CREAMS MS.WAJIHA IFFAT OBJECTIVES: After the end of this topic, the student will be able to : Define creams Classify creams Method of preparation prepare.

CREAMSCREAMSMS.WAJIHA IFFATMS.WAJIHA IFFAT

OBJECTIVES:

After the end of this topic, the student will be able to :

•Define creams•Classify creams •Method of preparation•prepare a cream from first principles• incorporate solids and liquids into a cream base

Creams Creams BP DEFINES : “Creams are formulated to provide

preparation that are essentially miscible with skin secretion. they are intended to be applied to the skin or certain mucous membranes for protective ,therapeutic, or prophylactic purposes especially when occlusive effect is not necessary.”

CreamsCreamsIn USPXVIII ,creams are defined

as“ semisolid emulsions of either oil

in water or water in oil type.”“ semisolid emulsions usually

medicated ,intended for external application.”

CreamsCreamsAqueous cream: aqueous cream ,

cetrimide cream, cetomacrogol creamOily cream: oily cream /hydrous

ointmentCosmetic creams:All purpose cream, baby cream,

barrier cream, bleaching cream, cleansing cream cold cream, hair cream, hand cream, vanishing cream.

Medicated creams:

CreamsCreamsCreams are reserved for external

preparation.A cream may be water in oil or oil in

water depending on the emulsifying agent used.

They are soft ,easy to apply ,cooling to skin ,easily water-removable.

w/o cream: oily creams Contains: emulsifying agents of natural

origins( bees wax, wool alcohols, wool fatproperties :Emollient.Creamy, white or translucent and

stiff.

CreamsCreams

o/w creams: aqueous creamsContains: synthetic waxes e.g., cetomacrogols & macrogols Properties:Causes rapid absorption &

penetrationThin ,white & smooth consistency

CreamsCreamsMETHOD OF PREPARATION:TRITURATION:Used for finely divided insoluble powder

particles or liquidsinsoluble powder are added by

geometric dilutionLiquids are added by making well in

centre.Air pocket formation avoided.Involved the use of glass slab when small

quantities are usedMortar and pestle used when we have

large quantities.

CreamsCreamsLEVIGATION:

Incorporation of insoluble coarse particles.

Also known as “Wet grinding”.insoluble coarse powder is rubbed

with molten base or liquid or a semi solid base.

A considerable shearing force is applied to avoid grittiness.

CreamsCreamsHygiene: ( aseptic condition)All equipment & spatula to be cleaned by

IMS. (70% ethanol should be used)Determine the miscibility of the substances

being incorporated.Melt the fatty base .substances with the

highest melting point to be melt first. These bases then cooled to 60°C.

Temperature of the aqueous phase to be adjusted to 60°C.

The disperse phase to be incorporated to the continuous phase at the same temperature.

Avoid air pockets & hasty cooling.

CreamsCreamsIncorporation Of solid

Ingredients Into Cream Base:Solid particles can be

incorporated after the bases coolsSoluble solids: added to the

molten cream at the lowest possible temperature& the mixture stirred until cold.

Insoluble solids: incorporated by using tile & spatula or mortar and pestle using doubling technique.

CreamsCreamsCoarse powder: minimum

quantity of cream should be placed in the centre of the tile & used to levigate the powders.

Fine powders : may be triturated to into other wise finished creams on ointment tile. (geometric dilutions.

CreamsCreamsIncorporation Of Liquids:Non volatile ,miscible liquids: may

be mixed with molten cream in evaporating basin. if a pre-prepared base is used then follow procedure for volatile or immiscible liquids.

Volatile or immiscible liquids:E.gs coal tar should be triturated with

creams on tile .a very small amount of creams should be placed on tile and a well made in centre. small quantities are folded gently to avoid splashing.

CreamsCreamsDiluted creams:If the diluents is stated in the

manufacturer data sheetFreshly preparedNo heating should be involved.Should be carried out in aseptic

conditions.Should not be used more than 2

wks.

REFERENCESREFERENCESCompounding and Dispensing by

Christopher A Langley & Dawn Belcher pg. 65-91.

Compounding and Dispensing by john F. Marriot, Keith A. Wilson Christopher A Langley & Dawn Belcher pg.147-151

Pharmaceutical Practice by D M Collett pg:116-117

Sprowls’ American Pharmacy pg:273-274

Pharmaceutics practice by Winfield.

CreamsCreams

THANK YOU!!

ANY QUESTION???

ASSIGNMENT :MAKE A LIST OF MEDICATED

CREAM WITH THEIR BRAND NAME.