Consumption of antibiotics before and after sales regulations in Chile, Colombia and Venezuela Juan Jose Herrera Patiño, Yared Santa-Ana-Tellez, , Anahi Dreser, Ralph Gonzales, Veronika J. Wirtz Center for Health Systems Research & Center of Evaluation and Survey Research, National Institute of Public Health, Mexico
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Consumption of antibiotics before and after sales regulations in Chile, Colombia and Venezuela
Consumption of antibiotics before and after sales regulations in Chile, Colombia and Venezuela. Juan Jose Herrera Patiño, Yared Santa-Ana-Tellez, , Anahi Dreser, Ralph Gonzales, Veronika J. Wirtz Center for Health Systems Research & Center of Evaluation and Survey Research, - PowerPoint PPT Presentation
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Consumption of antibiotics before and after sales regulations in Chile,
Colombia and Venezuela
Juan Jose Herrera Patiño, Yared Santa-Ana-Tellez, , Anahi Dreser, Ralph Gonzales, Veronika J. Wirtz
Center for Health Systems Research &Center of Evaluation and Survey Research, National Institute of Public Health, Mexico
Background
• One of the main drivers of antimicrobial resistance is antibiotic consumption.
• To combat resistance the WHO has recently recommended that sales restrictions of antibiotics should be reinforced.
• Several middle-income countries have enforced sales restriction of antibiotics (AB) – Chile in 1999,
– Colombia in 2005
– Venezuela in 2006.
• Enforcement may have an impact on use of antibiotics, but little systematic evaluation of its effect over time.
Study aim and methodsTo analyze the change in consumption of antibiotics (AB) in Chile, Colombia and
Venezuela between 1997 and 2010.
Design: Interrupted time series analysis of systemic AB consumption for Chile, Colombia and Venezuela and one other LA country (Mexico) as control group between 1997 and 2010.
Setting: Market intelligence data of AB sales aggregated at national level
WHO ATC code J01 quarterly between 1997 and 2010.
Study Population: The total AB consumption and
Stratification by
a) broad-spectrum therapeutic groups:
quinolones, macrolides/ lincosamides and third generation cephalosporins.
b) narrow spectrum groups: penicillin, trimethoprim-sulfamethoxazole, and first and second generation cephalosporins.
Methods (cont.) Interrupted time series with control group
Outcome: AB sales aggregated by country, expressed in defined daily dose per 1,000 inhabitants per day (DDD).
Intervention: • Venezuela: sale regulation only included the broad spectrum groups
• Chile and Colombia: sale regulation for all AB
• Control country: no sales regulation implemented