmXWJnOSLGqN64&hl=en&sa=X&ei=l5SGVeW1L4
mNuASGj6bQDQ&ved=0CB4Q6AEwAA#v=onepage&q
=sucrose%20uploading&f=false
Ans: 3
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Explanation: Pheopytin‐>QA‐>QB‐>b6f ‐>PC‐>P700
P700‐>PQ ‐>FeSx‐>FeSA‐>FeSB‐>FD
Ref : Figure 7.21: Page 125. Taiz and Zinger
Ans: 4
Explanation: Changes in 2,3 BPG concentration are not
related to biochemical changes during physical
excercise. It only decreases the oxygen affnity of Hb at
high altitudes. Metabolites like lactic acid that
accumulate after excercise they decrease the pH thus
leading to decrease in affinity of Hb to oxygen (right
shift). Thus the statement D is also incorrect as it says
that accumulation of metabolites lead to increase in
affinity of Hb to oxygen
Ref :
http://ceaccp.oxfordjournals.org/content/4/6/185.full.pdf,http://link.springer.com/article/10.1007%2FBF00511232
Ans: 4
Explanation: Recessive epistasis ratio is 9:3:4, moreover
in chi squared test we assume null hypothesis to be true. Null hypothesis will be that plants with red and
white fruits will occur in 1: 1ratio. While interpreting the
results, If the calculated chi squared is less than the
critical value we accept the null hypothesis. Only when
this value is greater we reject it. In the question,
Observed Chi sq value is less than the critical value so
we accept the null hypothesis. Therefore statements B
and D are true
Ref :
http://www.ndsu.edu/pubweb/~mcclean/plsc431/mendel/
mendel4.htm, https://en.wikipedia.org/wiki/Chi-squared_test
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AnS: 2
Explanation : Since the glomerulus is negatively
charged, therefore, fractional clearance of cationinc
dextrans would be more as compared to the fractional
clearance of neutral dextrans which should be the of
the same molecular size. With increase in Stokes Radius or the molecular size, the fractional clearance keeps on
decreasing gradually. Hence, this is justified by graph 2.
Ref :
https://www.google.co.in/search?q=the+fractional+cleara
nce+of+cationic+and+neutral+dextrans+from+kidney&bi
w=1137&bih=752&source=lnms&tbm=isch&sa=X&ei=IK
yGVbiFE86VuATv3IL4Bg&ved=0CAYQ_AUoAQ&dpr=0.
9#imgrc=m5LJZ2fzb5FblM%253A%3BswP4yps_qBZ54
M%3Bhttp%253A%252F%252Fd6igaq6njxgjh.cloudfront
.net%252Fcontent%252Fphysrev%252F88%252F2%25
2F451%252FF11.large.jpg%3Bhttp%253A%252F%252F
physrev.physiology.org%252Fcontent%252F88%252F2%252F451%3B1280%3B770
Chapter 26: Urine Formation by the Kidneys, Page 317,
Textbook of Medical Physiology by Guyton (11th Edition)
Ans: 1
Explanation:
https://en.wikipedia.org/wiki/Loktak_Lake
https://en.wikipedia.org/?title=Nanda_Devi_National_Par
k
https://en.wikipedia.org/wiki/Rajaji_National_Park
https://en.wikipedia.org/wiki/National_Chambal_Sanctua
ry
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Ans: 3
Explanation: Statement C is false. Plant would
accumulate a larger amount of solute in it's cell rather
than relasing.
Ref : https://books.google.co.in/books?id=zDIaumF3MCYC&p
g=PA153&lpg=PA153&dq=plant+cells+tend+to+release
+solute+during+osmotic+stress&source=bl&ots=7GoP-
x2I6k&sig=rxIj3EjneB0zkAQiG8sF4asytxA&hl=en&sa=X
&ei=1Z2GVZzFK8ifugTA2ZHgBg&ved=0CCIQ6AEwAA#
v=onepage&q=plant%20cells%20tend%20to%20release
%20solute%20during%20osmotic%20stress&f=false
Ans: 4
Explanation: Somatic hybridization would cause, other
wise heterozygous individual to transform into
homozygous and hence patches of mutants cells and
homozygous wild type. Some of the tissue might end up
with only one kind of alleles and hence would cause
tissue specific expression of the allele.
Ans: 3
Explanation: Could not be X linked recessive as for the
trait to appear in daughter, it has to be present in
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father.
Could not be autosomal recessive as the trait is becuase
of rare allele and person coming from outside the family
would not have the allele (male in the second
generatioe) and hence his offspring would not have the
trait, which is not the case.
