Core Course Overview AY 2011 The chemistry department offers 11 core courses, 10 of which are taught in any one year. These are: • CHEM 2110 Chemical Symmetry: Applications in Spectroscopy and Bonding • CHEM 2120 Descriptive Inorganic Chemistry • CHEM 2210 Electroanalytical Chemistry • CHEM 2220 Chemical Separations • CHEM 2230 Analytical Spectroscopy • CHEM 2310 Advanced Organic Chemistry 1 • CHEM 2320 Advanced Organic Chemistry 2 • CHEM 2430 Quantum Mechanics & Kinetics • CHEM 2440 Thermodynamics & Statistical Mechanics • CHEM 2810 Biological Chemistry 1 • CHEM 2820 Biological Chemistry 2 Two of the italicized courses are taught each year. For AY 2011 (beginning August 2010), we are offering in the Fall term (2011) the following courses (Instructor) • CHEM 2120 Descriptive Inorganic Chemistry (Meyer) • CHEM 2230 Analytical Spectroscopy (Saxena) • CHEM 2310 Advanced Organic Chemistry 1 (Nelson) • CHEM 2430 Quantum Mechanics & Kinetics (Coalson) • CHEM 2810 Biological Chemistry 1 (Weber) In the spring (term 2014), we are offering these courses (Instructor) • 2110 – Chemical Symmetry: Applications in Spectroscopy and Bonding (H. Liu) • 2220 – Chemical Separatioins (Robinson) • 2320 – Advanced Organic Chemistry 2 (X. Liu) • 2440 – Thermodynamics and Statistical Mechanics (Jordan) • 2820 – Biological Chemistry 2 (Horne) On the following pages, please find syllabuses for the courses that will be taught next year. In some cases, an older syllabus is provided.
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Core Course Overview AY 2011
The chemistry department offers 11 core courses, 10 of which are taught in any one year. These are: • CHEM 2110 Chemical Symmetry: Applications in Spectroscopy and Bonding • CHEM 2120 Descriptive Inorganic Chemistry • CHEM 2210 Electroanalytical Chemistry • CHEM 2220 Chemical Separations • CHEM 2230 Analytical Spectroscopy • CHEM 2310 Advanced Organic Chemistry 1 • CHEM 2320 Advanced Organic Chemistry 2 • CHEM 2430 Quantum Mechanics & Kinetics • CHEM 2440 Thermodynamics & Statistical Mechanics • CHEM 2810 Biological Chemistry 1 • CHEM 2820 Biological Chemistry 2 Two of the italicized courses are taught each year. For AY 2011 (beginning August 2010), we are offering in the Fall term (2011) the following courses (Instructor) • CHEM 2120 Descriptive Inorganic Chemistry (Meyer) • CHEM 2230 Analytical Spectroscopy (Saxena) • CHEM 2310 Advanced Organic Chemistry 1 (Nelson) • CHEM 2430 Quantum Mechanics & Kinetics (Coalson) • CHEM 2810 Biological Chemistry 1 (Weber) In the spring (term 2014), we are offering these courses (Instructor) • 2110 – Chemical Symmetry: Applications in Spectroscopy and Bonding (H. Liu) • 2220 – Chemical Separatioins (Robinson) • 2320 – Advanced Organic Chemistry 2 (X. Liu) • 2440 – Thermodynamics and Statistical Mechanics (Jordan) • 2820 – Biological Chemistry 2 (Horne) On the following pages, please find syllabuses for the courses that will be taught next year. In some cases, an older syllabus is provided.
Chem 2110 Spring 2010
Group Theory and Physical Inorganic Chemistry Topics and Readings
Topic Cotton I. Group Theory and Molecular Symmetry A. Introduction 1 B. Symmetry operations and symmetry elements 1. Definitions 3.1, 3.2 2. Types of symmetry operations 3.3-3.10 C. Symmetry point groups 1. Criteria for abstract groups 2.1, 2.2 2. Symmetry point groups 3.11, 3.12 3. Assignment of point groups 3.14, 3.15 4. Subgroups and classes 2.3, 2.4, 3.13 D. Matrix representations of symmetry operations and symmetry point groups
1. Matrices Appendix 1 2. Matrix representations of symmetry operations 4.1 3. Representations of groups 4.2 4. Irreducible representations 4.3 5. Reducing reducible representations 4.3 6. The character table 4.4, 4.5 7. The direct product 5 II. Molecular vibrations A. Introduction 10.1 1. Molecular energy levels and spectra 10.1 2. Vibrational spectroscopic methods B. Molecular vibrations 1. Harmonic oscillator 2. Anharmonic oscillator 3. Normal modes C. Projection Operators 6 D. Construction of symmetry coordinates 1. Internal coordinates 2. A worked example: [PtCl4]2- 10.7 3. Correlations with decreasing symmetry E. Selection rules 1. Direct product 5 2. Infrared selection rules 10.6, 10.8 3. Raman selection rules
Chem 2110 Spring 2010
Topic Cotton III. Chemical Bonding A. Introduction 1. Models of electronic structure a. Lewis structures b. Atomic orbital model c. Hybrid orbital (Valence bond) model d. Valence-shell electron-pair repulsion (VSEPR) model 2. Photoelectron spectroscopy a. Technique b. PES of atoms c. Molecular PES B. Basic concepts of bonding and orbital interaction 1. Molecular orbital theory 7.1, 7.2 a. Definitions b. Orbital overlap c. Orbital interaction energy d. Energetics of 2-center, 2-orbital interactions e. Molecular orbital coefficients 2. The construction of MOʼs a. Molecular orbitals of H2 b. Potential energy surfaces c. PES of H2 d. Diatomic molecules e. Molecular orbital coefficients C. Case studies 8.1-8.4 1. ABn-type molecules a. General procedures b. A worked example: NH3 c. Walsh correlation diagrams 2. Polyenes and conjugated systems 7.3-7.5, 7.7 IV. Metal complexes 8.6-8.8 A. Coordination complexes B. Rearrangements C. Organometallic complexes D. M-M bonded complexes E. M-L multiple bonding V. Optional Topics (Crystals, Materials, etc.)
