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Muscle Fiber Type
Classified according to two characteristics:
1. Speed of contraction: slow fibers or fast fibers
2. Metabolic pathways for making ATP:
• Oxidative fibers—use aerobic pathways
• Glycolytic fibers—use anaerobic glycolysis
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Muscle Fiber Type
Three types:
• Slow oxidative fibers
• Fast oxidative fibers
• Fast glycolytic fibers
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Slow Oxidative Fibers(*dark meat*)
• Contract slowly
• Depend on oxygen delivery and aerobic pathways
• Fatigue resistant High endurance
• Rich capillary supply (to deliver more O2)
• Red in color (good supply of myoglobin)
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Fast Glycolytic Fibers(*white meat*)
• Contract rapidly
• Anaerobic
• Depends on glycogen reserves for fuel
• Powerful contractions but tires quickly (fatigable)
• Appears white, little myoglobin and low capillary density
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Fast Oxidative
• Intermediate between other two types
• Contract quickly
• Oxygen dependent
• Good supply of myoglobin and capillaries
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Copyright © 2010 Pearson Education, Inc. Table 9.2
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Copyright © 2010 Pearson Education, Inc. Figure 9.24
FO
FG
SO
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Effects of Exercise
Aerobic (endurance) exercise:
• Leads to increased:
• Muscle capillaries
• Number of mitochondria
• Myoglobin synthesis
• Results in greater endurance, strength, and resistance to fatigue
• May convert fast glycolytic fibers into fast oxidative fibers
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Effects of Resistance Exercise
• Resistance exercise (typically anaerobic) results in:
• Muscle hypertrophy (due to increase in fiber size)
• Increased mitochondria, myofilaments, glycogen stores, and connective tissue
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The Overload Principle
• Forcing a muscle to work hard promotes increased muscle strength and endurance
• Muscles adapt to increased demands
• Muscles must be overloaded to produce further gains
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Smooth Muscle
• Found in walls of most hollow organs(except heart)
• Usually in two layers (longitudinal and circular)
• Involuntary, controlled by the autonomic nervous system
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Copyright © 2010 Pearson Education, Inc. Figure 9.26
Smallintestine
(a) (b) Cross section of theintestine showing thesmooth muscle layers(one circular and theother longitudinal)running at rightangles to each other.
Mucosa
Longitudinal layerof smooth muscle (shows smooth muscle fibers in cross section)
Circular layer ofsmooth muscle (shows longitudinalviews of smooth muscle fibers)
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Contraction of Smooth Muscle
• Slow, synchronized contractions
• Can be controlled by nerves, hormones, or local chemical changes
• Rate and intensity of contraction may be modified by neural and chemical stimuli
***We will go into further detail when we discuss each body system individually
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Developmental Aspects
• Muscular development reflects neuromuscular coordination
• Development occurs head to toe (cephalocaudal), and proximal to distal
• Peak natural neural control occurs by mid-adolescence
• Athletics and training can improve neuromuscular control
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Developmental Aspects
• Female skeletal muscle makes up 36% of body mass
• Male skeletal muscle makes up 42% of body mass, primarily due to testosterone
• Body strength per unit muscle mass is the same in both sexes
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Developmental Aspects
•With age, connective tissue increases and muscle fibers decrease
• By age 30, loss of muscle mass (sarcopenia) begins
• Regular exercise reverses sarcopenia
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Muscular Dystrophy
• Group of inherited muscle-destroying diseases
• Muscles enlarge due to fat and connective tissue deposits
• Muscle fibers atrophy
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Muscular Dystrophy
Duchenne muscular dystrophy (DMD):
• Most common and severe type
• Inherited, sex-linked, carried by females and expressed in males (1/3500) as lack of dystrophin
• Diagnosed between 2-7 years of age. 1st sign, victims become clumsy and fall frequently; usually die of respiratory failure in their 20s
• No cure, but viral gene therapy or infusion of stem cells with correct dystrophin genes show promise