Role of Soy Protein in Nutrition & Health
May 12, 2015
Role of Soy Protein
in Nutrition & Health
Presentation Outline
• Nutrition and Functional foods
• Soy Protein Quality
• Health Benefit Overview
– Diabetes
– Heart health
– Cancer
– Bone Health and Menopause
Symptoms
• Summary
How Important is Nutrition?
• Essential nutrients: to maintain body functions
• Usually nutrition reminds us of what we should
avoid or restrict (Saturated fat, cholesterol,
sodium etc)
• The other side of the nutrition coin is what we
should eat, which in today’s context is probably
more important
Functional Foods
• These are foods that may have the potential to prevent
disease or be used as part of disease treatment or
management
• These are foods which in general promote better health
(Foods which have good amount of protein and good
quality protein, foods that have calcium, foods that have
good amount of fiber etc)
• “Foods that by virtue of physiologically active food
components, provide health benefits beyond basic
nutrition”
International Food Information Council
Importance of Functional Foods
• Food which is traditionally viewed as
nourishment needed for growth, strength
and energy is now considered to have
beneficial effects in helping reduce risk of
chronic diseases such as
– Cardiovascular disease
– Cancer
– Obesity
– Diabetes
What Consumers Want!
Unprecedented consumer focus on Taste and Health
Taste
Brand
Health
Price
Packaging
Convenience Other67%
59%
54%
52%
39%
27%
6%
Presentation Outline
• Nutrition and Functional foods
• Soy Protein Quality
• Health Benefit Overview
– Diabetes
– Heart health
– Cancer
– Bone Health and Menopause
Symptoms
• Summary
Composition of the Soybean
40% Protein
15% Sugars & Oligosaccharides
15% Dietary Fiber
20% Oil
10% Other
storage proteins
sucrose, raffinose, stachyose
soluble & insoluble fiber
lecithin, sterols, vitamin E
moisture, ash
whey proteins
isoflavones saponins
SolaeTM and the Solae logo are trademarks of Solae, LLC
Protein
• Quantity – 1gram per kg body weight
• Quality
– Essential amino acid content and their ratio
– Digestibility
– Relevance to Human Requirements
Protein Functions
• Body building and repair
• Enzyme and hormones
• Immunity
• Cell functions
• Nails and hair etc
Protein Digestibility-Corrected
Amino Acid Score (PDCAAS)
• Amino acid profile testing done at designated labs
• Digestibility testing by the rat nitrogen balance study
• PDCAAS value is determined according to the FAO/WHO published method
Protein Quality Evaluation Report published as FAO Food and Nutrition Paper 51, Rome, 1991
PDCAAS Determination • Protein value
• Amino Acid content
• True Digestibility – determined by rat nitrogen balance study
• Calculations
– AA content is expressed as mg/g protein
– Calculate the Amino Acid Score*
– Calculate PDCAAS**
• PDCAAS scores of greater than 1 are truncated to 1
*Amino Acid Score (AAS) = amino acid content of test protein/Ref AA pattern
for 2-5 year old child
**PDCAAS = AAS x True Digestibility
Protein Quality Evaluation Report published as FAO Food and Nutrition Paper 51, Rome, 1991
• Values for SUPRO® Brand Isolated Soy Protein provided by Solae as determined through actual analysis.
• † Protein Quality Evaluation, Report of the Joint FAO/WHO Expert Consultation.
• Rome: FAO Food and Nutrition Paper No. 51, 1991.
Product PDCAAS
Isolated Soy Protein* 1.00
Casein 1.00
Egg White 1.00
Beef 0.92
Pea Flour 0.69
Kidney Beans (Canned) 0.68
Pinto Beans (Canned) 0.63
Peanut Meal 0.52
Rice 0.47
Whole Wheat 0.40
Wheat Gluten 0.25
PDCAAS of Selected Foods†
Bioactive Peptides
• Bioactive peptides may be present in
independent entities or encrypted in the native
protein
• It is known that during digestion in the GI tract or
during Food Processing, these peptides are
released from the parent protein and these act as
regulatory compounds with hormone like
activities
• Food derived bio-active peptides commonly
contain 2 to 9 amino acids. However, this range
may extend to 20 or more amino acids.
• Lunacin, a food derived peptide with anticancer
bioactivity contains 43 amino acids
Soy Protein
• Complete protein with all the essential
amino acids is therefore essential
• Most animal proteins are closer to
complete proteins
• Do we take our daily requirement of
complete proteins? Even if we are non-
vegetarians?
What is Soy Protein Isolate
Aqueous
Extraction
of Sugars
Drying
SOY PROTEIN
CONCENTRATE*
(60-65%)
Alcohol
Extraction
of Sugars
Solvent
Removal
SOY PROTEIN
CONCENTRATE*
(60-65%)
Protein
Precipitation
Aqueous
Extraction
of Sugars
Drying
SOY PROTEIN
ISOLATE
(>90%)
DEFATTED
FLAKES
Grinding
and Sizing
SOY
FLOUR*
(52%)
Isoflavones
* Can Be Manufactured in Texturized Soy Protein (TSP) Products.