Chemical Symmetry: Applications in Spectroscopy & BondingInstructor: Geoff Hutchison
Homework assignments will be graded for completeness only. Working in groups is encouraged but each individual must hand in a separate set of answers.
Important Dates:
January 5th – First classFebruary 4th – Exam 1March 6-14th – No class, Spring BreakMarch 23rd – No class, ACS MeetingMarch 25th – Exam 2 DueApril 29th – Final Due
Reserve Reading List
Group Theory• F. A. Cotton, Chemical Applications of
Group Theory; 3rd ed., Wiley, 1990.• A. Vincent, Molecular Symmetry and
Group Theory; 2nd ed., Wiley, 2001.• J. S. Ogden, Introduction to Molecular
Symmetry, Oxford UP, 2001.
General Inorganic Chemistry• D. F. Shriver, P. W. Atkins, C. H.
E-mail: [email protected] Class: T,Th 5:30-6:45 pm Eberly 228 Textbooks/Readings: Crabtree The Organometallic Chemistry of the Transition Metals, 4th ed. John Wiley & Sons, 2005. Other Required Readings will be distributed throughout the semester. I encourage you to supplement your studies by reading sections of an undergraduate inorganic textbook (I have placed several on reserve in the science library) which may be relevant to the topics discussed in class. This is particularly important during the first two sections of the course.
Course Outline:
I. Introduction and Review of Basic Concepts, Elementary Group Theory
II. Coordination Chemistry III. Main Group and Organometallic
Chemistry IV. Special Topics
Grading: Problem Sets (100 pts total) 3 Exams (I, 100pts; II, 100pts; III/Final, 200 pts) Office Hours Schedule an Appointment on Monday, Tuesday, or Wednesday afternoons. For more details, see next page under ‘Office Hours’.
Chemistry 2120 Prof. N.L. Rosi Fall 2009 Description Modern inorganic chemistry is an incredibly broad field. Chemists belonging to the ‘sub-fields’ of bioinorganic chemistry, organometallic chemistry, supramolecular coordination chemistry, solid-state chemistry, synthetic nanoscience, and polymer chemistry (among others) often have received formal training in inorganic chemistry. This diversity, naturally, is very exciting. In constructing a course on “Descriptive Inorganic Chemistry”, however, one must pick and choose only a few topics. Because students generally have different backgrounds and depths of experience in inorganic chemistry, we will begin by reviewing a selection of fundamental core topics. We will then proceed to focus mainly on coordination chemistry and organometallic chemistry. Throughout the semester, relevant papers and topics from the current literature will be used to illustrate the concepts addressed in the course. The last few class periods will be devoted to special topics. Participation Feel free to participate in class and ask questions. If you have a question, chances are other students have the same question. I’ll do my best to answer them! In cases where a question requires a lengthy explanation, it is better to ask after class or schedule an appointment with me to discuss the topic 1-on-1. Homework There will be a number of homework assignments which will be collected and graded. Homework counts for 20% of your grade. Homework is provided for practice and study purposes. As long as you demonstrate exceptional effort (see below) on the homework assignments, you can expect to earn most of the points. I will collect homework at very specific times (typically before lecture). I will not accept late homework. Exceptional effort is defined as follows:
1) Clear, thorough, and thoughtful answers to all the questions 2) Neat and clean presentation of answers (you should give me the final draft of your
homework, not a working draft) 3) Acknowledge your co-workers (if you worked in groups)
Exams Exam I will cover introductory and fundamental concepts material and will be worth 20% of your grade. Exam II will cover coordination chemistry and will be worth 20% of your grade. Exam III/Final will cover main group, organometallic chemistry, special topics, and selected topics from Exam I and II and will be worth 40% of your grade. Although each of the exams cover specific blocks of material, you can expect to see concepts on the second exam which were covered on the first exam and likewise concepts on the third exam which were covered on the previous two exams. Office Hours I do not keep formal office hours. If you would like to schedule a meeting with me to discuss the coursework, please e-mail me with a few possible meeting times. I am typically available to meet on Tuesdays and Thursdays. Disability If you have a disability for which you are or may be requesting an accommodation, please contact both me and the office of Disability Resources and Services (Contact info below) as soon as possible so that we can make any necessary arrangements. The Disability Resources and Services office is located in William Pitt Union, Room 216. Their phone number is (412) 648-7890. They will be able to verify the disability and determine reasonable accommodations for this course.
Chemistry 2120 Prof. N.L. Rosi Fall 2009 Summary of Lectures and Readings (in italics)
1. September 1
Distributed Reading a. Course Information b. Basic Quantum c. Periodic Table d. Shielding e. Electron Configurations f. Periodic Trends g. Rules and Exceptions
2. September 3
Relevant Chapters from Undergraduate Inorganic Text
a. Bonding b. Lewis Dot Structures c. VSEPR d. Distribute Problem Set #1
3. September 8
My notes extract information from various texts, primarily the distributed chapters from Miessler and Tarr
a. Intro to group theory b. Symmetry elements c. Symmetry operations
4. September 10
See Sept. 8 for reading a. Matrices b. Groups c. Character tables d. COLLECT PROBLEM SET #1 e. Distribute Problem Set #2
5. September 15
See September 8 a. Character Tables (ctd) b. Bonding Theories c. Valence Bond Approach d. MO Theory
6. September 17
See September 8 a. MO Theory b. Walsh diagrams c. COLLECT PROBLEM SET #2
7. September 22
a. Begin Coordination Chemistry b. Common Ligands/e- counting c. Nomenclature d. Structure e. Isomerism
8. September 29—EXAM I
9. October 1
Distributed Reading/Undergraduate Inorganic Text
a. Bonding Theories b. Valence Bond Theory c. Crystal Field Theory d. MO Theory e. Distribute Problem Set #3
10. October 6
Distributed Reading a. Crystal Field Theory (in depth)
11. October 8
Distributed Reading a. Preparative methods b. Trans effect c. Mechanisms d. COLLECT PROBLEM SET #3 e. Distribute Problem Set #4
12. October 13—NO CLASS
13. October 15
Distributed Reading; Crabtree Chapter 13
a. Isolobal Analogy b. Applications c. Modern Coordination Chemistry
i. Bioinorganic ii. Supramolecular
iii. Solid-State
Chemistry 2120 Prof. N.L. Rosi Fall 2009
14. October 20 My notes extract information from various texts. All essential information will be included in my lecture and lecture notes.
