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Declaration by experts contributing to the EIA of Concord Biotech Ltd.
I, hereby, certify that I was a part of the EIA team in the following capacity
that developed the above EIA.
EIA Coordinator:
Name: Dr. Mahendra Sadaria
Signature & Date:
Period of involvement July, 2015
Contact Information: 079-26583077
Functional Area Experts
Functional Areas
Name of the Expert
Involvement (Period and Task)
Signature & date
Air Pollution Monitoring & Control (AP)
Dr. Mahendra Sadaria
Planning of meteorological AAQM baseline monitoring, site visit/ survey, select monitoring locations, data verification & approval, interpretation of baseline condition of air environment. Evaluation of results of Ambient Air Quality Monitoring (AAQM). Contribution in EIA documentation.
Air Quality Modeling and Prediction (AQ)
Dr. Mahendra Sadaria
Meteorology file generation, Air quality model (ISCST-3) run using meteorology data, identifying source & receptor. Prediction of GLC & plotting isopleths. Study of GLCs obtained & calculating cumulative concentration of pollutants. Contribution in EIA documentation.
Water Pollution (WP)
Dr. Mahendra Sadaria
Site visit, selection of sampling locations, review & interpret baseline water quality, water balance calculation for the project, prediction of impacts & proposed mitigation measures, contribution in EIA documentation.
Ecology and Bio-diversity Conservation (EB)
Dr. Khyati Thacker
Site visit/survey for ecology study, review of Greenbelt development requirement of the project-suggestion for species, type of plantation and contribution in EIA documentation.
Solid and Hazardous Waste Management (SHW)
Dr. Mahendra Sadaria & Dr. Khyati Thacker
Identified source of generation of Hazardous waste & disposal methods, studying adequacy of mitigation measures for management of hazardous waste.
Socio Economy (SE)
Shobhana Sadaria
Site visit, data collection, evaluation of Socio-Economic status of the study area, assessment of the possible chances to socio-economic issues arising out of the proposed activity & contribution in EIA documentation.
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San Envirotech Pvt. Ltd., Ahmedabad
EIA Report of Concord Biotech Ltd. 1
Index Particulars Page No.
Contents 1-9
List of Tables 10-12
List of Figures 13-14
List of Annexures 15
Contents CHAPTER CONTENT PAGE NO.
Chapter 1 Introduction
1.1 Preface 1-1
1.2 Purpose of the report 1-1
1.3 Identification of project & project proponent 1-2
1.3.1 Identification of project site with site specific criteria 1-2
The unit is located in Dholka Taluka of Ahmedabad District of Gujarat
State. The geographical co-ordinates of the site are 22041’59.55” N
Latitude and 72026’48.63” E Longitude. The location map showing project
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EIA Report of Concord Biotech Ltd. 1-6
site is given in Figure 1.1 and satellite image/Google earth image is
shown in Figure 1.2. Boundary co-ordinates latitude and longitude of all
four corners of the site are given in Table 1.2 and shown in Figure 1.3.
Table 1.2Four corner co-ordinates of site
Corner Latitude Longitude A 22°41'58.74"N 72°26'43.58"E B 22°41'53.19"N 72°26'53.21"E C 22°41'58.18"N 72°26'56.85"E D 22°42'09.44"N 72°26'48.41"E
1.5 APPLICABLE ENVIRONMENTAL REGULATORY FRAMEWORK
The proposed project will abide and function under the purview of the
following Rules, Acts & Regulations which are formulated by the Govt. of
India to protect the environment and development in a sustainable way.
• The Water (Prevention & Control of Pollution) Act, 1974
• The Air (Prevention & Control of Pollution) Act, 1981
• The Environmental (Protection) Act, 1986
• Environmental Impact Assessment Notification dated 14th September
2006 and subsequent amendments
• The Hazardous & Other Waste (Management and Transboundary
Movement) Rules, 2016
• Noise Pollution (Regulation and Control) Rules, 2000 and its
amendments
• The Public Liability Insurance Act, 1991
1.6 SCOPE OF THE STUDY
The scope of the EIA study is based on the guideline provided by
MoEF&CC, Government of India for structure of Environmental Impact
Assessment document. The scope of the study broadly includes:
Field sampling of environmental attributes at various representative
locations in the study area to establish the baseline status;
Collect & compile secondary data including socio-economic data;
Identification, assessment and evaluation of the beneficial and adverse
impacts on surrounding environment due to proposed project activities
considering the existing baseline status along with compilation of other
information.
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EIA Report of Concord Biotech Ltd. 1-7
Analysis of project proposal and data analysis.
Assessment of pollution potential due to proposed project.
Predict the incremental levels of pollutants in the study area;
Evaluate the predicted impacts on the various environmental
attributes by using scientifically developed and widely accepted
models.
Identification and assessment of risks associated with the proposed
project and their appropriate management through proper Risk
Assessment (RA) and Disaster Management Plan (DMP).
Prepare an Environmental Management Plan (EMP) to mitigate the
predicted impacts; and
Identify critical environmental attributes required to be monitored
during the project execution and to suggest post project monitoring.
The scope also includes all the conditions outlined in the TOR issued by
MoEF&CC and the compliance to the TOR is given below.
1.7 COMPLIANCE TO TERMS OF REFERENCE
Based on the presentation made before 2nd Expert Appraisal Committee
(Industry-2) on 16th – 17th December, 2015; Terms of Reference (TOR)
was issued by MoEF&CC; vide letter no. J-11011/268/2015-IA II (I),
dated 28.01.2016 and directed to prepare detailed EIA/EMP including
terms of reference. Compliance of TORs is as below:
Sr. No.
Conditions Compliance
A. Specific TOR
1. Details on solvents to be used, measures for solvent recovery and for emissions control.
Pls. refer sec. 10.7.1.2, page no. 10.6 for list of solvent &its recovery. Schematic Diagram of solvent recovery system is given in figure 2.4, page no. 2-46.
2. Details of process emissions from the proposed unit and its arrangement to control.
There will be no process emission anticipated from the unit.
3. Ambient air quality data should include VOC, etc.
Pls. refer table 3.21, page no. 3-30 of chapter-3 for ambient air quality details (VOCs).
4. Work zone monitoring arrangements for hazardous chemicals.
How to select locations for work zone monitoring is summarized in section 10.13.1, page no. 10-21 of chapter-10.
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Conditions Compliance
Monitoring programme of work area is summarized in Table 6.1, page no. 6-4.
5. Details effluent treatment scheme including segregation of effluent streams for units adopting ‘Zero’ liquid discharge.
Pls. refer sec. 2.15.1 and Table 2.8, page no. 2-15 and 2-32 respectively of chapter-2 for ETP scheme. No effluentwill bedischarged outside the plant premises.
6. Action plan for odor control to be submitted.
Pls. refer sec. 10.7.1.3, page no. 10-8 for action plan for odor control.
7. Details of incinerator along with pollution control device to be provided.
We are not going to install incinerator, hence not applicable in our case.
8. A copy of the memorandum of Understanding signed with cement manufacturers indicating clearly that they co-process organic solid/ hazardous waste generated.
Copy of MoU made with Ambuja Cement indicating that they co-process generated organic solid/ hazardous waste is enclosed as Annexure-II.
9. Authorization/Membership for the disposal of liquid effluent in CETP and solid/hazardous waste in TSDF, if any.
Unit is not going to discharge effluent in CETP so membership of CTEP is not required. Membership certificate of approved TSDF & CHWIF site is enclosed as Annexure-III.
10. Action plan for utilization of MEE/dryers salts.
We have explored the possibility for utilization of MEE/dryer salt and currently not any industry is utilizing MEE/dryer salt. We continuous try to explore the possibility to utilize salt of MEE/dryer by any actual users.
11. Material Safety Data Sheet for all the Chemicals are being used/will be used.
MSDS of Haz. chemicals are attached as Annexure-IV.
12. Authorization/Membership for the disposal of solid/hazardous waste in TSDF is being used/will be used.
Membership certificate for the disposal of Hazardous waste in TSDF & CHWIF site is enclosed as Annexure-III.
13. Authorization/Membership for the disposal of solid/hazardous waste in TSDF.
Membership certificate for the disposal of Hazardous waste in TSDF & CHWIF site is enclosed as Annexure-III.
14. Risk assessment for storage and handling of hazardous chemicals/ solvents. Action plan for handling & safety system to be incorporated.
Separate chapter-7 ‘Additional Studies’ is cover risk assessment study.
15. Arrangement for ensuring health and safety of workers engaged in handling of toxic materials.
There is no use of any toxic material because processes itself biotechnology based and
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even trace toxicity can destroy the biotechnology process.
B. Additional TOR i. Public hearing to be conducted and
issues raised and commitments made by the project proponent on the same should be included in EIA/EMP Report in the form of tabular chart with financial budget for complying with the commitments made.
Public hearing was held on 27.04.2017. Issues raised and its replied by the project proponentis tabulated below.
ii. A separate chapter on status of compliance of Environmental Conditions granted by State/Centre to be provided. As per circular dated 30th May, 2012 issued by MoEF, a certified report by RO, MoEF on status of compliance of conditions on existing unit to be provided in EIA-EMP report.
A certified report by RO, MoEF&CC is enclosed as Annexure-V.
iii. To analyze/enlist microbes in extraction and disposal.
Pls. refer sec. 2.15.4, page no. 2-18 of chapter-2.
3.0 These ‘TORs’ should be considered for the preparation of EIA/EMP for expansion of bulk drug manufacturing unit (from 103.83 MTPA to 189.03 MTPA) at plot no. 1482-1486, Trasad Road, Taluka Dholka, District Ahmedabad, Gujarat by M/s Concord Biotech Ltd. in addition to all the relevant information as per the ‘General Structure of EIA’ given in Appendix III and IIIA in the EIA Notification, 2006. The EIA/EMP as per TORs should be submitted to the Chairman, Gujarat Pollution Control Board, for public consultation. The SPCB shall conduct the public hearing/public consultation as per the provisions of EIA Notification, 2006.
Agreed, We have prepared EIA report based on TOR & generic structure of EIA.
4.0 You are requested to kindly submit the final EIA/EMP prepared as per TORs and incorporating all the issues raised during Public Hearing/Public Consultation to the Ministry for considering the proposal for environmental clearance within 3 years as per the MoEF O.M. No. J-11013/41/2006-IA.II (I) dated 8th October, 2014.
Public Hearing was conducted on 27.04.2017 and final EIA/EMP after public hearing is submitted within a due course i.e. within validity of TOR.
5.0 The consultants involved in the preparation of EIA/EMP report after accreditation with Quality Council of India/National Accreditation Board of
QCI/NABET accreditation certificate of the consultant is attached as Annexure-VI in EIA report.
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Education and Training (QCI/NABET) would need to include a certificate in this regard in the EIA/EMP reports prepared by them and data provided by other Organization(s)/Laboratories including their status of approvals etc.
Generic Terms of Reference (TOR) in respect of Industry Sector 1. Executive Summary Executive summary of the
project is given in Chapter-11 of EIA report.
2. Introduction i. Details of the EIA Consultant including
NABET accreditation. Details of EIA consultant is given in chapter-12 ‘Disclosure of Consultant engaged’. NABET accreditation certificate is enclosed as Annexure-VI.
ii. Information about the project proponent
Pls. refer sec. 1.3.3, page no. 1-3 of chapert-1 for details of project proponent.
iii. Importance and benefits of the project.
It is described in chapter-8 of EIA report.
3. Project Description i. Cost of project and time of
completion. Cost of the project is given in sec. 2.4, page no. 2-2. Time of completion of project: Around 8-10 months after accordance of EC.
ii. Products with capacities for the proposed project.
Pls. refer table 2.3, page no. 2-4 of chapter-2 for product details with capacity.
iii. If expansion project, details of existing products with capacities and whether adequate land is available for expansion, reference of earlier EC if any.
Pls. refer table 2.3, page no. 2-4 of chapter-2 for existing product details with capacity. Unit has total land of 112302m2 which is adequate for the existing as well as proposed expansion. Earlier EC is attached as Annexure-VII.
iv. List of raw materials required and their source along with mode of transportation.
Pls. refer table 2.6, page no. 2-23 for list of raw material required, its source along with mode of transportation.
v. Other chemicals and materials required with quantities and storage capacities.
Pls. refer table 7.1, page no. 7-4 for bulk storage details of other chemicals.
vi. Details of Emission, effluents, hazardous waste generation and their management.
Emission: Pls. refer table 2.12 on page no. 2-37 for sources of air emission. Effluent: Pls. refer table 2.8& figure2.3 on page no. 2-32&2-
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45 respectively for effluent treatment details. Hazardous waste: Pls. refer table 2.16 on page no. 2-41 for Haz. waste generation & its management.
vii. Requirement of water, power, with source of supply, status of approval, water balance diagram, man-power requirement (regular and contract).
Pls. refer sec. 2.12, page no. 2-12 of chapter-2 for all the details.
viii. Process description along with major equipments and machineries, process flow sheet (quantities) from raw material to products to be provided.
Pls. refer Annexure-I for process description, process flow diagram. Pls. refer table 2.4, page no. 2-5 of chapter-2 for major equipment & machineries.
ix. Hazard identification and details of proposed safety systems.
Pls. refer sec. 7.2, page no. 7-1. Its safety system is given in sec. 7.16, page no. 7-24.
x. Expansion/modernization proposals: a. Copy of all the Environmental
Clearance(s) including Amendments thereto obtained for the project from MoEF/SEIAA shall be attached as an Annexure. A certified copy of the latest Monitoring Report of the Regional Office of the Ministry of Environment and Forests as per circular dated 30th May, 2012 on the status of compliance of conditions stipulated in all the existing environmental clearances including Amendments shall be provided. In addition, status of compliance of Consent to Operate for the ongoing/existing operation of the project from SPCB shall be attached with the EIA-EMP report.
Copy of all Environmental Clearance is enclosed as Annexure-VII. A certified copy of the latest Monitoring Report of the RO MoEF&CC is enclose as Annexure-V.
b. In case the existing project has not obtained environmental clearance, reasons for not taking EC under the provisions of the EIA Notification 1994 and/or EIA Notification 2006 shall be provided. Copies of Consent to Establish/No Objection Certificate and Consent to Operate (in case of units operating prior to EIA Notification 2006, CTE and CTO of FY 2005-2006) obtained from the SPCB shall be submitted. Further,
Unit has obtained EC for its existing set up and it is enclosed asAnnexure-VII.
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Conditions Compliance
compliance report to the conditions of consents from the SPCB shall be submitted.
4. Site Details: i. Location of the project site covering
village, Taluka/ Tehsil, District and State, Justification for selecting the site, whether other sites were considered.
Location of the project site covering village, Taluka/Tehsil, District and State on Indian map is attached as figure 1.1, page no. 1-24 of chapter-1.
ii. A toposheet of the study area of radius of 10km and site location on 1:50,000/1:25,000 scale on an A3/A2 sheet. (Including all eco-sensitive areas and environmentally sensitive places).
Topo sheet of study area with site location on 1:25,000 scale followed by 1:50,000 scale of a circle of a radius of 10 kms is incorporated in EIA/EMP report. Pls. refer figure no. 3.13& 3.14 on page no. 3-56& 3-57.
iii. Details w.r.t. option analysis for selection of site.
Expansion project is in the existing premises so no option analyze for alternate site.
iv. Co-ordinates (lat-long) of all four corners of the site.
Coordinates (Lat long) of all four corners of the site is given in sec. 1.4.3 & figure 1.3, on page no. 1-6 & 1-26 of chapter-1.
v. Google map-Earth downloaded of the project site.
Google map of 10 km radius is attached as figure 1.2 on page no. 1-25 of chapter-1.
vi. Layout maps indicating existing unit as well as proposed unit indicating storage area, plant area, greenbelt area, utilities etc. If located within an Industrial area/Estate/Complex, layout of Industrial Area indicating location of unit within the Industrial area/Estate.
Layout map indicating existing set up as well as storage area, plant area, greenbelt area, utilities etc. are given as figure 2.5, page no. 2-47 of chapter-2.
vii. Photographs of the proposed and existing (if applicable) plant site. If existing, show photographs of plantation/greenbelt, in particular.
Photographs of existing & proposed plant site along with Plantation/Greenbelt are attached as Annexure-VIII.
viii. Land use break-up of total land of the project site (identified and acquired), government/private - agricultural, forest, wasteland, water bodies, settlements, etc. shall be included. (not required for industrial area).
Details of total land & its breakup are given in table 2.1, page no. 2-2 of chapter-2.
ix. A list of major industries with name and type within study area (10km radius) shall be incorporated. Land use details of the study area.
List of industries (name and type of industries)located within 10 km radius is mentioned in sec. 1.10, page no. 1-21 of chapter-1. Land use details of the study area based on satellite
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Conditions Compliance
imaginary is given in Table 3.2, page no. 3-3.
x. Geological features and Geo-hydrological status of the study area shall be included.
Hydrogeological status of the study area is given in sec. 3.9.1, page no. 3-10 of chapter-3.
xi. Details of Drainage of the project upto 5km radius of study area. If the site is within 1 km radius of any major river, peak and lean season river discharge as well as flood occurrence frequency based on peak rainfall data of the past 30 years. Details of Flood Level of the project site and maximum Flood Level of the river shall also be provided. (Mega green field projects).
There is not any river & flood Hazard zone within 1 km radius from the site hence this point is not applicable.
xii. Status of acquisition of land. If acquisition is not complete, stage of the acquisition process and expected time of complete possession of the land.
Unit is already in existence and land is owned by the company. Land documents are enclosed as Annexure-IX. Hence no need of mutual agreement for land acquisition. Proposed expansion will be done in existing premises.
xiii. R&R details in respect of land in line with state Government policy.
Proposal is for expansion of plant in the plant premisesso no R&R is required.
5. Forest and wildlife related issues (if applicable): i. Permission and approval for the use of
forest land (forestry clearance), if any, and recommendations of the State Forest Department. (if applicable)
No forest land is involved hence permission from State Forest Department is not required.
ii. Land use map based on High resolution satellite imagery (GPS) of the proposed site delineating the forest land (in case of projects involving forest land more than 40 ha).
Not applicable as no forest land is involved.
iii. Status of Application submitted for obtaining the stage I forestry clearance along with latest status shall be submitted.
Not applicable
iv. The projects to be located within 10 km of the National Parks, Sanctuaries, Biosphere Reserves, Migratory Corridors of Wild Animals, the project proponent shall submit the map duly authenticated by Chief Wildlife Warden showing these features vis-à-vis the project location and the recommendations or comments of the
Not applicable as no forest land is involved.
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Chief Wildlife Warden-thereon. v. Wildlife Conservation Plan duly
authenticated by the Chief Wildlife Warden of the State Government for conservation of Schedule I fauna, if any exists in the study area.
Not applicable
vi. Copy of application submitted for clearance under the Wildlife (Protection) Act, 1972, to the Standing Committee of the National Board for Wildlife.
Not applicable
6. Environmental Status i. Determination of atmospheric
inversion level at the project site and' site-specific micro-meteorological data using temperature, relative humidity, hourly wind speed and direction and rainfall.
One season site-specific micro- meteorological data are given in sec. 3.7.2 & table 3.6 on page no. 3-6.
ii. AAQ data (except monsoon) at 8 locations for PM10, PM2.5, SO2, NOX, CO and other parameters relevant to the project shall be collected. The monitoring stations shall be based CPCB guidelines and take into account the pre-dominant wind direction, population zone and sensitive receptors including reserved forests.
AAQ data at 8 locations are tabulated in table no. 3.17 to 3.21 on page no. 3-26 to 3-30. Figure 3.7 shows Air monitoring stations on page no. 3-50.
iii. Raw data of all AAQ measurement for 12 weeks of all stations as per frequency given in the NAQQM Notification of Nov. 2009 along with - min., max., average and 98% values for each of the AAQ parameters from data of all AAQ stations should be provided as an annexure to the EIA Report.
AAQM of all station is summarized in table no. 3.17 to 3.21 on page no. 3-26 to 3-30 of EIA report.
iv. Surface water quality of nearby River (100m upstream and downstream of discharge point) and other surface drains at eight locations as per CPCB / MoEF&CC guidelines.
This point is not applicable in our case because no river is passing in the vicinity and no w/w disposal outside of factory premises.Pls. refer table 3.24, page no. 3-34 of chapter-3 for surface water quality.
v. Whether the site falls near to polluted stretch of river identified by the CPCB/ MoEF&CC, if yes give details.
Not applicable
vi. Ground water monitoring at minimum at 8 locations shall be included.
Ground water monitoring at 8 locations is given in Table 3.23, page no. 3-33 of chapter-3.
vii. Noise levels monitoring at 8 locations within the study area.
Noise level monitoring is given in Table 3.26, page no. 3-36 of
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chapter-3. viii. Soil Characteristic as per CPCB
guidelines. Soil Characteristic is given in Table 3.28, page no. 3-37 of chapter-3.
ix. Traffic study of the area, type of vehicles, frequency of vehicles for transportation of materials, additional traffic due to proposed project, parking arrangement etc.
Traffic study of the area is given in Table 3.31, page no. 3-42 of chapter-3.
x. Detailed description of flora and fauna (terrestrial and aquatic) existing in the study area shall be given with special reference to rare, endemic and endangered species. If Schedule-I fauna are found within the study area, a Wildlife Conservation Plan shall be prepared and furnished.
Description of flora is given in Table 3.29, page no. 3-38 and fauna is given in table 3.30, page no. 3-40 of chapter-3.
xi. Socio-economic status of the study area.
Pls. refer sec. 3.14, page no. 3-20 of chapter-3 for socio-economic status of the study area.
7. Impact and Environment Management Plan i. Assessment of ground level
concentration of pollutants from the stack emission based on site-specific meteorological features. In case the project is located on a hilly terrain, the AQIP Modeling shall be done using inputs of the specific terrain characteristics for determining the potential impacts of the project on the AAQ. Cumulative impact of all sources of emissions (including transportation) on the AAQ of the area shall be assessed. Details of the model used and the input data used for modeling shall also be provided. The air quality contours shall be plotted on a location map showing the location of project site, habitation nearby, sensitive receptors, if any.
All the points mentioned are covered in cheapter-4 of EIA report. Cumulative impact of all sources of emissions on AAQ of the area is given in table 4.2, page no. 4-15. Pls. refer figure 4.1 to 4.3, page no. 4-19 to 4-21 for Isoplethsplotted on location map.
ii. Water Quality modeling - in case of discharge in water body.
Unit is not disposing w/w in water body so this point is not applicable.
iii. Impact of the transport of the raw materials and end products on the surrounding environment shall be assessed and provided. In this regard, options for transport of raw materials and finished products and wastes (large quantities) by rail or rail-cum
The road transport system will be utilized for this project is nearby village road, which is open at state highway (Dholka-Vataman) and is sufficient to accommodate the proposed expansion project. Rail or
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road transport or conveyor-cum-rail transport shall be examined.
conveyor transport system is not proposed in present scenario of development.
iv. A note on treatment of wastewater from different plant operations, extent recycled and reused for different purposes shall be included. Complete scheme of effluent treatment. Characteristics of untreated and treated effluent to meet the prescribed standards of discharge under E(P) Rules.
Pls. refer sec. 2.15.1, page no. 2-16 for effluent treatment process. Refer figure 2.2, page no. 2-44 for recycle/reuse details of treated effluent. Pls. refer table 2.9, page no. 2-33 for characteristics of untreated and treated effluent.
v. Details of stack emission and action plan for control of emissions to meet standards.
Pls. refer table 2.12, page no. 2-37 for stack emission and APCM details.
vi. Measures for fugitive emission control.
Pl. refer sec. 10.7.1.1, page no. 10-6 for fugitive emission control details.
vii. Details of hazardous waste generation and their storage, utilization and management.Copies of MOU regarding utilization of solid and hazardous waste in cement plant shall also be included.EMPshall include the concept of waste-minimization, recycle/reuse/recover techniques, Energy conservation,and natural resource conservation.
Pls. refer table 2.16, page no. 2-41 for hazardous waste generation & management. Copy of MOU with Ambuja Cement is attached as Annexure-II. Concept of waste-minimization, recycle/ reuse/ Energy conservation is given in sec. 10-9, page no. 10-16 of chapter-10.
viii. Proper utilization of fly ash shall be ensured as per Fly Ash Notification, 2009. A detailed plan of action shall be provided.
No generation of fly ash as FO is used as fuel.
ix. Action plan for the green belt development plan in 33% area i.e. land with not less than 1,500 trees per ha. Giving details of species, width of plantation, planning schedule etc. shall be included. The green belt shall be around the project boundary and a scheme for greening of the roads used for the project shall also be incorporated.
Detailed greenbelt development plan is given in sec. 10.8, page no. 10-14 of chapter-10.
x. Action plan for rainwater harvesting measures at plant site shall be submitted to harvest rainwater from the roof tops and storm, water drains to recharge the ground water and also to use for the various activities at the project site to conserve fresh water and reduce the water requirement from other sources.
Rainwater harvesting details are given in sec. 2.16; page no. 2-20 of chapter-2.
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EIA Report of Concord Biotech Ltd. 1-17
Sr. No.
Conditions Compliance
xi. Total capital cost and recurring cost/ annum for environmental pollution control measures shall be included.
Total capital cost and recurring cost/annum for environmental pollution control measures is given in sec. 2.4, page no. 2-2 for chapter-2.
xii. Action plan for post-project environmental monitoring shall be submitted.
Post-project environmental monitoring is given in Table 10.13, page no. 10-21.
xiii. Onsite and Offsite Disaster (natural and Man-made) Preparedness and Emergency Management Plan including Risk Assessment and damage control. Disaster management plan should be linked with District Disaster Management Plan.
Pls. refer sec. 7.19, page no. 7-32& sec. 7.24, page no. 7-42 for onsite& offsite emergency plan.
8. Occupational health: i. Plan and fund allocation to ensure the
occupational health & safety of all contract and casual workers.
