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Corticosteroid after etomidate in Critically Ill

Apr 05, 2018

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    Giurfan tre}efzazbif

    Jr Lbufk

    ]utersb}ir7 Jr ]`afzb. Jr Zab

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    BFZ_I

    Ezihbjaze epmennefz `ehijfahbmtricbne. cbr}z nbfe bfjumzbif akefz bf _]Bcir `ehijfahbmann uf}zaone tazbefz

    }bfkne ji}e oniml} mirzb}in }fz`e}b}na}zbfk cir :0 `r} ti}z bfjumzbif ji}e

    @bk`er raze} ic hirzanbz afj hirobjbz bf

    BMU bf tazbefz} ajhbzzej cir zrauha ir}etzbm }`iml

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  • 8/2/2019 Corticosteroid after etomidate in Critically Ill

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    BFZ_I

    Hijeraze ji}e `jrimirzb}ife ( ?44=44hk)ja"

    isermihe mrbzbman bnnfe}}renazejajrefan bf}uccbmbefm. tarzbmunarn bf}etzbm tazbefz} re}tifjbfk tiirn zicnubj re}u}mbzazbif afj sa}itre}}ir

    akefz} rejume} firajefanbfe requbrehefzbf orabf jeaj tazbefz}

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    ABH

    Zi bfse}zbkaze z`e eccemzbsefe}} ic

    }uttnehefzazbif az jemrea}bfkz`e tritirzbif ic sa}itre}}irjetefjefz tazbefz} {bz`iuz }etzbm

    }`imlaczer }bfkne ji}eezihbjaze&

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    HEZ@IJ]

    Tri}temzbse rafjihb}ej mifzrinnej jiuoneonbfj zrban Gun ?440 Gun ?414. bf ufbser}bz`i}tbzan bfmnujej = BMU}

    Bfcirhej {rbzzef mif}efz tazbefz. renazbse}.

    nekann auz`irb}ej retre}efzazbse} Tazbefz }enemzbif}7

    Ajunz tazbefz} requbrbfk }ejazbif cir _]B bf

    E_ ir bf z`e cbenj (ezihbjaze afj}upahez`ifbuh"

    ]ejazbif} hbjawinah. triticin.}ucefzafn afj cefzafn

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    HEZ@IJ]

    Epmnujej }etzbm }`iml , }zeribj m`rifbm ajrefan bf}uccbmbefm. tbzubzar j}cufmzbif.

    @BS bfcemzbif. lezimifawine ir cnumifawine. tresbiu} mirzbmizrit`bf }zbhunazbif ze}z.}ursbsan>:0`r}.

    5`r} ti}z bfjumzbif.}ejazbif {bz` ezihbjaze6 ?:`r}

    Attrisej o niman ez`bm} mihbzzee

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    ]ZUJR T_IZIMIN

    Bfjumzbif zbhe @4

    U}ake ic ezihbjaze b} necz zi z`ejb}mrezbif ic t`}bmbaf bfm`arke

    Tazbefz} {ere rafjihn a}}bkfej bf a171 razbi zi remebse ebz`er `jrimirzb}ifeir }anbfe crih @3 zi @:0

    Mihtuzerb}ej rafjihb}azbif. `afjnejo }zazb}zbmbaf fiz bfsinsej

    BMU t`}bmbaf} afj fur}e} onbfjej

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    ]ZUJR T_IZIMIN

    Aczer 3 `iur} ic bfjumzbif ( mihtnezbif ic oniij}ahtnbfk cir z`e mirzbmizrit`bf ze}z"

    mifzrin kriut 54hn} ic F] @M kriut ?44hk @M jbnuzej bf 54hn} }anbfe

    A oinu} ic 1?&5 hN ic z`e }inuzbif. mifzabfbfk54 hk @M {a} bfbzbann bfgemzej iser =4 hbf} aza raze ic ?5 hN)`r&

    Z`e }inuzbif {a} z`ef mifzbfuiu}n bfcu}ej aza raze ic

    ?&1 hN)`r ufzbn @:0. ufne}} z`e tazbefz {a}jb}m`arkej oecire`afj&

    Bf zizan @M ?44hk)ja

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    ]ZUJR T_IZIMIN

    Sarbaone} {ere minnemzej if ajhb}}bifafj

    az 3. 1?. ?:. afj :0 `r} e}tembann z`e

    marjbisa}munar ]equefzban Irkaf CabnureA}}e}}hefz (]ICA" }mire

    HAT 3524 o firajrefanbfe bc requbrej

    afj ZOB HAT 0424 Bf}unbf ajhbfb}zerej zi habfzabf knumi}e

    >14hhin)n

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    @I_HIFAN A]]AR

    Ajrefan cufmzbif a}}e}}ej u}bfk `bk` ji}emirzbmizrit`bf }zbhunazbif ze}z

    ]eruh zizan mirzb}in afj mifmihbzafz 11O

    jeipmirzb}in mifmefzrazbif} {erejezerhbfej az @5 afj 34 hbf} aczer z`e BSajhbfb}zrazbif ic ?54 hk ic }fz`ezbm 1?:ajrefimirzbmizritbm `irhife

