Contributors Angela M. Acquaviva, Section on Growth and Development, Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205 Eli Y. Adashi, Department of Obstetrics and Gynecology, University of Maryland, Baltimore, Maryland 21201 Kerstin Albertsson-Wikland, Department of Physiology, University of Goteborg, S-400 33 Goteborg, Sweden G. P. August, Department of Pediatrics, Children's Hospital, National Medical Center, Washington, D.C., 20010 Sameul D. Balk, Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts 02116 D. R. Bangham, National Institute for Biological Standards and Control, London NW3 6RB, England J. J. Bell, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 CarolJ. Berry, Department of Medicine and Clinical Research Facility, Emory University School of Medicine, Atlanta, Georgia 30322 Thomas A. Bewley, Laboratory of Molecular Endocrinology, University of California, San Francisco, California 94143 Juergen R. Bierich, Department of Pediatrics, University of Tubingen, 74 Tubingen, Federal Republic of Germany Louise Bilezikjian, The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037 S. L. Blethen, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri 63110 Robert M. Blizzard, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22901 P. Bohlen, Neuroendocrinology Laboratories, Salk Institute, San Diego, California 92037 Johnny Brandt, KabiVitrum AB, Research and Development, Departments of Biochem- istry and Analytical Chemistry, S-112 87 Stockholm, Sweden P. Brazeau, Laboratoire de neuroendocrinologie experimentale, H6pital Notre-Dame, Montreal, Quebec, H21 4K8 Canada A. Briskin, Neuroendocrinology Laboratories, Salk Institute, San Diego, California 92037 D. R. Brown, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455 643
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Contributors
Angela M. Acquaviva, Section on Growth and Development, Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205
Eli Y. Adashi, Department of Obstetrics and Gynecology, University of Maryland, Baltimore, Maryland 21201
Kerstin Albertsson-Wikland, Department of Physiology, University of Goteborg, S-400 33 Goteborg, Sweden
G. P. August, Department of Pediatrics, Children's Hospital, National Medical Center, Washington, D.C., 20010
Sameul D. Balk, Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts 02116
D. R. Bangham, National Institute for Biological Standards and Control, London NW3 6RB, England
J. J. Bell, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
CarolJ. Berry, Department of Medicine and Clinical Research Facility, Emory University School of Medicine, Atlanta, Georgia 30322
Thomas A. Bewley, Laboratory of Molecular Endocrinology, University of California, San Francisco, California 94143
Juergen R. Bierich, Department of Pediatrics, University of Tubingen, 74 Tubingen, Federal Republic of Germany
Louise Bilezikjian, The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037
S. L. Blethen, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri 63110
Robert M. Blizzard, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22901
P. Bohlen, Neuroendocrinology Laboratories, Salk Institute, San Diego, California 92037 Johnny Brandt, KabiVitrum AB, Research and Development, Departments of Biochem
istry and Analytical Chemistry, S-112 87 Stockholm, Sweden P. Brazeau, Laboratoire de neuroendocrinologie experimentale, H6pital Notre-Dame,
Montreal, Quebec, H21 4K8 Canada A. Briskin, Neuroendocrinology Laboratories, Salk Institute, San Diego, California 92037 D. R. Brown, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
55455
643
644 Contributors
C. Bruno Bruni, Section on Growth and Development, Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205
Pierre Chatelain, INSERM U 34, Hopital Debrousse, 69005 Lyon, France Rajender K. Chawla, Department of Medicine and Clinical Research Facility, Emory
University School of Medicine, Atlanta, Georgia 30322 David R. Clemmons, Department of Pediatrics, University of North Carolina, School of
Medicine, Chapel Hill, North Carolina 27514 Vittorio Coiro, Department of Physiology, University of Massachusetts Medical School,
Worcester, Massachusetts 01605 The Committee on Growth Hormone Usage (S. L. Kaplan, G. P. August, S. A. Kaplan, M.