a. Main group chemistry b. COLLECT PROBLEM SET #4
15. October 22—EXAM II
16. October 27
Crabtree Chapter 2 a. Start organometallic b. Ligand types c. Electron counting d. Basics of catalysis e. Important background
17. October 29
Crabtree Chapter 3 & 4 a. Lewis Base Ligands b. Carbonyls c. Phosphines d. Hydrides e. Distribute Problem Set #5
18. November 3—NO CLASS 19. November 5
Crabtree Chapters 3&11 a. Alkyls b. Aryls c. Carbenes d. Alkylidenes e. Carbynes
20. November 10
Crabtree Chapter 5 a. Alkenes b. Alkynes c. Arenes d. Cp Ligands
21. November 12 Crabtree Chapter 4 & 6
a. Substitution Reactions b. Oxidative Addition c. Reductive Elimination d. COLLECT PROBLEM SET #5 e. Distribute Problem Set #6
22. November 17
Crabtree Chapters 7&8 a. Migratory Insertion b. Nucleophillic and Electrophilic
Addition
23. November 19 Crabtree Chapter 9
a. Intro to Catalysis b. Hydrogenation
24. November 24
Crabtree Chapters 9&12 a. Hydroformylation b. Carbonylation c. Polymerization d. Coupling Reactions e. COLLECT PROBLEM SET #6
25. Thanksgiving—No Class
26. December 1 Crabtree Chapters 9&12
a. Coupling Reactions b. Metathesis
27. December 3
Crabtree Chapters 9&12 a. More Catalysis b. Special Topics
TEXTBOOK: Required: Inorganic Chemistry 4/E Authors: Miessler and Tarr ISBN 97801 361 28663 Publisher: Prentice Hall (An E-textbook subscription is available from CourseSmart: 978-0-321-67707-5).
Optional: Solutions Manual 4/E Authors: Miessler and Tarr ISBN 97801-361-28670 Publisher: Prentice Hall
COURSE OUTLINE:
I. Bonding and Periodicity
II. Main Group Chemistry
III. Coordination Chemistry
IV. Organometallic Chemistry/Catalysis
V. Materials and Solid State Chemistry
VI. Bioinorganic Chemistry
Note: Symmetry, Group Theory and Spectroscopy will not be emphasized since those are the topics of focus in 2110 (offered in the Spring).
GRADING:
Mid-term exam 100
Final exam 150
Homework 25
Frontiers Project and Presentation 100
IMPORTANT DATES
Aug 30th First Day of Classes
October 6th (Exam 1-tentative)
October 11th: Fall Break (Class will meet on the
12th instead)
November 24-28th Thanksgiving Break
December 13-18th Final exam
PROJECT
There will be an ongoing project with
assignments given throughout the semester
focused on identifying the frontiers and growth
areas of Inorganic Chemistry. Using the
Chemical Literature and the Internet, class
members will define the frontiers, identify the
leaders and the rising stars in the field, examine
the problems driving the research, and judge
which areas will see the greatest growth in the
next decade. Some assignments will be
individual and some will be done in groups.
REVIEW
Our textbook is an advanced undergraduate
book which some of you may have used as a
text previously. We will review some of the
more basic material at the beginning of class
but we will proceed quite rapidly and move
through to the later chapters that were likely
never discussed (or covered only briefly) in your
undergrad classes. Thus, a great deal of the
responsibility for mastering the basics will be
yours. I will, of course, be available to help you
Chemistry 2210: Electroanalytical Chemistry Fall Semester, 2009. Instructor: Prof. Adrian C. Michael [email protected] (preferred mode of contact) Rm 901, Chevron Science Center (the chemistry building) Office hours: by appointment Textbook: Electrochemical Methods: Fundamentals and Applications, second edition By Allen J. Bard and Larry R. Faulkner Published by John Wiley and Sons (The solutions manual is optional but recommended) Software: During this course, students will develop their own code to simulate electrochemical
experiments. Students may select any programming language and graphics package for this work. The instructor recommends Excel and will provide instruction on the use Excel’s Visual Basic macro language.
Objectives: The main objective of this course is to understand electroanalytical experiments
involving the flow of current under potential control. This requires an appreciation of thermodynamics, kinetics (heterogeneous and homogenous), and mass transport as they apply to electrochemical systems.
A secondary objective is to know the major figures in the field of electroanalysis and to
know their respective contributions to the field. To meet this objective, readings from the original literature will be used to complement the text book.
A secondary objective is to foster independent thought and creativity. Students will
develop a proposal that either develops or applies electroanalytical systems and/or techniques. Students will submit their proposal in written form to the instructor and will present (defend) their proposal to the class. Details will be provided in class.
Course Outline: Please note: this class schedule is only approximate and is provided mainly to give an overview of the course topics and the order of the reading assignments.
Week 1 M, Aug 31 W, Sept 2
Overview of Echem Basics of electrodes, cells, pot’l, and current. Estimates of i‐t and i‐V
Chapter 1
Week 2 M, Sept 7 W, Sept 9
Enjoy the week off!! No Class (Labor Day) No Class (Dr Michael travelling)
Potential Sweeps The i‐t‐V response Kinetics & Microelectrodes
Chapter 6
Week 9 M, Oct 26 W, Oct 28
Instrumentation Op amps/analog circuits Application of computers
Chapter 15
Week 10 M, Nov 2 W, Nov 4
Hydrodynamic Methods RDE and RRDE Electrochemical detectors (LC, CE, etc.)
Chapter 9 Parts of Chap 11
Week 11 M, Nov 9 W, Nov 11
Coupled Homogenous Reactions Kinetic schemes Pulse and sweep results
Chapter 12
Week 12 M, Nov 16 W, Nov 18 Sat, Nov 21
The Double Layer Models of the electrode‐solution interface Adsorbates SECOND EXAM
Chapter 13
Week 13 M, Nov 23 W, Nov 25
Modified Electrodes Polymers, films, enzymes, etc. No Class (Thanksgiving Break)
Chapter 14
Week 14 M, Nov 30 W, Dec 2
Scanning Probe Techniques Scanning electrochemical microscopy (SCEM), AFM, STM, etc.