It is covered in fund for EMS Table 10.3, page no. 10-22.
ii. Details of exposure specific health status evaluation of worker. If the workers' health is being evaluated by pre designed format, chest x rays, Audiometry, Spirometry, Vision testing (Far & Near vision, colour vision and any other ocular defect) ECG, during pre-placement and periodical examinations gives the details of the same. Details regarding last month analyzed data of above mentioned parameters as per age, sex, duration of exposure and department wise.
Pls. refer sec. 10.11, page no. 10-18 of chapter-10.
iii. Details of existing Occupational & Safety Hazards. What are the exposure levels of hazards and whether they are within Permissible Exposure Level (PEL)? If these are not within PEL, what measures the company has adopted to keep them within PEL so that health of the workers can be preserved.
Unit has done periodical medical checkup of its workers. As per the medical record, no adverse impact observed till date.
iv. Annual report of health status of workers with special reference to Occupational Health and Safety.
Unit maintains health record of workers. Health report of 2 workers is attached as Annexure-X.
9. Corporate Environment Policy i. Does the company have a well laid
down Environment Policy approved by its Board of Directors? If so, it may be detailed in the EIA report.
Yes, Environment policy of the unit is attached as Annexure-XI.
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EIA Report of Concord Biotech Ltd. 1-18
Sr. No.
Conditions Compliance
ii. Does the Environment Policy prescribe for standard operating process/ procedures to bring into focus any infringement/deviation/ violation of the environmental or forest norms / conditions? If so, it may be detailed in the EIA.
Yes
iii. What is the hierarchical system or Administrative order of the company to deal with the environmental issues and for ensuring compliance with the environmental clearance conditions? Details of this system may be given.
Details are given in Environment management cell sec. 10.5, page no. 10-2. Hierarchical system of the unit is given in figure 10.1, page no. 10-3.
iv. Does the company have system of reporting of non-compliances / violations of environmental norms to the Board of Directors of the company and / or shareholders or stakeholders at large? This reporting mechanism shall be detailed in the EIA report.
Pls. refer sec. 10.14, page no. 10-19 of chapter-10.
10. Details regarding infrastructure facilities such as sanitation, fuel, restroom etc. to be provided to the labor force during construction as well as to the casual workers including truck drivers during operation phase.
All facilities like sanitation, fuel, restroom etc. to be provided to the labor force during construction as well as to the casual workers including truck drivers during the operation phase.
11. Enterprise Social Commitment (ESC) i. Adequate funds (at least 2.5% of the
project cost) shall be earmarked towards the Enterprise Social Commitment based on Public Hearing issues and item-wise detailsalong with time bound action plan shall be included. Socio-economic development activities need to be elaborated upon.
Covered in sec. 10.12, on page no. 10-19 of EIA report.
12. Any litigation pending against the project and/or any direction/order passed by any Court of Law against the project, if so, details thereof shall also be included. Has the unit received any notice under the Section 5 of Environment (Protection) Act, 1986 or relevant Sections of Air and Water Acts? If so, details thereof and compliance/ATR to the notice(s) and present status of the case.
No
13. A tabular chart with index for point wise compliance of above TORs.
Done
14. The TORs prescribed shall be valid for Noted the point
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EIA Report of Concord Biotech Ltd. 1-19
Sr. No.
Conditions Compliance
a period of three years for submission of the EIA-EMP reports.
The following general points shall be noted: i. All documents shall be properly
indexed, page numbered. Noted and complied
ii. Period/date of data collection shall be clearly indicated.
Noted and complied
iii. Authenticated English Translation of all material in Regional languages shall be provided.
Noted and complied
iv. The letter/application for environmental clearance shall quote the MoEF file no. and also attach a copy of the letter.
Noted and complied
v. The copy of the letter received from Ministry shall be also attached as an annexure to the final EIA-EMP Report.
Complied ToR letter received from MoEFCC is attached as Annexure-XII.
vi. The index of the final EIA-EMP report must indicate the specific chapter and page no. of the EIA-EMP Report.
Noted and complied
vii. While preparing the EIA report, the instructions for the proponents and instructions for the consultants issued by MOEF vide O.M. No. J-11013/41/2006-IA.II (I) dated 4th August, 2009, which are available on the website of this Ministry shall also be followed.
Undertaking of proponent & consultant is enclosed as Annexure-XIII.
viii. The consultants involved in the preparation of EIA-EMP report after accreditation with Quality Council of India (QCI)/ National Accreditation Board of Education and Training (NABET) would need to include a certificate in this regard in the EIA-EMP reports prepared by them and data provided by other organization/ Laboratories including their status of approvals etc. Name of the Consultant and the Accreditation details shall be posted on the EIA-EMP Report as well as on the cover of the Hard Copy of the Presentation material for EC presentation.
NABET/QCI certificate is enclosed as Annexure-VI.
Issues/objections raised by the participants and responded to by the representative of the applicant during the Public Hearing: Sr. No.
Name and Address
Point Represented Reply from Project Proponent
1. Name: Hasmukhbhai B
• He expressed the gratitude of the company and said that
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EIA Report of Concord Biotech Ltd. 1-20
Patel Vill: Dholka
expansion in this company will create employment opportunities. This unit does not seem to consider highly polluting industry and it will create better development opportunity of Dholka and its surrounding area.
2. Name: Rajnikant Manilal Thakkar Vill: Dholka
• We have a business of ginning mill next to Concord biotech and we are residing close to the factory. We also have two ginning factories on the Trasad road and we are regularly passing through this area. For 20 years, we have not felt that there is any pollution or odor in the air. We have not seen pollution even when we go for Picnic with our family at a temple of BootBhavani Maata, which is near to factory. Water flowing nearby which is also not seem to polluted. We have no any kind of damage in terms of health due to this company till date. Expansion will generate employment. Educated people will get job, so the village of Dholka will be developed and benefitted.
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3. Name: Govind Dodiya Vill: Dholka
• Surrounding villages get benefits from Concord Biotech. We get benefit for expansion. There is no noticeable water or air pollution.
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4. Name: Snehlatta Patel Vill: Dholka
• How to dispose of waste water from this unit?
• Representative of the company's informed that, the main source of waste water generation is from the fermentation process; the second source is the Cooling bleed off and the Boiler Blow Down. The unit has a primary, secondary and tertiary unit treatment plant. Then it will be passed through RO, permeate is reused and reject is evaporated in MVR/MEE and condensate is recover and reuse. Hence at the end of process, no effluent is released outside the factory premises.
5. Name: Ranachhodbhai Maljibhai
• Our land is surrounding the Concord Biotech and unit is emitting Gas (air pollution)
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EIA Report of Concord Biotech Ltd. 1-21
Rabari Vill: Dholka
after 9 pm. In this regard, we have 2 times made application. 2 times negative report comes from Gujarat Pollution Control Board that they are generating pollution. I have copy of this report. 3rd time they said that, close this case. So 4th time I have taken online action to central level. We cannot live in our farm after 9 pm and we have threatened by saying that do whatever you want to. I have written papers of Gujarat Pollution Control Board in which it is mention that, there is an odour issue. Same papers I have submitted to Gandhinagar also. Now, if you wish, then we will migrate from here and leave this place.
6. Name: Hasmukhbhai Modi Vill: Dholka
• I have been working as the Secretary of GIDC industrial estate for last 17 years and if there is any question, we will immediately resolve mutually. We are doing any kind of work for the development of Dholka. Some elements are always objectionable & against the development. And if any new factory comes or expands in this area, their objections are immediately come in front. If they are facing any problem, then represent it, so we can resolve the problem. But we do not tolerate false objections against the development of our area.
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7. Name: Parimal H Rabari Vill: Dholka
• I have submitted complain in writing to stop toxic pollution generated by Concord Biotech. We cannot live in our farm which is adjoining to the unit, after 9 pm. Our workers cannot work after 9 pm in our farm. In this regard, I am giving you written application. Take strict action against this unit in this matter.
• Reply of written representation is attached with Minutes.
8. Name: Paresh Rathod Vill: Dadusar
• There is no noticeable pollution from Concord Biotech. No harm by this unit and around 700 to 800 people are getting employment since its inception. Due to closure of Kenco Overseas near Valthera, the employment of around 500-700 people was snatched off.
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EIA Report of Concord Biotech Ltd. 1-22
These workers have get employment in Concord Biotech. This unit is giving salary around Rs. 9000 to 10000 salary and PF. Apart from this, Concord Biotech provide free ambulance service along with free diagnosis & medicines. It is my opinion that, this company has progressed further. My personal request is to free develop Concord Biotech.
9. Name: Mahammad Yunus Ahemad Malik Vill: Renvad, Dholka
• My farm is adjacent to Concord Biotech in Survey No. 1491-1492. We are not against of development but we are against of spread of pollution.
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10. Name: Dhiren Patel Vill: Dholka
• It is true that Concord Biotech gives employment to everyone, but takes appropriate measures to control pollution along with employment.
---
11. Name: Ashwin D Jamod Vill: Jalalpur Godhaneshwar
• What steps will you take to control Air pollution?
• Representative of the company’s informed that, no air emission during process because this is a biotechnology process and if any poisonous substance present, then product cannot produce. This process is complete after 8 to 9 days once it starts and this process is done in closed reactor. Once it starts then it cannot be stopped in between and restarted again. So there is no air pollution until the process is over. This process is like the same process of fermentation we are doing at home.
• Chemical water comes out from the unit, so what safety measures will you take to avoid any harm to people?
• Representative of the company’s informed that, this process is fermentation based process, in which mainly edible substances like Soybean flour, Sucrose, Dextrose and edible oil are used and no inedible substance are used in it. If any inadequate substance is used, then the fermentation process does not go forward. w/w generated at the end of
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EIA Report of Concord Biotech Ltd. 1-23
this process has little TDS and high COD, which is bio degradable. It is treated in existing ETP and reuse after treatment. Not any w/w discharge outside the premises.
• What steps will you take to ensure that the people of the surrounding villages get jobs after its expansion?
• Representative of the company’s informed that, at present local people are preferred for employment and after expansion also local people will be given priority for employment.
14. Name: Janki Patel Vill: Dholka
• Explain briefly about the manufacturing of medicine from biotechnology.
• Representative of the company's informed that, this is a fermentation process in which certain types of Enzymes are used in specific types of medicine. It produces 1 to 2% of the drug. The process lasts for 8 to 10 days. The medicine made at the end of this process is extracted and purified. Fermentation is the main part of the process.
1.8 OBJECTIVE OF EIA
EIA is a policy and management tool for both planning and
decisionmaking. EIA assists in identification, prediction and evaluation of
theforeseeable environmental consequences of proposed developmental
andindustrial projects.
The objectives of the present EIA Study is to assess the impacts
onvarious environmental components due to the proposed project
activity, identify potential source of pollution, evaluate impact on
Production Plant – 15 (Fermentation) 1 Fermenter 3 nos. 15 KL each 2 Seed Tank 4 nos. 1.5 KL each 3 Media Preparation Tank 1 no. 5.0 KL 4 Inoculum Tank 3 nos. 100 Ltr. each
Production Plant – 16 (Recovery) 1 Reactor 4 no. 500 Ltr. each
Noise is anticipated from boilers, machineries, D. G. set, reactors etc. The
D. G. set shall be kept in a separate room with acoustic enclosure. The
motors and compressors shall be mounted properly to ensure the
reduction of noise and vibration. The employees working in noise
generating areas shall be provided with appropriate Personnel Protective
Equipments (PPEs). The greenbelt area will be developed within industrial
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EIA Report of Concord Biotech Ltd. 2-20
premises and around the periphery to prevent the noise pollution in
surrounding area.
2.16 RAIN WATER HARVESTING
Rainwater harvesting is the accumulation and deposition of rainwater for
reuse on-site, rather than allowing it to run off. It is widely used system
throughout the world. Rain water from terraces/rooftop areas shall be
collected through rain water down-take pipes & collected to catch basins
or stored in rain water tanks. However, the rain water from plant area
and parking area may contaminated and not advise to collect directly to
catch basins. Rain water harvesting pits shall be provided wherever
feasible so that maximum rain water recharged into the ground before it
reaches the storm water mains.
In designing any Rainwater harvesting structure, capturing rainfall and
runoff for local use is the key concept. Hard surface such as roof
pavements and roads that decrease groundwater percolation constitute
catchments and generate the high runoff which has to be diverted into
the storage tank & recharged into ground water regime through simple
filtration & injection well system for subsequent extraction by service
wells. To improve water availability, rainwater harvesting is the most
imminent & short-term solution.In view of above, rainwater harvesting
structures at this point can serve the purpose of arresting roof top
rainwater and runoff generated through roads in the area. The design is
based on average annual rainfall and its intensity and the intake capacity
of the water by the aquifers.
Design of Rain Water Harvesting:
For good design of rainwater harvesting, following points are to be kept
under consideration:
• Ideal location with good ground slope
• The location has adequate subsurface permeability of the aquifer to
accommodate maximum recharge of rainwater through injection
well.
• Rate of filtration should exceed average rainfall intensity.
• Clogging of filtration media should be cleaned periodically.
• Ground water pollution does not take place.
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EIA Report of Concord Biotech Ltd. 2-21
Schematic design of rooftop rainwater harvesting structure at Concord Biotech Ltd. plant premises
Schematic design of road and open area rainwater harvesting structure at Concord Biotech Ltd. Plant premises
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EIA Report of Concord Biotech Ltd. 2-22
2.17 GREEN BELT DEVELOPMENT
The unit has done extensive plantation in 23653 m2 in its existing unit
and some more area of about 61347m2 will be added for greenbelt
development. After expansion, total area of greenbelt area will be 85000
m2which will be more than 33% of total land area.
2.18 OCCUPATIONAL HEALTH & SAFETY
The company is concerned with the health, safety and environment
protection. The company will formulate and develop an ‘Occupational
Health & Safety Policy’ to ensure good health and safety of its employees.
Following key safety measures shall be a part of the Health & Safety
policy of the company and shall be followed after the project
implementation.
• Safety Training shall be provided to the employees.
• Safety Sirens with Alarm System in case of emergency shall be
provided.
• Fire Hydrant System shall be installed.
• Fire Extinguishers shall be provided.
• Mock drills shall be periodically conducted and factors like response
time shall be evaluated.
• First Aid Facility and training shall be provided.
• Personnel protective Equipment shall be provided to the employees.
• Health check-ups shall be organized at regular intervals.
• Safety/Health records and MSDS shall be maintained.
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EIA Report of Concord Biotech Ltd. 2-23
Table 2.6
Raw Material Consumption, Source & transportation details
Sr. No.
Name of Product Quantity (MTPA) Source Transportation Existing Proposed Total
A Enzyme 1 Penicillin G Amidase Enzyme - 25.0 MTPA 1 Constip liquor 0.214 0.143 0.357 Local By road 2 Ammo solution 42.857 28.572 71.429 Local By road 3 Potassium Phosphate 2.143 1.428 3.571 Local By road 4 Sodium Phosphate 2.143 1.428 3.571 Local By road 5 MgSO4 0.214 0.143 0.357 Local By road 6 CaCl2 0.043 0.028 0.071 Local By road 7 Sugar 32.143 21.428 53.571 Local By road 8 NaCl 8.571 5.715 14.286 Local By road 9 Glutar 2.143 1.428 3.571 Local By road 10 Polymin 2.143 1.428 3.571 Local By road 11 Ammonia 3.214 2.143 5.357 Local By road 12 NaOH 0.857 0.572 1.429 Local By road B Antibiotic 2 Vancomycin - 4.0 MTPA 1 Dextrose 0.252 0.084 0.336 Local By road 2 Dextrine 15.126 5.042 20.168 Local By road 3 Potato Protein 3.630 1.21 4.840 Local By road 4 CaCO3 0.227 0.076 0.303 Local By road 5 Soya flour 3.630 1.21 4.840 Local By road 6 Salt minerals 0.252 0.084 0.336 Local By road 7 Ethanol 0.378 0.126 0.504 Local By road 8 IPA 0.378 0.126 0.504 Local By road 3 Teicoplanin - 2.0 MTPA 1 Dextrose 14.857 14.857 29.714 Local By road 2 Dextrine 48.571 48.572 97.143 Local By road 3 Cotton seed flour 22.714 22.715 45.429 Local By road 4 CaCO3 1.786 1.785 3.571 Local By road 5 Soya flour 22.714 22.715 45.429 Local By road 6 Salt minerals 3.571 3.572 7.143 Local By road 7 Ethanol 1.429 1.428 2.857 Local By road 4 Daptomycin - 0.5 MTPA 1 Dextrose 1.833 0.0 1.833 Local By road 2 Dextrine 12.500 0.0 12.500 Local By road 3 CaCO3 0.156 0.0 0.156 Local By road 4 Soya flour 0.292 0.0 0.292 Local By road 5 Salt minerals 0.156 0.0 0.156 Local By road 6 IPA 0.417 0.0 0.417 Local By road 5 Fidaxomycin - 3.0 MTPA 1 Dextrose 7.364 0.0 7.364 Local By road 2 Tapioca Starch 21.545 0.0 21.545 Local By road 3 Soybean flour 8.018 0.0 8.018 Local By road 4 Veg Peptone 4.364 0.0 4.364 Local By road 5 Yeast Extract 6.000 0.0 6.000 Local By road 6 Minerals 2.182 0.0 2.182 Local By road 7 Ethyl acetate 0.927 0.0 0.927 Local By road 8 Isopropyl alcohol 0.655 0.0 0.655 Local By road 9 Methanol 3.273 0.0 3.273 Local By road
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EIA Report of Concord Biotech Ltd. 2-24
6 Mupirocin& salts - 8.5 MTPA 1 Dextrose Monohydrate 15.714 6.548 22.262 Local By road 2 Soybean meal 16.057 6.691 22.748 Local By road 3 Wheat Gluten meal 4.857 2.024 6.881 Local By road 4 Corn Syrup powder 4.571 1.905 6.476 Local By road 5 Salt & minerals 2.000 0.833 2.833 Local By road 6 Antifoam (Silicon) 0.286 0.119 0.405 Local By road 7 Ethyl acetate 0.103 0.043 0.146 Local By road 8 Sulphuric acid 0.686 0.285 0.971 Local By road 9 Sodium bicarbonate 2.857 1.191 4.048 Local By road 10 n-heptane 0.286 0.119 0.405 Local By road 7 Fosfomycin - 1.0 MTPA 1 Fosfomycinphenylethyl amine 1.600 0.0 1.600 Local By road 2 25 % sodium hydroxide
solution 1.250
0.0 1.250
Local By road
3 MIBK - Methyl isobutyl ketone 0.500 0.0 0.500 Local By road 4 Activated carbon 0.050 0.0 0.050 Local By road 5 Hyflow 0.050 0.0 0.050 Local By road 8 Dalbavancin - 0.5 MTPA 1 Yeast Extract 1.667 0.0 1.667 Local By road 2 Yeast autolysate 1.667 0.0 1.667 Local By road 3 Peptone 1.667 0.0 1.667 Local By road 4 Dextrose Monohydrate 1.667 0.0 1.667 Local By road 5 Sodium chloride 0.500 0.0 0.500 Local By road 6 Calcium carbonate 0.667 0.0 0.667 Local By road 7 n-butanol 1.000 0.0 1.000 Local By road 8 Ethyl acetate 0.833 0.0 0.833 Local By road 9 Telavancin - 0.5 MTPA 1 Soya flour 2.500 0.0 2.500 Local By road 2 Potato protein 2.500 0.0 2.500 Local By road 3 Calcium Chloride 2.500 0.0 2.500 Local By road 4 Sodium Chloride 1.500 0.0 1.500 Local By road 5 Maltodextrin 1.000 0.0 1.000 Local By road 6 Mineral salts 1.500 0.0 1.500 Local By road 7 Isobutyl acetate 1.500 0.0 1.500 Local By road
10 Capreomycin - 0.1 MTPA 1 Bacto Peptone 0.417 0.0 0.417 Imported Sea 2 Casamino acid 0.208 0.0 0.208 Imported Sea 3 Cerelose 1.250 0.0 1.250 Local By road 4 Magnesium sulphate 0.250 0.0 0.250 Local By road 5 Ferrous sulphate 0.000 0.0 0.000 Local By road 6 Calcium Chloride 0.021 0.0 0.021 Local By road 7 Ethyl acetate 2.917 0.0 2.917 Local By road 8 n-Heptane 0.075 0.0 0.075 Local By road
11 Tobramycin Sulphate - 2.5 MTPA 1 Starch 8.102 0.0 8.102 Local By road 2 Soya peptone 20.833 0.0 20.833 Local By road 3 Dextrose 23.380 0.0 23.380 Local By road 4 Corn Gluten 13.889 0.0 13.889 Local By road 5 Soya flour 19.676 0.0 19.676 Local By road 6 Soyabean Oil 2.315 0.0 2.315 Local By road 7 Calcium Carbonate 1.111 0.0 1.111 Local By road 8 Magnesium Sulphate 0.278 0.0 0.278 Local By road 9 Ammonium Chloride 0.278 0.0 0.278 Local By road
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10 Zinc Sulphate 0.056 0.0 0.056 Local By road 11 Ethyl acetate 6.944 0.0 6.944 Local By road 12 Oritavancin - 0.5 MTPA 1 Dextrose 7.500 0.0 7.500 Local By road 2 soyabean Flour 4.500 0.0 4.500 Local By road 3 Potato Protin 9.000 0.0 9.000 Local By road 4 CaCO3 0.750 0.0 0.750 Local By road 5 Corn Steep Liquid 0.900 0.0 0.900 Local By road 6 PPG 2000 0.900 0.0 0.900 Local By road 7 Soya Peptone 1.500 0.0 1.500 Local By road 8 Antifoam 0.600 0.0 0.600 Local By road 9 Methanol 3.000 0.0 3.000 Local By road 10 Isopropyl alcohol 0.050 0.0 0.050 Local By road 11 Chlorobiphenylcarboxaldehyde 0.900 0.0 0.900 Local By road C Antiparasitic
13 Milbemycinoxime - 1.9 MTPA 1 Sucrose 10.000 9.000 19.000 Local By road 2 Yeast extract 7.000 6.300 13.300 Local By road 3 Soya flour 5.000 4.500 9.500 Local By road 4 Magnesium sulphate 1.000 0.900 1.900 Local By road 5 Di-potassium hydrogen
phosphate 0.300 0.270 0.570 Local By road