H. MacGillivray, W. V. Moore,j. S. Parks, A. F. Parlow, A. W. Root, T. P. Foley, A. E. Wilhelmi, and L. E. Underwood, A. j. johanson), The National Hormone andPituitary Program, University of Maryland School of Medicine,Baltimore,Maryland 2120 1
Michael P. Czech, Department of Biochemistry, University of Massachusetts Medical School, Worcester, Massachusetts 01605
William H. Daughaday, Metabolism Division, Washington University School of Medicine, St. Louis, Missouri 63110
Heather j. Dean, Departments of Physiology and Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
A. joseph D'Ercole, Department of Pediatrics, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27514
David B. Donner, Memorial Sloan-Kettering Cancer Center and The Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021
Andrea Dorato, Memorial Sloan-Kettering Cancer Center and The Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021
Staffan Eden, Department of Physiology, University of Goteborg, S-400 33 Goteborg, Sweden
Catherine A. Egli, Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143
F. Esch, Neuroendocrinology Laboratories, Salk Institute, San Diego, California 92037 Rina Eshet, Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical
Center, Petah Tikva 49 100, Israel, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
William S. Evans, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22901
Angel Ferrandez, Hospital Infantil, E-S0009, Zaragosa, Spain Timothy j. Fields, Department of Life Sciences, Indiana State University, Terre Haute,
Indiana 47809 T. P. Foley, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania
15213 S. Douglas Frasier, Department of Pediatrics and Physiology/Biophysics, University of
Southern California School of Medicine and the Los Angeles County-University of Southern California Medical Center, Los Angeles, California 90033
Ulf Friberg, Department of Histology, Karolinska Institutet, S-l 040 1 Stockholm, Sweden Henry G. Friesen, Departments of Physiology and Pediatrics, University of Manitoba,
Winnipeg, Manitoba, Canada R3E OW3
Contributors 645
Luciano G. Frigeri, The Whittier Institute for Diabetes and Endocrinology, La Jolla, California 92037
Herwig Frisch, Department of Endocrinology, University-Kinderklinik Stien, A-1090 Wien IX-Vienna, Austria
Lawrence A. Frohman, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Lindo Fryklund, KabiVitrum AB, Research and Development, Departments of Biochemistry and Analytical Chemistry, S-112 87 Stockholm, Sweden
Richard Furlanetto, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104
Lynne A. Gaynes, Endocrine Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205
Michael D. Geier, Genentech, Inc., South San Francisco, California 94080 Marie C. Gelato, Developmental Endocrinology Branch, National Institutes of Health,
Bethesda, Maryland 20205 G. Yancey Gillespie, Department of Surgery and Cancer Research Center, University of
North Carolina, School of Medicine, Chapel Hill, North Carolina 27514 James H. Goldman, Endocrine Division, Department of Medicine, Tufts University School
of Medicine, New England Medical Center, Inc., Boston, Massachusetts 02111 H. Maurice Goodman, Department of Physiology, University of Massachusetts Medical
School, Worcester, Massachusetts 01605 Genevieve Grichting, Department of Physiology, University of Massachusetts Medical
School, Worcester, Massachusetts 01605 Melvin M. Grumbach, Department of Pediatrics, University of California-San Francisco,
San Francisco, California 94143 R. Guillemin, Neuroendocrinology Laboratories, Salk Institute, San Diego, California
92037 Magnus Hagerman, KabiVitrum AB, Research and Development, Departments of Bio
chemistry and Analytical Chemistry, S-112 87 Stockholm, Sweden David A. Harris, Department of Pediatrics, University of California-San Francisco, San
Francisco, California 94143 Berthold P. Hauffa, Departments of Pediatrics, University of California-San Francisco,
San Francisco, California 94143 William P. Heath, Department of Medicine and Clinical Research Facility, Emory Uni
versity School of Medicine, Atlanta, Georgia 30322 Raymond L. Hintz, Department of Pediatrics, Stanford University, Stanford, California
94305 N.J. Hopwood, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
48109 James P. Hughes, Department of Life Sciences, Indiana State University, Terre Haute,
Indiana 47809 J. Anthony Hulse, Department of Pediatrics, University of California-San Francisco, San
Francisco, California 94143 Rene E. Humbel, Biochemisches Institut, Universitat Zurich, Switzerland Chung Ho Hung, Section of Pediatric Endocrinology, Department of Pediatrics, University
of Kansas Medical Center; Kansas City, Kansas 66103 Ruth IUig, Universitatas Kinderklinik, CH-8032 Zurich, Switzerland
646 Contributors