    ]uo}equefz hea}urehefz} ic }eruh zizanmirzb}in afj 11Ojeipmirzb}inmifmefzrazbif} {ere tercirhej az @1?.@?:. afj @:0

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    @I_HIFAN A]]AR

    Ezihbjazerenazej ajrefan bf}uccbmbefm{a}

    jecbfej a} m`afkebf }eruh mirzb}in

    mifmefzrazbif} >?54 fhin)N (2 hmk)jN"aczer M]Z a}}imbazej {bz` }eruh 11Ojeipmirzb}in mifmefzrazbif} 60 fhin)N

    (4&?0 hmk)jN"

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    T_BHA_R IUZMIHE

    Z`e trbhar }zuj iuzmihe {a} z`e miur}eic tazbefz} {bz` a marjbisa}munar ]ICA}mire ic = ir :. b&e&. requbrehefz icfiretbfet`rbfe zi zreaz hijerazezi}eseremarjbisa}munar cabnure az @3. @1?. @?:. afj@:0

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    ]EMIFJA_R IUZMIHE

    miur}e ic firetbfet`rbfe ji}e hapbhuh }eruh knumi}e.

    z`e fuhoer ic tazbefz} zreazej o bf}unbf. hapbhuh marjbisa}munar ]ICA }mire jurbfk z`e }zuj terbij& ?0ja annmau}e hirzanbz.

    z`e jurazbif ic hem`afbman sefzbnazbif fuhoer ic BMU ja} {bz` firetbfet`rbfe

    }uttirz&

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    ]ZAZB]ZBMAN AFANR]B]

    ]zazb}zbman afan}b} {a} tercirhej u}bfk]zaza ser}bif 11&4 (]zaza Mirt.Minneke]zazbif. ZP"&

    ]zazb}zbman }bkfbcbmafme {a} jemnarej{`ef t> &45&. ti{er 4&0

    M`b }q(fif tarahezrbm" afj Haff[`bzfe ze}z} (mazekirbman)mifzbfuiu}"

    Tazbefz} {bz` trehazure efjbfk ic z`e@M bfcu}bif {ere mif}bjerej bf z`eafan}b}

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    _E]UNZ]

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  • 8/2/2019 Corticosteroid after etomidate in Critically Ill

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    _E]UNZ]

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    @bk`er }eruh mirzb}in mifmefzrazbif} az @1?. @?:. afj @:0 bf z`e @M kriut mihtarej{bz` z`e mifzrin kriut

    Z`e ammuhunazbif ic }eruh 11Ojeipmirzb}in trikre}}bsen jemnbfej iser zbhe (t >&41"{bz` fijbccerefme oez{eef z`e z{i kriut}

    ]eruh anouhbf m`af e} }bhbnar oez{eef oiz riu } >4&41

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    ]ICA }mire

    Ann ic z`e}e tazbefz} remebsejfiretbfet`rbfe. afj jiouzahbfe {a}ajjbzbifann ajhbfb}zerej az }bhbnar

    crequefmbe} bf z`e @M afj mifzrinkriut}

    Bf z`e @M afj mifzrin kriut}. z`etritirzbif ic tazbefz} {bz`

    marjbisa}munar ]ICA }mire} ic = ir :jemnbfej mihtaraon iser zbhe oez{eef@3 afj @:0 (t >&41"

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    Heaf Arzerban Tre}}ure}

    HAT mihtaraone oez{eef oiz` kriut}.{bz` `bk`er reajbfk} az @:0 s} @3

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    Firajrefanbfe ji}e}

    Zbhe renazej esinuzbif ic ji}e afjkriut

    (t>4&41"

    Ni{er ji}e} requbrej az @?: afj @:0s} @3 bf z`e @M kriut (t>4&41"

    Fi jbccerefme} epb}zej rekarjbfk z`e

    ji}e} ic jiouzahbfe oez{eef z`e z{ikriut}&

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  • 8/2/2019 Corticosteroid after etomidate in Critically Ill

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    ]emifjar iuzmihe}

    Fi }bkfbcbmafz jbccerefme epmetz `bk`erhapbhuh knumi}e nesen bf @M kriut

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  • 8/2/2019 Corticosteroid after etomidate in Critically Ill

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    JB]MU]]BIF]

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    Bf z`b} }zujr

    Mifmihbzzefz a}}e}}hefz ic nesen} ic }eruhmirzb}in afj 11Ojeipmirzb}in bf z`e }earm` cirezihbjazerenazej ajrefan bf}uccbmbefm&