Soy Fiber
Soybeans (40%)
Oil
Presentation Outline
• Nutrition and Functional foods
• Soy Protein Quality
• Health Benefit Overview
– Diabetes
– Heart health
– Cancer
– Bone Health and Menopause
Symptoms
• Summary
Diabetes Figures
• Diabetes
• India - No.1 Rank
• Growth -79.4 million 2030 from 31.7
million in 2000.
– Currently estimated to be about 50 million
Glycemic Index (GI)
• High GI foods
– Food cravings
– Disordered eating patterns
– Repeated surges and falls in blood-glucose ("sugar spikes")
• Low GI foods
– Reduced appetite
– Lower energy intake
– Aids in weight loss and weight management
How does protein help reduce appetite?
• Protein stimulates “Satiety Hormones”
• Cholescystokinin
– The ingestion of protein is known to stimulate the gut
hormone, cholecystokinin (CCK) in animals
– Release of CCK suppresses food intake by inducing a
feeling of satiety in animals
– The major protein component of soy protein (-conglycinin)
stimulates CCK release and subsequently suppresses food
intake
• Reduced glycemic index
– Low-glycemic index foods provide greater satiety and
reduced hunger compared to high-glycemic index foods
– Soy protein is a low glycemic index food
Presentation Outline
• Nutrition and Functional foods
• Soy Protein Quality
• Health Benefit Overview
– Diabetes
– Heart health
– Cancer
– Bone Health and Menopause
Symptoms
• Summary
Heart Problems Figures
• Heart diseases
• In 2002, India > China >
Russian federation.
• By 2020, 60% of the world’s
heart patients will be Indians
Soy Protein and Cholesterol
Maintains HDL
“Healthy” Cholesterol
Meta-Analysis: 38 Clinical Studies on Soy and Blood Lipids,
Anderson, NEJM 1995;333:276-282
Reduces Total
Cholesterol
4-9%
Reduces LDL
“Lousy” Cholesterol
6-12%
The FDA Claim
The US Food & Drug Administration has
(October 26th 1999) endorsed a health claim
on relationship between consumption of soy
protein.
The health claim says that “25 grams of soy
protein a day as part of a diet low in
saturated fat and cholesterol, may reduce
the risk of heart disease”.
American Heart Association
American Heart Association (AHA) experts announced their official recommendations for consumers to eat more soya protein, in order to lower their cholesterol and the risk of heart disease.
“There is increasing evidence that consuming soya protein may help lower blood cholesterol levels in some people with elevated cholesterol levels and may provide other cardiovascular benefits”. Circulation: Journal of American Heart Association, November 14, 2000
Soy Protein: CHD Risk
Soy protein/other vegetable protein
decrease cholesterol
Soy protein binds bile acids
7 S globulin fractions may affect liver LDL
receptors
Soy Protein and Heart Health
• For every 1% decrease in serum cholesterol there
is a 2-3% reduction in the rate of CHD (AHA*).
• The totality of evidence on “Soy Protein &
Cholesterol Lowering” suggests,
– As part of a healthy diet, a 4 - 6% reduction in serum
cholesterol with soy protein - as observed in this meta-
analyses - can make a significant & meaningful
contribution to reducing the risk of Coronary Heart
Disease.
*Rosamond W. Circulation 2008:117:e25
Presentation Outline
• Nutrition and Functional
foods
• Soy Protein Quality
• Health Benefit Overview
– Diabetes
– Heart health
– Cancer
– Bone Health and Menopause
Symptoms
• Summary
• Breast Cancer and Prostrate Cancer
– Antioxidant activity of isoflavones:
• At concentrations from 5 – 50 M genistein inhibits the growth of a wide range of cancer cells including hormone dependent & independent breast and prostate cancer cells
– Blocks estrogen receptors: cancer cell activity reduces
– Inhibits certain enzymes in the cancer cell
Soy and Cancer
Presentation Outline
• Nutrition and Functional
foods
• Soy Protein Quality
• Health Benefit Overview
– Diabetes
– Heart health
– Cancer
– Bone Health and
Menopause Symptoms
• Summary
Osteoporosis and Bone Health
• World wide 30-40 % of women and 13 %
of men have life time risk of fracture due
to osteoporosis
• Risk factors
• High intake of protein, especially animal
protein
• Intake of diets with low calcium content
• Rapid bone loss due to estrogen deficiency
Study Conducted at All Indian Institute of Medical Sciences, 2006
Effect of Soy on Alleviating Menopause
Problems
Summary: Soy Protein • Soy protein is a high-quality protein with an
excellent nutritional profile
• Promotes growth
• Soy protein is associated with several health
benefits:
– Manging diabetes
• Low Glycemic Index
– Promotes Heart health
– Cancer risk reduction
– Helps in managing osteporosis
– Alleviating menopause symptoms
• Reducing Anemia
NutriPlus • Balanced Protein Supplement for kids and
adults
• Better tasting product
• Added with DHA
– Good for the brain and heart
– DHA is critical nutrient for growth and functional
development of brain, improves learning ability
and visual acuity
• Provides L-Lysine
– indispensable amino acid that cannot be
synthesized in the body
– Limiting in Indian diets
• Quality proteins (Combination of soy & milk)