Chapter 16
Week 15 M, Dec 7 W, Dec 9
Electrochemiluminescence (ECL) Systems Applications
Chapter 18 Proposals due today
Week 16 Final Exam Week
Time, date, and location TBA
Class Activities: Examinations: There will be three exams during the course, on the dates listed above. Details regarding the exam expectations will be given in class well prior to each exam. Please note that the two midterms are scheduled for Saturdays. This benefits students by removing the time constraint of the class period. However, the exams will not be open ended – again, we’ll discuss this closer to the time. The exams will take place on the scheduled dates – the covered material will depend on our progress through the material. The final exam will be partially comprehensive but the main focus will be material covered in the last third of the course. All exams will be in‐class (no take homes) and students are expected to work independently and in a manner consistent with the University’s academic code of conduct. Homework: Students are urged to work the majority of the problems in the text book, using the Solutions Manual as an aid (but not a crutch!). However, these problems will not be collected and graded. Please consider this independent homework as necessary preparation for the exams. Some problems will be discussed in class, as appropriate and/or useful. Students wishing to hear a discussion of any particular problem should feel free to say so. Projects: Throughout the semester, students will develop simulations of potential pulse and sweep experiments that include the effects of diffusion geometry (simple cases), heterogeneous kinetics, and coupled chemical reactions. These simulation projects must be completed in order to pass the course. However, since there can be no ‘partially correct’ simulation results (the simulations are either right or wrong, no one cares about the latter!), these simulation projects will not be graded. The idea is that the simulations will be a learning tool to promote your understanding: of course, examination questions based on the simulations are possible. For the advanced simulation projects later in the semester, small groups of students will be asked to tackle specific problems and report back to the class on their results – details will be discussed as the date approaches. Biographies: Each student will research the life, times, and accomplishments of a prominent electroanalytical chemist and give a brief (5‐10 min) synopsis of the individual’s contributions to the field. Students should discuss their choice with Prof. Michael after preliminary research. Students may complete this assignment at any point during the semester (actually, the earlier the better). Several electrochemists have received Nobel Prizes and other internationally recognized awards (ACS Awards, etc.) or are (were) members of the National Academy in US or other prominent bodies in Europe and Asia – these should be high on your list of choices! Proposal: Each student will develop a proposal idea that is based on, utilizes, or advances electroanalytical systems, principles, or techniques. The proposal will be in the form of a 10‐page (double spaced) paper, with appropriate citations. Each student will give an in‐class presentation of their proposal to the group: the audience (including Prof. Michael!) will ask “difficult” questions and the student presenter will vigorously defend his or her idea(s). The proposals will include a) a properly researched literature review to support a clearly stated hypothesis or main objective and b) a brief outline of a research plan. Each student will discuss his or her proposal idea with Prof. Michael before the end of October, after conducting preliminary literature research. Presentations will take place during November. Students may rewrite or otherwise adjust their written proposal based on feedback to the presentation. Proposals in their final form are due Dec 7th. Determination of Semester Grades: Semester grades will be determined on the basis of your three exam scores, your grade on the proposal, and class participation (including but not limited to your
biography and proposal presentations, response to questions, and questions posed, etc.). The three exams and the proposal will contribute roughly equally to the final semester grade. Class participation will be 10‐15% of the overall evaluation. Reminder: although the simulation projects will not be formally assigned a grade, your semester grade will be “F” if they are not completed properly and in a timely fashion.
Electronic Transitions: Molecular Orbitals, Absorptions and UV/Vis Spectroscopy,
Fluorescence, Green Fluorescent Proteins, applications to single molecule biophysics and
polymer physics. Instrumentation
Transitions between Zeeman Levels: Spins, Zeeman levels, Magnetization and its
evolution, detecting magnetic resonance signals, Spectrometer. Relaxation, multiple
Pulses, 2D NMR/ESR, Applications: diffusion, Imaging, and dynamics.
Course Schedule
Note: The schedule of lectures is tentative, although every effort will be made to stay on
schedule. However, the dates of the exams are definite.
January 6 (T) 8 (Th)
Lecture 1
- Syllabus
- Introduction to Spectroscopy
Lecture 2
- Radiation
13 (T) 15 (Th)
Lecture 3
- Review of Quantum Mechanics
Lecture 4
- Quantization of Energy levels
20 (T) 22 (Th)
Lecture 5
- Interaction of Radiation with matter
Lecture 6
- Selection Rules, Einstein Coefficients, populations
27 (T) 29 (Th)
Lecture 7
- Diatomics-Electronic and Vibrational levels
Lecture 8
- anharmonic oscillators
February 3 (T) 5 (Th)
Lecture 9
- Rotational-vibrational spectra of Gaseous
molecules
(Research Summary Due)
Lecture 10
- IR spectroscopy of Polyatomics
Application: Photoactive Yellow Protein
10 (T) 12 (Th)
Lecture 11 - Raman Spectroscopy, CARS Imaging
Lecture 12
-Electronic Transitions, Molecular Orbits
17 (T) 19 (Th)
Midterm Exam 1
(OUT OF TOWN)
Lecture 13
- UV/Vis: Selection Rules
February 24 (T) 26 (Th)
Lecture 14
- Fate of the Excited State
Lecture 15
- single molecule biophysics, optical tweezers, and
thermal motions of DNA
March 2 (T) 4 (Th)
Lecture 16
- Flourescence Resonance Energy Transfer
Lecture 17
- Spins, magnetization, T1
16 (T) 18 (Th)
Lecture 18
- Spins in a magnetic field, precession
Lecture 19
Midterm Exam 2
23 (T) 25 (Th)
Lecture 20
- RF pulses, MR Spectrometer
Lecture 21
- Details: Chemical Shifts and couplings
30 (T) April 1 (Th)
- J-coupling continued
Lecture 22
- multiple pulses, T1, dynamics, correlations and 2D
NMR
6 (T) 8 (Th)
Lecture 23
- COSY and J-couplings Imaging (one-