Autosomal dominant with incomplete penetrance, can
explain the pedigree. the female in the first generation
would be heterozygous and she would pass this
dominant allele to her daughter, but the trait is not
seen because of incomplete penetrance. In the next
generation it would be again expressed.
Ans: 1
Explanation: androstenedione is synthesized from
cholesterol which in turn gets converted to estrone or
estradiol directly or gets converted to testosterone first
and then to estradiol. Since LHR is present on Theca
Interna cells and FSHR on Granulosa cells. Therefore,
option 1 would be correct.
Ref : http://lsresearch.thomsonreuters.com/maps/849/
http://omicsonline.org/estradiol-synthesis-and-
metabolism-and-risk-of-ovarian-cancer-in-older-women-
taking-prescribed-or-plant-derived-estrogen-
supplementation-2157-7536.S12-003.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327826/
Ans: 1
Explanation: Statements A, B and E are correct. Based
on the MspII digestion profile, we can observe that the
mother is normal phenotype (since she has both active
restriction site clear from the band pattern), father is a
carrier (since the digestion profile shows the presence
of bands coresponding to both presence as well as
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absence of the site‐heterozygous for the RFLP allele),
Son (I) is expressing the phenotype so he is the
proband. Son (II) again has normal phenotype. Daughter
also is a carrier for the RFLP allele.
Ans: 1
Explanation: Only oaks have flowers and rest 3 don’t
have any flowers. Ferns are peteridophytes, pine is a
gymnosperm and hornwort is a bryophyte
Ans: 4
Explanation: sound localiztion is the ability of an
induvidual to to first locate the origin of sound. Hence it
depends on time between the arrival of stimulus in 2
ears as the ear closer to the sound source percieves it
earlier compared to the other. At the same time th
phase also plays a role in sound localization. when
sound comes from one side the ear on the other side
percieves the sound shadow. the tuning curves of
auditory nerves help in sensing sound but not
localization and the tuning curves of auditory nerves
have many over laps. hence option c is false. The
superior olivatiry nucleus and the auditory cortex play a
role in sound localization hence option D is also wrong
Ans: 3
Ref : https://en.wikipedia.org/?title=Aardvark, https://books.google.co.in/books?id=4abcBwAAQBAJ&
pg=PA739&lpg=PA739&dq=opposite+thumbs,+forward
+facing+eye+well+developed+cerebral+cortex,+omnivor
ous&source=bl&ots=hN7618F2rv&sig=CCBSlve4ayMOc9
Pkvko‐
FaD9jVM&hl=en&sa=X&ei=QcCGVfvdJMSjugTzrbL4Bw&
ved=0CDgQ6AEwBQ#v=onepage&q=opposite%20thum
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bs%2C%20forward%20facing%20eye%20well%20develo
ped%20cerebral%20cortex%2C%20omnivorous&f=false,
https://en.wikipedia.org/wiki/Even‐toed_ungulate
Ans: 3
Explanation: In case of A, as both the species are
negatively affected so it would be competition. In B, one
of the species is benefitted another species is negatively
affected so it is a type of predation. In C, both the
species are positively aff ected, so it is mutualism. In D,
one of the species is negatively affected while other is
not affected at all so this would be ammensalism
Ans: 4
Explanation: transcription factors and erythropoitin
secretion and cytochrome oxidase levels and myoglobin
content are elevated in hypoxia. hence C and d are
wrong
Ref : http://www.ncbi.nlm.nih.gov/pubmed/11035279,
http://jeb.biologists.org/content/215/5/806.full
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Ans:
Explanation:
Ans: 1
Explanation: Since endotherms lose much of their energy as heat and in respiration, therefore they would
be having low digestion and ecological efficiency as
compared with ectotherms. This is because ectotherms
do not need to maintain their body temperature thus
they would be more efficient in deriving maximum
benefit from the consumed food
Ref : https://books.google.co.in/books?id=EwPwPHDM-
YsC&pg=PA175&lpg=PA175&dq=assimilation+and+ecol
ogical+efficiency+of+endotherms+and+ectotherms&sour
ce=bl&ots=AIFyH6cPYU&sig=qlv_BsweGmEIU39yCW_
L6SXYR_Q&hl=en&sa=X&ei=BnKGVbSMMpSIuwSTlYKQBQ&ved=0CCgQ6AEwAQ#v=onepage&q=assimilation
%20and%20ecological%20efficiency%20of%20endother
ms%20and%20ectotherms&f=false
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Ans: 2
Explanation: Species richness is highest in area of
intermediate disturbances. This is because very
frequent disturbance eliminates sensitive species,
whereas very infrequent disturbance allows time for
superior competitors to eliminate species that cannot
compete. Hence, all the other statements are correct
except for statement C.