    (fuheriu} mau}e} ic arefan bf}uccbmbefm bf bnntazbefz}"

    Z`e trikre}}bse jemnbfe bf }eruh 11Ojeipmirzb}in o :0 `r} mifcbrh} z`e zraf}befzonimlaje ic mirzb}in }fz`e}b} ti}z ezihbjaze

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    Hijeraze ji}e @m jie} fiz m`afke z`etrbhar iuzmihe

    ]ukke}z} z`az ezihbjaze afj bz} re}unzbfkzraf}befz ajrefan jerafkehefz tna fi hagir

    rine bf z`e esinuzbif ic marjbisa}munar }zazu}&

    Ouz hi}z tazbefz} `aj }zaobnb}ej

    `ehijfahbm} oecire remrubzhefz. hi}zorabf bfgur tresefzbif ic arzerban`tizef}bif tresefz ife hagir trejbmzir ictiir iuzmihe

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    @M ajhbfb}zrazbif cir > :0`r} ef`afme}mazem`inahbfe }ef}bzbsbz . z`erecireHAT }zaone bfjetefjefz ic ezihbjaze

    renazej ajrefimirzbman bf}uccbmbefm

    Eptnabf} z`e }bkfbcbmafz jemrea}e bf

    requbrej nesen} ic firajrefanbfe az @?:s} @:0`r}

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    NBHBZAZBIF]

    Jemb}bif cir ezihbjaze u}e b} az jbmrezbif icE_ t`}bmbaf. fiz bfsinsej bf }uo}equefzmare

    Fi BMU bfzuoazbif}. z`erecire fizretre}efzazbse ic ann mnbfbman }bzuazbif} reqezihbjaze cir bfzuoazbif} e}t }etzbm }`iml

    req sa}itre}}ir} @M kbsef az @3 fiz @4 ( if bfjumzbif" eccemz

    {arrafz} curz`er BP

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    A trikre}}bse bf`bobzbif ic z`eajrefimirzbmizritbm `irhife }fz`e}b}}emifjar zi @M bfcu}bif hbk`z oe

    ti}}bone. eptnabfbfk a jemrea}ebf }eruhmirzb}in nesen

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    MIFMNU]BIF

    Mrbzbmann bnn tazbefz} {bz`iuz }etzbm }`imljbj fiz oefecbz crih @M ajhbfb}zerej zi

    isermihe ezihbjazerenazej ajrefanbf}uccbmbefm&

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    MIFMNU]BIF

    Fi hagir eccemz} if `ehijfahbm}zazu} {ere ciufj bf z`e zreazej kriut&

    Z`e}e cbfjbfk} }ukke}z z`az }bfkne ji}e

    ezihbjaze miunj oe mif}bjerejbfmrbzbmann bnn tazbefz} ufjerkibfk _]Bbfz`e cbenj ir bf z`e eherkefm riih

    {bz`iuz hagir mifmerf} aoiuz bz} jrukbfjumej `irhifan jerafkehefz&

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    ATT_AB]AN

    [a} z`e a}}bkfhefz ic tazbefz} zizreazhefz} rafjihb}ej9

    _afjihbwazbif {a} a}}urej u}bfk a

    mihtuzerbwej rafjihfuhoer keferazir nb}z [ere z`e kriut} }bhbnar az z`e }zarz ic

    z`e zrban9

    Re}. mihtaraone oa}enbfe m`aramzerb}zbm}

    00% }`i{ej ezihbjaze renazej ajrefanbf}uccbmbefm

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    [ere ann tazbefz} {`i efzerej z`e zrbanammiufzej cir9 afj {ere z`e afan}ej

    bf z`e kriut} zi {`bm` z`e {ererafjihb}ej9

    RE] . ann tazbefz} cinni{ej ut zbnn :0`r} cirtrbhar iuzmihe&

    Trehazure efjbfk ic @M bfcu}bif} afan}ej

    (bfzefzbif zi zreaz"

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    [ere hea}ure} iogemzbse ir {ere z`etazbefz} afj mnbfbmbaf} letz onbfj zi

    {`bm` zreazhefz {a} oebfk remebsej9

    Re}. bfse}zbkazir} afj fur}e} letz onbfjej

    @i{ tremb}e {a} z`e e}zbhaze ic z`ezreazhefz eccemz9

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    Attnbmaobnbz

    Ezihbjaze maf oe u}ej bf orabf bfgurtazbefz} a} z`e rb}l ic arzerban `tizef}bifiuz{ebk`} z`e oefecbz ic fiz u}bfk

    Ajrefan }uttre}}bif fiz a} }esere . @M}uttnehefzazbif jie} fiz anzer z`e miur}e

    ic z`e bnnfe}}

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    Z`afl iu