dimensional)
Lecture 24
- 2D Spectroscopy
(Write-Up due)
13 (T) 15 (T)
Lecture 25 - Special Topics
Lecture 26
- Special Topic
20 (Th) 22 (T)
Lecture 27
- Special Topics
Final Examination
(tentative)
Chemistry 2310 Advanced Organic Chemistry
MW 12:00-1:15 PM Instructor Paul Floreancig CHVRN 1203 (412)624-8727 [email protected] Course Overview In addition to being a vibrant field on its own, physical organic chemistry is the cornerstone for many other diverse disciplines of study such as synthesis, medicinal chemistry, molecular design, and bioorganic chemistry. A solid foundation in physical organic principles will be essential for organic chemists to explore applications in nanotechnology. Physical organic chemistry encompasses numerous areas of study, and cannot be covered completely in one semester. This course approaches the subject largely from a qualitative perspective, with the ultimate objective being the ability to apply first principles to relevant issues like enhancing reactivity, manipulating equilibria, improving binding interactions, and suppressing undesired reactions. The course will cover thermodynamic analyses of molecules and reactive intermediates, kinetics, and reaction mechanisms. If time permits we will cover molecular recognition. While the material will focus on principles, literature examples that highlight applications of topics to synthesis and other disciplines. Prerequisites A strong background in undergraduate level organic chemistry and a good work ethic are required. Grading Grades will be based on two midterm exams, one final exam, and one special project. Tentative dates for the midterms are October 6 and November 15. Problem sets will be handed out weekly but will not be graded. We will discuss the problem sets in recitation. Feel free to work in groups. Most of your future work will be done at least somewhat collectively, so get used to working together as soon as possible. Recitation We will have one recitation each week. The time will be set through class consensus. No new material will be introduced at the recitation, but we will look at course topics in greater detail. Text Modern Physical Organic Chemistry by Eric Anslyn and Dennis Dougherty. A solutions manual can also be purchased and is recommended. While we will not be using it directly for the class, The Art of Writing Reasonable Organic Reaction Mechanisms by Robert Grossman is a good resource for the topic.
Order of Topics • Molecular geometries - Classical models - Deviations from the ideal - Molecular orbital theory - Structures of reactive intermediates • Thermodynamics - Entropy explained (sort of) - Bond dissociation energies - Heats of formation and additivity tables - Conjugation and aromaticity - Sources of strain • Conformational analysis - Saturated acyclic and cyclic systems - Unsaturated systems - Molecular mechanics • Stability trends in reactive intermediates - Cation stability - Acidity and anion stability • Stereochemistry - Terminology and examples - Transient chirality - Analytical methods • Transition state theory - Rates and rate constants - Practical consequences • Mathematical kinetics - Analysis of numerous scenarios - Steady state approximation • Experimental kinetics - Isotope effects - Linear free energy relationships • Catalysis - Origins - Various models • Reaction mechanisms - Nucleophilic displacement reactions - Enolate reactions - Elimination reactions - Additions to carbonyl groups - Additions to alkenes and alkynes - Radical reactions - Migrations - Pericyclic reactions • Molecular associations
Syllabus: Advanced Organic Chemistry II Chem 2320, Spring 2010 Course Number 12612
MW 12:00-1:15, Eberly 228
Instructor: Professor Kay M. Brummond, Ph.D. E-mail: [email protected] Office Location: 807 Chevron Science Center Office Hours: By Appointment Course Schedule: Jan 6, 11, 13 *Chapter #1, The Basics
¶ Pages 1-79 The basics of retrosynthetic analysis and synthetic
strategies.
Synthesis of six membered rings and the Diels-Alder reaction
January 20 quiz #1
Jan 25, 27, Feb 1 *Chapter #2, Polar Reactions Under Basic Conditions
And §Pages 3-54, Planning Organic Synthesis and Selectivity
$Study Named reactions from the Grossman Chapter #2 in
“Strategic Applications of Named Reactions in Organic Synthesis”
Feb 3 quiz #2
Feb 8, 10, 15 *Chapter #3, Polar Reactions Under Acidic Conditions
$Study Named reactions from the Grossman Chapter #3 in
“Strategic Applications of Named Reactions in Organic Synthesis”
Feb 17 quiz #3
Feb 22, 24, March 1, Synthesis of five membered rings and the Pauson-Khand reaction
§Pages 71-87, Planning Organic Synthesis and Selectivity
March 3 Midterm Exam
March 8, 10 Spring Break
March 15, 17, 22, 24, 29 *Chapter #4, Pericyclic Reactions
$Study Named reactions from the Grossman Chapter #4 in
“Strategic Applications of Named Reactions in Organic Synthesis”
Additional Reading, Chapter #6, Thermal Pericycic Reactions in Ian
Feming’s “Molecular Orbitals and Organic Chemical Reactions”
March 31 quiz #4
April 5, 7 *Chapter #5, Free Radical Reactions
$Study Named reactions from the Grossman Chapter #5 in
“Strategic Applications of Named Reactions in Organic Synthesis”
April 12 quiz #5
April 14, 19 *Chapter #6, Transition Metal Catalyzed and Mediated Reactions
$Study Named reactions from the Grossman Chapter #6 in
“Strategic Applications of Named Reactions in Organic Synthesis”
April 21 quiz #6
April 28 Final Exam (9:00-noon) Chevron 135
Exams and Grading: There will be one midterm exam and one final exam and each is worth 150 points. The final exam will be comprehensive. Six quizzes will be assigned periodically, and will count 300 points toward your final grade. Textbooks: *The chapters in the syllabus are referring to this textbook. “The Art of Writing Reasonable Organic Reaction Mechanisms, second edition” by Robert B. Grossman. § Page numbers refer to the textbook “Organic Synthesis Strategy and Control” by Paul Wyatt and Stuart Warren. ¶ Page numbers refer to the textbook “The Logic of Chemical Synthesis” by E.J. Corey and Xue-Min Cheng $“Strategic Applications of Named Reactions in Organic Synthesis” by Lazlo Kurti and Barbara Czako. Academic Integrity: Students in this course will be expected to comply with University of Pittsburgh's Policy on Academic Integrity. Disabilities: If you have a disability that requires special testing accommodations or other classroom modifications, you need to notify both the instructor and the Disability Resources and Services no later than the 2nd week of the term. The Office is located in 216 William Pitt Union.