6 Calcium carbonate 2.000 1.800 3.800 Local By road 7 Ferrous sulphate 0.030 0.027 0.057 Local By road 8 Ethyl acetate 22.500 20.250 42.750 Local By road 9 Isopropyl alcohal 1.750 1.575 3.325 Local By road D Antifungal 14 Pneumocandin Bo - 0.2 MTPA 1 Dextrose 0.536 0.0 0.536 Local By road 2 KH2PO4 0.518 0.0 0.518 Local By road 3 Corn Steep Liquor 0.054 0.0 0.054 Local By road 4 Trace Salt Solution 0.007 0.0 0.007 Local By road 5 L-Proline 0.893 0.0 0.893 Local By road 6 Antifoam 0.001 0.0 0.001 Local By road 7 Methanol 0.071 0.0 0.071 Local By road 8 Acetonitrile 0.357 0.0 0.357 Local By road 9 Salts and Minerals 0.054 0.0 0.054 Local By road 10 IBA 3.036 0.0 3.036 Local By road 11 Acetonitrile 0.036 0.0 0.036 Local By road 15 Caspofungin - 0.2 MTPA 1 PnBo 0.318 0.0 0.318 Local By road 2 DMF 0.318 0.0 0.318 Local By road 3 CyCl2 0.064 0.0 0.064 Local By road 4 Ammonium acetate 0.229 0.0 0.229 Local By road 5 Catalyst 0.032 0.0 0.032 Local By road 6 Acetonitrile 21.975 0.0 21.975 Local By road
16 Micafungin - 0.93 MTPA 1 FR 901379 Nucleus 7.440 0.0 7.440 Local By road 2 Side Chain 5.580 0.0 5.580 Imported Sea 3 DMAP 6.045 0.0 6.045 Local By road 4 DMF 0.465 0.0 0.465 Local By road 5 Ethyl acetate 0.223 0.0 0.223 Local By road
17 Anidulafungin - 0.65 MTPA 1 Echinocandin Nucleus 0.975 0.0 0.975 Local By road
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2 Side Chain 0.429 0.0 0.429 Imported Sea 3 KH2PO4 0.163 0.0 0.163 Local By road 4 Acetone 0.910 0.0 0.910 Local By road E Immunosuppressant
18 Tacrolimus - 1.0 MTPA 1 Dextrose 143.542 0.0 143.542 Local By road 2 Dextrin 229.167 0.0 229.167 Local By road 3 Milk 0.313 0.0 0.313 Local By road 4 CaCO3 2.396 0.0 2.396 Local By road 5 Soya Peptone 15.625 0.0 15.625 Local By road 6 Yeast extract 10.417 0.0 10.417 Local By road 7 Proteose peptone 0.313 0.0 0.313 Imported Sea 8 Sodium acetate 11.875 0.0 11.875 Local By road 9 PEG 400 5.938 0.0 5.938 Local By road 10 Citric acid 24.063 0.0 24.063 Local By road 11 Salt & minerals 4.167 0.0 4.167 Local By road 12 Toluene 208.333 0.0 208.333 Local By road 13 Acetone 2.083 0.0 2.083 Local By road 14 Ethyl acetate 2.083 0.0 2.083 Local By road 19 Mycophenolic Acid - 0.5 MTPA 1 Dextrose 9.444 0.0 9.444 Local By road 2 Glycine 0.611 0.0 0.611 Local By road 3 Methionone 0.024 0.0 0.024 Local By road 4 Salts and minerals 0.556 0.0 0.556 Local By road 5 IBA 1.250 0.0 1.250 Local By road 6 Activated carbon 0.025 0.0 0.025 Local By road
20 Cyclosporine - 7.0 MTPA 1 Dextrose 4.00 0.0 4.000 Local By road 2 Fructose 480.00 0.0 480.000 Local By road 3 Soyaflour 4.00 0.0 4.000 Local By road 4 L-valine 50.00 0.0 50.000 Local By road 5 L-leucine 40.00 0.0 40.000 Local By road 6 Corn steep liquor 0.70 0.0 0.700 Local By road 7 Salt & minerals 30.00 0.0 30.000 Local By road 8 Toluene 160.00 0.0 160.000 Local By road 9 Acetone 2.00 0.0 2.000 Local By road 10 Methanol 2.00 0.0 2.000 Local By road 11 Cyclohexane 2.00 0.0 2.000 Local By road 21 Rapamycin - 0.5 MTPA 1 Dextrose 7.50 5.000 12.500 Local By road 2 Dextrin 420.00 280.000 700.000 Local By road 3 Soyaflour 243.75 162.500 406.250 Local By road 4 CaCO3 5.63 3.745 9.375 Local By road 5 Soyapeptone 28.13 18.745 46.875 Local By road 6 Yeast Extract 0.75 0.500 1.250 Local By road 7 Proteose peptone 0.75 0.500 1.250 Local By road 8 NaCl 22.50 15.000 37.500 Local By road 9 Citric acid 18.75 12.500 31.250 Local By road 10 PEG 400 15.00 10.000 25.000 Local By road 11 Salts minerals 7.50 5.000 12.500 Local By road 12 Toluene 300.00 200.000 500.000 Local By road 13 Acetone 3.75 2.500 6.250 Local By road 14 Ethyl acetate 3.75 2.500 6.250 Local By road 22 MycophenolateMofetill&Mycophenolate sodium - 113.0 MTPA
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EIA Report of Concord Biotech Ltd. 2-27
(a) MycophenolateMofetil 1 IBA 48.000 72.533 120.533 Local By road 2 Xylene 36.000 54.400 90.400 Local By road 3 Dipyridyl carbonate 6.000 9.067 15.067 Local By road 4 Sodium bicarbonate 5 %sol 3.900 5.893 9.793 Local By road 5 Acetone 9.000 13.600 22.600 Local By road 6 Activated Carbon 3.000 4.533 7.533 Local By road Or (b) Mycophenolate Sodium 1 Acetone 20.833 31.482 52.315 Local By road 2 Sodium 2 Ethyl Hexanoic acid 25.000 37.778 62.778 Local By road F Oncology
23 Ixabepilone - 0.1 MTPA 1 Epothilone B 0.20 0.0 0.200 Imported Sea 2 Tetrabis (TPP) Palladium 0.001 0.0 0.001 Imported Sea 3 Sodium azide 0.038 0.0 0.038 Local By road 4 Triphenyl phosphine 0.10 0.0 0.100 Local By road 5 Diphenylphosphorylazide 0.03 0.0 0.030 Local By road 6 Ethyl acetate 0.50 0.0 0.500 Local By road
24 Romidepsin - 0.1 MTPA 1 Dextrose 1.000 0.0 1.000 Local By road 2 Glycerol 0.083 0.0 0.083 Local By road 3 Yeast extract 0.250 0.0 0.250 Local By road 4 Corn starch 0.200 0.0 0.200 Local By road 5 Ammonium Sulphate 0.008 0.0 0.008 Local By road 6 Magnesium sulphate 0.005 0.0 0.005 Local By road 7 Potassium Di Hydrogen
phosphate 0.042 0.0 0.042 Local By road
8 Sodium Chloride 0.050 0.0 0.050 Local By road 9 Isobutyl acetate 0.250 0.0 0.250 Local By road
25 Temsirolimus - 0.05 MTPA 1 Sirolimus 0.060 0.0 0.060 Local By road 2 Dichloromethane 0.064 0.0 0.064 Local By road 3 Side Chain 0.080 0.0 0.080 Imported Sea 4 DMAP 0.020 0.0 0.020 Local By road 5 Hydrochloric acid 0.010 0.0 0.010 Local By road 6 Tetrahydro furan 0.024 0.0 0.024 Local By road 7 n-Heptane 0.024 0.0 0.024 Local By road
26 Everolimus - 1.0 MTPA 1 Sirolimus 0.720 0.480 1.200 Local By road 2 Toluene 0.384 0.256 0.640 Local By road 3 2-(t-butyldimethylsilyl)
oxyethyltriflate) 0.480 0.320 0.800 Local By road
4 2,6-lutidine 0.300 0.200 0.500 Local By road 5 Methanol 0.156 0.104 0.260 Local By road 6 Formic acid 0.060 0.040 0.100 Local By road 7 Dichloromethane 0.480 0.320 0.800 Local By road 8 n-Heptane 0.210 0.140 0.350 Local By road
27 Ridaforolimus - 0.05 MTPA 1 Sirolimus 0.063 0.0 0.063 Local By road 2 Dimethyl PhosphonicChloride 0.019 0.0 0.019 Local By road 3 Pyridine 0.006 0.0 0.006 Local By road 4 Dichloromethane 0.063 0.0 0.063 Local By road 5 N-Hexane 0.035 0.0 0.035 Local By road 6 Sodium bicarbonate 0.025 0.0 0.025 Local By road
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EIA Report of Concord Biotech Ltd. 2-28
28 Pimecrolimus - 0.5 MTPA 1 Ascomycin 0.750 0.0 0.750 Local By road 2 Toluene 1.000 0.0 1.000 Local By road 3 Acetonitrile 0.675 0.0 0.675 Local By road 4 Trifloromethane sulfonic
anhydride 0.325
0.0 0.325
Local By road
5 Ethyldiisopropylamine 0.250 0.0 0.250 Local By road 6 Benzenetriethylammonim
chloride 1.000
0.0 1.000
Local By road
7 Acetone 0.675 0.0 0.675 Local By road 29 Doxorubicin - 0.85 MTPA 1 Bromodunarubicin 6.000 2.500 8.500 Imported Sea 2 Acetone 4.500 1.875 6.375 Local By road 3 Dichromethane 3.600 1.500 5.100 Local By road 4 Hydrobromic acid 0.750 0.313 1.063 Local By road
30 Daunorubicin - 0.6 MTPA 1 Yeast powder 2.592 0.864 3.456 Local By road 2 Soluble starch 1.800 0.6 2.400 Local By road 3 Yeast extract 0.540 0.18 0.720 Local By road 4 Sodium Chloride 0.360 0.12 0.480 Local By road 5 Calcium carbonate 0.540 0.18 0.720 Local By road 6 Mineral salt 0.216 0.072 0.288 Local By road 7 Oxalic acid 0.360 0.12 0.480 Local By road 8 Acetone 0.216 0.072 0.288 Local By road 9 Methanol 0.405 0.135 0.540 Local By road
31 Epirubicin - 0.2 MTPA 1 Epi-TFA daunorubicin 0.300 0.0 0.300 Imported Sea 2 Sodium hydroxide 0.040 0.0 0.040 Local By road 3 Dichloromethane 0.400 0.0 0.400 Local By road 4 n-Hexane 0.200 0.0 0.200 Local By road
32 Idarubicin - 0.1 MTPA 1 Corn Gluten 0.740 0.0 0.740 Local By road 2 Cotton seed meal 0.490 0.0 0.490 Local By road 3 Glucose 0.750 0.0 0.750 Local By road 4 Glycerol 0.750 0.0 0.750 Local By road 5 Yeast Extract 0.500 0.0 0.500 Local By road 6 Calcium Carbonate 0.200 0.0 0.200 Local By road 7 MIBK - Methyl isobutyl ketone 0.675 0.0 0.675 Local By road 8 Actonitrile 0.090 0.0 0.090 Local By road
33 Bleomycin - 0.1 MTPA 1 Starch 1.250 0.0 1.250 Local By road 2 Glucose 0.833 0.0 0.833 Local By road 3 Soyameal 1.250 0.0 1.250 Local By road 4 Di potassium hydrogen
phosphate 0.167
0.0 0.167
Local By road
5 Zinc Sulphate 0.083 0.0 0.083 Local By road 6 Copper sulphate 0.167 0.0 0.167 Local By road 7 Corn steep liquor 0.500 0.0 0.500 Local By road 8 Ethyl acetate 2.083 0.0 2.083 Local By road
34 Geldanamycin - 0.1 MTPA 1 Starch 1.667 0.0 1.667 Local By road 2 Cotton seed meal 0.417 0.0 0.417 Local By road 3 Glucose 0.417 0.0 0.417 Local By road 4 Corn steep liquor 0.833 0.0 0.833 Local By road
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EIA Report of Concord Biotech Ltd. 2-29
5 Yeast Extract 0.417 0.0 0.417 Local By road 6 Calcium Carbonate 0.167 0.0 0.167 Local By road 7 MIBK 0.208 0.0 0.208 Local By road 8 Ethyl acetate 0.125 0.0 0.125 Local By road
35 Mitomycin - 0.1 MTPA 1 Dextrose 0.0 0.900 0.900 Local By road 2 Starch 0.0 2.250 2.250 Local By road 3 Soyabean Flour 0.0 1.350 1.350 Local By road 4 Dry Yeast 0.0 0.225 0.225 Local By road 5 CaCO3 0.0 0.675 0.675 Local By road 6 Corn Steep Liquid 0.0 0.450 0.450 Local By road 7 Yeast Extarct 0.0 0.270 0.270 Local By road 8 K2HPO4 0.0 0.900 0.900 Local By road 9 MgSO4.7H2O 0.0 0.045 0.045 Local By road 10 Antifoam 0.0 0.045 0.045 Local By road 11 Phosphoric acid 0.0 0.050 0.050 Local By road 12 Ethyl acetate 0.0 0.400 0.400 Local By road 13 Methanol 0.0 0.550 0.550 Local By road 36 Dactinomycin - 0.1 MTPA 1 Dextrose 0.0 1.000 1.000 Local By road 2 Starch 0.0 1.750 1.750 Local By road 3 Soyabean Powder 0.0 1.000 1.000 Local By road 4 Dry Yeast 0.0 0.500 0.500 Local By road 5 CaCO3 0.0 0.250 0.250 Local By road 6 (NH4)2SO4 0.0 0.250 0.250 Local By road 7 Yeast Extract 0.0 0.250 0.250 Local By road 8 K2HPO4 0.0 0.050 0.050 Local By road 9 Antifoam 0.0 0.050 0.050 Local By road 10 Toluene 0.0 0.350 0.350 Local By road 11 Acetone 0.0 0.040 0.040 Local By road 12 Diisopropylether 0.0 0.010 0.010 Local By road 37 Trabectedin - 0.1 MTPA 1 Dextrose 0.0 1.200 1.200 Local By road 2 Manitol 0.0 2.400 2.400 Local By road 3 Yeast Extract 0.0 1.200 1.200 Local By road 4 (NH4)2SO4 0.0 0.600 0.600 Local By road 5 K2HPO4 0.0 0.240 0.240 Local By road 6 KCl 0.0 0.480 0.480 Local By road 7 FeCl3 0.0 0.001 0.001 Local By road 8 L-Glycine 0.0 0.060 0.060 Local By road 9 CaCO3 0.0 0.480 0.480 Local By road 10 PPG 2000 0.0 0.030 0.030 Local By road 11 Antifoam 0.0 0.120 0.120 Local By road 12 Sodium Hydroxide 0.0 0.010 0.010 Local By road 13 Ethyl acetate 0.0 0.400 0.400 Local By road 14 Methanol 0.0 0.040 0.040 Local By road 15 Acetonitrile 0.0 0.010 0.010 Local By road 16 Silver Nitrate 0.0 0.120 0.120 Local By road G Statin 38 Lovastatin - 6.0 MTPA 1 Dextrose 182.609 -26.087 156.522 Local By road 2 Sucrose 0.350 -0.05 0.300 Local By road 3 Milk 29.217 -4.174 25.043 Local By road 4 CaCO3 3.652 -0.522 3.130 Local By road
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EIA Report of Concord Biotech Ltd. 2-30
5 Soyabean flour 12.783 -1.826 10.957 Local By road 6 Yeast Extract 0.091 -0.013 0.078 Local By road 7 Preotease peptone 0.091 -0.013 0.078 Local By road 8 Sodium acetate 3.652 -0.522 3.130 Local By road 9 PEG 400 1.522 -0.218 1.304 Local By road 10 Citric acid 6.087 -0.87 5.217 Local By road 11 Salt & minerals 1.522 -0.218 1.304 Local By road 12 Toluene 41.391 -5.913 35.478 Local By road 13 IPA 1.217 -0.174 1.043 Local By road 14 Activated Carbon 0.335 -0.048 0.287 Local By road 39 Pravastatin - 1.0 MTPA 1 Dextrose 7.738 0.0 7.738 Local By road 2 Cotton seed meal 0.818 0.0 0.818 Local By road 3 NaCl 1.563 0.0 1.563 Local By road 4 CaCO3 0.744 0.0 0.744 Local By road 5 Soyabean flour 7.887 0.0 7.887 Local By road 6 Corn steep liquor 1.563 0.0 1.563 Local By road 7 Salt & minerals 0.372 0.0 0.372 Local By road 8 IBA 17.113 0.0 17.113 Local By road 9 IPA 0.372 0.0 0.372 Local By road 10 Acetonitrile 0.744 0.0 0.744 Local By road 11 Activated Carbon 0.104 0.0 0.104 Local By road 40 Orlistat - 2.0 MTPA 1 Glycerol 3.810 0.0 3.810 Local By road 2 Soya Floor 7.619 0.0 7.619 Local By road 3 Yeast Extract Powder 0.060 0.0 0.060 Local By road 4 Gluten Flour 1.667 0.0 1.667 Local By road 5 Sun Flower Oil 1.905 0.0 1.905 Local By road 6 ZnSO4 0.024 0.0 0.024 Local By road 7 Calcium Carbonate 0.024 0.0 0.024 Local By road 8 Vitamin C 0.030 0.0 0.030 Imported Sea 9 Vitamin E 0.030 0.0 0.030 Imported Sea 10 Catalyst 0.060 0.0 0.060 Imported Sea 11 n-Haptane 13.333 0.0 13.333 Local By road
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EIA Report of Concord Biotech Ltd. 2-31
Table 2.7
Details of water consumption &wastewater generation
Water consumption
Sr. No.
Usage Existing Water Consumption
(KLD)
Total Water Consumption after expansion (KLD)
1 Domestic 25 60
2 Gardening 190* 399*
3 Industrial i) Water treatment 90 08
ii) Process 60 125
iii) R & D 4.5 10
iv) Washing 50** 50
v) Cooling 40 168
vi) Boiler 130 135
Total Industrial 374.5 496 Total (I+II+III) 589.5 955
Less recycle 240 399 Actual fresh water
requirement 349.5 556
Source of water supply: Borewell
* Treated water utilize for greenbelt
** Reject from water treatment utilize for washing
Wastewater Generation
Sr. No.
Usage Existing wastewater Generation
(KLD)
Total w/w generation after
expansion (KLD)
1 Domestic 20 48
2 Industrial i) Water treatment 40 03
ii) Process 55 240
iii) R & D 04 08
iv) Washing 50 50
v) Cooling 20 40
vi) Boiler 21 10
Total Industrial 190 351 Total (I+II) 210 399
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EIA Report of Concord Biotech Ltd. 2-32
Table 2.8
Size and dimension of Effluent Treatment Plant
Sr. No.
Name of Unit MOC Capacity (m3)
Size Dimension (m)
Quantity
1 Collection Tank (01 No.) RCC 20.83 Dia.6.0 x 2.0 1
2 Oil & Grease Trap (01 No.) RCC 18.75 8.0 x 2.0 x 1.2 1
Quantity (MTPM) Disposal method Existing Proposed Total
1 ETP Sludge& MEE salt
35.3 60.0
50.0 + 27.0 (MEE
salt)
137.0 Collection, Storage, decontamination, Transportation, Disposal at SEPPL-TSDF site Kutch.
2 Distillation residue
20.3 12.00 8.0 20.0 Collection, Storage, decontamination, Transportation, Disposal by Incineration at CHWIF of SEPPL-Kutch. Or Co-process at RSPL-Panoli
3 Spent Carbon
28.3 7.234 4.766 12.0 Collection, Storage, decontamination, Transportation, Disposal by Incineration at CHWIP of SEPPL-Kutch Or Co-process at RSPL-Panoli/Co-processing at Ambuja Cement Ltd.
4 Discarded Container
33.1 3000 Nos./ month
2000 Nos./mon
th
5000 Nos./ month
Collection, Storage, decontamination, Transportation, Disposal by selling to authorized recycler or reuse.
5 Used oil -- 1.596 MT/yr.
1.404 MT/yr.
3.00 MT/yr.
Collection, storage, transportation, disposal by selling registered recycler.
6 Off specification Product & date expire product
28.4 & 28.5
-- Whatever generated
Whatever generated
Collection, Storage, decontamination, Transportation, Disposal of SEPPL-Kutch or Co-process at RSPL-Panoli.
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EIA Report of Concord Biotech Ltd. 2-42
Table 2.17
Estimated Characteristics of Hazardous waste
S. No.
Parameters Unit Result (ETP Sludge)
AS IS BASIS 1. Moisture (%) - 20.4
2. Ether Soluble gm/Kg 0.96
3. TIS at 5500C gm/Kg 655
WATER LEACHATE (10% Solution in Distilled Water) 1. pH pH Unit 7.5
2. Sulphate gm/Kg 11.3
3. Chloride gm/Kg 10.5
4. Total Alkalinity gm/Kg 6.8
5. Total Dissolved Solid gm/Kg 27.1
6. COD gm/Kg 5.9
7. Iron gm/Kg 1.12
8. Total Chromium gm/Kg <0.01
9. Hexavalent Chromium gm/Kg <0.01
10. Total Nitrogen (as N) % 5.42
11. Total Phosphate (as P2O5) % 4.29
ACID LEACHATE 1. Iron gm/Kg 41.3
2. Total Chromium gm/Kg <0.01
3. Hexavalent Chromium gm/Kg <0.01
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EIA Report of Concord Biotech Ltd. 2-43
Figure 2.1
Water Balance Diagram (Existing)
Total Water Consumption = 589.5 KLD (fresh water - 349.5 KLD + Recycle water – 240 KLD)
Industrial 324.5
Domestic 25
Soak pit 20
Water treatment 324.5
Reject 90
Water used 234.5
Washing 50
Process 60
Boiler 130
Cooling 40
ETP 55+4+21+20+40+50 = 190
Bleed off 20
50
55
R & D 4.5
4.0
21
40
50
Used for Greenbelt development within
premises
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EIA Report of Concord Biotech Ltd. 2-44
Figure 2.2 Water Balance Diagram (after expansion)
Total Water Consumption – 955 KLD (fresh water - 556 KLD + Recycle water – 399 KLD)
Industrial 496
Domestic 60
Process 125
Boiler 135
ETP 48+240+8+10+50+40+3 = 399
240
R & D 10
8.0
Water treatment (DM/softener) 43
48
Direct steam inject 120
Indirect heating
10
Greenbelt (total greenbelt area 85000 sqm)
Water treatment (1st stage RO) 453
Reject (2st stage RO) 133
Product water 320
Permeate 80
Reject 53
Blow down
Washing 50
50
MVR/MEE 53
Condensate 48
Salt 0.9
Loss 4.1
Cooling 80+48+40
= 168
40
Blow down Bleed off 40
3
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EIA Report of Concord Biotech Ltd. 2-45
Figure 2.3
ETP flow Diagram
San Envirotech Pvt. Ltd., Ahmedabad
EIA Report of Concord Biotech Ltd. 2-46
Figure 2.4
Schematic Diagram of Solvent Recovery System
Addition Tank
Reaction Vessel
Distillation Colum
Receiving Tank
Chillcondenser
Chillcondenser
Spent Solvent
Aquarius Layer
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EIA Report of Concord Biotech Ltd. 2-47
Figure 2.5 Plant Layout
San Envirotech Pvt. Ltd., Ahmedabad
EIA Report of Concord Biotech Ltd. 3-1
Chapter-3 Description of Environment
3.1 GENERAL
To assess environmental impacts from proposed project at a specific
location, it is essential to monitor the existing environmental quality
prevailing in the surrounding area prior to implementation of the project.
The environmental status within the impact zone could be used for
identification of significant environmental issues to be addressed in the
impact assessment study. Baseline data generation forms a part of the
Environmental Impact Assessment (EIA) study and helps to evaluate the
predicted impacts on the various environmental attributes in the study
area by using scientifically developed and widely accepted impact
assessment methodologies.
This section contains the description of baseline studies of 10 km radius
surrounding the project site. The baseline study was carried out to
understand following environmental parameters.
• Land Environment
• Meteorology
• Air Environment
• Water Environment
• Soil Environment
• Noise Environment
• Biological Environment
• Socio-economic Environment
The data collected has been used to understand the existing environment
scenario around the project site against which the potential impacts of
the proposed project can be assessed.
3.2 STUDY AREA
The unit is located at Plot No. 1482-1486, Trasad Road, Taluka: Dholka,
Dist.: Ahmedabad, Gujarat. An area of 10 km radius from the boundary
of the project site is considered as study area for the EIA study as per the
TOR issued by MoEF&CC.
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EIA Report of Concord Biotech Ltd. 3-2
Table 3.1 Environmental setting of the study area
1. General Particular i) Latitude 22°41'59.55" N ii) Longitude 72°26'48.63" E iii) Taluka Dholka iv) District Ahmedabad
2. Site specific details i) Nearest village Trasad (2.3 km) ii) Nearest City Ahmedabad (38.0 km) iii) National Highway/
State Highway SH (Dholka-Vataman) – 1.3 km NH 8A (A’bad-Rajkot) - 15.0 km
iv) Nearest Railway Station Dholka (3.85 km) v) Sanctuary/National park None within 10 km radius
3.3 STUDY PERIOD
Baseline environmental quality represents the background scenario of
various environmental components. As part of EIA study, baseline
environmental monitoring was done over a radial distance of 10 km
around the project site during the period of Mar, 2016 to May, 2016.
3.4 SOURCE OF ENVIRONMENTAL DATA GENERATION
Baseline information on micrometeorology, ambient air quality, water
quality, noise level, soil quality and ecology (flora-fauna) are generated
by M/s. San Envirotech Pvt. Ltd., an Environment Consultants,
Ahmedabad. Apart from these, secondary data have been collected from
census book, revenue records, soil survey and forest department,
meteorological department etc. The generation of primary as well as
collection of secondary data &information from the site and surrounding
was carried out during the period of Mar, 2016 to May,2016.
3.5 METHODOLOGY
The process & methodology adopted for various environmental attributes
in the study is as follows:
To assess the Air environment in the study area, monitoring of the Air
quality was done by setting up reconnaissance. The samples were
collected by installation of Respirable Dust Sampler (RDS) Sampler
(with gaseous attachment & FPS facility) at different locations for
monitoring of primary air pollutants to work out the existing status of
air quality.
San Envirotech Pvt. Ltd., Ahmedabad
EIA Report of Concord Biotech Ltd. 3-3
Ground water samples& surface water samples were analyzed for the
parameters necessary to determine water quality (based on IS:
10500-2012 criteria) and those which are relevant from the point of
view of environmental impacts of the project site.
Soil samples were collected using an Auger and analyzed for relevant
physico-chemical characteristics in order to assess the impact on soil.
The noise level monitoring was done at various locations at different
intervals of time with the help of sound level meter.
Socio-economic data was collected from field studies and secondary
sources like Census of India 2011, Revenue record, etc.
3.6 LAND ENVIRONMENT
Land Cover is the physical material at the surface of the earth (includes
grass, trees, bare ground, water etc.); whereas Land use is the human
use of land. Studies on land use aspects of eco-system play an important
role in identifying susceptible issues and to take appropriate action to
uphold ecological equilibrium in the region. Main objective is to provide a
baseline status of the study area so that temporal changes due to the
proposed activities on the surroundings can be assessed in future.
3.6.1 Land use pattern of the Study Area
The study area of 10-km around the project site is considered in the land
use pattern study. The term land-use indicates the way in which the land
is utilized for different purposes. The land-use distribution of the study
area is given in Table 3.2.Land-use map is given in Figure 3.12.
Table 3.2 Land use statistics work out based on satellite imaginary
Sr. No.
Level 1 Level 2 Area (Sq. km.)
Area in %
1 Built-up Land Residential/Commercial 18.655 5.938 Industrial
2 Agricultural Land
Crop Lands 260.360 82.88 Fallow Land Plantations
3 Vegetation Cover
Scrub 23.090 7.35 Open vegetation Close vegetation
4 Wastelands Salt-Affected Land 8.410 2.677 Waterlogged Land Marshy/Mud Land Area
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EIA Report of Concord Biotech Ltd. 3-4
Land without Scrub Sandy Area
5 Water Bodies Reservoir/Lakes/Ponds 3.628 1.155 River Beds
Total 314.143 100 3.6.2 Objective of Land Use Studies
The objectives of land use studies are:
• To develop land use & land cover map using land coordinates of the
project area.
• To identify and mark important basic features according primary
and secondary data.
• To suggest measures for conservation and sustainable use of land.
3.6.3 Topography
The site area is plain with little undulating at few places. Agriculture and
allied activities are most predominant in this area. Fallow land and barren
lands were less observed near project site. There was no any Eco Fragile
Zone or Natural Forest near project site in study area.
3.6.4 Seismicity of the area
The project site falls under seismic zone III which is a moderate damage
corresponding toMSK intensity VII. The Seismic Zone Map of Gujarat is
given below Figure 3.1.
Figure 3.1 Seismic zone map of Gujarat
3.7 METEOROLOGY
Meteorology is the key to understand the air quality. Wind fluctuations
over a very wide range of time, accomplish dispersion and strongly
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EIA Report of Concord Biotech Ltd. 3-5
influence other processes associated with them. The micrometeorological
conditions at the project site will be regulating the transport and diffusion
of air pollutants released into the atmosphere.
3.7.1 IMD meteorological data
Wind data generated at site were also compared with the climatological
data obtained from the closest Indian Meteorological Department (IMD)
station at Ahmedabad. Predominant month wise wind directions recorded
at IMD Ahmedabad is given in Table 3.3 & average meteorological
condition recorded at IMD Ahmedabad is given in Table 3.4.