oUe G. P. Isaksson, Department of Physiology, University of Goteborg, S-400 33 Goteborg, Sweden
H. Iwamoto, Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143
John-Olov Jansson, Department of Physiology, University of Goteborg, S-400 33 Goteborg, Sweden
Ann J. Johanson, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22901
Andrew J. S. Jones, Genentech, Inc., South San Francisco, California 94080 Susan Joyce, Department of Psychology, University of Virginia, Charlottesville, Virginia
22901 Donald L. Kaiser, Department of Pediatrics, University of Virginia School of Medicine,
Charlottesville, Virginia 22901 Selna L. Kaplan, Department of Pediatrics, University of California-San Francisco, San
Francisco, California 94143 Susan Kasper, Departments of Physiology and Pediatrics, University of Manitoba, Win
nipeg, Manitoba, Canada R3E OW3 R. T. Kirkland, Department of Pediatrics, University of Texas, Houston, Texas 77030 J. Kitterman, Department of Pediatrics, University of California-San Francisco, San
Francisco, California 94143 Jack L. Kostyo, Department of Physiology, University of Michigan Medical School, Ann
Arbor, Michigan 48109 Karen Kover, Section of Pediatric Endocrinology, Department of Pediatrics, University
of Kansas Medical Center, Kansas City, Kansas 66103 A. Avinoam Kowarski, Department of Pediatrics, University of Maryland School of
Medicine, Baltimore, Maryland 21201 Michael H. Kutner, Department of Biometry and Clinical Research Facility, Emory
University School of Medicine, Atlanta, Georgia 30322 ZviLaron, Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical Center,
Petah Tikva 49 100, Israel, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Urban J. Lewis, The Whittier Institute for Diabetes and Endocrinology, La Jolla, California 92037
Choh Hao Li, Laboratory of Molecular Endocrinology, University of California, San Francisco, California 94143
Samuel Libber, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
N. Ling, Neuroendocrinology Laboratories, Salk Institute, San Diego, California 92037 Kenneth E. Lipson, Memorial Sloan-Kettering Cancer Center and The Sloan-Kettering
Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021
Robert H. Lustig, Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143
Margaret H. MacGillivray, Department of Pediatrics, State University of New York at Buffalo School of Medicine and The Children's Hospital of Buffalo, Buffalo, New York 14222
Kjell Madsen, Department of Histology, Karolinska Institutet, S-10401 Stockholm, Sweden
Joseph B. Martin, Neuroendocrinology Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
Contributors 647
Synthia H. Mellon, Metabolic Research Unit, Department of Medicine, University of California, San Francisco, California 94143
George R. Merriam, Developmental Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20205
Claude J. Migeon, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Tina Mitchell, Department of Psychology, University of Virginia, Charlottesville, Virginia 22901
Mark E. Molitch, Center for Endocrinology, Metabolism, and Nutrition and Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611
Wayne V. Moore, Section of Pediatric Endocrinology, Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas 66103
Cristina MoUola, Department of Biochemistry, University of Massachusetts Medical School, Worcester, Massachusetts 01605
S. Peter Nissley, Endocrine Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205
John V. O'Connor, Genentech, Inc., South San Francisco, California 94080 Yoshitomo Oka, Department of Biochemistry, University of Massachusetts Medical School,
Worcester, Massachusetts 01605 Kenneth C. Olson, Genentech, Inc., South San Francisco, California 94080 M. R. Pandian, Nichols Institute, San Juan Capistrano, California 92675 John S. Parks, Department of Pediatrics, Emory University School of Medicine, Atlanta,
Georgia 30322 Bohdan Pavlu, KabiVitrum AB, Research and Development, Departments of Biochem
istry and Analytical Chemistry, S-112 87 Stockholm, Sweden Marilyn Perrin, The Clayton Foundation Laboratories for Peptide Biology, The Salk
Institute, La Jolla, California 92037 Athalia Pertzelan, Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical
Center, Petah Tikva 49 100, Israel, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
John A. Phillips III, Division of Genetics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
L. S. Phillips, Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303
W. Jackson Pledger, Department of Pharmacology and Cancer Research Center, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27514
Leslie P. Plotnick, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Michael A. Preece, Department of Growth and Development, Institute of Child Health, University of London, London WCIN lEH, England
