Departement für Kleintiere Abteilung für Radio-Onkologie Universität Zürich Departement für Kleintiere Winterthurerstrasse 260 CH-8057 Zürich Conventional Radiotherapy vs. FLASH-Radiotherapy Cancer research project Cats with squamous cell carcinoma of the nasal planum For more details and questions don`t hesitate to ask us. Thank you for your trust! Team Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich (in cooperation with CHUV Lausanne) contact: [email protected] What is the study duration? What are the costs of participation? • 5 days total hospital stay at the Small Animal Clinic, University of Zurich • Follow-up: after 2, 4, 6 weeks • Follow-up: after 3, 6, 9, 12, 18 months • Cost participation for therapy: CHF 650.- (instead of CHF 3'500.-) • Follow-up: free of cost Possible advantages of participation? Possible disadvantages of participation? • You`re supporting cancer research • Your cat will be treated with the standard treatment therapy (10 sessions) or with an experimental treatment (1 session) • Lower costs • Maybe more side effects with FLASH- Radiotherapy, because it`s still experimental • General anesthesia- and radiotherapy-risks (discussed individually) Treatment schedule Conventional Radiotherapy FLASH-Radiotherapy Treatment will be allocated randomly (by chance) 5 days total hospital stay at the Tierspital Zurich • Radiotherapy with the linear accelerator at the Tierspital Zurich • Radiotherapy duration 1-2 Min; 2x daily, 5 consecutive days • Ultra-high dose rate radiotherapy (100x faster) with FLASH-RT prototype, CHUV Lausanne • Radiotherapy duration <1 Sec; only 1 unit of radiotherapy Follow-ups: after 2, 4, 6 weeks and after 3, 6, 9, 12, 18 months Goals of the project • Compare treatment outcome after 10 conventional vs. 1 FLASH-session • Future improvement of radiotherapy with fewer treatments / anesthesias • Comparability of the side effects of both treatments • Cancer research – translation to human medicine