Table 3.3 Predominant Month-wise Wind Directions at IMD Ahmedabad
Month Predominant Wind First Second Third
Morning Evening Morning Evening Morning Evening January E N NE NW N NE February E/NE NW NW N N W March NW NW W W NNW SW April NW NW W W NNW SW May W W NW SW SW NW June SW SW W S S W July SW SW W W S S August SW SW W W NW S September NW SW W W SW NW October NW NW E N N NE November E N NE E N NE December E N NE E N NE/NW
Table 3.4 Average Meteorological Condition at IMD Ahmedabad
Month Mean Daily Temperature
Rainfall (mm)
Monthly Total
No. of Rainy days
Relative Humidity
(%), (Morning)
Relative Humidity
(%), (Evening)
Max Min
January 28.3 11.9 1.8 0.2 59 32 February 30.9 14.0 1.1 0.1 53 25 March 35.8 18.9 1.0 0.1 49 20 April 39.8 23.5 2.7 0.2 54 20 May 41.7 26.2 7.1 0.7 65 23 June 38.5 27.1 98.7 4.2 74 45 July 33.4 25.6 262.3 11.2 85 67 August 31.9 24.7 239.6 11.2 85 67 September 33.7 24.2 108.9 5.3 82 58 October 36.0 21.0 16.2 0.4 64 37 November 33.1 16.6 11.5 0.6 55 35 December 29.6 13.2 3.8 0.2 60 35
Total -- -- 762.7 34.0 -- -- Average 34.4 20.6 - - 66 39
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EIA Report of Concord Biotech Ltd. 3-6
3.7.2 Site specific micro-meteorological data
The data on surface meteorological parameters in the study area were
collected from Mar, 2016 toMay, 2016, by setting up portable weather
monitoring station placed at project site. The sensor of the equipment
was kept at sufficient height (about 10 m) from ground level with free
exposure to the atmosphere. The monitoring methodology is given in
Table 3.5 &data collected are presented in Table 3.6. The following
parameters were recorded at hourly intervals during monitoring period:
• Wind speed & Wind direction
• Temperature
• Relative humidity
• Rainfall
Table 3.5: Monitoring Methodology of Meteorological Data
S. No.
Sampling Parameters
Sample Collection Total Sampling
Period
Sampling Frequency
Methodology Sampling
Equipment Sensitivity/ Detection
Limit 1 Wind Speed Anemometer
cup counter (0 to 65 m/s)
0.25 m/s March to May,2016
Hourly As per manufacturer’s manual, Instruments are Calibrated
8 hours ** 100 100 UV photometric Chemiluminescence Chemical Method
1hours** 180 180
Lead (Pb) µg/m3
Annual Average*
0.50 0.50 AAS/ICP method after sampling on EPM 2000 or equivalent filter paper
ED-XRF using Teflon filter
24 hours** 1.0 1.0
CarbonMonoxide (CO) mg/m3
8 hours** 02 02 Non Dispersive Infra Red (NDIR) spectroscopy
1 hour** 04 04
Ammonia (NH3) µg/m3
Annual Average*
100 100 Chemiluminescence Indophenol Blue Method 24 hours** 400 400
Benzene (C6H6) µg/m3
Annual* 05 05 Gas chromatography based continuous analyzer
Adsorption and desorption followed by GC analysis
Benzo(a)Pyrine (BaP)-particulate phase only,µg/m3
Annual* 01 01 Solvent extraction followed by HPLC/GC analysis
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EIA Report of Concord Biotech Ltd. 3-32
Arsenic (As), µg/m3
Annual* 06 06 AAS/ICP method after sampling on EPM 2000 or equivalent filter paper
Nickel (Ni) µg/m3
Annual* 20 20 AAS/ICP method after sampling on EPM 2000 or equivalent filter paper
* Annual Arithmetic mean of minimum 104 measurements in a year taken twice a week 24 hourly at uniform interval.
** 24 hourly/8 hourly or 01 hourly values, as applicable, shall be complied with 98% of the time in a year. 2% of the time, they may exceed the limits but not two consecutive days of monitoring.
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Table 3.23: Results of Groundwater Quality in the Study Area (Date of Sampling: 25/04/16 to 27/04/16)
1 Pond Heron ArdeolaGrayli 2 Cattle Egret Bulbulcus ibis 3 Pariah Kite Milvusmigrans 4 Red Wattled Lapwing Vanellusindicus 5 Blackwinged stilt HimanatopusHimantopus 6 Common Sandpiper Tringahypoleucos 7 Spotted dove StreptopeliaChinensis 8 Red turtle Dove Streptopliatrenquebarica 9 Blue Rock pigeon Columbia livia 10 Common Kingfisher Alcedoathis 11 White Breasted Kingfisher Halcyon smyrensis 12 Small Green Bee-Eater Meropsorientalis 13 Indian Roller Corvussplendens 14 House Crow Corvussplendens 15 Common myna Aceredotherestristis 16 Red Vented Bulbal Pycnontuscafer 17 Jungle babbler Turdoidesstriatus 18 Indian Robin SaxicoloidesFulicata 19 House Sparrow Passardomesticus
1 House Cricket Achetadomesticus 2 cockroach Blattagermanica 3 House fly Muscadomestica 4 Mosquito Anopheles sp. 5 Striped tiger Danausgenutiagenutia 6 Mosquito Culex Sp. 7 Common Grass Yellow Euremahecabe simulate 8 Common Crow Euploea core core 9 Black Ant Pheidole sp. 10 Red Ant Oecophyllasmar 11 Wasp Vespa sp. 12 Bumble Bee Bombus sp. 13 Social Spider Stegodyphusarasinorum 14 Jumping spider Phidippuspunjabensis 15 Lynx Spider Oxyopesshweta 16 Funnel Web spider Hippasa sp. 17 Wolf spider Pardosemukundi 18 Wolf Spider Lycosa sp. 19 Garden Spider Argiopeanasuja
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EIA Report of Concord Biotech Ltd. 3-42
Table 3.31 Traffic Survey
TRAFFIC SHEET
LOCATION Near plant site Dholka-Trasad Road TIME 09.00 to 10.00 DATE 25/04/2016
TOTAL PCU calculation Total PCU/hr BUSES* 19 PCU x 3 57 CARS/VANS 95 PCU x 1 95 MOTORCYCLES / BICYCLES 172 PCU x0.5 86
Total 238
TIME 18.00 to 19.00 DATE 24/04/2016
TOTAL PCU calculation Total PCU/hr BUSES* 27 PCU x 3 81 CARS/VANS 117 PCU x 1 117 MOTORCYCLES / BICYCLES 218 PCU x0.5 109
Total 307 Note: *Mini-bus, Chartered Bus, School Bus, have been collectively classified as Buses.
Additional traffic from our project will be estimated 60 PCU/day [20 trucks/tankers (in & out) x 3] and 100 PCU/day from car and motorcycle, which have insignificant impact on existing traffic load. Existing Traffic Scenario and Level of Services
The road from Dholka-Trasadis double track road, all types of vehicles move on the
road.
Capacity of road as per IRC = 1500 PCU’s/hr
Total Volume during Peak Hours = 307
Existing Volume/Capacity ratio = 307/1500= 0.205
The level of service is “B” that is Very Good LEVEL OF SERVICE
Sr. No.
Existing Volume/Capacity Ratio
Level of Services
1. 0.0 to 0.2 “A” (Excellent) 2. 0.2 to 0.4 “B” (Very Good) 3. 0.4 to 0.6 “C” (Good) 4. 0.6 to 0.8 “D” (Fair) 5. 0.8 to 1.0 “E” (Poor)
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Table 3.32
Land Use Pattern
Name of Village Total Area of the
Village(ha)
Irrigated by source
(ha)
Un-irrigated
(ha)
cultivable waste (ha)
Area not available for cultivation
(ha) Juvalrupavati 847.6 692.6 45.8 41.7 67.5
VasnaKeliya 821.4 500.0 203.4 69.6 48.4
Shekhdi 219.9 201.6 - 8.3 10.0
Sindhraj 2013.3 834.9 620.9 92.9 464.6
Lana 678.1 437.3 205.2 16.6 19.0
Sakodara 1105.2 218.2 887.0 - -
Dholka (Rural) 9607.1 1521.0 1780.0 125.4 6180.7
Ranoda 971.8 772.3 65.1 6.2 128.2
Rajpur 193.1 140.0 39.5 4.9 8.7
Ambaliyara 1081.6 925.6 - 110.1 45.9
Sathal 1761.4 1033.1 170.3 371.4 186.6
JalalpurVazifa 662 209.8 220.8 60.3 171.1
Mujpur 316.1 - 300.8 11.5 3.8
Ambareli 1210.1 400.0 615.8 70.3 124.0
Kadipur 195 - 187.7 4.4 2.9
Kaliyapura 216.2 - 195.8 5.9 14.5
Virpur 666.6 170.2 453.9 40.3 2.2
Andhari 304.8 5.0 263.8 13.7 22.3
Paldi 1425.4 561.6 276.0 142.8 445.0
Sahij 1157.1 431.6 385.0 198.6 141.9
Rampur 403.6 202.3 150.9 48.1 2.3
Khanpur 526.7 9.0 301.0 66.7 150.0
Nesda 645.4 7.5 581.8 43.6 12.5
Dadusar 805.8 209.2 509.2 45.9 41.5
Transad 630.6 246.8 310.2 37.7 35.9
Khatripur 315.1 80.9 205.6 1.7 26.9
Pisawada 2168.6 91.0 1797.2 138.5 141.9
Sarandi 1512.7 2.0 1168.0 94.3 248.4
Vautha 1034.7 486.5 169.8 70.9 307.5
JalalpurGodhaneshwer 707.2 290.3 174.7 54.7 187.5
Ambethi 475.6 246.8 155.2 37.7 35.9
Bhetawada 403.9 298.3 25.0 14.7 65.9
Kauka 1940.3 - 1680.7 7.8 251.8
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EIA Report of Concord Biotech Ltd. 3-44
Table: 3.33 Summary of Socio-economic status of Study area (Demography)
Abbreviations: Educational P - Primary School C - College, Any college (Graduate level & above) like Arts, Science,
Commerce Ac - Adult Literacy Class/Centre S - Higher Secondary schools PUC - Higher Secondary/Intermediate/Pre-University/Junior College or Senior Secondary
Medical Facility
H - Hospitals MCW - Maternity & Child welfare Centre PHC - Primary Health Centre PHS - Primary Health Sub-Centre RMP - Registered Private Medical Practitioner CWC - Child Welfare Centre CHW - Common Health Worker D - Dispensary FWC - Family Welfare Centre SMP - Subsidized Medical Practitioner NH - Nursing Home
Drinking Water T - Tap Water W - Well Water TW - Tube well Water TK - Tank Water R - River HP - Hand pump O - Other facility
Post and Telegraph PO - Post Office PH - Telephone Connection PTO - Post & Telegraph Office
Transportation BS - Bus RS - Railway Station
Approach to Village PR - Paved Road MR - Mud Road FP - Foot Path
Power Supply EA - Electricity for all Purposes
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EIA Report of Concord Biotech Ltd. 3-50
Figure3.7
Location of AAQM station
Indicating AAQM stations
Project site
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EIA Report of Concord Biotech Ltd. 3-51
Figure 3.8
Wind Rose diagram
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EIA Report of Concord Biotech Ltd. 3-52
Figure 3.9
Water sampling Locations
Indicating Ground Water sampling location
IndicatingSurface Water Sampling location
Project site
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EIA Report of Concord Biotech Ltd. 3-53
Figure 3.10
Noisemonitoring locations
Indicating Noise Monitoring location
Project site
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EIA Report of Concord Biotech Ltd. 3-54
Figure 3.11
Soil Sampling Locations
Indicating locations of Soil sampling
Project site
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EIA Report of Concord Biotech Ltd. 3-55
Figure 3.12
LULC map (10 km radius)
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EIA Report of Concord Biotech Ltd. 3-56
Figure 3.13
Topo sheet of location with site location map of 10 km radius
(1:25,000 scale)
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EIA Report of Concord Biotech Ltd. 3-57
Figure 3.14
Topo sheet of location with site location map of 10 km radius
(1:50,000 scale)
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EIA Report of Concord Biotech Ltd. 4-1
Chapter-4 Anticipated Environmental Impacts&
Mitigation Measures
4.1 GENERAL
Environmental Impact can be defined as any change in environmental
conditions which may be adverse or beneficial; occurred due to action or
set of actions under consideration.
It can be assessed by identifying the sources of the impact and predicting
the same. The identification of environmental impacts has been made by
co-relating the relationship between project activity and environmental
parameters. As a part of present EIA study, anticipated environmental
impacts associated with the project activity of the unit have been
identified. The project activities are usually divided into two phases:
Construction Phase and Operation Phase. For evaluation of impacts due
to proposed activities, baseline data has been utilized. Changes in the
environmental parameters & their impact in terms of short term or long
term, positive or negative, reversible & irreversible are identified &
predicted.
The next step is prediction of impacts, which is an important component
in environmental impact assessment process. Several techniques and
methodologies are in vogue for predicting the impacts due to proposed
industrial development on physical, chemical, biological and socio-
economic components of environment. Such predictions delineate
contribution in existing baseline condition for the proposed project. The
additional impacts due to proposed activities are analyzed by keeping in
mind the baseline status. This helps to assess the assimilative capacity of
the environment and in turn the gravity of the impacts. Based on the
identification & prediction of the nature of impact, it can be evaluated
qualitatively and quantitatively.
In this chapter, the effect due to construction & operational activity of the
proposed expansion project is explained.
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4.2 IDENTIFICATION OF IMPACT
This chapter deals with the assessment of project impacts on
environment. Mitigation measures are suggested to minimize the likely
negative impacts. The network method (Cause - effect) was adopted to
identify potential impact of the proposed expansion activity. It includes
stepwise study of relationship between an activity and its environmental
parameters. This method involves in the “Road Map” type of approach to
the identification of second&third order effect. The basic idea is to
account for the project activity & identify the type of impact that could
initially occur followed by the identification of secondary and tertiary
impact.
The project will have impacts of varying magnitude on different
environmental components. These impacts could be categorized as -
• Primary impacts, i.e. impacts which occur as a direct result of the
project activities.
• Secondary and tertiary impacts, i.e. impacts that occur as a result
of primary impacts.
4.2.1 Identification of Impacting Activities
Various activities involved in the project are divided viz.:
A. Construction phase activities: impacts are immediate, in the vicinity
and sporadic
B. Operation phase activities: impacts are long term, in wide area and
continuous
The activities identified for the project under each phase are:
Construction phase
• Excavation
• Foundation & Civil work
• Transportation of construction materials, equipments & machineries
• Installation of equipments & machineries
Operation phase
• Plant operation
• Material storage & handling
• Utilities and services
• Green belt development
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4.2.2 Identification of Environment Attributes
There are various types of impacts arise due to the proposed expansion
activities which will be evaluated considering the following environment
parameters in construction and operational phase,
• Impact on Topography
• Impact on Air Environment
• Impact on Water Environment
• Impact on Noise Environment
• Impact on Land Environment (Hazardous/solid waste generation)
• Impact on Biological Environment
• Impact on Socio-Economic Environment
• Impact on Occupational Health & Safety
4.3 IMPACT ON TOPOGRAPHY
Proposed expansion will be carried out in the existing premises. During
the construction, excavated soil will be restored to its original shape.
Thus, the impact during the construction is reversible, for short terms
and insignificant. Construction of plant & building will be carried out for
proposed expansion. During the operational phase of the project being an
existing unit, no major impact is envisaged on the topography.
4.4 IMPACT ON AIR ENVIRONMENT
a. Construction Phase impact & mitigation measures
Proposed expansion will be done in the existing premises wherein the
construction activities will be carried out as per the plant design. So,
there will be chances of dust generation. It will be limited up to working
area only and not likely to spread in wider area. To mitigate the impact,
regular sprinkling of the water will be done.Vehicular traffic lead to
increased concentration pollutants through exhaust gases, affecting the
ambient air quality of surrounding areas. Vehicles only with PUC
certificates will be allowed. However, this effect remains localized near to
the plant site during the time of vehicular movement only. So this impact
is envisaged as short term negative &reversible in nature. Hence, looking
to the overall facts described above, it can be concluded that, the impacts
on air due to the construction & erection activities will be minimum or
negligible.
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EIA Report of Concord Biotech Ltd. 4-4
b. Operational phase impact & mitigation measures
Long term impacts on the air quality are anticipated due to operational
activities. It depends on various factors like process technology,
operation&maintenance, raw material, fuel, air pollution control
measures. For the study of impact assessment for air environment, all
probable emissions are studied including fugitive emission. The sources
and expected emission level are described in below section.
Emission from the project
Main source of air emission will be point source & fugitive emission. There
will be no process gas emission. At present, flue gas emission is from one
common stack of 2 nos. of steam Boilers. FO is used as fuel. After
expansion, one boiler will be modified/replace in terms of capacity from 3
TPH to 8 TPH. Therefore, consumption of FO will be increased.Emitted
pollutants will be SPM, SO2 and NOx.Unit has installed D.G. Sets with
capacity of 1000 kVA & 680 kVA. After expansion, D. G. set of 680 kVA
will be dismantled and 3 new stand-by D. G. Sets with capacity of 1000
kVA each will be installed to fulfill power requirement in case of non-
availability of power/emergency. HSD will be used as a fuel.
Mitigation measures
Due to use of liquid fuel i.e. FO, no need of APCM. Adequate stack height
and facility for sampling such as ladder &sampling point is provided as
per the SPCB guidelines for proper dispersion of pollutants.
4.4.1 Air Pollution Dispersion Modeling of stack
Following sub-section give air dispersion modeling details for prediction of
changes in GLC of pollutants emitted from the above stacks.
Objective: The objective of dispersion modeling is to predict the ground
level concentration during the operation of the project and its impact on
ambient air quality of the area concentrations and compare with
applicable NAAQS.
Model used: The impact on air quality due to emissions from single
source or group of sources is evaluated by use of mathematical models.
The impacts of air pollutants were predicted usingGaussian air dispersion
model, which is selected on the basis of existence of multiple point
sources within the industrial complex and the plain terrain at the project
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site. In order to predict the impact of air pollutants on ambient air
quality, ISCST3 model (Industrial Source Complex – Short Term
(ISCST3) dispersion model) of United State Environmental Protection
Agency (USEPA) was used by considering guidelines stipulated by CPCB
for air pollution dispersion modeling. The Gaussian model provides
estimates of pollutant concentrations at various receptor locations.
It is an hour-by-hour steady state Gaussian model which takes into
account the following:
• Terrain adjustments
• Stack-tip downwash
• Gradual plume rise
• Buoyancy-induced dispersion, and
• Complex terrain treatment and consideration of partial reflection
• Plume reflection off elevated terrain
• Building down wash
• Partial penetration of elevated inversions is accounted for Hourly
source emission rates, exit velocity and stack gas temperature
Only two stability conditions based on the meteorology aspects were used
to calculate the theoretical maximum ground level concentration is
comparing the actual data and data generated from mathematical
modeling, it highlights that the stability condition E & A-Bwere
predominant in the region.
Following are the assumptions made while using the model:
- No dry and wet depletion of pollutants
- Receptors are on flat terrain
The key emitted pollutants will be SPM, SO2 and NOx.
4.4.2 Micrometeorology
Hourly micrometeorological data collected during the study period
(March, 2016 to May, 2016) have been used for modeling. The hourly
wind speed, solar insolation & total cloudiness during day time and wind
speed & total cloudiness during night time were used to determine the
hourly atmospheric stability classes (defined by Pasquill and Gifford as A
to F, A being most unstable and F being most stable). The hourly stability
classes were determined based on the technique suggested by Turner.
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Turner’s system used for determining the stability classes is as follows:
- For day or night: If total cloud cover (TC) = 10/10 and ceiling
<7000 ft (2134 m), NR=0
- For night-time (defined as period from one hour before sunset to
one hour after sunrise):
a) If TC<4/10, use NR = -2
b) If TC>4/10, use NR = -1
- For daytime: determine isolation class number (IN)
a) If TC<5/10, use NR=IN
b) If TC>5/10, modify IN by the sum of the following applicable
criteria
If ceiling<7000 ft (2134 m), modification = -2
If ceiling>7000 ft but <16000 ft (4877 m), modification = -1
- If TC=10/10 and ceiling>7000 ft, modification = -1 and let modified
value of IN=NR, except for day-time NR cannot be <+1.
During the study period, stability calculated based on above-mentioned
Turner method gives average stability as A-B class during Day time and E
class during Night time.
4.4.3 Input data
Stack emissions data have been used for prediction of incremental GLC
values of PM, SO2, NOx using one season meteorological data during
March, 2016 to May, 2016. Input data includesquantitative expected
emission levels, temperature, mixing height from the stack. Input data is
given in Table 4.1.
4.4.4 Receptor Network
Uniform polar grid and ambient air monitoring locations are considered as
discrete Cartesian receptor network for entire study area of 10 km radius.
4.4.5 Output of model (24-hourly GLCs)
The 24-hourly average Ground Level Concentration (GLC) values from
proposed project have been computed for PM, SO2, NOx considering
topographical features around the plant & applicable stability classes. The
maximum 50 (24-hr) average concentration values for PM, SO2, NOx are
given in Table 4.3 to 4.5. Corresponding Isopleths for 24-hourly
predicted value is generated which is shown in Figure 4.1 to 4.3.
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It may be noted from the computed result for the proposed scenario that,
the highest 24-hourly average GLCs value of PM, SO2, NOx from the
proposed expansion activity are 0.434 μg/m3, 0.173 μg/m3, 0.182μg/m3,
respectively. These GLCs are expected to occur at a distance of 1.0 km
from the source in E direction for PM, SO2& NOx. With this marginal
contribution due to the proposal of the project, the levels of PM10, SO2&
NOx will remain well below the 24-hourly ambient air quality standards
There will not be any discharge of effluent from the plant into any water
body; hence there will not be any impact on aquatic ecology of the
surrounding area. GLCs of air pollutants will remain low and hence no
significant impact on terrestrial ecology is expected. Thus, there will not
be any significant impact on ecological environment due to proposed
expansion activities.
4.9 IMPACT ON SOCIO-ECONOMIC ENVIRONMENT
a. Construction Phase Impacts & mitigation measures
During the peak construction phase, construction manpower including
construction workers will be employed.However, to the maximum extent
possible, construction workers will be employed from within the study
area. Since the construction phase of this project will be for short time
period, the socio-economic impact due to construction of this project is
going to be temporary.Around 25-30 workers will be employed in the
construction work. This will increase construction employment in the
study area. As the construction phase for the proposed project will be few
months, the impact would be temporary.
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b. Operation Phase Impacts & mitigation measures
The proposed expansion activities will be carried out in the existing plant
premises. Therefore, no displacement of person is envisaged. Unit will
provide employment opportunity to locally available skilled and un-skilled
labours at different level as per the requirement, which in turn result into
a positive impact on prevailing socio-economic environment. For the
proposed expansion, additional 100 nos. of workers will be employed. In
addition, employment will be generated by the secondary supporting
activities e.g. transportation, communication, daily utility services.
Surrounding area has got good educational facilities and most of
employees will come from the surrounding area. Thus, overall impacts on
socio-economic environment are long term and positive in nature.
4.10 IMPACT ON OCCUPATIONAL HEALTH & SAFETY
a. Construction Phase Impacts & mitigation measures
In the Construction phase, some effects on occupational health &safety of
the employees working in the site are envisaged. Major health issues
encountered will be physical hazards & accidental Hazard. All plans and
construction schedule will be followed as per relevant laws approved by
competent authority, so as to minimize the occupational health hazards.
Sr. No.
Environmental Attribute
Mitigation Measures
1 Safety & Health • Necessary PPEs like helmets, ear plug/ear muff, safety shoes, goggles etc. will be provided to workers.
• Incident/accident reporting system will be developed and all the employees will be made aware for the same.
• Periodic inspection & testing of equipments & machineries will be done.
b. Operational Phase Impacts & mitigation measures
In operational phase, various effects on occupational health and safety of
the employees working in the plant are envisaged. Major health and
safety issues encountered will be physical hazards, respiratory hazards,
electrical hazards, noise, fire hazards associated while working within the
plant.
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Preventive safety measures shall be taken to minimize the risk of
accident with respect to chemical handling.
Sr. No.
Environmental Attribute
Mitigation Measures
1 Safety & Health Emergency preparedness plan should be implemented. First aid/other emergency treatment should be provided. Workers shall be well equipped with personal protective equipments. Only authorized persons will be allowed inside the plant. A health monitoring program shall be in place to monitor the health of the persons working on the site to ensure the health status of all concerned. Fire hydrant system, fire extinguishers will be installed at different locations within premises. Sign boards will be displayed at designated locations indicating appropriate hazard warnings. Good house-keeping will be ensured within the factory premises.
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EIA Report of Concord Biotech Ltd. 4-14
Table 4.1
Input data for air quality modeling
Sr. No.
Stack attached to
Stack Temp. (0K)
Velocity (m/s)
Stack Height
(m)
Dia. (m)
Fuel Used
SPM mg/ Nm3
SO2 mg/ Nm3
NOX mg/ Nm3
Existing performance of air emission 1 Steam Boiler
(2 nos.- one stand by)
448 7.9 45 0.8 Furnace Oil
78 32.0 28.2
2 D.G. Set (1000 kVA)
468 15.5 30 0.4 HSD 72 27.4 32.5
Estimated air emission of proposed stacks 1 DG set (1000
minimum value for damage (e.g. IDLH, over pressure, radiation flux)
to assess the impact on environment.
• Risk Quantification: Quantitative techniques are used considering
effect/impact due to weather data, population data, and frequency of
occurrences and likely hood of ignition/toxic release. Data are
analyzed considering likely damage (in terms of injury/fatality,
property damage) each scenarios is likely to cause.
QRA provides a means to determine the relative significance of a number
of undesired events, allowing analyst and the team to focus their risk
reduction efforts where they will be beneficial most.