Chemistry 2430 Fall Term, 2002
Quantum Chemistry
Any fundamental description of a chemical phenomenon requires the use of quantum mechanics, since chemistry is the science of molecules, and molecules are very small. In this course, we will discuss the principles of quantum mechanics, describe the various ways that such principles manifest themselves in chemical phenomena, and show how one can take advantage of such principles in modern science and technology. An approximate syllabus for the course is given overleaf. The required text is Principles of Quantum Mechanics, by Donald D. Fitts, Cambridge U. P., 1999. Also recommended is The Physical Basis of Chemistry, by Warren S. Warren, Academic Press, 2000 and a number of books on reserve in the library (Eberly Hall). Both texts are available in paperback editions. Lectures will be given on Mondays, Wednesdays, and Fridays from 8-9:00 AM in Room 130 Chevron Science Center beginning August 26. Problem sets will be handed out weekly, to be turned in and graded. Answers will be placed on reserve or on CourseWeb. Two one-hour exams will be given, the first in late September/early October. A term paper, presentation, and/or final exam also will be required. Grading guidelines will be provided. The instructor is Professor David Pratt (605 CHVRN, (412) 624-8660, email: [email protected]). His office hours are Mondays, Wednesdays, and Fridays from 11-12:30 PM. USE THEM!
CRN 03075
Chemistry 2430 Fall Term, 2002
Approximate Syllabus
Week Topic(s) August 26 Waves and wavefunctions September 2 Schroedinger wave mechanics September 9 Postulates/principles of QM September 16 Harmonic oscillator September 23 Angular momentum September 30 Review and exam October 7 The hydrogen atom October 14 Spin October 21 Systems of identical particles October 28 Approximation methods November 4 Molecular structure November 11 Review and Exam November 18 Applications November 25 Applications December 2 Applications December 9 Applications December 16 Review and Final Exam
Several applications that come to mind include Hückel theory, magnetic resonance, IR and Raman spectroscopy in biological systems, high resolution electronic spectroscopy, analytical instrumentation, sensors, potential energy surfaces and reaction dynamics, orbital symmetry control, surface science and materials, teleportation, Bose-Einstein condensation, and a variety of time-dependent phenomena. Students are encouraged to contribute to this list, by suggesting topics in applied quantum mechanics that they would like to see discussed.
Chemistry 2430 Fall Term, 2002
Course Grades Your final grade in this course will depend on your ability to assimilate the material, and to demonstrate knowledge of the principles and applications of quantum mechanics to chemical problems. This knowledge will be revealed by your active participation in class activities, including (but not limited to) lectures, study groups, office hours, email exchanges, and student presentations. Twenty percent (20%) of your final grade will be based on this participation. Your acquired knowledge also will be tested by problem sets, hour examinations, and class presentations. Problem sets will be assigned weekly, turned in, and graded. A total of 20% of your grade will be based on your problem sets. Two hour exams, each also worth 20% of your fina l grade, will be given during the course of the term. Finally, each student will be asked to make a 30-minute oral presentation to the class, during the last four weeks of the term. This activity also will contribute to 20% of your final grade. Students who do not wish to give such presentations may write a 10-page term paper, in lieu of a final exam. The topic to be addressed in your presentation/term paper is a specific application of quantum mechanics to a current problem in chemistry. This could be a problem with which you are already familiar, a problem that you might pursue as a Ph.D. student, or just a topic about which you would like to know more. Each student will be required to select his/her topic by Friday, October 18 in consultation with Dr. Pratt. One-page outlines (with references) of your presentation or paper, also to be approved by Dr. Pratt, will be due on Monday, November 4, and scheduled for presentation at that time. Copies of these outlines will be distributed to the class one week in advance of your presentation, to give your classmates time to read the background material prior to coming to class. Their participation in the 20-minute discussion that will follow your presentation will be an essential component of their final grade.
Chemistry 2430 Fall Term, 2002
Books on Reserve. In addition to the required and recommended texts, the following books have been placed on reserve in the Chemistry Library (200 Eberly Hall) for your use in this course. P. W. Atkins, Physical Chemistry (6th edition), Freeman, 1998. P. W. Atkins, Quanta (2e), Oxford, 1991. P. W. Atkins and R. S. Friedman, Molecular Quantum Mechanics, Oxford, 1997. F. A. Cotton, Chemical Applications of Group Theory, Wiley, 1990. C. A. Coulson (revised by R. McWeeny), The Shape and Structure of Molecules, Oxford, 1982. P. A. Cox, The Electronic Structure and Chemistry of Solids, Oxford, 1987. D. D. Fitts, Principles of Quantum Mechanics, Cambridge University Press, 1999. R. K. Harris, NMR Spectroscopy, Longman, 1986. G. Herzberg, Atomic Spectra and Atomic Structure, Dover, 1944. G. Herzberg, Electronic Spectra and Electronic Structure of Polyatomic Molecules (Vol 3), Van Nostrand, 1966. G. Herzberg, Infrared and Raman Spectra of Polyatomic Molecules (Vol 2), Van Nostrand, 1945. J. M. Hollas, Modern Spectroscopy, (2nd edition), Wiley, 1996. M. Karplus and R. N. Porter, Atoms and Molecules, Benjamin, 1970. C. Kittel, Introduction to Solid State Physics, Wiley, 1996. I. N. Levine, Quantum Chemistry, (5th edition), Prentice Hall, 2000. R. G. Mortimer, Mathematics for Physical Chemistry, Macmillan, 1981. L. Pauling, The Nature of the Chemical Bond, Cornell, 1960. L. Pauling and E. B. Wilson, Introduction to Quantum Mechanics, McGraw-Hill, 1985. C. H. Townes and A. L. Schawlow, Microwave Spectrosopy, McGraw-Hill, 1955. W. S. Warren, Physical Basis of Chemistry, Academic Press, 2000. J. E. Wertz and J. R. Bolton, ESR. Elementary Theory and Practical Applications, McGraw-Hill, 1986.
