ADIPOCYTE DERIVED STEM CELLS AND Mesenchymal Product as REGENERATIVE MEDICINE Indah Yulianto .,Endra Yustin., (Sebelas Maret University)., Titi Moertolo (Trisakti University).,Dewi Margono (Medical Dentist Indonesia University).,Yuyun R A(National Seoul University).,Yuda H Fibrianto (Medical Veterinary Gajah Mada University)
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Conditioned medium – of adipocyte derived stem cells
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ADIPOCYTE DERIVED STEM CELLS AND Mesenchymal Product as REGENERATIVE
MEDICINE
Indah Yulianto.,Endra Yustin., (Sebelas Maret University)., Titi Moertolo (Trisakti University).,Dewi Margono (Medical Dentist Indonesia University).,Yuyun R A(National Seoul University).,Yuda H Fibrianto (Medical Veterinary Gajah Mada University)
By definition, a stem cell is characterized by its ability to self-renew and its ability to differentiate along multiple lineage pathways.
Ideally, a stem cell for regenerative medicinal applications should meet the following criteria:
Regenerative Medicine :Uses the body’s own stem cells and growth factors is an alternative therapeutic strategy for repair of damage tissue, and becoming predominant cell base therapy
Can be found in abundant quantities (millions to billions of cells)
Can be harvested by a minimally invasive procedure
Can be differentiated along multiple cell lineage pathways in a regulatable and reproducible manner.
Can be safely and effectively transplanted to either an autologous or allogeneic host
Regenerative medicinal applications should meet the following criteria:
Human subcutaneous adipose tissue depots as a potential source of adult or somatic stem cells;
With the increased incidence of obesity in the Indonesia and abroad, subcutaneous adipose tissue is abundant and readily accessible.
Approximately 400,000 liposuction surgeries are performed all over the world each year,
These procedures yield anywhere from 100 mL to >3 L of lipoaspirate tissue
Hasil lemak dari liposuction
pellet
Adipocyte after 24 hours
Adipocyte after 24 hours
ADSC pasage 1 : hari ke 3
A. ADSCs hari ke 7 dan B. ADSC hari ke 14
A B
by dr Indah Yulianto – Yuyun Rindiastuti – Dewi M
Transdifferensiasi ADSCs to Odontoblast(immunocitokimia)
Ditujukan untuk regenerasi dan renewal Pulpitis
Courtesy by Indah Yulianto – Yuyun Rindiastuti – Dewi M