Concord Biotech Ltd. project is hazardous in nature. The QRA for this
plant is based on Level 1 and Level 2. Table 2.3 in Chapter 2 gives the
list of products (and their monthly production capacity) to be
manufactured in the proposed project. Table below gives the bulk
storages of liquid and gaseous raw materials and their consumption.
7.3 HAZARDOUS MATERIALS STORAGE
The solid materials will be kept in bags or drums and will be stored in
chemicals godowns. The products (liquid or solid) will be packed in drums
and stored in product godowns as per market demand. The bulk storages
of liquid hazardous materials are given in below Table 7.1.
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In addition, CONCORD will store fuels mainly FO for boiler (15 KL x 3
tanks) and HSD for D G Set (in drums; during power failure only.)
The solid material powder or granules spillage can results in polluting
small area only. The damage to personnel can be through ingress- dermal
(if individual come in contact), oral (if individual food gets infected
through fugitive dust) or inhalation (fugitive dust). The main route is
fugitive dust which in covered area will move to short distance only. The
risk is through liquid materials which are volatile material. The toxic
vapours due to spillage of such material can travel to some distance (as
they are stored in covered godowns) and cause damage.
Table 7.1: Bulk Storage of Hazardous Chemicals
Sr. No.
Name of Hazardous chemicals
Physical form
Maximum Storage at a time (MT)
Type of container
1 Acetone Liquid 28.0 Tank
2 Acetonitrile Liquid 14.0 Tank
3 Ammonia Liquid 1.0 Carboys
4 Cyclohexane Liquid 5.0 Drum
5 DMF Liquid 1.0 Drum
6 Ethanol Liquid 0.4 Drum
7 Ethyl Acetate Liquid 30.0 Tank
8 IBA Liquid 18.0 Tank
9 IPA Liquid 14.0 Tank
10 Methanol Liquid 25.0 Tank
11 N-Heptane Liquid 6.0 Drum
12 Sulphuric acid Liquid 5.0 Tank
13 Toluene Liquid 30.0 Tank
14 Xylene Liquid 5.0 Drum
Drums capacity ~ 200 liters
7.4 Risk Screening Approach
Proposed Plant: Risk screening of Concord Biotech Ltd. plant was
undertaken through process study and study of data/information
provided by unit. Data of major/bulk storages of raw materials,
intermediates and other chemicals were collected. MSDS of hazardous
chemicals were studied vis a vis their inventories and mode of storage.
Concord plant will be using number of hazardous chemicals and also
producing organic chemicals – hazardous in nature. The chemicals stored
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in bulk (liquid or gaseous) and defined under MSHIC Rule will be
considered for detailed analysis:
Bulk Drugs Products: Concord is manufacturer of Active Pharmaceutical
Ingredients through the process of Fermentation, Semi-synthetic and
synthetic processes. The existing production of the unit is 103.83 MTPA,
which will be increased to 189.03 MTPA after expansion of the unit.
Currently, company is manufacturing around 36 nos. of products, which
will get increased to 40 nos. with increase in production capacity of
existing products and addition of 4 new products. Product details with its
capacity are given in Table 2.3. The products are drugs and not
hazardous if used in limited quantity as per medical doctor’s prescription.
Many of the Concord raw materials/chemicals are hazardous in nature.
However, hazards potential (for damage) of chemicals and other
materials to plant personnel, environment and off-site area is different for
different materials. Concord will be using a number of raw materials but
only 14 are stored in bulk and are listed under “List of hazardous and
Toxic Chemicals” category under MSIHC Rules, 1989. The raw materials
coming under hazardous category as specified by MSIHC Rules, 1989
(including subsequent amendments) is given in Table 7.2 below.
Table 7.2: Hazards Analysis – Raw materials (stored in Bulk) S.
No. Raw Material S. No & Threshold
Quantity (TQ in MT) as per
MSHIC Rules
Chemicals Hazards Potential Remarks
Schedule- 1,
Part-II
Schedule-2, Part-I
Schedule-3, Part-I
Hazards Toxic
1 Acetone [C3H6O] CAS No: 67-64-1 Colourless liquid; Pleasant Etheral odour BP-56.2 0C
4 -- -- Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator). Flammable: Limits- Lower-2.6%; Upper- 12.8%
2 Acetonitrile CAS No:75-05-8 UN No:1648 A colourless limpid liquid with an aromatic odour. Flash point 42°F
7 --- -- Highly flammable; toxic vapours (HCN /NOX) are generated when heated; Vapor heavier than air and may travel a considerable distance to a source of ignition and flash back. Health Hazards: Exposure
to 160 ppm for 4 hours causes flushing of the face and a feeling of constriction in the chest; 500 ppm for brief periods is irritating to the nose and throat.
3 Ammonia 31 2 TQ-1: 60 MT TQ-2: 600 MT
105 TQ-1: 50 MT TQ-2: 500 MT
Fire Hazards: (Gas); Mixing of ammonia with several chemicals can cause fire hazards, / or explosions; vapours are toxic- irritation to eyes and respiratory tract.
5 DMF Dimethyl formamide CAS No:68-12-2 UN No: 2265 A water-white liquid with a faint fishy odour. Flash point 136°F. Slightly less dense than water
--- Flammable. Water soluble. Fire Hazard Special Hazards of Combustion Products: Vapors are irritating (USCG, 1999) Health Hazard Irritation of eyes, skin and nose. May cause nausea.
6 Ethanol Ethyl Alcohol CAS No:64-17-5 (200 Proof) (Pure DMA) Liquid with alcohol/wine like odour BP: 78.50C FP(CC):18.50C LFL:3.3%; UFL: 19%
248 ----
---- Hazardous in case of skin contact (irritant), of eye contact (irritant). Slightly hazardous in case of skin contact (permeator), of ingestion. Non-corrosive for skin. Non-corrosive to the eyes. Non-corrosive for lungs
7 Ethyl Acetate (C4H8O2) CAS No: 141-78-6 Colourless liquid; Pleasant Etheral odour BP-77 0C
247 --- --- Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator), of eye contact (irritant). FLAMMABLE: FP (Closed Cup)- -4.4 0C Flammable Limits_ Lower 2.2%; Upper-9%
flammable in presence of shocks. Auto Ignition Temp-415.56 0C Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).
377 -- --- A colorless fairly volatile liquid with a faintly sweet pungent odor like that of ethyl alcohol. Highly Flammable; Behaviour in Fire: Containers may explode.
Health Hazards: Exposure to excessive vapor causes eye irritation, head- ache, fatigue and drowsiness. 50,000 ppm will probably cause death in 1 to 2 hrs. Swallowing may cause death or eye damage.
11 N-Heptane[C7 H16] CAS No:142-82-5 Liquid with Gasoline like odour; BP-98.4 0C
-- -- -- Flammable; Auto Ignition Temp-203.89 0C; Risks of explosion of the product in presence of mechanical impact:
VAPOR (LC50): Acute: 103000 mg/m 4 hours [Rat].
Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
13 Toluene CAS No: 108-88-3 UN No: 1294 A clear colourless liquid with a characteristic aromatic odour. Flash point 40°F
628 -- --- Flammability: Ignites at normal temperatures; Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back; Health Hazard Vapors irritate eyes and upper respiratory tract; cause dizziness, headache, nesthesia, respiratory arrest. Liquid irritates eyes and causes drying of skin. If aspirated, causes coughing, gagging, distress, and rapidly developing pulmonary edema. If
14 Xylene 442 Highly Flammable: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Health Hazards: Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation.
TEEL-1: 130 ppm
O-Xylene May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes.
Table 7.3: Fuels Hazards Classification
Item Physical Impact on Man, Animal & Eco-System Physical Chemical
HSD UN No.-1202 Flammable Liquid-Class-3 Hazardous Waste ID No.-17 Hazchem Code-3Y* NFPA Hazards Signal Health-0 Flammability-2 Reactivity/Stabilty-0
BP- 150 – 400°C Vapour Pressure (35°C)- <1 mm at 38°C Specific Gravity-0.81 – 0.91 at 20°C
LEL - 0.6% (V/V) UEL - 7.5% (V/V) Flash Point>32° C Auto ignition Temp.-256° C Stable compound Incompatible with oxidizing agents
Entry through inhalation, ingestion and skin; Inhalation Effects: Dizziness and headache, Aspiration – Rapidly developing, potential fatal chemical pneumonities Ingestion Effect: Nausea and Vomiting; Contact Effects: Irritation, Eyes- Irritation; Dermatitis may develop on prolonged contact.
LSHS/FO UN No.-1270 Flammable Liquid-Class-3 Hazardous Waste ID No.-17 Hazchem Code-3Y*E NFPA Hazards Signals Health-0 Flammability-2 Reactivity/Stabilty-0
BP- 185 – 5000C Vapour Pressure (350C)- <1 mm at 200C Specific Gravity-0.8 – 0.9 -- 1.05 at 15.50C
LEL - 1% (V/V) UEL - 5% (V/V) Flash Point > 660C Auto ignition Temp.-2630 C Stable Compound
Entry through inhalation, and skin; Inhalation: Dizziness and headache. Ingestion: Nausea and Vomiting Contact: Irritation, Eyes: Irritation. Dermatitis may result from prolonged contact.
Solubility in water- Insoluble in water
Incompatible with oxidizing agents.
Vapour Density (Air-1)-3 - 5
Note: 1. TQ-I: Threshold quantity (for application of rules 4,5,7 to 9 and 13 to 15)
TQ-II: Threshold quantity (for application of rules 10 to 12)
• ERPG-3 is "the maximum airborne concentration below which it is
believed that nearly all individuals could be exposed for up to 1 hour
without experiencing or developing life-threatening health effects."
• ERPG-2 is "the maximum airborne concentration below which it is
believed that nearly all individuals could be exposed for up to 1 hour
without experiencing or developing irreversible or other serious health
effects or symptoms which could impair an individual's ability to take
protective action."
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-10
• ERPG-1 is "the maximum airborne concentration below which it is
believed that nearly all individuals could be exposed for up to 1 hour
without experiencing other than mild transient health effects or
perceiving a clearly defined, objectionable odor."
7.4.3 Temporary Emergency Exposure Limits (TEELs)
TEELs are used in similar situations as the 60-minute AEGLs and ERPGs.
However, in situations where the concentration varies over time, the
TEEL developers recommend using a conservative 15-minute time-
weighted average concentration. A chemical may have up to 4 TEEL
values, each of which corresponds to a specific tier of health effects.
The 4 TEEL tiers are defined as follows:
• TEEL-3 is "the maximum concentration in air below which it is believed
nearly all individuals could be exposed without experiencing or
developing life-threatening health effects."
• TEEL-2 is "the maximum concentration in air below which it is believed
nearly all individuals could be exposed without experiencing or
developing irreversible or other serious health effects or symptoms that
could impair their abilities to take protective action."
• TEEL-1 is "the maximum concentration in air below which it is believed
nearly all individuals could be exposed without experiencing other than
mild transient health effects or perceiving a clearly defined
objectionable odor."
• TEEL-0 is "the threshold concentration below which most people will
experience no appreciable risk of health effects."
• The National Institute of Occupational Safety and Health (NIOSH)
defines an immediately dangerous to life or health condition as a
situation "that poses a threat of exposure to airborne contaminants
when that exposure is likely to cause death or immediate or delayed
permanent adverse health effects or prevent escape from such an
environment."
• The IDLH limit represents the concentration of a chemical in the air to
which healthy adult workers could be exposed (if their respirators fail)
without suffering permanent or escape-impairing health effects.
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-11
7.5 QRA APPROACH
Identification of hazards and likely scenarios (based on Level-1 and
Level-2 activities) calls for detailed analysis of each scenario for potential
of damage, impact area (may vary with weather conditions/wind
direction) and safety system in place. Subsequently each incident is
classified according to relative risk classifications provided in Table 7.4.
Table 7.4: Risk Classification
Stage Description
High (> 10-2/yr.)
A failure which could reasonably be expected to occur within the expected life time of the plant. Examples of high failure likelihood are process leaks or single instrument or valve failures or a human error which could result in releases of hazardous materials.
Moderate (10-2 --10-4/yr.)
A failure or sequence of failures which has a low probability of occurrence within the expected lifetime of the plant. Examples of moderate likelihood are dual instrument or valve failures, combination of instrument failures and human errors, or single failures of small process lines or fittings.
Low (<10-4)
A failure or series of failures which have a very low probability of occurrence within the expected lifetime of plant. Examples of ‘low’ likelihood are multiple instruments or valve failures or multiple human errors, or single spontaneous failures of tanks or process vessels.
Minor Incidents Impact limited to the local area of the event with potent for ‘knock – on- events’
Serious Incident One that could cause: Any serious injury or fatality on/off site; Property damage of $ 1 million offsite or $ 5 million
onsite. Extensive Incident
One that is five or more times worse than a serious incident.
Assigning a relative risk to each scenario provides a means of prioritising
associated risk mitigation measures and planned actions.
7.6 THERMAL HAZARDS
In order to understand the damages produced by various scenarios, it is
appropriate to understand the physiological/physical effects of thermal
radiation intensities. The thermal radiation due to tank fire usually results
in burn on the human body. Furthermore, inanimate objects like
equipment, piping, cables, etc. may also be affected and also need to be
evaluated for damages. Table 7.5, Table 7.6 and Table 7.7 (below),
respectively give tolerable intensities of various objects and desirable
escape time for thermal radiation. Thermal hazards could be from fires or
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-12
explosion. Fire releases energy slowly while explosion release energy very
rapidly (typically in micro seconds). Explosion is rapid expansion of gases
resulting in rapidly moving shock wave. Explosion can be confined (within
a vessel or building) or unconfined (due to release of flammable gases).
BLEVE (boiling liquid expanding vapour explosion) occurs if a vessel
containing a liquid at a temperature above its atmospheric boiling point
ruptures. The subsequent BLEVE is the explosive vaporization of large
fraction of its vapour contents; possibly followed by combustion or
explosion of the vaporized cloud if it is combustible. Thermal hazards
have been considered for various scenarios including: Fire in inflammable
chemicals storage tanks.
Table 7.5: Effects due to Incident Radiation Intensity
Incident Radiation kW/m2
Damage Type
0.7 Equivalent to Solar Radiation 1.6 No discomfort on long duration 4.0 Sufficient to cause pain within 20 sec.
Blistering of skin (first degree burn are likely). 9.5 Pain threshold reached after 8 sec. Second
degree burn after 20 sec. 12.5 Minimum energy required for piloted ignition
of wood, melting of plastic tubing etc. 25
Minimum Energy required for piloted ignition of wood, melting, plastic tubing etc.
37.5 Sufficient to cause damage to process equipment.
62.0 Spontaneous ignition of wood.
Table 7.6: Thermal Radiation Impact to Human
Exposure Duration
Radiation Energy {1% lethality;
kW/m2}
Radiation Energy for 2nd degree burns;
kW/m2
Radiation Energy for 1st degree burns;
kW/m2 10 sec 21.2 16 12.5
30 9.3 7.0 4.0
Table 7.7: Tolerable Intensities for Various Objects
Sl. No.
Objects Tolerable Intensities (kw/m2)
1 Drenched Tank 38 2 Special Buildings
(No window, fire proof doors) 25
3 Normal Buildings 14 4 Vegetation 10-12
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-13
5 Escape Route 6 (up to 30 secs.) 6 Personnel in Emergencies 3 (up to 30 secs.) 7 Plastic Cables 2 8 Stationary Personnel 1.5
7.7 DAMAGE DUE TO EXPLOSION
The explosion of a dust or gas (either as a deflagration or detonation)
results in a reaction front moving outwards from the ignition source
preceded by a shock wave or pressure front. After the combustible
material is consumed the reaction front terminates but the pressure wave
continues its outward movement. Blast damage is based on the
determination of the peak overpressure resulting from the pressure wave
impacting on the object or structure. Damage estimates based on
overpressure are given in Table 7.8 below:
Table 7.8: Damage due to Overpressure
Sr. No.
Overpressure (psig/bar)
Damage
1. 0.04 Loud Noise/sonic boom glass failure 2. 0.15 Typical pressure for glass failure 3. 0.5 - 1 Large and small windows usually shattered 4. 0.7 Minor damage to house structure 5. 1 Partial demolition of houses, made uninhabitable 6. 2.3 Lower limit of serious structure damage 7. 5 - 7 Nearly complete destruction of houses 8. 9 Loaded train box wagons completely demolished 9. 10 Probable total destruction of houses 10. 200 Limits of crater lip
In Concord case explosion probability is remote.
7.8 TOXIC RELEASE
Hazardous materials handled and stored in bulk in CONCORD complex are
hazardous materials (as detailed in Table 7.1) as defined in MSHIC rules
and indicated in Table 7.2 and Table 7.3. Some of these chemicals are
stored in bulk (in tank farm).
Damage criteria: For toxic release the damage criteria considered is IDLH
concentration (if data are available). In the absence of non-availability of
IDLH, ‘Inhalation Toxicity (IT) data for rats’ are considered. ‘IT’ data are
used for such chemicals for whom IDLH are not available for these
chemicals.
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-14
7.8.1 Acid/Alkali Hazards
Various hazards that can occur due to the acid and alkali incidents are -
• Skin irritation and corrosive effects after spillage
• Spill pool evaporation of acid or Caustic lye storage tanks catastrophic
failure are limited only
• Catastrophic failure giving rise to spill pool evaporation dispersion up
to LC50, IDLH and TLV level
The more hazardous scenario likely is if spilled acid comes in contact with
metal and hydrogen is generated resulting in fire/explosion hazards.
Based on the outcome of the risk assessment, following recommendation
has been made to avoid any risk associated with the storage and use of
acids in the plant:
• Double drain valve will be provided to sulphuric acid storage tank.
• Full body protection will be provided to operator.
• Caution note and emergency first aid will be displayed.
• All employees will be trained for use of emergency first aid.
• Safety shower and eye wash will be provided in storage tank area and
plant area.
• Total close process will be adopted for Sulphuric acid handling.
• Dyke wall will be provided to storage tank.
• Tanker unloading procedure will be prepared.
• SOP will be prepared for acid handling.
• Training programme will be conducted for safe handling and
emergency handling of Sulphuric Acid.
• In Storage Tank Area, reaction with water generating fumes should be
displayed and avoided.
• Suitable extinguishing media-Extinguish with dry powder/sand. DO
NOT USE WATER.
7.9 DATA LIMITATIONS
Concord is handling various toxic raw materials. The main use of the
products is for human consumption to kill bacteria’s in the human body
system directly or indirectly. It is also observed that very little data or
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-15
information (regarding physical properties required for modeling) is
available about these drugs and modeling cannot be done for these.
7.10 LIKELY FAILURE SCENARIOS
Few likely failure scenarios have been selected after critical appraisal of
raw materials and storage inventories. Failure scenarios selected are as
In case of mishap or accident like fire, toxic gas leakage, explosion in the
factory, The Emergency Control Centre will be Office of Head- Operations.
• The plot plan indicating all the activities in the factory premises
including that of storage’s utility services, production area,
administration, will be kept for ready reference, showing the location
of fire hydrant and fire-fighting aids.
• Normal roll of employees, work permits, gate entries and documents
for head count, employees blood group, other information and
addresses will be available and the person, who will handle this
operation will HOD P & A.
• Stationery required is available in the Control Centre (ECC) and HOD
(P & A) looks after it.
• The requirement of personnel protective equipment and other
material, like torches, have been worked out and the quantity required
during emergency will be kept in the Control Room (ECC). The
responsible person for maintaining the said requirement/inventory will
be HOD-HSE.
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-36
7.19.5 Fire & Toxicity Control Arrangements
The plant will be well equipped with suitable numbers of fire-fighting and
personnel protective equipment. The staff will be trained regularly to
handle the various emergency situations.
7.19.6 Medical Arrangements
Availability of first aid facilities in sufficient quantity will be always
ensured. In case of emergency arrangements will be made to avail
outside medical help immediately. Emergency transport facility will be
available.
7.19.7 Transport & Evacuation, Mutual Aid Arrangements
Transport & Evacuation and Mutual Aid arrangements will be available in
the factory.
7.20 COMMUNICATION SYSTEM
7.20.1 Declaring the Emergency
In case of any emergency in the plant, speedy and effective
communication of the same to all concerned in least possible time is the
most important aspect of any emergency-handling plan. An early
communication increases the chances of control of emergency in the bud
stage. Blowing siren will be adopted as method of communication of
emergency, to all employees in the plant.
7.20.1.1 Types of Sirens
Three different types of sirens have been identified for communication of
emergency.
Alert Siren: Single Continuous Siren for One Minute. This indicates
that there is some accidental happening in the plant. All have to become
alert. Incident controller will be rush to the site of emergency. Plant area
people have to start safe shut down. Rescue team and other emergency
control teams have to reach at the site of emergency.
Siren for evacuation: wailing & waning siren for three minutes.
This siren indicates that emergency is of serious proportion and
everybody has to leave his work place. All people having their role in
emergency control have to assume their assigned role. All non-essential
workers have to proceed immediately to assembly area and wait for
further instruction.
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-37
All clear siren: Long continuous siren for two minutes. This is a sign
of return of normalcy. On hearing this siren everybody should go back to
his or her respective workplace.
7.20.1.2 Location of Siren
Siren will be located in centre of the pant for wide coverage of the whole
campus. Switch for siren will be provided at security gate. The switch at
Security gate should be operated only as a general rule.
Emergency manual call bell will be installed which will be used in case of
total failure of electricity. It is responsibility of HOD (HSE) to maintain the
upkeep of electric call bell and HOD- Security and administration to
maintain manual and Hand operated siren.
7.20.1.3 Raising Alarm
Any person noticing any emergency situation in the plant should
immediately call security gate with following information:
• Identify oneself
• State briefly the type of emergency i.e. whether fire, explosion, toxic
gas release etc.
• Give the location of the incident
• Estimated severity of the incident.
Security personnel after ensuring genuineness of the call shall raise the
ALERT SIREN. At the same time he will also contact the incident
controller and ECC in order and inform about the incident. He will keep
the gate open and rush his two security personnel at the site of
emergency. ECC will be located at the office of Head- Operations on
normal working hours and at Security gate after normal working hours
(during night). ECC shall be immediately manned on hearing alert siren.
If the authorized people to handle ECC are not available, any senior most
people out of the available person nearby shall occupy ECC till authorized
person comes. Incident controller, on hearing alert siren or by any other
way of information of the emergency, will immediately reach at the site of
incident and assess the situation. He will immediately give his feed back
to ECC. ECC shall direct security gate to raise evacuation siren, if the
need arise. SIREN FOR EVACUATION shall be raised on instruction from
Site Main Controller or any Manager of the plant in the ECC. Security gate
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-38
person will be authorized to raise ALL CLEAR SIREN on instruction from
Site Main Controller or ECC, after the emergency is over. Incident
controller shall assume the responsibility of site main controller in his
absence.
7.20.2 Internal Communication
It shall be responsibility of ECC to communicate to all employees in the
plant. They may take help of telephone operator for such communication.
However, telephone operator can directly communicate information about
emergency to all internal departments, if such message comes from
incident controller or site main controller. Telephone operator will
continue to operate the switchboard advising the callers that staffs are
not available and pass all calls connected with the incident to ECC.
7.20.2.1 Availability of Key Personnel outside Normal Working Hours
The details of key personnel availability after working hours will be made
available at Security Gate, ECC, telephone operator as well as production
units. Security personnel shall call required key personnel from their
residence in case emergency occurs outside normal working hours.
Availability of emergency vehicle/Ambulance will be ensured to fetch the
key personnel residing outside. It will be the responsibility of HOD (P & A)
to maintain it.
7.20.2.2 To the Outside Emergency Services
Decision to call outside help to deal with emergency like fire brigade,
ambulance, police, etc., shall be taken by Site Main Controller. However,
in absence of Site Main Controller, if the incident controller realizes the
situation going out of control, he may ask for immediate help from
outside. ECC will be responsible for calling help from outside. A list of
emergency services available in the area with their telephone numbers
will be provided at ECC, at Security gate and with telephone operator.
Facilities such as phones, emergency vehicle, and security personnel will
be available to help calling outside emergency services and authorities.
7.20.3 Communication to the Authorities
The emergency will be immediately communicated to the government
officers and other authorities such as SPCB, police, district emergency
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EIA report of Concord Biotech Ltd. 7-39
authority, Factory Inspectorate, hospital etc. by Emergency Control
Centre.
7.20.3.1 To Neighboring Firms & the General Public
In case of emergency having its outside impact, public will be cautioned
regarding the same. Co-ordination of police will be sought for speedy
action. This is to be ensured by ECC.
7.21 Pre-emergency activities
Internal Safety survey with regard to identification of hazards, availability
of protective equipment’s, checking for proper installation of safety
devices will be carried out periodically.
• Periodic pressure testing of equipment
• Periodic pressure testing of lines
• Periodic safety/relief valve testing
• Periodic fire hydrant system testing
• Mock drill to check up level of confidence, extent of preparedness of
personnel to face emergency is being contemplated
• Regular training is being imparted to all personnel to create awareness
• Adequate safety equipment will be made available
• Periodic check-up of emergency lights
• Safer assembly points will be identified
• Storage of adequate first aid treatment facilities
7.22 POST-EMERGENCY ACTIVITIES
Following post emergency actions will be carried out to study in detail and
preventive measures to be taken
• Collection of records
• Inquiries
• Insurance claims
• Preparation of reports comprising suggestion and modification
• Rehabilitation of affected personnel
• Normalization of plant
7.22.1 Evacuation and Transportation
In case of emergency, evacuation and transportation of non-essential
workers will be carried out immediately. The affected personnel will be
transported for medical aid.
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-40
7.22.2 Safe Close Down
During emergency plant shut down will be carried out if situation
warrants. This will be as per the instruction of site main controller under
guidance of incident controller.
7.22.3 Use of Mutual Aid
Mutual aid agreement with nearby industries will be ensures to provide
help to each other in the emergency,
7.22.4 Use of External Authorities
As and when necessary, statutory authorities, police, pollution control
personnel, medical aid/center, ambulance etc. will be contacted.
7.22.5 Medical Treatment
The affected personnel will be brought to safer place immediately to give
them first aid. Immediate medical attention will be sought.