Salvatore Raiti, The National Hormone and Pituitary Program, University of Maryland School of Medicine, Baltimore, Maryland 21201
Matthew M. Rechler, Section on Growth and Development, Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205
Seymour Reichlin, Endocrine Division, Department of Medicine, Tufts University School of Medicine, New England Medical Center, Inc., Boston, Massachusetts 02111
Jean Rivier, The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037
648 Contributors
Alan D. Rogol, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22901
Joyce A. Romanus, Section on Growth and Development, Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205
Stephen M. Rosenthal, Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143
Michael J. Ross, Genentech, Inc., South San Francisco, California 94080 DanielRudman, Department of Medicine and Clinical Research Facility, Emory University
School of Medicine, Atlanta, Georgia 30322 A. M. Rudolph, Department of Pediatrics, University of California-San Francisco, San
Francisco, California 94143 William E. Russell, Department of Pediatrics, University of North Carolina, School of
Medicine, Chapel Hill, North Carolina 27514 Libbie J. Russo, Section of Pediatric Endocrinology, Department of Pediatrics, University
of Kansas Medical Center, Kansas City, Kansas 66103 Genevieve Sassolas, Centre de Medecine Nucleaire, Hopital Neuro-Cardiologique, 69394
Lyon Cedex 3, France Paul SawchenkO, Developmental Neurobiology Laboratory, The Salk Institute, La Jolla,
California 92037 Jeanette M. Schepper, Department of Life Sciences, Indiana State University, Terre
Haute, Indiana 47809 Elizabeth A. Schriock, Department of Pediatrics, University of California-San Francisco,
San Francisco, California 94143 Hans Seifert, The Clayton Foundation Laboratories for Peptide Biology, The Salk
. Institute, La Jolla, California 92037 Morton B. Sigel, The Whittier Institute for Diabetes and Endocrinology, La Jolla,
California 92037 Aviva Silbergeld, Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical
Center, Petah Tikva 49 100, Israel, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Bo Skoog, KabiVitrum AB, Research and Development, Departments of Biochemistry and Analytical Chemistry, S-112 87 Stockholm, Sweden
Eric P. Smith, Department of Pediatrics, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27514
Joachim Spiess, The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037
D. M. Styne, Department of Pediatrics, University of California-Davis, Davis, California 95616
Marjorie E. Svoboda, Department of Pediatrics, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27514
Larry Swanson, Developmental Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037
Marta Szabo, Division of Endocrinology and Metabolism, Michael Reese Hospital, Chicago, Illinois 60616
J. M. Tanner, Department of Growth and Development, Institute of Child Health, University of London, London WCIN lEH, England
Jeffrey E. Terrell, Section on Growth and Development, Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205
Contributors 649
Jennifer L. Tlwminet, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
MichaelO. Thorner, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22901
Robert A. Tolman, Endocrinology Research Program, Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205
Gene F. Tutwiler, McNeil Pharmaceutical, Spring House, Pennsylvania 08540 Louis E. Underwood, Department of Pediatrics, University of North Carolina, School of
Medicine, Chapel Hill, North Carolina 27514 T. G. Unterman, Center for Endocrinology, Metabolism and Nutrition, Northwestern
University Medical School, Chicago, Illinois 60611 Wylie Vale, The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute,
La Jolla, California 92037 Mary Lee Vance, Department of Pediatrics, University of Virginia School of Medicine,
Charlottesville, Virginia 22901 Willard P. Vanderlaan, The Whittier Institute for Diabetes and Endocrinology, La Jolla,
California 92037 G. Van Vliet, Department of Pediatrics, University of California-San Francisco, San
Francisco, California 94143 Judson J. Van Wyk, Department of Pediatrics, University of North Carolina, School of
Medicine, Chapel Hill, North Carolina 27514 Joan Vaughan, The Clayton Foundation Laboratories for Peptide Biology, The Salk
Institute, La Jolla, California 92037 W. B. Wehrenberg, Neuroendocrinology Laboratories, Salk Institute, San Diego, Cali
fornia 92037 Lisa L. Wheeler, Department of Life Sciences, Indiana State University, Terre Haute,
Indiana 47809 Robert M. White, Howard University Cancer Center, Departments of Oncology and
Medicine, Howard University School of Medicine, Washington, D.C. 20059 Harvey J. Whitfield, Section on Growth and Development, Molecular, Cellular, and
Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Insitutes of Health, Bethesda, Maryland 20205