Ref:
http://www.biology.uco.edu/personalpages/CButler/BI
O3543/lectures/Week_10_Thursday.pdf
http://www.eoearth.org/view/article/156216/
Ans: 1
Explanation: Shannon Diversity index = ‐ summation of
(pi) x (ln pi)
pi = No. of organisms in a species/ Total no. of
organisms of all the species
Community 1
pi of A = 25/100 = 0.25
Same would be the pi of B, C and D
Shannon Diversity Index for Community 1 = ‐4 x (0.25) x
(‐1.4) = 1.4
Community 2
pi of A = 80/100 = 0.8
pi of B = 5/100 = 0.05
pi of C = 5/100 = 0.05
pi of D = 10/100 = 0.1
Shannon Diversity Index of Community 2 = ‐ (0.8) x (‐
0.2) + 2 x (0.05) x (‐3.) + (0.10) (‐2.3) = 0.69
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Ans:
Explanation:
Ans: 1
Explanation: Lyme disease, also known as Lyme
borreliosis, is an infectious disease caused bybacteria of
the Borrelia type. H. pylori causes chronic gastritis,
Typhus fevers are caused by the rickettsiae bacteria and
transmitted by arthropod. Scarlet fever from
streptococcus pyogenes
Ref :
https://en.wikipedia.org/?title=Lyme_disease,
http://www.healthline.com/health/gastritis‐
chronic#Causes2,
http://www.healthline.com/health/typhus#Overview1,
https://en.wikipedia.org/wiki/Scarlet_fever
Ans: 1
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Explanation: In experiment I, both the pigeons will be
able to find the rightdirection on basis of sunlight. While
in second experiment the control group will be able to
find the direction by using magnetic field while the test
one will not.
Ans: 1
Explanation: R‐selected species have smaller body size,
reproduce only once in their lifetime producing many
offsprings (semelparous reproduction) and develop
rapidly
Ref : Part VII: Population Ecology, Page 510, Biology by
Raven (6th Edition)
Ans: 3
Explanation: rB>C. Here C=30 and r=0.25 (for step
siblings)
So B>30/0.25 or B>120
Ans: 1
Explanation: tracheids ‐chief water conducting element
in gymnosperms, vessel elements are chief water‐
conducting element in angiosperms, Sieve cell is the
food conducting element in gymnosperms and Sieve
tube element is the food conducting element in
angiosperms
Ref :
https://books.google.co.in/books?id=kGYdBQAAQBAJ&
pg=PA557&dq=chief+water+conducting+elements+in+g
ymnosperms&hl=en&sa=X&ei=nbiGVd_WCsa9ugTZ14P
wDQ&ved=0CBwQ6AEwAA#v=onepage&q=chief%20wa
ter%20conducting%20elements%20in%20gymnosperms
&f=false
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Ans: 4
Explanation: Crustacea is a class of Arthropoda.
Hominidae is a family. Dermaptera is an order in
Arthropoda. Ctenophora is a phylum while Archae is a
Domain
Ref :
https://www.google.co.in/?gfe_rd=cr&ei=RGaGVYX5N4v
C8gezvKsI&gws_rd=ssl#q=dermaptera
https://en.wikipedia.org/wiki/Hominidae
https://en.wikipedia.org/?title=Crustacean
https://en.wikipedia.org/wiki/Ctenophora
http://www.ucmp.berkeley.edu/archaea/archaea.html
Ans: 3
Explanation: Frequency of A= homozygous frequency
+1/2*heterozygous
=0.59+1/2 (0.16)=0.67. Frequency of 'a'=1‐0.67=0.33
Ans:
Explanation:
Ans: 3
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Explanation: The procedure is for Western blotting: C‐
A‐B‐D
Ans: 3
Explanation: Cre‐Lox recombination is known as a site‐
specific recombinase technology, and is widely used to
carry out deletions, insertions, translocations and
inversions at specific sites in the DNA of cells.The
system consists of a single enzyme, Cre recombinase,
that recombines a pair of short target sequences called
the Lox sequences. Placing Lox sequences appropriately
allows genes to be activated, repressed, or exchanged
for other genes
Ref : http://cre.jax.org/introduction.html
Ans: 3
Explanation: Inbreeding causes decrease in growth rate,
fecundity, and survival
Ref:
http://www.fao.org/docrep/006/x3840e/X3840E07.htm
Ans: 2
Explanation: PTMs on serine can be either
phosphorylation or glycosylation among the 4 options
given. Ubiquitination occurs on Lysine and ADP‐
ribsoylation occurs on Arginine. Among phosphorylation
or glycosylation, both will cause increase in molecular
weight leading to a slowly moving protein. However,
phosphorylation ac bring about change in the isoelectric
point of the protein as phosphoryl group is a charged
molecule and thus will affect the ionization of the
protein.