7.22.6 Accounting for Personnel
Proper accounting for personnel will be laid down in all the shifts. The
number of persons present inside the plant premises, their duty etc. will
be available with the P & A. This record will be regularly updated and will
be made available.
7.22.7 Access to Records
The relatives of affected personnel will be informed. The details regarding
all employees will be made available to Administration building.
7.22.8 Public Relations
In case of emergency, Manager P & A will be available for official release
of information pertaining to the incident.
7.22.9 Rehabilitation
The affected area will be cleared from emergency activities only after
positive ascertaining of the system in all respects. The entry to affected
area will have to be restricted until statutory authorities visit and inspect
the spot of incident. Nothing should be disturbed from the area till their
clearance. The site main controller will be in charge of the activities to be
undertaken. The plan will cover emergencies, which can be brought under
control by the works with the help of emergency team/fire services. The
DISASTER CONTROL PLAN for gas leak and fire will be prepared for entire
factory.
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-41
7.23 CAUSES OF EMERGENCY
7.23.1 Risk
7.23.1.1 Nature
In the plant, the nature of dangerous events could be of the following:
• Fire : Chemical/Electrical
• Toxic Release : From chemicals
• Leakages : Equipment, pipe lines, valves, etc.
7.23.1.2 Various Emergency Actions
a) Onsite
• Safe shut down of the plant and utilities
• Emergency control measures.
• To attempt with the help of trained crew in firefighting to contain the
fire spread up/gas emission and limit within limited space.
• To cut off source of oxygen by use of firefighting appliances/to cut off
source of gas emission.
• Cut off fall sources of ignition like electrical gadgets.
• To protect fire prone area from the fire.
• To remove material which can catch fire to the extent possible from
fire prone area.
• Evacuation of non-essential persons.
b) Medical Facilities/Treatment
• The Plant will have a Health centre which is manned with trained male
nurse on continuous basis who can render medical first aid. Doctor
will visit two times a week for two hour each time. The Plant is
searching for a full time medical officer and will appoint as and when
available.
• Depending on seriousness the injured person shall be shifted to any
other hospital.
• Vehicle will be available round the clock for transportation. Ambulance
will be also made available in the campus on regular basis.
c) In the event of Fatal Accidents
The information shall be given to following authorities:
• Inspector of Police
• Inspector of Factories
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-42
• Mamlatdar
• Corporate Office
• Regd. Office
• Insurance the plant
• Regional Officer, SPCB
d) Emergency Siren
Emergency siren shall be blown for announcing the emergency which
shall have different sound for identification/differentiation than the
normally used for commencement of factory working etc.
• Location of Siren Above Plant
• Type of Siren Industrial Siren
• Position of siren switch Located at Main Gate
e) Seeking help from neighboring industries/sources for fire engine
f) Advise for vacation of other areas
• Since the effect of fire/gas emission shall be contained within the area
of the plant advice of vacation of other areas is not necessary
7.23.1.3 Response Time-Minutes
Hazard Fire Fighting Police Medical Services
Fire & Explosion
Immediate with whatever facilities available with the plant
10 min.
10 minutes
External Help within 15 minutes
7.24 OFF-SITE EMERGENCY PLAN
7.24.1 Need of the Site Emergency Plan
Depending upon the wind direction and velocity of the effects of accident
in factory may spread to outside its premises. To avert major disaster it
is essential to seek guidance/assistance of statutory authorities, police
and health department. The movement of traffic may have to be
restricted. Required information will be given to the authority and
consultation will be sought for remedial measures.
A purpose of the off-site emergency plan is:
• To provide the local/district authorities, police, fire, brigade, doctors,
surrounding industries and public the basic information of risk and
environmental impact assessment and appraise them of the
consequences and the protection/prevention measures and to seek
their help to communicate with public in case of major emergency.
San Envirotech Pvt. Ltd., Ahmedabad
EIA report of Concord Biotech Ltd. 7-43
• To assist district authorities for preparing the off-site emergency plan
for district or particular area and to organize rehearsals from time to
time and initiate corrective actions on experience.
7.24.2 Structure of the Off-Site Emergency Plan
Available with concerned authorities.
7.24.3 Role of the Factory Management
The site main controller will provide a copy of action plan to the statutory
authorities in order to facilitate preparedness of district/area off-site
emergency plan.
7.24.4 Role of Emergency Co-ordination Office (ECO)
He will be a senior police or fire officer co-ordination with site main
controller. He will utilize emergency control centre.
7.24.5 Role of Local Authority
Preparation of Off Site Plan lies with local authorities. An emergency-
planning officer (EPO) works to obtain relevant information for preparing
basis for the plan and ensures that all those organization involved in
offsite emergency and to know their role and responsibilities.
7.24.6 Role of Fire Authorities
The fire authorities will take over the site responsibility from incident
controller after arrival. They will be familiarized with site of flammable
materials, water and foam applies points, fire-fighting equipment.
7.24.7 Role of the Police and Evacuation Authorities
Senior Police Officer designed, as emergency co-ordination officer shall
take over all control of an emergency. The duties include protection of
life, property and control of traffic movement.
Their functions include controlling standards, evacuating public and
identifying dead and dealing with casualties and informing relatives of
dead or injured. There may be separate authorities/agencies to carry out
evacuation and transportation work. Evacuation depends upon the nature
of accident, in case of fire only neighboring localities shall be alerted.
Whole areas have to be evacuated in case of toxic release.
7.24.8 Role of Health Authorities
After assessing the extent of effect caused to a person the health
authorities will treat them.
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7.24.9 Role of Mutual Aid Agencies
Various types of mutual aid available from the surrounding factories and
other agencies will be utilized.
7.24.10 Role of Factory Inspectorate
In the event of an accident, the Factory Inspector will assist the District
Emergency Authority for information and helping in getting Neighbouring
Industries/mutual aid from surrounding factories. In the aftermath,
Factory Inspector may wish to ensure that the affected areas are
rehabilitated safely.
7.25 MOCK DRILLS AND RECORDS
7.25.1 Need of Rehearsal & Training
Regular training and rehearsal program of emergency procedures shall be
conducted with elaborate discussions and testing of action plan with mock
drill. If necessary, the co-operation/guidance of outside agencies will be
sought.
7.25.2 Some Check Points
• The extent of realistic nature of incidents.
• Adequate assessment of consequences of various incidents.
• Availability of sufficient resources such as water, fire-fighting aids,
personnel.
• The assessment of time scales.
• Logical sequences of actions.
• The involvement of key personnel in the preparation of plan.
• At least 24 hours covers to take account of absences due to sickness
and holiday, minimum shift manning.
• Satisfactory co-operation with local emergency services and district or
regional emergency planning offices.
• Adequacy of Site.
7.25.3 Records and Updating the Plan
All records of various on-site and off-site emergency plans of the factory
will be useful alone with those of the factors by which statutory
authorities draw a detailed plan for the whole area/district. The records of
the activity will be updated regularly.
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(B) Social Impact Assessment
There will be no R & R require as proposed expansion will be done in the
existing premises. No any negative Social Impact envisaged from the
proposed expansion project activities. In fact, positive social impact will
occur as necessity of unskilled and skilled person will increase for
proposed activities and unit will give opportunity to the local people.
(C) Public Consultation
The public hearing was held on 27.04.2017 on the basis of the draft
EIA/EMP incorporating the Terms of References. Report is finalized after
incorporating the comments and suggestions by the public during pubic
consultation is given below.
Table 7.11 Points raised during public hearing
Issues/objections raised by the participants and responded to by the representative of the applicant during the Public Hearing: Sr. No.
Name and Address
Point Represented Reply from Project Proponent
1. Name: Hasmukhbhai B Patel Vill: Dholka
• He expressed the gratitude of the company and said that expansion in this company will create employment opportunities. This unit does not seem to consider highly polluting industry and it will create better development opportunity of Dholka and its surrounding area.
---
2. Name: Rajnikant Manilal Thakkar Vill: Dholka
• We have a business of ginning mill next to Concord biotech and we are residing close to the factory. We also have two ginning factories on the Trasad road and we are regularly passing through this area. For 20 years, we have not felt that there is any pollution or odor in the air. We have not seen pollution even when we go for Picnic with our family at a temple of BootBhavani Maata, which is near to factory. Water flowing nearby which is also not seem to polluted. We have no any kind of damage in terms of health due to this company till date. Expansion will generate employment. Educated people will get job, so the village of Dholka will be developed and benefitted.
---
3. Name: Govind • Surrounding villages get ---
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EIA report of Concord Biotech Ltd. 7-46
Dodiya Vill: Dholka
benefits from Concord Biotech. We get benefit for expansion. There is no noticeable water or air pollution.
4. Name: Snehlatta Patel Vill: Dholka
• How to dispose of waste water from this unit?
• Representative of the company's informed that, the main source of waste water generation is from the fermentation process; the second source is the Cooling bleed off and the Boiler Blow Down. The unit has a primary, secondary and tertiary unit treatment plant. Then it will be passed through RO, permeate is reused and reject is evaporated in MVR/MEE and condensate is recover and reuse. Hence at the end of process, no effluent is released outside the factory premises.
• Our land is surrounding the Concord Biotech and unit is emitting Gas (air pollution) after 9 pm. In this regard, we have 2 times made application. 2 times negative report comes from Gujarat Pollution Control Board that they are generating pollution. I have copy of this report. 3rd time they said that, close this case. So 4th time I have taken online action to central level. We cannot live in our farm after 9 pm and we have threatened by saying that do whatever you want to. I have written papers of Gujarat Pollution Control Board in which it is mention that, there is an odour issue. Same papers I have submitted to Gandhinagar also. Now, if you wish, then we will migrate from here and leave this place.
---
6. Name: Hasmukhbhai Modi Vill: Dholka
• I have been working as the Secretary of GIDC industrial estate for last 17 years and if there is any question, we will immediately resolve mutually. We are doing any kind of work for the development of Dholka. Some elements are always objectionable & against the development. And if any new factory comes or expands in
---
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EIA report of Concord Biotech Ltd. 7-47
this area, their objections are immediately come in front. If they are facing any problem, then represent it, so we can resolve the problem. But we do not tolerate false objections against the development of our area.
7. Name: Parimal H Rabari Vill: Dholka
• I have submitted complain in writing to stop toxic pollution generated by Concord Biotech. We cannot live in our farm which is adjoining to the unit, after 9 pm. Our workers cannot work after 9 pm in our farm. In this regard, I am giving you written application. Take strict action against this unit in this matter.
• Reply of written representation is attached with Minutes.
8. Name: Paresh Rathod Vill: Dadusar
• There is no noticeable pollution from Concord Biotech. No harm by this unit and around 700 to 800 people are getting employment since its inception. Due to closure of Kenco Overseas near Valthera, the employment of around 500-700 people was snatched off. These workers have get employment in Concord Biotech. This unit is giving salary around Rs. 9000 to 10000 salary and PF. Apart from this, Concord Biotech provide free ambulance service along with free diagnosis & medicines. It is my opinion that, this company has progressed further. My personal request is to free develop Concord Biotech.
---
9. Name: Mahammad Yunus Ahemad Malik Vill: Renvad, Dholka
• My farm is adjacent to Concord Biotech in Survey No. 1491-1492. We are not against of development but we are against of spread of pollution.
---
10. Name: Dhiren Patel Vill: Dholka
• It is true that Concord Biotech gives employment to everyone, but takes appropriate measures to control pollution along with employment.
---
11. Name: Ashwin D Jamod Vill: Jalalpur Godhaneshwar
• What steps will you take to control Air pollution?
• Representative of the company’s informed that, no air emission during process because this is a biotechnology process and if any poisonous substance present, then product cannot produce. This process is complete
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after 8 to 9 days once it starts and this process is done in closed reactor. Once it starts then it cannot be stopped in between and restarted again. So there is no air pollution until the process is over. This process is like the same process of fermentation we are doing at home.
• Chemical water comes out from the unit, so what safety measures will you take to avoid any harm to people?
• Representative of the company’s informed that, this process is fermentation based process, in which mainly edible substances like Soybean flour, Sucrose, Dextrose and edible oil are used and no inedible substance are used in it. If any inadequate substance is used, then the fermentation process does not go forward. w/w generated at the end of this process has little TDS and high COD, which is bio degradable. It is treated in existing ETP and reuse after treatment. Not any w/w discharge outside the premises.
• What steps will you take to ensure that the people of the surrounding villages get jobs after its expansion?
• Representative of the company’s informed that, at present local people are preferred for employment and after expansion also local people will be given priority for employment.
14. Name: Janki Patel Vill: Dholka
• Explain briefly about the manufacturing of medicine from biotechnology.
• Representative of the company's informed that, this is a fermentation process in which certain types of Enzymes are used in specific types of medicine. It produces 1 to 2% of the drug. The process lasts for 8 to 10 days. The medicine made at the end of this process is extracted and purified. Fermentation is the main part of the process.
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Chapter-8 Project Benefits
8.1 INTRODUCTION
Project benefit focus on those points which will become beneficial to the
surrounding area or community in terms of infrastructural development,
social development, employment and other tangible benefits due to the
project. Proposed expansion project has a potential for employment of
skilled, semi-skilled and unskilled employees during construction phase as
well as operational phase.
8.2 IMPROVEMENT IN PHYSICAL INFRASTRUCTURE
Unit has proposed to expand manufacturing capacity in the same plant
premises. Project will have requirement of an additional infrastructure
and so direct benefit of infrastructures development is anticipated. The
project proposes to employ local people which will help to increase the
income of local people & improve their standard of living.
The construction and commissioning phase will require a substantial man-
power and resources. The unit has proposed to employ local contractual
services for this. Hence, with the growth in the economic conditions, the
project may lead to growth in the social stature & improvement of the
quality of life in the surrounding area. It will also help in improvement in
local amenities. Thus, the project will have considerable indirect benefits
to the public physical infrastructures.
8.3 IMPROVEMENT IN SOCIAL INFRASTRUCTURE
The company will conduct social welfare activities which include the
funding & contribution for public infrastructure/facilities development,
maintenance & improvement on basis of as & when required.
Due to proposed project activity, social infrastructure will improve by
means of civilization, vocational training and basic amenities.
Civilization: Due to the project, employment and other infrastructural
facilities will boost up income of surrounding people and improve
qualityof life. This will indirectly boost up the civilization of the
surrounding people.
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Vocational Training: Moreover, unit will provide vocational training
opportunity to the surrounding people and greed for employment will
motivate the education activities that will lead the change in life style of
the surrounding and affected people hence social infrastructure will be
8. Source of Air emission Existing: Boiler & D. G. set Proposed: D. G. set
9. Haz. waste generation ETP sludge, spent carbon, distillation residue, used oil, discarded containers, off specific product
10. Total Manpower 719 nos.
11.1.3 Location of Project
The unit is located in Dholka Taluka of Ahmedabad District.
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Details of the project site are given in following table:
Sr. No. Particulars Details 1 Plant location
Plot No. 1482-1486 Taluka Dholka District Ahmedabad State Gujarat
2 Site Co-ordinates Latitude 22°41'59.55" N Longitude 72°26'48.63" E
3 Nearest Village Trasad (2.3 km) 4 Nearest Railway Station Dholka (3.85 km) 5 Nearest Airport Ahmedabad(45.0 km) 6 Nearest City Ahmedabad (38.0 km) 7 Nearest Highway SH (Dholka-Vataman) – 1.3 km
NH 8A (A’bad-Rajkot) - 15.0 km 8 Wildlife
sanctuary/National park
None within 10 km radius
Note: Aerial distances are given in above table.
11.1.4 Investment of the project
Total cost of the existing project is Rs. 172.0crores. Estimated cost of the
proposed expansion will be around Rs. 20.0 crores. Out of this, Rs. 3.0
crore will be earmarked as capital investment for additional EMS and Rs.
3.25 crorewill be recurring/operating cost per annum.
11.1.5 List of products
Product details with its capacity are given in table below.
Sr. No.
Name of Products Quantity (MTPA) Existing Proposed Total
Color: All the samples were colorless meeting desirable norms.
pH: All the samples meet the desirable standards (pH ranges from 7.54
to 7.92).
Total Dissolved Solids (TDS):TDS in samples ranges from 985 mg/L
(Lana) to 1659 mg/L (Project Site). All the samples meet the permissible
limit of 2000 mg/L, (If alternate sources of potable water are not
available).
Calcium: Calcium contents in the water ranges from 69 mg/L (Lana) to
189 mg/L (Project Site), all the samples meet the permissible limit of 200
mg/L, (If alternate sources of potable water is not available).
Magnesium: Magnesium content in the water ranges from 53 mg/L
(Paldi) to 98 mg/L (Project Site). All the samples meet the permissible
limit of 100 mg/L (if alternate source of potable water in not available).
Sulfate: Sulfate content in the water ranges from 82 mg/L (Lana) to 259
mg/L (Paldi). All the samples meet the permissible limit of 400 mg/L for
drinking water (if alternate source of potable water in not available).
Fluoride: Fluoride content in the water ranges from 0.69 mg/L (Andhari)
to 0.97 mg/L (Mujpur). All the samples meet the permissible limit (1.5
mg/L).
Total Alkalinity: Total alkalinity in the water samples ranges from 161
mg/L (Sathal) to 294 mg/L (Project Site). All the samples are within the
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permissible limit of drinking water (600 mg/L) (if alternate source of
portable water is not available).
Other Parameters: Potassium (ranges from 43 mg/L to 160 mg/L),
Sodium (ranges from 158 mg/L to 358 mg/L) and Chloride (ranges from
399 mg/L to 753 mg/L).
Heavy metalslike copper, lead, chromium and zinc are found below
detectable limit in all samples.
Conclusions:
Ground water samples from villages meet the permissible limit set by the
authority (BIS).
11.2.4 Noise Environment
Noise monitoring has been conducted at eight locations in the study area.
The Leq(Ld) values of noise levels during day-time varied from 51.7 to
61.2 dB(A) and the night time Leq (Ln) varied from 42.5 to 54.5 dB(A)
within the study area. Higher noise value of 61.2 dB(A) was recorded
during day time at project site & lower noise value of 42.5 dB(A) was
recorded during night time in village Khanpur.
11.2.5 Soil Quality
Soil samples were collected from 6 different locations and analyzed to
assess the soil quality prevailing in the study area. Physical
characteristics of soil have been delineated through specific parameters,
viz. particle size distribution (grain size analysis), porosity, water holding
capacity and permeability whereas data for chemical characterization of
soil, viz. pH, electrical conductivity, cation exchange capacity and sodium
absorption ratio have been analyzed.
11.2.6 BIOLOGICAL ENVIRONMENT
Baseline data for flora & fauna has been collectedwith its family. It was
found that, none of the species of conservation importance exists in the
study area andno endangered species found in the study area.
11.2.7 SOCIO-ECONOMIC ENVIRONMENT
Socio-economic study includes description of demography, available basic
amenities like housing, health care services,transportation, education
facilities. Information on the above saidparameters has been collected to
define the socio-economic profile of the study area(10-km radius).
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11.3 ANTICIPATED ENVIRONMENTAL IMPACTS AND MITIGATION
MEASURES
Impact identification has been carried out for various activities involved in
construction as well as operational phase of the project and prediction
has been done for significant impacts. The summary of anticipated
adverse environmental impacts due to proposed expansion project and
mitigation measures is given below.
11.3.1 Summary of impacts on Air Environment:
(a) During construction phase &Mitigation measures
Main sources of impact during construction phase are due to movementof
vehicles &construction equipment at site, foundation works,
transportation of construction material etc.Water sprinkling in the vicinity
of the construction areawill be done to control dust. PUC certified vehicles
will be used.Temporary barricades will be provided to reduce spreading
ofparticulates from construction area.
(b) During operation phase&Mitigation measures
There is no process gas emission anticipated from the process. At
present, flue gas emission is from one common stack of 2 nos. of steam
boilers, where furnace Oil (FO) is used as fuel. After expansion, one boiler
will be modified/replace in terms of capacity from 3 TPH to 8 TPH.
Therefore, FO consumption will also increase.Flue gas emission is also
from stack attached with D. G. Set (1000 kVA & 680 kVA); after
expansion, D. G. set of 680 kVA will be dismantled and 3 new stand-by
D.G. sets of 1000 kVA each will be added. HSD will be used as a fuel. The
impact on air quality is assessed based on emissions of the boilers& D.
G.set in the plant.
Prediction of impacts on air environment is quantified using ISCST3
model. Maximum Ground level concentrationsof 24-hr averagefor PM,
SO2, NOx were found 0.434 μg/m3, 0.173 μg/m3, 0.182 μg/m3
respectively. The point of maximum concentration by unit would be 1.0
km from centre of industry in E direction.The obtained GLCs are well
within the24-hourly ambient air quality standards stipulated by CPCB.
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However, to mitigate the impact due to the proposed expansion, unit will
provide adequate stack height for proper atmospheric dispersion as per
the norms.
11.3.2 Summary of impacts on Water Environment
(a) Impacts during construction phase & Mitigation measures:
Temporary impacts are likely to occur due to water
consumption&sewagegeneration. It will not be significant as water
requirement would be temporaryduring construction phase. Proper
sanitation facilities with adequate disposal system are already exists
within the operational plant.
(b) Impacts during operation phase & Mitigation measures:
Fresh water requirement of the unit is satisfy from own bore well. At
present, total water requirement is 589.5 KLD. Out of which; 349.5 KLD
is fresh water & 240 KLD is recycle water. After expansion; water
requirement will be increase up to 955 KLD; Out of which, 556 KLD will
be fresh water requirement.
Total w/w generation will be 399.0 KLD. Currently, the effluent is treated
in an adequate Effluent Treatment Plant having primary & secondary
treatment units followed by RO &MVR/MEE. Condensate of MVR/MEE &
permeate of second stage RO is used in Cooling. Treated effluent from
ETP is utilizedfor greenbelt development. After expansion, unit will treat
its effluent in exiting ETP. Hence, no impact on the water environment is
envisaged.
11.3.3 Impacts on Noise quality & Mitigation measures
(a) Impacts during construction phase & Mitigation measures:
During construction phase, major sourcesof noise are vehicle’s
movement&construction activities.High noiseproducing activities will be
restricted to daytime only.Well maintained equipment will be used to
prevent noise generation. Usage ofPPE by workers&proper maintenance
of machineries will be done to reduce impact of noise.
(b) Impacts during operation phase & Mitigation measures:
During the operation phase, the noise levels may increase due to the
operation of boiler, reactors, D. G. set and other machineries. The impact
is found to be insignificant outside the premises. Unit will provide
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necessary PPEs like earplugs or earmuffs to all workers where exposure is
85 dB(A) or more and selection of any new plant equipment will be made
with specification of low noise levels.
11.3.4 Summary of Impacts on Land Environment
(a) Impacts during construction phase &Mitigation measures:
The construction activities like excavation, leveling & vehicular
movements will change the landscape, which are expected to be of short
duration and insignificant. Preliminary activities like proper storage of
construction materials& proper management will be done within the
project area. Therefore, impact will be negligible. Unit will provide
sanitation facilities for the staff engaged in construction work which will
prevent the impacts on land.
(b) Impacts during operation phase &Mitigation measures:
Hazardous wastes havesignificant negative impacts if disposed
unsystematically. Unithas provided all required structural facilities like
separate hazardouswaste storage room with RCC floor, leachate collection
system, concretefloors within premises. Hence, no significant negative
impact is envisaged on the land environment.
11.3.5 Summary of impact on Socio Economy
(a) Impacts during construction phase &Mitigation measures:
As the proposed expansion will be in the existing unit, no R&R is required.
Local contractors to be employed for construction, so no other issues like,
social conflict are envisaged.Temporary employment generated during
construction of project will have beneficial impacts on economic
environment.
(b) Impacts during operation phase &Mitigation measures:
Expansion project will require about 100additional persons forits
operation, which result into a positive impact on prevailing socio-
economic environment. Project will also have potential ofindirect
employment due to the increase transportation activities, contractual
worksas well as opportunity of trade.Thus, overall impacts on socio-
economic environment are long term and positive in nature.
11.3.6 Summary of impact onEcology
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Unit is under operation and proposed expansion will bedone in the
existing premises only. There are no protected areas like National
Park/Wildlife Sanctuary within the 10 km radial periphery of the project
site so there will not be any significant impact on ecology.
11.4 ENVIRONMENT MONITORING PROGRAMME:
The unit has a dedicated Environment Management Cell to monitor and
evaluate the environmental performanceand to supervise the
environment management measures. Budgetaryprovision for environment
& safety management system has been made in the projectplanning with
additional Rs. 3.0croreof capital cost and 3.25 crorerecurring cost per
annum. BelowPost-project monitoring programmewill be followed.
Environment Monitoring Program
Nature of Analysis Frequency of analysis with its analyzer
Parameters
Wastewater analysis Monthly by external agency pH, TDS, SS, Oil & Grease, etc.
Stack Monitoring of each stack
Monthly by external agency PM, SO2, NOX
Ambient Air Quality Monitoring
Monthly for 24 hours or as per the statutory conditions by external agency
PM10, PM2.5, SO2, NOX
Noise level Monthly as per the statutory conditions by external agency
Nr. main gate, Nr. boiler, Nr. D. G. Set, Process area etc.
Work zone fugitive monitoring
Monthly by external agency RPM, VOCs, acid mist
Health check-up of workers
As per the statutory guideline All workers
11.5 ADDITIONAL STUDIES
11.5.1 Risk Assessment
Risk analysis and study have been carried out for identification of
accident hazards, selection of credible scenarios, Risk Mitigation
measures etc. All the hazardous chemicals will be stored and handled as
per MSDS guidelines. The detail study is prescribed in Chapter-7.
11.6 PROJECT BENEFITS
Proposed expansion project has apotential for employment of skilled,
semi-skilled & unskilled employees. The direct employment potential after
proposed expansion is estimated as 719 personsand many other willbe
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indirectly employed.Indirectly, the proposed expansion will help the
Government by payingdifferent taxes (sales tax, excise duty, etc.) from
time to time, which is a part of revenue and thus, will helpin developing
the area.The company has allocated a budget of 1.0 crorefor CSR
activities, which can lead to improve social infrastructure.