Anders Wichman, KabiVitrum AB, Research and Development, Departments of Biochemistry and Analytical Chemistry, S-112 87 Stockholm, Sweden
Kazuyo Yamada, Memorial Sloan-Kettering Cancer Center and The Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021
Yvonne W.-H. Yang, Section on Growth and Development, Molecular, Cellular, and Nutritional Endocrinology Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205
Kin-Tak Yu, Department of Biochemistry, University of Massachusetts Medical School, Worcester, Massachusetts 01605
Klaus Zuppinger, Inselspital, CH-30 1 0 Bern, Switzerland
dopamine agonists in, 314 GH in, 36-40 GHRH and, 41 GRF-secreting pancreatic tumor in, 326 hpGRF-40 in, 365-366 hyperprolactinemia in, 30, 381 somatomedin C in, 615 TRH in, 310
hGRF 1-44-NH2 and, 394 Forskolin, somatomedin C and, 597 FSH, see Follicle stimulating hormone
Ganglioneuroblastoma, GRF and, 352 Gas chromatography, 235 Gastrin
hpGRF-40 and, 363 as tumor marker, 375
Gel electrophoresis, in analysis of MSA, 529 Gel filtration, 450 Germinoma, GH deficiency and, 59, 383 GH, see Growth Hormone GHRH, see Growth hormone-releasing factor Giant cell granuloma, hypopituitarism
from, 381 mechanism of action, 309 menstrual cycle and GH responses to, 397 in normal prepubertal children, 382 versus other peptides, 308 overstimulation by, 342 pancreatic tumor secreting, 326, see also
Human pancreatic growth-releasing factor
pharmacokinetics, 370 porcine, 338 production of, 212 purification, 325 radioimmunoassay, 375 rat, 338
insulin-potentiating properties, 443, 444-445 internalization to Golgi area, 496 international standard, 229-230 lactogenic activity, 468 longitudinal bone growth and, 564-566 lymphocyte binding, 495 melatonin and, 317 methionyl, 242, 243 methysergide and release of, 316 molecular structure, 303 molecule, flexibility in solution, 483 monocyte binding, 495 mRNA coding sequence multiple forms, 439-453 N gene, 202 phosphorus and, 271 phosphorylation, 445 piribedil and stimulation of, 315 pituitary, versus met-hGH, 247, 267-268,
270 preparation
contaminants, 236 purification, 236
produced by recombinant DNA, 237-239 production of, 205
release and, 211 prohormone hypothesis for, 440 prostaglandin E2 and, 317 radioimmunoassay, 2 receptors, see also Growth hormone, receptor
lactogenic nature, 476 on macrophages, 491 molecular weight, 496
somatedin C and, 271, 597, 640 spontaneous fluctuations in, 304
lruks
Human growth hormone (cont.) therapy, 67-75
long-term, 93-106 psychosocial evaluation of patients in, 93-
106 response to, 69-71 schedule of administration, 71-73 in short normal children, 123-126 subcutaneous versus intramuscular, 85-91 thyroid function in,. 119 in Turner's syndrome, 109-113, 115-121
birth weight of children with, 165 blood chemistry in, 169 congenital malformations in, 165 dentition in, 168 diurnal variation of hGH in, 172 as an example of resistance to GH, 171 facial appearance in, 167 genetic aspects, 164-165 hair growth in, 168 maximum height, 170 motor development in, 166
Laron-type dwarfism (cant.) sexual maturation in, 169
Index
similarity to idiopathic GH deficiency, 166 skeleton development in, 169 subcutaneous fat tissue, 168
molecular weight, 579, 580 in serum, 581 in urine, 581
plasma, 553-554 platelet-derived factor and, 588 purification, 554 radioreceptor assay, 575 role in mediation of GH, 303 in uremia, 578
Somatonorm, see also Methionyl human growth hormone (met-hGH)
adsorbents for, 259 antibodies against, 293-297 antigenicity, 215, 260-264 contaminants, 261 versus Crescormon, 258, 287-300 E. coli polypeptide in biosynthesis, 288 radiolabeled, preparation of, 259
Somatonorm I, 279-286 allergic skin reactions from, 294
Somatonorm I (cant.) chronic treatment, 298 versus Crescormon, 290
Somatonorm II, 289 Somatostatin, 309, 310, 405-415; see also
Preprosomatostatin, structure of acetylcholine and, 316
661
,,/-aminobutyric acid and release of, 414, 416, 418
as an autocrine regulator, 407 in brain stem, 407 calcium and, 414, 420 comparisons of, 411 in cerebral cortex, 407 CNS distribution of, 407 discovery, 405 dopamine and, 316 effect on membrane permeability to calcium,
420 in feedback control of GH secretion, 317 GH inhibition of, 309 GH secretion and, 413 hGRF-NH 2 and, 394 in hippocampus, 407 hpGRF-40 and, 363 in the hypothalamus, 407, 409, 415-416 mechanism of action, 419-421 in neurophypophysis, 407 norepinephrine and, 316 oxytocin and, 407 as a paracrine regulator, 407 as prohormones, 413 purification, 325 receptors, 419-420 somatomedin C and, 317 in spinal cord, 407 structure, 405, 406 TSH and, 413, 417-419 as tumor marker, 375 vasopressin and, 407 verapamil and, release of, 414
Somatostatinoma syndrome, as marker of endocrine tumor, 382
Spinal cord, somatostatin in, 407 Strabismus, in LTD, 165 Substance P