Ref : https://en.wikipedia.org/wiki/Post‐
translational_modification
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Ans: 3
Explanation: Since the cells were resistant to ganciclovir
this means that the region of DNA construct between
the homology regions will not carry TK gene (thymidine
kinase). This is because ganciclovir along with TK is a
suicidal combination. TK converts it into a toxic product
that is generally used for elemination of TK+ cells. But
the knock out mice was resistant to it so it means it did
not carry a TK genes. These cells were sensitive to G418,
this is an antibiotic similar to gentamicin and resistance
is conferred by neo resistance genes. Since the cells
were sensitive to G418, so the region between
homology also doesn't have neo gene. So option 3
seems to be the construct that doesn't contain either
neo or TK gene
Ref : https://en.wikipedia.org/wiki/G418,
https://en.wikipedia.org/wiki/Thymidine_kinase
Ans: 2
Explanation: more stringent washing will remove non‐
sepcific hybridization mainly. More stringent the wash
is, the partially complementary sequence will be pulled
apart. More stringency is brought about by low salt and
high temeperature. the role of salt is to shield the
negative charges on the DNA thus stablizing the hybrid.
Ref :
http://www.cliffsnotes.com/sciences/biology/biochemistry
-ii/molecular-cloning-of-dna/dna-hybridization,
https://lifescience.roche.com/shop/PrintView?langId=-
1&storeId=15016&articleId=66008
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Ans: 3
Explanation:
https://books.google.co.in/books?id=4abcBwAAQBAJ&p
g=PA527&lpg=PA527&dq=angiosperm+dominance+incr
eases,+continued+radiation+of+most+present+day+ma
mmalian+order&source=bl&ots=hN7617J5tu&sig=AaGh
hGJjnk6UwfA6pnR22l8_lNQ&hl=en&sa=X&ei=EaqGVY_
2FZeUuASd9LiwCg&ved=0CB0Q6AEwAA#v=onepage&
q=angiosperm%20dominance%20increases%2C%20co
ntinued%20radiation%20of%20most%20present%20day
%20mammalian%20order&f=false
Ans: 4
Explanation: According to the question, statement 1, 2
and 3 all can be justified. So, option 4 would be correct.
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Ans: 1
Explanation: Improving resolution means having a
lower value of D, which can be achieved by lower value of lambda or higher value of N.
Ans: 3
Explanation: The 95% of the data would be in between
u+ 2 sigma and u‐2sigma:
u=200 and sigma=24. Therefore null hypothesis will be
rejected with 95% confidence limit above
200+(2*24)=248
Ans: 2
Explanation: Auxin 2,4‐D is critical for Somatic
embryogenesis, maltose is more successful than
sucrose.
Ref: Book‐ Somatic embryogenesis in woody plants Vol
C, Jain et al. 2000,
https://books.google.co.in/books?id=HdboCAAAQBAJ&
pg=PA159&lpg=PA159&dq=plant+growth+medium+sucr
ose+%26+maltose&source=bl&ots=zyMWj9_2_a&sig=5‐
AR8_k8OaZoxfKLtwPFXJ6KWb0&hl=en&sa=X&ei=sdqGV
YKABNSRuASV5L‐
oCQ&ved=0CC4Q6AEwAg#v=onepage&q=plant%20gro
wth%20medium%20sucrose%20%26%20maltose&f=fals
e
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Ans: 4
Explanation: Since in case of Retrovirus, gene for Factor
IX would be integrated in non‐dividing cells, therefore,
these will keep on expressing Factor IX. In Adeno‐
associated virus, the gene for Factor IX is integrated in
non‐dividing cells so it would be expressed for the time
till non‐dividing cells survive. In adenovirus, the gene for
Factor IX is not integrated and only transfected in both
dividing and non‐dividing cells, so they would be
showing only a transient expression of factor IX.
Ans: 1
Explanation: Sulphonylureas inhibit ALS (acetolactate
synthase) by binding to the enzyme. Glyphosate's mode
of action is to inhibit a plant enzyme involved in the
synthesis of the aromatic amino acids
Ref : https://en.wikipedia.org/?title=Glyphosate,
http://www.jstor.org/stable/4045526?seq=1#page_sca
n_tab_contents
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