Copyright Alcohol Medical Scholars Program 1 Fetal Alcohol Syndrome Fetal Alcohol Syndrome (FAS) (FAS) An Overview An Overview Lauren D. Williams, M.D. Lauren D. Williams, M.D. University of Miami School University of Miami School of Medicine of Medicine
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Copyright Alcohol Medical Scholars Program1 Fetal Alcohol Syndrome (FAS) An Overview Lauren D. Williams, M.D. University of Miami School of Medicine.
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University of Miami School of University of Miami School of MedicineMedicine
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DefinitionDefinition
• FAS is a serious developmental disorder caused by FAS is a serious developmental disorder caused by prenatal alcohol exposure of the fetus and prenatal alcohol exposure of the fetus and characterized bycharacterized by
• FAS:FAS:- First described by Lemoine in 1968First described by Lemoine in 1968- Term coined by Jones and Smith in 1973Term coined by Jones and Smith in 1973
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Facies in FASFacies in FAS
Source: Streissguth and Little 1994Source: Streissguth and Little 1994
• Central nervous system dysfunction: Central nervous system dysfunction: neurological, developmental, cognitive neurological, developmental, cognitive
• At least 2 facial featuresAt least 2 facial features
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PathogenesisPathogenesis
• Direct toxic effects of alcoholDirect toxic effects of alcohol
• Toxic effects of acetaldehydeToxic effects of acetaldehyde
• FASFAS- Severe developmental disability resulting from Severe developmental disability resulting from
prenatal alcohol exposureprenatal alcohol exposure- One of the leading causes of mental retardationOne of the leading causes of mental retardation- Not just a childhood problemNot just a childhood problem- Early diagnosis and intervention importantEarly diagnosis and intervention important- PreventablePreventable