11.7 ENVIRONMENTAL MANAGEMENT PLAN
EMP includes the protection & mitigation measures to be implemented to
reduce the adverse impact on the environment. Management plan of
impacts identified is detailed below:
Air Pollution Management
There is no process gas emissions envisage from the process. Flue gas
emission is from FO fired boilers. Due to use of liquid fuel i.e. FO, no need
of APCM. Appropriate stack height and SMF is provided as per the
guideline.To control the fugitive emissions,unit will adopt following
mitigation measures.
• Regular maintenance of valves, pumps and other equipment will be
done to prevent leakages.
• Mechanical seals will be provided toall the reactors.
• Regular periodic monitoring of work area to check the fugitive
emission.
Water Pollution Management
• Industrial wastewater will be treated in adequate in-house ETP.
• Treated effluent from ETP water will be utilized for plantation.
• Sewage will be treated in ETPalong with industrial effluent.
• Regular monitoring of working of ETP.
• Condensate of MVR/MEE & permeate of second stage RO will be used
in Cooling.
• Unit will maintain the records for the total water consumption.
• Rain water harvesting structure is installed in the unit.
Hazardous Waste Management
Entire quantity of hazardous waste will be handled and disposed as per
Hazardous & Other Waste (Management & Transboundary Movement)
Rules, 2016. ETP sludge is disposed off at approved TSDF site.There is
possibility to use ETP sludge as organic manure as it is having good
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nutrient value and primarily no hazardous characteristics found because
its major source is from biotechnology based fermentation. Distillation
residue is sent to SEPPL for incineration or to RSPL for co-processing,
spent carbon is sent to SEPPL for incineration or to RSPL for co-
processing or for co-processing at Ambuja Cement Ltd., used lubricating
oil is used within premises as a lubricant and in case of excess; disposed
by selling to registered re-refiners. Whereas discarded drums/containers
are disposed off by selling to registered recyclers. Off specific products
will be disposed to CHWIF or for co-processing/sent for co-processing.
The unit has provided isolated area with impervious flooring for the
storage of hazardous waste. Thus, hazardous waste management system
proposed by the unit is adequate. There will not be any major impact on
the environment due to hazardous waste management.
Noise Pollution Management
• Extensive oiling, lubrication and Regular maintenance will be carried
out for the machineries and equipments to reduce noise generation.
• PPEs will be provided to the workers working in high noise area.
• Noise control equipments are provided for D.G. set.
• Greenbelt will be increased within industrial premises to prevent the
noise pollution.
• Periodic monitoring of noise levels will be done.
Green Belt Development
The unit has done extensive plantation in 23653m2 in its existing unit and
some more area of about 61347m2 will be added. After expansion, total
greenbelt area will be 85000 m2and it will be more than 33% of total land
area.
11.8 CONCLUSION
Based on the study it is concluded that-
• There will be no major impact on water environment as effluent will
be treated in ETP followed by RO &MVR/MEE and treated effluent will
be utilize for greenbelt development.
• Condensate of MVR/MEE will be reuse/recycled.
• Due to use of liquid fuel i.e. FO, no need to install APCM.
• No process emission from the unit.
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• To prevent fugitive emission various step will be taken like regular
sprinkling of water and paved road.
• Adequate arrangement for handling and disposal of Hazardous solid
waste is made as per regulatory norms.
• Fire protection and safety measures will be provided to take care of
fire hazard.
• Direct and indirect employment opportunities will have positive
impact.
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Chapter-12 Disclosure of Consultant engaged
12.1 DETAILS OF EIA CONSULTANT ORGANIZATION
a) Introduction San Envirotech Pvt. Ltd. (An ISO 9001:2008, 14001:2008 and OHSAS
18001 certified company) is a leading multi-disciplinary testing laboratory
in Gujarat. SEPL provides testing services in the areas of environmental
assessment and analytical testing.
SAN Envirotech Pvt. Ltd. (henceforth SEPL) has started its work in 1990
to serve the environment as a trustee of a next generation with a small
infrastructure under the dynamic leadership of Dr. Mahendra Sadaria.
During last two decade, SEPL has been taking care of client’s unique
problems and concerns in order to develop cost effective strategies to
meet their regulatory obligations. We focus on strategic planning and
comprehensive solutions to address both the short and long term needs
of the clients. Consequently we have developed long-term relationship
with our clients to provide them the services necessary to meet their
changing needs.
To protect and preserve the natural resources on earth for future
generation, it offers extensive consultancy services in the field of
environment. With its rich experience, multidisciplinary expertise and
with the support of its state-of the-art analytical equipments, the services
offered by the division are wide ranging and encompasses entire scope of
environment management and monitoring services. With its emphasis on
quality services over the years, it has evolved itself into a single
reference point in India for comprehensive environmental services.
We conduct analytical works pertaining to various Environmental
Parameters. We perform effluent treatability studies also. To conduct the
analysis work, we follow National & International Quality Standard and
update our process regularly.
“Quality Assurance Team” always welcomes any suggestion and
feedback, to improve the Quality, Performance and Standards of the
San Envirotech Pvt. Ltd., Ahmedabad
EIA Report of Concord Biotech Ltd. 12-2
services. These suggestion and feedback are considered for reviewing of
the services and complied immediately.
b) Major Milestones and Accreditation
SEPL is a recognize schedule-II Environmental Auditor appointed by
Gujarat Pollution Control Board as per the directives of the Honorable
High Court of Gujarat. Recognize laboratory under Environment
Protection (EP) Act, 1986 by Government of India (GOI). SEPL has listed
as accredited EIA consultant organization by NABET/QCI for EIA report
preparation.
12.2 List of Exerts involved in EIA study
SEPL has necessary manpower and expertise in various fields and also
the required infrastructure facilities to carry out work related to EIA. SEPL
team consists of qualified & experienced personnel. Experts involved in
the preparation of this EIA/EMP report are given in EIA report as
‘declaration by experts’.
Annexure-I
Manufacturing Process, chemical reaction & Mass
Balance of all products
Concord Biotech Limited A-1
Manufacturing Process, chemical reaction & Mass Balance
A. Enzyme
1. Penicillin G Amidase Enzyme
Process Description
Penicillin G Amidase Enzyme is produced in two parts–Fermentation and Recovery.
Fermentation – Penicillin G Amidase Enzyme is produced by E. Coil strain through a fed
batch fermentation process. The microorganism is grown up in a shake flask, then
seeds fermenter and finally transferred to main fermenter. The total fermentation time
is 72 hr under strictly controlled parameter like sterility, pH, temperature, aeration and
Dissolved Oxygen. During fermentation productivity is measured by taking sample at
different intervals.
Recovery-After completion of fermentation the harvested broth is transferred to the
broth–holding vessel and biomass is separated by using high-speed centrifuge. The
biomass is immobilized with specific polymer and processed through basket centrifuge.
The cake is taken in granulation form, dried and washed with water. The enzyme is
finally stored at 40C in airtight containers for sale. The total time cycle for fermentation
and recovery will be 8 days.
Flow Diagram
Concord Biotech Limited A-2
B. Antibiotic
2. Vancomycin
Process Description
Vancomycin is produced in a single stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetative state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for 36-48 hours) where sterile air, nutrients and controlled friendly
environment (pH and temperature 27oC) for the microorganisms is maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw Material, nutrient,
sterilized air, microorganisms etc. are fed in the vessel. Suitable environment that is,
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues for nearly 240 hrs.
The fermentation product is recovered in the harvester through ware and passed in the
micro filter lead to rich aqueous layer which is followed nano-filteration and
subsequent resign column. The concentrated mass is then dried. The dried product is
further purified by crystallization, drying and analyzed and if found meeting the
desired specification is packed and sent to warehouse.
The recovery and purification steps are operated carefully for the safety of the system.
After each campaign the total plant is thoroughly cleaned, washed, sterilized and
recalibrate. After each pass the column is regenerated by washing. Water used for
regeneration of column and washing of vessels goes to ETP for the treatment.
Concord Biotech Limited A-3
Process flow diagram
Concord Biotech Limited A-4
3. Teicoplanin
Process Description
Teicoplanin is produced in a single stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetative state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for 36-48 hr) where sterile air, nutrients and controlled friendly
environment (pH and temperature 27oC) for the microorganisms is maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw Material, nutrient,
sterilized air, microorganism’s etc. are fed in the vessel. Suitable environment that is,
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues for nearly 240 hrs.
The fermentation product is recovered in the harvester through ware and passed in the
micro filter lead to rich aqueous layer which is followed nano-filteration and
subsequent resign column. The concentrated mass is then dried. The dried product is
further purified by crystallization, drying and analyzed and if found meeting the
desired specification is packed and sent to warehouse.
The recovery and purification steps are operated carefully for the safety of the system.
After each campaign the total plant is thoroughly cleaned, washed, sterilized and
recalibrate. After each pass the column is regenerated by washing. Water used for
regeneration of column and washing of vessels goes to ETP for the treatment.
Process Flow Diagram
Concord Biotech Limited A-5
4. Daptomycin
Process Description
Daptomycin is cyclic lipopeptide antibacterial agent produced by Streptomyces
roseoporus through fermentation process. Daptomycin is recovered from fermentation
broth through different steps of recovery. Manufacturing of Daptomycin is carried out
in three different stages:
Preparation of Seed: Laboratory inoculum comprises of Vegetative growth (2000-
3000 ml).Vegetative growth is developed by inoculating 100/200 ml of seed media
contained in 500/1000 ml conical flasks with spore suspensions from working cell
bank. The inoculated flasks are incubated on rotary shaker at 30 ± 3 ºC and 250 ± 10
RPM. The matured vegetative growth from different flasks is collected in sterilized
inoculation assembly under aseptic condition on laminar air flow work bench. This
matured vegetative growth is used to inoculate seed fermenter. Seed fermenter is
prepared by sterilizing 500 – 1000 Liters seed medium at 123 ± 3 ºC for 40 to 50
minutes and inoculated with laboratory inoculum under aseptic conditions. The seed is
incubated at 27–33 ºC for 40–90 hrs and checked periodically for purity, pH and PMV
(%). After achieving desired criteria seed culture is being transferred to main
fermenter.
Fermentation: Daptomycin production is carried out in production fermenter by
aseptically transferring the seed (5–7%) to production medium (8 to 14 KL) sterilized
at 123 ± 3 ºC for 40 to 50 minutes. The fermenter is incubated at 27–33 ºC. During
the fermentation cycle the appropriate culture conditions like aeration, agitation and
back pressure are maintained. Methyl oleate & cupric acid are added as precursors
from 20 hrs onwards. pH are maintained in the range of 6.3 to 6.9 throughout
fermentation cycle with 50 % Dextrose solution. Foaming is controlled by addition of
the mixture of antifoaming agent and Soya oil. The fermentation broth samples are
checked periodically for pH, PMV (%), purity and activity. The fermentation batch is
harvested at around 150–200 hrs when there is no significant increase in Daptomycin
concentration as is ascertained by HPLC analysis.
Recovery: After completion of fermentation the harvested broth is transferred to the
broth-holding vessels and biomass is removed by micro-filtration and concentration by
neon filtration. And purification by multiple resign reaction and ppt out with addition of
anti-solvent addition.
The dried product is further purified by crystallization, drying and analysed and if
found meeting the desired specification is packed and sent to warehouse.
Concord Biotech Limited A-6
Process Flow diagram
Concord Biotech Limited A-7
5. Fidaxomycin
Process description
Fidaxomycin is produced in a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where optimum environmental condition like sterile air, nutrients and controlled
friendly environment for the microorganisms is maintained. When sufficient seed has
been developed, it is transferred to fermenter. Fermenter is a large vessel with
agitator and cooling coils. Raw materials, nutrients, sterilized air, microorganisms etc.
are fed in the vessel. Suitable process parameters i.e. Temperature, pH, dissolved
oxygen and agitation are maintained in the fermenter for production of the desired
product.
The broth is filtered and washes the cake with RO water and the wet cake is extracted
with methanol and then concentrate up to last drop under vacuum. The residue mass
is further extracted with ethyl acetate. The organic layer is concentrate under vacuum.
Isopropyl is added and stir to get required crystallized product. The wet cake is
suspended in Isopropyl alcohol and filter to get the pure Fidaxomycin. The recovered
solvents are stored in the respective solvent tanks for reused and the residue mass
send to incinerator.
Concord Biotech Limited A-8
Process flow diagram
Concord Biotech Limited A-9
6. Mupirocin & salts
Process description
Mupirocin is produced in a single stage fermentation process. The microorganisms are
activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw materials, nutrients,
sterilized air, microorganisms etc. are fed in the vessel. Suitable process parameters
i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the fermenter
for production of the desired product.
The fermentation broth containing active mupirocin is harvested and the pH of the
broth is adjusted to about 4.0-4.5 by slow addition of aqueous sulphuric acid solution.
The fermentation broth is then extracted with Ethyl acetate by adding ethyl acetate
under stirring. The ethyl acetate is then separated from the broth using decanter and
rich ethyl acetate obtained. Rich ethyl acetate is then washed with water and the 2%
solution of sodium bicarbonate is added to it, stirred and allowed to settle. The rich
aqueous layer is then separated and organic layer is again treated with 2% sodium
bicarbonate solution. Both the aqueous layers are combined together and ethyl acetate
is added to it. The pH of the solution mixture is adjusted to about 4.0-4.5 by slow
addition of aqueous sulphuric acid solution so that Mupirocin get transferred in ethyl
acetate as a free acid. After adjusting the pH and stirring, the solvent mixture is
passed through decanter to separate the organic layer and aqueous layer. The organic
layer of ethyl acetate thus obtained treated with charcoal and filtered. The filtered
clear solution treated with anhydrous sodium Sulphate to dry the organic layer and
again filtered. The rich ethyl acetate thus obtained is concentrated at 25-30°C till the
required concentration of Mupirocin. The ambient amount of n-Heptane is added to this
solution and allowed to stir for about 20-72 hrs to crystallize the Mupirocin crude. It is
filtered and dried under vacuum till its LOD is less than 1.0% to get the Mupirocin
crude.
Take the Mupirocin crude and dissolve in the ethyl acetate so that the concentration of
mupirocin is 150-200 g/L. Heat the solution to 40-45°C so that mupirocin crude get
dissolved completely. Filter the solution to get the clear solution. This clear solution is
taken in a reactor and required quantity of n-Heptane is added. The turbid solution
kept on stirring till crystallization of mupirocin started. The stirring continued for 20-24
hrs and then at 10-15°C for further 5-10 hrs. The crystallized Mupirocin is filtered on a
nutch filter to get the wet cake of Mupirocin pure. Wet cake is washed with cold (10-
Concord Biotech Limited A-10
15°C) ethyl acetate and dried under vacuum at 30-35°C. After drying the material is
packed and analyzed for Mupirocin purr.
Process flow diagram
Concord Biotech Limited A-11
7. Fosfomycin
Process Description
Charge RO water, Fosfomycin phenyl ethyl amine and MIBK under stirring at room
temperature. Cool the reaction mass and add sodium hydroxide solution under cooling.
Maintain the stirring for 1 hour and then separate the layer. The rich aqueous layer is
taken for carbon treatment and then loads the aqueous layer for lypophillization.
Unload the required product after 65 hours and packed after analysis. The organic
layer is taken for solvent recovery and phenyl ethyl amine as byproduct which can be
sold in market. The residue is sent for incineration.
Process flow diagram
Concord Biotech Limited A-12
8. Dalbavancin
Process Description
Dalbavancin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
The harvested broth is filter and filtrate is taken for nano filtration while mycelia send
to ETP. The product is extracted with n-butanol from retentant and spent aqueous
mass along with permeate is send to ETP. The n-butanol layer is concentrate up to last
drop under vacuum and residue is precipitate with ethyl acetate. Filter the required
product and dry. The mother liquor send for solvent recovery and residue send for
incineration.
Concord Biotech Limited A-13
Process flow chart: Dalbavancin
Concord Biotech Limited A-14
9. Telavancin
Process Description
Telavancin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
Process flow diagram
Concord Biotech Limited A-15
10. Capreomycin
Process Description
Capreomycin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
The Harvested broth is extracted with ethyl acetate and spent broth is sent for ETP.
While rich ethyl acetate is concentrated under vacuum. The residual mass is
crystallized with n-heptane at lower temperature. The wet cake of the required product
is taken for drying. The filtrate is taken and sends for solvent recovery for reused and
residual mass is sent for incineration.
Process flow diagram
Concord Biotech Limited A-16
11. Tobramycin Sulphate
Process Description
Tobramycin Sulphate is produced by a single stage fermentation process. The
microorganisms are activated from dormant state to vegetative state in microbiological
Laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank where sterile air, nutrients and controlled friendly environment for the
microorganisms is maintained. When sufficient seed has been developed, it is
transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
The harvested broth is filter and filtrate is pass from resin while mycelia send to ETP.
The product is extracted with Ethyl Acetate and spent aqueous mass along with
permeate is send to ETP. The Ethyl acetate layer is concentrate up to last drop under
vacuum and residue is precipitate with ethyl acetate. Filter the required product and
dry. The mother liquor send for solvent recovery and residue send for incineration.
Concord Biotech Limited A-17
Process flow diagram
Concord Biotech Limited A-18
12. Oritavancin
Process Description
Oritavancin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiology Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, suitable raw materials and controlled environment for the growth of
microorganisms is maintained. When sufficient growth of microorganism in form of
seed has been developed, it is transferred to main fermenter for the production.
Fermenter is a large vessel having mixing device and heating/cooling coils. Raw
materials, nutrients, sterilized air, microorganisms in form of seed etc. are fed in the
vessel. Appropriate process parameters i.e. Temperature, pH, dissolved oxygen,
agitation etc. are maintained in the fermenter which helps in desired growth of
microorganisms as well as for the production of desired product.
Oritavancin is fermentation and synthesis product. Oritavancin is two step products,
first Isolate intermediate A82846B by fermentation and second single step synthesis.
Filter the broth of A82846B and wash the cake with RO water, load the filtrate in to
resin and elute with mix solvent (water + isopropyl alcohol), distil out pool fraction and
pure with preparative HPLC to give pure A82846B. Take pure A82846B and add chloro
biphenyl carboxaldehyde with methanol to reflux it and concentrate the mass to give
oily mass. Crystallisation the oily mass with Isopropyl alcohol to give pure Oritavancin.
The recovered solvents are stored in the respective solvent tanks for reused and the
residue mass send to incinerator.
Concord Biotech Limited A-19
Process Flow Diagram
Concord Biotech Limited A-20
C. Antiparasitic
13. Milbemycin oxime
Process Description
Milbemycin is produced by a single stage fermentation process. The microorganisms
are active ted from dormant state to vegetative state in microbiological Laboratory.
The vegetative state microorganisms are further germinated to seed stage in the seed
tank where sterile air, nutrients and controlled friendly environment for the
microorganisms is maintained. When sufficient seed has been developed, it is
transferred to fermenter. Fermenter is a large vessel with mixing device and cooling
coils. Raw materials, nutrients, sterilized air, microorganisms etc. are fed in the vessel.
Suitable process parameters i.e. Temperature, pH, dissolved oxygen and agitation are
maintained in the fermenter for production of the desired product.
Extract the broth with Ethyl acetate and spent broth is transfer to ETP. The rich Ethyl
acetate is filtered to remove the suspension mass. The filtrate is concentrate up to last
drop under vaccum at room temperature. Charge isopropyl alcohal to oily mass under
stirring. Stir the mass to get clear solution then cool slowly. Chill the mass and
maintain for 5 hrs to crystallized the required product. Filtered and then unload the
material for drying. Packed the final product after analysis. Filtrate is sent for solvent
recovery and the residual mass is sent for incineration.
Concord Biotech Limited A-21
Process flow diagram
Concord Biotech Limited A-22
D. Antifungal
14. Pneumocandin B0
Process Description
Pneumocandin B0 is intermediate for the Caspofungin which is an antifungal drug.
Pneumocandin B0 is produced by the fungal strain Zalerion arboricola through
fermentation process. Pneumocandin B0 is recovered from fermentation broth through
different steps of recovery. Manufacturing of Pneumocandin B0 is carried out in three
different stages:
Preparation of Seed: Laboratory inoculums comprises of Vegetative growth (2000-
3000 ml).Vegetative growth is developed by inoculating 100/200 ml of seed media
contained in 500/1000 ml conical flasks with spore suspensions from working cell
bank. The inoculated flasks are incubated on rotary shaker at 22-28ºC and 250 ± 10
RPM. The matured vegetative growth from different flasks is collected in sterilized
inoculation assembly under aseptic condition on Laminar air flow work bench. This
matured vegetative growth is used to inoculate seed fermenter. Seed fermenter is
prepared by sterilizing 500-1000 Liters seed medium at 123 ± 3 ºC for 40 to 50
minutes and inoculated with laboratory inoculum under aseptic conditions. The seed is
incubated at 22-28ºC for 40-120 hrs and checked periodically for purity, pH and PMV
(%). After achieving desired criteria seed culture is being transferred to Main
fermenter.
Fermentation: Pneumocandin production is carried out in production fermenter by
aseptically transferring the seed (5-7%) to production medium (8 to 14 KL) sterilized
at 123 ± 3 ºC for 40 to 50 minutes. The fermenter is incubated at 22-28 ºC. During
the fermentation cycle the appropriate culture conditions like aeration, agitation and
back pressure are maintained. L-Proline is added as a precursor from 90 hrs onwards.
D-Mannitol is used as feed from 180 hrs onwards. It serves the dual purpose as energy
source and also maintains the pH of fermenter broth in the range of 6.5 to 8.0.
Foaming is controlled by addition of the mixture of antifoaming agent and soya oil. The
fermentation broth samples are checked periodically for pH, PMV (%), purity and
activity. The fermentation batch is harvested at around 250-360 hrs when there is no
significant increase in Pneumocandin B0 concentration as is ascertained by HPLC
analysis.
Recovery: The fermentation broth is harvested and extracted with Iso-butyl acetate.
The rich isobutyl acetate is then concentrated to get the concentrated mass. A binder
is prepared from Calcium chloride and Potassium phosphate which is then added to the
concentrate mass. Stirred well and filtered and dried to get the Pneumocandin B0
crude. The filter is then washed with methanol. The methanol containing
Concord Biotech Limited A-23
Pneumocandin B0 is concentrated and crystallized by adding Acetonitrile. Precipitated
product is then filtered and dried to get the Pneumocandin B0 pure.
Process Flow Diagram
Concord Biotech Limited A-24
15. Caspofungin
Process Description
Caspofungin is a semisynthetic API manufactured from Pneumocandin B0 by multistep
synthetic process. The pneumocandin B0 is treated with Cyanuric chloride in Dimethyl
formamide at -30°C for 20-30 hrs. After the reaction is complete it is decomposed by
addition of water and the product 1 is isolated in liquid solution by solid phase
extraction technique. To this solution a catalyst is added and catalytic hydrogenataion
is carried out in the presence of Ammonium acetate and acetic acid. After complete
hydrogenation the solution is filtered using hyflo and the product 2 (An amine
intermediate) is obtained again by solid phase extraction.
This amine intermediate is taken in acetonitrile and treated with tetrazole at -10°C in
presence of Phenyl Boronic acid and Triflic acid. After completion of the reaction
monitored by HPLC, the reaction is quenched by addition of methanol. The resultant
solution containing product 3 is allowed to react with 1,2-diaminoethane in presence of
ethyl acetate for 2-3 days. Once the reaction completes, the caspofungin formed is
purified by SPXL resin using ethanol water mixture. The rich cuts are taken together
and the repurified on preparative HPLC using acetonitrile as a mobile phase. The pure
fractions are taken together and precipitated out by addition of 10% aq. NaCl solution.
The precipitated solid is filtered and again recrystallized using ethanol, acetic acid and
ethyl acetate mixture. The crystallized material is filtered and dried under nitrogen to
get the Caspofung in diacetate as the final drug substance.
Concord Biotech Limited A-25
Process Flow Diagram
Concord Biotech Limited A-26
16. Micafungin
Process Description
Mixture of Nucleus FR901379, [4-[5-(4-pentyloxyphenyl) isoxazol-3-yl] benzoyloxy]-
1H-1, 2, 3-benzotriazole (Side chain) in N, N-dimethylformamide, DMF and 4-(N,N-
dimethylamino) pyridine (DMAP) are stirred for 12 hours at ambient temperature. The
reaction mass is then diluted with ethyl acetate and further wet cake is obtained by
filtration. Mother liquor send for the solvent recovery. Wet cake is suspended in the
mixture of acetone and ethyl acetate. Stir and filter the material, after drying white
color solid powder of micafungin is obtained. Mother liquor is sent to solvent recovery.
Process flow chart
Concord Biotech Limited A-27
17. Anidulafungin
Process description
Mixture of Echinocandin Nucleus, Side chain (TOBt), KH2PO4, acetone and water are
stirred for 3 hours at 55°C. Cool the reaction mixture at room temperature and filter it.
Wet cake is suspended in RO water and stir for 1 hour. Filter the product, after drying
solid powder of Anidulafungin is obtained. The aqueous filtrate is send to ETP while
aqueous acetone filtrate is distilled to recover the solvent and aqueous residual mass
is also send for incineration.
Process flow diagram
Concord Biotech Limited A-28
E. Immunosuppressant
18. Tacrolimus
Process Description
Tacrolimus is produced in a single stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetative state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for 36-48 hr) where sterile air, nutrients and controlled friendly
environment (pH and temperature 27oC) for the microorganisms is maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw Material, nutrient,
sterilized air, microorganism’s etc. are fed in the vessel. Suitable environment that is,
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues for nearly 240 hrs.
The fermentation product is recovered in the harvester through solvent (Toluene)
extraction and purified through multiple solvent washing, concentration in vacuum and
dried. The dried product is further purified by crystallization, drying and analyzed and
if found meeting the desired specification is packed and sent to warehouse. Spent
solvent are recovered in the solvent recovery units. The recovery and purification steps
are operated carefully for safety of the system. After each campaign total plant is
thoroughly cleaned, washed, sterilized and recalibrate.