Chemistry 2430 – Quantum Chemistry
Instructors: Professors K. D. Jordan and R. D. Coalson
Rm: 330 and 321 Eberly Hall
Text: Molecular Quantum Mechanics bt Atkins and Friedman
Lectures: Mon. and Wed. 5:30 PM – 6:45
Office hours: by appointment
Grading: two 1 hr. exams (25% each); homeworks (10%), final exam (40%). All exams are open
book, i.e., you can use your text and notes, but no other sources. Makeup exams are permitted
Chemistry 2440, Thermodynamics and Statistical Mechanics Instructors: Ken Jordan ([email protected]), Rob Coalson ([email protected]) Offices: 330 EH (KJ), and 321 EH (RC) Course web page: www.pitt.edu/~jordan/education/chem2440 Lectures: M, W. F, 11:00 AM – 10:50 AM, 228 EH Office Hours: anytime we are free Required texts:
D.A. McQuarrie, Statistical Mechanics
D. Chandler, Introduction to Statistical Mechanics Grading: two one-hour exams (25% each), final exam (40%), homeworks (10%) Tentative syllabus: Week 1: Review of thermodynamics fundamentals (Chandler, Ch. 1) Week 2: Conditions for Equilibrium and Stability (Chandler, Ch. 2) Weeks 3-5: Stat. Mechanics Foundations (ensembles) (Chandler, Ch. 3; McQ., Chs. 1-3) Hourly Exam: Feb. 10 Weeks 6-8: Applications of Eq. Stat. Mech. to Non-interacting Systems, I (Chandler, Ch. 4; McQ., Chs. 4-6;8,11)
(i) Harmonic solids (ii) Ideal Gases
Week 9: Applications of Eq. Stat. Mech. to Non-interacting Systems, I (Chandler, Ch. 4; McQ., Chs. 9,10)
(i) Chemical Equilibrium (ii) Quantum Statistics
Week 10-11: Classical Stat Mech: Theory and Numerical Simulation Techniques (Molecular Dynamics, Monte Carlo) (Chandler, Ch. 6,7; McQ., Ch. 7) Hourly Exam: March 19
Week 12-14: Application of Equil. Stat. Mech. to Interacting Systems (Chandler, Ch. 5,7; McQ., Chs. 12-14)
(i) Phase Transitions (ii) Imperfect gases and liquids
Week 15: Non-equil. Stat. Mech. (Chandler, Ch. 8; McQ., Chs. 20-22) Final Exam: April 26???
Syllabus Chem 2810 Biological Chemistry 1 Fall 2010 This course is intended to provide a foundation for a research program that studies biological molecules, systems, or similar, complex systems.
Prerequisite Bachelor’s degree in chemistry. A course in biochemistry will be helpful, but it is not a prerequisite.
Overview Biological systems are made of chemicals, so shouldn’t the study of chemistry be sufficient to study biological systems? Yes and no. First, the ‘yes’. The core undergraduate curriculum applies well to biological systems. Weak acid/weak base chemistry and related chemical equilibria help to explain respiration; electrochemistry is a key component to energy use; proteins, DNA, lipids are all organic compounds; inorganic coordination compounds are very important in oxygen carriers and many enzymes – and of course the skeleton! Principles of physical chemistry apply broadly, and form the basis for posing many of the key questions about life such as how do self-organization, protein folding, selective transport work for example. And the ‘no’. The ‘no’ arises from the level of complexity displayed in biological systems, and from the remarkable techniques that have been created specifically to study aspects of biomolecules, biological structures, organelles, cells, and organisms. This course is based on chemistry, broadly speaking, but it will emphasize the study of biological systems. A focus will be on motion – molecular and ionic motion by diffusion and ‘pumps’ - as well as motion of parts of macromolecules with respect to other parts. We will look at some important techniques and tools for understanding these things as well.
Grading There will be two exams, a paper, and a presentation.
Tentative schedule 2810 BIOLOGICAL CHEMISTRY 1 MW 5:30-6:45 PM EBERLY 228 Nelson, Philip 2008. Biological Physics. Energy, Information, Life. New York: W.H. Freeman and Company. Other readings will be assigned. 1) Building blocks and biomolecular classes Amino acids peptides proteins Nucleic acids nucleosides nucleotides RNA DNA Fatty acids phospholipids Carbohydrates glycosaminoglycans
2) The cell
Membrane, cytoskeleton, integral membrane proteins Mitochondria – energy metabolism
Nucleus Endoplasmic reticulum – protein synthesis and processing Central dogma 3) Chemical Communication Diffusion Fluid flow 4) Free Energy and Boltzmann Osmotic pressure Electrostatics and the double layer Water 5) Chemical Forces and Self Assembly Membrane Polymers Helix – coil transition 6) Some important systems Synaptic release Glutathione
Begin - August 30, 2010 (M) End - December 18, 2010 (Sa) Last Undergraduate Day Class - December 10 (F) Reading Day – December 11 (Sa) Final Exam Period - December 13-18 (M-Sa) Grades Due - December 22 (W) Holidays: September 6 (M) - Labor Day November 24 - 28 (W-Su) - Thanksgiving recess for students Important Dates:
Begin - August 30, 2010 (M) End - December 18, 2010 (Sa) Last Undergraduate Day Class - December 10 (F) Reading Day – December 11 (Sa) Final Exam Period - December 13-18 (M-Sa) Grades Due - December 22 (W) Holidays: September 6 (M) - Labor Day November 24 - 28 (W-Su) - Thanksgiving recess for students
CHEM 2820 Biological Chemistry 2
Spring 2010 M W F 10:00-10:50 a.m.,
228 Eberle Instructor: Professor W. Seth Horne Office: 1405 Chevron Science Center Office Hours: by appointment E-mail: [email protected] Course Description:
This course covers current research in chemical biology. We will discuss how chemical principles are being applied to address complex problems in biological science.
Organization and Goals of the Course:
We will begin the semester with a discussion of the structure of major classes of biomolecules (proteins, nucleic acids, oligosaccharides) as well as the non-covalent forces that influence their intermolecular and intramolecular interactions. The goal in the first portion of the course will be to gain an appreciation of biomolecules as chemical entities. In the second part of the semester, we will examine commonly encountered methods used for the preparation and characterization of biomacromolecules. The goal here will be to understand these methods well enough to critically interpret their use in modern chemical biology research. The third part of the course will consist of a survey of research topics in the recent literature that are relevant to chemical biology. Our discussions will center on journal articles and will rely heavily on our understanding of the principles and methods covered in the early part of the semester. The goal in the late part of the course will be to highlight frontier scientific challenges and questions being addressed through research at the chemistry/biology interface. Beyond the goals outlined above, we will also work to develop each student’s written and verbal communication skills, which are essential for a successful career in the sciences. This goal will be achieved through an assigned term paper and oral presentation related to the course material.
Required Course Materials:
Essentials of Chemical Biology: Structure and Dynamics of Biological Macromolecules, by Miller and Tanner
A significant portion of the course material will come from recently published journal articles. References to relevant articles will be provided, and students will be expected to acquire and read these papers online or through the university library.
Chem 2820 W. Seth Horne
Supplemental Texts: (Placed on reserve in the Chemistry Library)
Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding, by Fersht
Fundamentals of Biochemistry, by Voet, Voet, and Pratt Introduction to Protein Structure, by Branden and Tooze
Exam Schedule:
Exam 1 - Structure and Function in Biomacromolecules February 5 Exam 2 - Preparation and Characterization of Biomacromolecules March 5 (Exam dates are tentative. Actual dates will be announced in class.)
Term Paper:
One of the main goals of the course is to provide students with the knowledge necessary to understand and critically interpret cutting edge research in chemical biology. Each student will be required to complete a written review of a research article in the recent literature. The article can be selected from any area related to chemical biology but must be approved by the instructor. In the written review, students will be expected to summarize the key conclusions of the paper and explain how the authors’ reach the conclusions based on the experiments performed. Students should place the results in context based on other published research in the area. Does the paper represent a significant advance in the field or incremental progress that builds on older work? Are the conclusions of the paper fully justified by the data presented? Are there alternate interpretations of the data? Did the authors do appropriate control experiments? If not, what additional experiments would strengthen the conclusions? Propose the next direction you would take this research if you were in charge of the project. Article selections should be provided for approval by Monday, March 1. The written review should be 4-5 pages in length (single spaced, 12 point font, excluding references). The due date for the assignment is Friday, April 2.
Student Presentation:
Students will be divided into groups of two, and each pair will give an in-class presentation reviewing a research article from the recent literature. The basis for selection of papers and expectations for the content of the presentations will be the same as outlined above for the written reviews. Group assignments and paper selections will take place in mid-March. Presentations will take place during the last two weeks of the semester. Talks should be 20 minutes in length with an additional 5 minutes for questions. A laptop and projector will be provided.
Grading:
Each of the two midterm exams will count 25% toward the final grade. The group presentation and term paper will each count 20% toward the grade for the course.
Chem 2820 W. Seth Horne
10% of the course grade will be based on attendance and participation in class discussions. There will be no final exam for the course.
Academic Integrity:
Students in this course will be expected to comply with University of Pittsburgh's Policy on Academic Integrity (http://www.bc.pitt.edu/policies/). Any student suspected of violating this obligation for any reason during the semester will be required to participate in the procedural process, initiated at the instructor level, as outlined in the University Guidelines on Academic Integrity.
Disability Resources:
If you have a disability for which you are or may be requesting an accommodation, you are encouraged to contact both your instructor and Disability Resources and Services, 140 William Pitt Union, 412-648-7890 or 412-383-7355 (TTY) as early as possible in the term. DRS will verify your disability and determine reasonable accommodations for this course.
Chem 2820 W. Seth Horne
CHEM 2820 Lecture Schedule (tentative) I. Structure and function in biomacromolecules
1. (Jan. 6) Introduction 2. (Jan. 8) Non-covalent interactions I 3. (Jan. 11) Non-covalent interactions II 4. (Jan. 13) Protein structure I – amino acids and amide bonds 5. (Jan. 15) Protein structure II – secondary and tertiary structure 6. (Jan. 20) Protein structure III – folding thermodynamics 7. (Jan. 22) Carbohydrates 8. (Jan. 25) Nucleic acids I 9. (Jan. 27) Nucleic acids II 10. (Jan. 29) Chemical catalysis – transition state theory and basic principles 11. (Feb. 1) Enzyme catalysis I – fundamentals and kinetics 12. (Feb. 3) Enzyme catalysis II – case studies 13. (Feb. 5) Exam 1
II. Methods for the preparation and characterization of biomacromolecules
14. (Feb. 8) Chemical synthesis of DNA and the polymerase chain reaction (PCR) 15. (Feb. 10) Manipulation of nucleic acids in biological systems 16. (Feb. 12) Heterologous protein expression, isolation and purification 17. (Feb. 15) Chemical synthesis of peptides 18. (Feb. 17) Native chemical ligation and the total synthesis of proteins 19. (Feb. 19) X-ray crystallography 20. (Feb. 22) NMR spectroscopy 21. (Feb. 24) UV-VIS, CD and IR spectroscopy 22. (Feb. 26) Fluorescence spectroscopy, including FRET and FP 23. (Mar. 1) Mass spectrometry 24. (Mar. 3) Microscopy and chemical approaches for chromophore generation in vivo 25. (Mar. 5) Exam 2
III. Advanced topics from the recent literature
26. (Mar. 15) Protein-protein interactions and their inhibition 27. (Mar. 17) Post-translational modification of proteins 28. (Mar. 19) Epigenetics – histones, chromatin and modifying enzymes 29. (Mar. 22) Protein engineering – biosynthesis of chemically modified proteins 30. (Mar. 24) Genomics – DNA sequencing and microarrays 31. (Mar. 26) Proteomics – activity based protein profiling 32. (Mar. 29) Biomaterials in nature 33. (Mar. 31) Prebiotic chemistry 34. (Apr. 2) In vitro evolution 35. (Apr. 5) Bio-orthogonal ligation techniques 36. (Apr. 7) Synthetic biology – folding and function in non-biological oligiomers 37. (Apr. 9) Student literature presentations – topics TBA 38. (Apr. 12) Student literature presentations – topics TBA 39. (Apr. 14) Student literature presentations – topics TBA
Chem 2820 W. Seth Horne
40. (Apr. 16) Student literature presentations – topics TBA 41. (Apr. 19) Student literature presentations – topics TBA 42. (Apr. 21) Student literature presentations – topics TBA 43. (Apr. 23) Student literature presentations – topics TBA