The solvent residue from the solvent distillation column is sent for incineration. Figure
shows the process flow diagram detailing the important step and raw material
requirement for each batch.
Concord Biotech Limited A-29
Process Flow Diagram
Concord Biotech Limited A-30
19. Mycophenolic Acid
Process Description
MPA is produced in a single stage fermentation process. The spores of microorganisms
are activated from dormant state to vegetative state in microbiological laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
(for 36 - 48 hr) where sterile air, nutrients and controlled friendly environment (pH
and temperature 27oC) for the microorganisms is maintained. When sufficient seed has
been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw Material, nutrient,
sterilized air, microorganism’s etc. are fed in the vessel. Suitable environment that is,
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues for nearly 240 hrs.
The fermentation product is recovered in the harvester through solvent (IBA)
extraction and purified through multiple solvent washing, concentration in vacuum and
dried. The dried product is further purified by crystallization, drying and analyzed and
if found meeting the desired specification is packed and sent to warehouse.
Spent solvent are recovered in the solvent recovery units. The recovery and
purification steps are operated carefully for safety of the system. After each campaign
total plant is thoroughly cleaned, washed, sterilized and recalibrate.
The solvent residue from the solvent distillation column is sent for incineration. Figure
shows the process flow diagram detailing the important step and raw material
requirement for each batch.
Concord Biotech Limited A-31
Process Flow Diagram
Concord Biotech Limited A-32
20. Cyclosporine
Process Description
Cyclosporine is produced in a single stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetative state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for 36-48 hours) where sterile air, nutrients and controlled friendly
environment (pH and temperature 27oC) for the microorganisms is maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw materials, nutrients,
sterilized air, microorganisms etc. are fed in the vessel. Suitable environment that is,
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues for nearly 240 hours.
The fermentation product is recovered in the harvester through solvent (Toluene)
extraction and purified through multiple solvent washing, concentration in vacuum and
dried. The dried product is further purified by crystallization, drying and analyzed and
if found meeting the desired specification is packed and sent to warehouse.
Spent solvent are recovered in the solvent recovery units. The recovery and
purification steps are operated carefully for safety of the system. After each campaign
total plant is thoroughly cleaned, washed, sterilized and recalibrate.
The solvent residue from the solvent distillation column is sent for incineration. Figure
shows the process flow diagram detailing the important step and raw material
requirement for each batch.
Concord Biotech Limited A-33
Process Flow Diagram
Concord Biotech Limited A-34
21. Rapamycin
Process Description
Rapamycin is produced in a single stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetation state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for 36 - 48 hours) where sterile air, nutrients and controlled friendly
environment (pH and temperature 27oC) for the microorganisms is maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw Material, nutrient,
sterilized air, microorganisms etc. are fed in the vessel. Suitable environment that is,
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues for nearly 240 hrs.
The fermentation product is recovered in the harvester through solvent (IBA)
extraction and purified through multiple solvent washing, concentration in vacuum and
dried. The dried product is further purified by crystallization, drying and analyzed and
if found meeting the desired specification is packed and sent to warehouse.
Spent solvent are recovered in the solvent recovery units. The recovery and
purification steps are operated carefully for safety of the system. After each campaign
total plant is thoroughly cleaned, washed, sterilized and recalibrate.
The solvent residue from the solvent distillation column is sent for incineration. Figure
shows the process flow diagram detailing the important step and raw material
requirement for each batch.
Concord Biotech Limited A-35
Process Flow Diagram
Concord Biotech Limited A-36
22. Mycophenolate Mofetill & Mycophenolate sodium
Manufacturing Process Description of Mycophenolate mofetil:
It is single stage reaction involving the condensation of Mycophenolic Acid with
Morphonline -2- ethanol in Xylene to give crude Mycophenolate Mofetil, which is then
purified through multiple solvent washing, drying and analysed and if found meeting
the desired specification is packed and send to finished goods.
Manufacturing Process Description of Mycophenolate sodium:
It is single stage reaction involving the reaction between Mycophenolic Acid with
Sodium 2 Ethyl Hexaunic acid. After this it is centrifuge, drying and analyzed and if
found meeting the desired specification is packed and send to finished goods.
Process Flow Diagram
Concord Biotech Limited A-37
F. Onco Products
23. Ixabepilone
Process description
Charge Ethyl acetate, Epothilone B, tetrabis (TPP) palladium and sodium azide in the
reactor under dry condition. Stir the mass for four hours and quinch in water and then
extract with ethyl acetate. The aqueous layer is send to ETP and organic layer distill up
to last drop under vacuum at room temperature. Charge ethyl acetate in the oily mass
then charge trihenyl phosphine and diphylphoryl azide. Heat the reaction to 50 - 55°C
and maintain for 2 hours. Cool the reaction and quinch with water. Extract the mass
with ethyl acetate and taken for distillation under vacuum to isolate the require
product. The distilled solvent is send to solvent tank. The aqueous layer sends to ETP.
The colorless oil which is product is pack after analysis.
Process flow diagram
Concord Biotech Limited A-38
24. Romidepsin
Process description
Romidepsin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
The harvested broth is filter and the filtrate is taken for nano filtration while mycilia
cake is send to ETP. The permeate from nano filter is send to ETP while retentate is
loaded on HP-20 resin and elute the product with 1 % hydrochloric acid. Pool the
fraction and extract with iso butyl acetate at basic pH. The spent aqueous is send to
ETP. The iso butyl acetate is concentrate and the residual mass is cool and chill to
crystallize the required product. The mother liquor is taken for solvent recovery and
residue send for incineration. The final product is packed after drying.
Concord Biotech Limited A-39
Process flow diagram
Concord Biotech Limited A-40
25. Temsirolimus
Process Description
Charge dichloromethane, sirolimus and DMAP in the reaction. Cool the mass and then
add mixed anhydride drop wise within two hours. Once the reaction is completed, add
water and stir. Separate the layers. The aqueous layer is send to ETP and organic layer
is distilled up to the last drop under vacuum. Add terahydro furan to oily mass and
hydrolyzed with hydrochloric acid to convert intermediate crude temsirolimus. Distilled
off tetra hydro furan and residue is crystallized with n-heptane. Filter the required
product and dry under vacuum then pack after analysis. Distil filtrate to remove the
solvent and send residue for incineration.
Process flow diagram
Concord Biotech Limited A-41
26. Everolimus
Process Description
Charge toluene, 2, 6 lutidine and sirolimus. Stir the mass and heat to 50 - 60°C and
then add triflate within one hour. Maintain the reaction for four hour. Once the reaction
is completed, cool the reaction mass and then add water. Stir and separate the layer.
Aqueous layer send to ETP while organic layer is distil up to last drop under vacuum.
Charge methanol to the residue under stirring and hydrolyse with formic acid to
convert intermediate everolimus. Distill off methanol up to last drop and residue is
taken in dichloromethane. Wash the organic layer with water and then distill off
dichloromethane under vacuum. Residue is crystallized with n-heptane. Filter and dry
the product and pack after analysis. The filtrate is distilled off to recover n-heptane
and residue is sent for incineration.
Process flow diagram
Concord Biotech Limited A-42
27. Ridaforolimus
Process Description
Charge in the reactor followed by the addition of siroliums under stirring. Add pyridine
then chill the reaction mass to 0°C and then start the addition of dimethyl phophoric
chloride drop wise with in 1hr. Once reaction is completed then quench in water under
chilling condition. Separate the organic layer and wash layer with bicorbonate solution.
Distil the organic layer up to last drop under vacuum and residue is crystallizing with
n-Hexane. Filter the mass and dry the product under vacuum. Unload the product and
pack after analysis while the filtrate is distilled to recover the solvent and residue is
send to incinerator.
Process flow diagram
Concord Biotech Limited A-43
28. Pimecrolimus
Process Description
Ascomycin is dried using Toluene then dissolved in toluene and acetonitrile. Then add
of triflic anhydirde followed by addition of Diisopropulamine in the reaction mass and
then add trific anhydride followed by addition of Diisopropyl amine in the reaction
mass and then add benzen .Once reaction is over added water washed with water and
separate organic layer. Organic phase is distilled under vacuum to obtain crude
Pimecrolimus as oily mass which is purified by aqueous acetone. Final product is
packed after analysis and collects the filtrate and send for solvent recovery and
residue send for incineration.
Process flow diagram
Concord Biotech Limited A-44
29. Doxorubicin
Process Description
Charge the RO water in the reactor followed by the addition of Bromo daunorubicin.
Stir the mass after addition of hydro-bromic acid then extract the product in
dichloromethane. Concentrate the organic layer under vacuum and the residue is
loaded on HP- 20 column for purification. Elute the residue product with 50% aqueous
acetone. Pool the fractions and concentrate. The aqueous residual portion is cool &
chill to crystallize the product. Filter, dry under vacuum and pack after analysis.
Mother liquor is send for solvent recovery.
Process flow diagram
Concord Biotech Limited A-45
30. Daunorubicin
Process Description
Daunorubicin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
Take broth which is containing Duanorubicin and adjust pH 1 to 3 with oxalic acid.
Remove mycelia from Microfiltration and then take Aq. Layer for nano-filtration. Take
Retentate and pure with resin column with elute Water: Methanol. Pool the fractions
and distillation. Add Acetone in residual mass and filter and dry to give daunarubicin
red-orange color and packaged the final material. Mother liquor send for solvent
recovery and residue send for incineration.
Concord Biotech Limited A-46
Process flow diagram
Concord Biotech Limited A-47
31. Epirubicin
Process Description
Charge RO water and sodium hydroxide under stirring & cooling. Charge EPi-TFA
daunorubicin and maintain the reaction mass under stirring for 1 hr. Extract the
reaction mass with dichromethane. Concentrate the organic layer and the residual is
precipitate with n-Hexane. Filtered the mass, unload the wet cake and dry under
vacuum and then packed after analysis. Filtrate is taken for solvent recovery. The
residual mass is sent for incineration.
Process flow diagram
Concord Biotech Limited A-48
32. Idarubicin
Process Description
Idarubicin is produced by a single stage fermentation process. The microorganisms are
activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
The harvested broth is filtered and filtrate is send to ETP. While solid mass is
suspended in MIBK, stir for 2 hr. then filter. The spent solid mass is send for
incineration and organic phase is taken for distillation up to last drop under vaccum.
The recovered solvent is send to respective solvent tank. The residual oilish mass is
crystallizing with acetonitrile and then filter. The require product is dried and packed
after analysis and filtrate is taken for solvent recovery and corresponding residue is
send for incineration.
Concord Biotech Limited A-49
Process flow diagram
Concord Biotech Limited A-50
33. Bleomycin
Process Description
Bleomycin is produced by a single stage fermentation process. The microorganisms are
activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
The harvested broth is filter and the filtrate is taken for nano filtration while mycilia
cake is send to ETP. The permeate from nano filter is send to ETP while retentate is
loaded on HP-20 resin and elute the product with 1% hydrochloric acid. Pool the
fraction and extract with ethyl acetate at basic pH. The spent aqueous is send to ETP.
The rich ethyl acetate is concentrate and the residual mass is cool and chill to
crystallize the required product. The mother liquor is taken for solvent recovery and
residue send for incineration. The final product is packed after drying.
Concord Biotech Limited A-51
Process flow diagram
Concord Biotech Limited A-52
34. Geldanamycin
Process Description
Geldanamycin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiological Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to fermenter.
Fermenter is a large vessel with mixing device and cooling coils. Raw materials,
nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable process
parameters i.e. Temperature, pH, dissolved oxygen and agitation are maintained in the
fermenter for production of the desired product.
The harvested broth is filter and filtrate is taken for nano filtration while mycelia send
to ETP. The product is extracted with MIBK from retentate and spent aqueous mass
along with permeate is send to ETP. The MIBK layer is concentrate upto last drop
under vacuum and residue is precipitate with ethyl acetate. Filter the required product
and dry. The mother liquor send for solvent recovery and residue send for incineration.
Concord Biotech Limited A-53
Process flow diagram
Concord Biotech Limited A-54
35. Mitomycin
Process description
Mitomycin is produced by a single stage fermentation process. The microorganisms are
activated from dormant state to vegetative state in microbiology Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, suitable raw materials and controlled environment for the growth of
microorganisms is maintained. When sufficient growth of microorganism in form of
seed has been developed, it is transferred to main fermenter for the production.
Fermenter is a large vessel having mixing device and heating/cooling coils. Raw
materials, nutrients, sterilized air, microorganisms in form of seed etc. are fed in the
vessel. Appropriate process parameters i.e. Temperature, pH, dissolved oxygen,
agitation etc. are maintained in the fermenter which helps in desired growth of
microorganisms as well as for the production of desired product.
Mitomycin is produced in a single stage fermentation process. Filter the broth and
wash the cake with RO water, pass the filtrate with Resin and distil out pool fraction.
Crystallisation mass with methanol and dry in oven to give pure Mitomycin. The
recovered solvents are stored in the respective solvent tanks for reused and the
residue mass send to incinerator.
Concord Biotech Limited A-55
Process flow diagram
Concord Biotech Limited A-56
36. Dactinomycin
Process description
Dactinomycin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiology Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, suitable raw materials and controlled environment for the growth of
microorganisms is maintained. When sufficient growth of microorganism in form of
seed has been developed, it is transferred to main fermenter for the production.
Fermenter is a large vessel having mixing device and heating/cooling coils. Raw
materials, nutrients, sterilized air; microorganisms in form of seed etc. are fed in the
vessel. Appropriate process parameters i.e. Temperature, pH, dissolved oxygen,
agitation etc. are maintained in the fermenter which helps in desired growth of
microorganisms as well as for the production of desired product.
Dactinomycin is produced in a single stage fermentation process. Add toluene in to
broth and filter it, take filtrate and concentrate up to oily mass. Purified oily mass with
column chromatography and pool fraction. Crystallisation in diisopropylether solvent to
give Pure Dactinomycin. The recovered solvents are stored in the respective solvent
tanks for reused and the residue mass send to incinerator.
Concord Biotech Limited A-57
Process flow diagram
Concord Biotech Limited A-58
37. Trabectedin
Process description
Trabectedin is produced by a single stage fermentation process. The microorganisms
are activated from dormant state to vegetative state in microbiology Laboratory. The
vegetative state microorganisms are further germinated to seed stage in the seed tank
where sterile air, nutrients and controlled friendly environment for the microorganisms
is maintained. When sufficient seed has been developed, it is transferred to main
fermenter for the production.
Fermenter is a large vessel with mixing device and heating/cooling coils. Raw
materials, nutrients, sterilized air, microorganisms etc. are fed in the vessel. Suitable
process parameters i.e. Temperature, pH, dissolved oxygen and agitation are
maintained in the fermenter which helps in desired growth of microorganism as well as
for the production of desired product.
Trabectedin is Fermentation and Semi synthesis Product. Extract the broth with ethyl
acetate, and concentrate the rich ethyl acetate to give oily mass. Load the mass in to
silica gel column, elute the material with mix solvent of ethyl acetate + methanol,
concentrate the pool fraction to give Safracin-B, to be proceed chemically synthesis
and extract it with solvent and distill out solvent completely under vacuum, wet
product dry under vacuum to give pure Trabectedin. The recovered solvents are stored
in the respective solvent tanks for reused and the residue mass send to incinerator.
Concord Biotech Limited A-59
Process Flow diagram
Concord Biotech Limited A-60
G. Statin
38. Lovastatin
Process Description
Lovastatin is produced in a single stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetative state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for 36-48 hr at 27oC) where sterile air, food and controlled friendly
environment (pH and temperature) for the microorganisms is maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw Materials, nutrient,
sterilized air, microorganism’s etc. are fed in the vessel. Suitable environment that is
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues for nearly 240 hrs.
The fermentation product is recovered in the harvester through solvent (Toluene)
extraction and purified through multiple solvent washing, concentration in vaccum and
dried. The dried product is further purified by crystallization, drying and analysed and
if found meeting the desired specification is packed and sent to warehouse.
Spent solvent is recovered in the solvent recovery units. The recovery and purification
steps are total plant is thoroughly cleaned, washed, sterilized and recalibrate.
The solvent residue from the solvent distillation column is sent for incineration. Figure
shows the process flow diagram detailing the important step and raw material
requirement for each batch.
Concord Biotech Limited A-61
Process Flow Diagram
Concord Biotech Limited A-62
39. Pravastatin
Process Description
Pravastatin is produced in two – stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetative state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for about 36-48 hours) where sterile air, food and controlled friendly
environment (pH and temperature 27oC) for the microorganisms are maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw materials, nutrients,
sterilized air, microorganism etc. are fed in the vessel. Suitable environment that is,
temperature, pH, dissolved oxygen and agitation are maintained in the fermenter for
production of the desired product. The fermentation continues about 120 hrs.
The fermentation product is recovered in the harvester through solvent (IBA)
extraction and purified through multiple solvent washing, concentration in vacuum and
dried. The dried product is further purified by crystallization, drying and analyzed and
if found meeting the desired specification is packed and sent to warehouse.
Spent solvent are recovered in the solvent recovery units. The recovery and
purification steps are operated carefully for safety of the system. After each campaign
total plant is thoroughly cleaned, washed, sterilized and recalibrate.
The solvent residue from the solvent distillation column is sent for incineration. Figure
shows the process flow diagram detailing the important step and raw material
requirement for each batch.
Concord Biotech Limited A-63
Process Flow Diagram
Concord Biotech Limited A-64
40. Orlistatin
Process Description
Orlistatin is produced in a single stage fermentation process. The spores of
microorganisms are activated from dormant state to vegetative state in microbiological
laboratory. The vegetative state microorganisms are further germinated to seed stage
in the seed tank (for 36-48 hrs at 270C) where sterile air, food, and controlled friendly
environment (pH and temperature) for the microorganisms is maintained. When
sufficient seed has been developed, it is transferred to the fermenter.
Fermenter is a large vessel with agitator and cooling coils. Raw material, nutrient,
sterilized air, microorganism’s etc. are fed in the vessel. Suitable environment that is,
temperature, pH, DO and agitation are maintained in the fermenter for production of
the desired product. The fermenter continues for nearly 240 hrs.
The fermentation product is recovered in the harvester through solvent (N- Heptane)
extraction followed by hydrogenation reaction and purified through multiple solvent
washing, concentration in vacuum and dried. The dried product is further purified by
crystallization, drying and analysed and if found meeting the desired specification is
packed and sent to warehouse. Spent solvent are recovered in the solvent recovery
units. The recovery and purification steps are operated carefully for the safety of the
system. After each campaign the total plant is thoroughly cleaned, washed, sterilized
and recalibrate. The mycelium, organics residue form the solvent distillation column,
vessel washing, etc. are all sent to ETP for treatment or incinerator for safe disposal.
Process Flow Diagram
Annexure-II
MoU from Ambuja Cement Ltd. for co-processing of
waste
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C W P WJJK LTO ~ ? i . r ? 2 5i :j !: - r : n a 8 7 :)fi* 2 . . , . b - . . , I , .
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---= :rmn HTT.OOQL?~GQ!-PF,~EG~ SERVICE AGREEMENT STWlk6P !>I$ i ' ~ BMJ,IT+_I.iT
This service agreement ("this agreement") is made at Ahmedabad o n e ~ a ~ of S E P ~ E ~ B B ~ ? 2016.
BETWEEN
Ambuja Cements Limited (CIN : L26942GJl981PLC004717), a company incorporated and registered under the provisions of the companies Act, 1956 and having its registered-office and factory at P.O. Ambuja'nagar, Taluka Kodinar, Dist. Gir Somnath, Gujarat 362 715 (India), having its division/ unit/ section as 'Geocycle" that provides specialized services for thermal destruction or recovery of hazardous/ non Hazardous waste material etc in cement. kilns (hereinafter referred to as "the First. Party" or "the Service Provider" which expression shall, unless repugnant to the context or meaning thereof, be deemed to mean and include its successors and assigns ) represented herein by Mr S Ramarao who is authorized to do so on behalf of company of the FIRST PART.
AND Concord ~ io tech Ltd (~1~:~24230~~1984~~~007440), a company incorporated under the provisions of the Companies Act, 1956' and having its registered office .and manufacturing facility. at 'Plot No.1482/1486, Village Trasad Rs, Tal- Dholka, Dist.- Ahmedabad, PIN- 382225, Gujarat (hereinafter referred to as "the Second Party" or 'the Generator' which expression shall, unless repugnant to the context of. meaning thereof, be deemed to mean a'nd include its successors in business and assigns) represented herein by R J Modi, who is authorized to do. so through the ',' resolution passed by its Board of directors of the SECOND PART. The Service Providerand Generator are individually referred to as Party and collectively as Parties. WHEREAS:
a) Ambuja Cements Ltd. ('the Service Provider') is in the business of manufacturing and selling Ambuja branded cement through its distributors/dealers throughout India.
b) Geocycle is a business unit of the Service Provider that provides specialized services for thermal destruction or recovery of hazardous/non hazardous waste material etc, in cement kilns.
c) The Generator, who is in the business of manufacturing of Pharmaceutical products desires to dispose of its waste and has requested the Service Provider to co-process the Spent Carbon (Category - 28.2) ("Material") and the Service Provider has agreed with the Generator to preprocess and/or transport and/or store and co-process the waste generated by the Generatdr upon the ,.-,, following terms and conditions.
I . "FACILITY" means 'Cement Kilns having capability to Co- process the waste generated by th'e Second Party'.
1.2 "SERVICES" means the providing waste management solutions through co-processing as defined below:-
1.3 "Co-processing" means treatment of Hazardous/Non Hazardous waste in Cement Kilns,
1.4 "Pre-processing" means pre-treatment of Hazardous/Non Hazardous waste making it suitable for co-processing,
1.5 "Hazardous Waste" means 'Hazardous Wastef as specified in Hazardous Wastes (Management, Handling and Trans- boundary Movement) Rules, 2016.
1.6 "Rules" means Hazardous Wastes (Management, Handling and Trans-boundary Movement) Rules, 2016
1.7 "SPCBff means 'State ~ollution Control Board' (a state pollution control board).
1.8 "CPCB" means 'Central Pollution Control Board'. 1.9 "Total Fees" means invoice amount raised by service provider
which contains Co-processing charges, applicable taxes, transportation charges if any.
1.10 The headings of or title to the Clauses in this Agreement shall not be deemed to be a part thereof or be taken into consideration in the interpretation or construction thereof of the agreement.
1.11 Words imparting the singular only also include the plural and vice versa where the context so require.
1.12 The present agreement is entered into by the Service Provider for Co-processing of Hazardous/Non' Hazardous Waste a
generated by the Generator. 2. 2 2.1 This Agreement shall be in force for the period of Two (2)
years & I1 (eleven) months commencing on the day of September 2016 and will end on day of July 2019.
2.2 Upon expiration of the term of this Agreement, both the parties hereto may mutually agree for renewal on terms and conditions as decided by the parties mutually.
2.3 The agreement shall be valid until all outstanding amounts are paid in full by the Generator even following the initial term of 2 years & eleven months are over.
A-66
3. SPECIFICATIONS '
Material requiring treatment will have certain specifications as stated in Annexure-A. Material that meets all of the Specifications stated in Annexure-A and Special Instructions, stated in Clause 3A, will be considered as "Conforming Material". Material will be considered 'Non-Conforming Material" if it fails to meet any one of the Specifications or Special Instructions. a) The Generator will ensure all Hazardous Waste sent for
treatment to the Service Provider shall, under all circumstances, conform to the norms specified by SPCB and as prescribed under the provisions of law in force at the relevant time.
b) At no time the Generator shall send Hazardous Waste containing toxic materials exceeding the limits of concentration as specified or that may be notified by the Service Provider / SPCB from time to time.
c) Subject to the availability of space with the Service Provider, the Generator agrees to send material requiring treatment on a regular basis to the Service Provider. Such quantity shall not be less than 10 MT annually and shall be called the "contracted minimum quantity".
d) The Generator shall send a t its costs and risks the contracted quantity to the site of the Service Provider.
4. NON-CONFORMING MATERIAL
At any time after receiving delivery of Material, if the Service Provider finds that some or all are Non-Conforming Material, the Service Provider may charge applicable.surcharges or, at sole cost of the Generator, may bring the Non-Conforming Material into conformance with the specifications or notify the Generator and require the Generator to arrange for immediate removal' of the Non-Conforming Material from the Service Provider's property ("Rejection"). The Service Provider will send written confirmation to the Generator of all such Rejections along with an estimated cost of whatsoever nature, which is likely to be incurred for the Non-Conforming Material. The Service Provider reserves the right, after waiting three (3) days from date the Generator receives notice of the Rejection, to transport such Non-Conforming Material to the Generator for proper disposal. The Service Provider shall be entitled to collect from the Generator any costs and expenses it incurs, including but not limited to transport, storage or disposal costs. The Generator designates the in-fact and authorizes it to sign any transport the Non-Conforming accordance with this Paragraph.
.i;.
0 A-67
Unless otherwise agreed to by the Service Provider, the title, risk of loss and spillage to Conforming Material shall be transferred to the Service Provider upon receipt of the Material and Confirmation of Conformity by the authorized personnel of the Service Provider. Unless otherwise agreed to by the Service Provider in writing, title to IVon-Conforming Material shall remain with the Generator even after the same is delivered to the Service Provider and Generator shall continue to be liable for all the risks. CO-PROCESSING CHARGES AND SURCHARGES:
Co-processing Charges ('the price applicable to the Conforming Material") is stated in Annexure- B I n addition to its right of rejection. The Generator agrees that the charges for the Co-processing of its HazardousjNon ~azaldous Waste as notified by +," d Service Provider shall be subject to revision during the validity of this Agreement. Such Revision shall be called for on the . grounds of escalation of Fuel cost and the cost of other major parameters including but not limited to Power tariff, Change in the disposal/ Co-processing technology/ pre-processing requirements, Hike in wages etc. The Service Provider shall inform the Generator in advance the revised'charges for the service and the same will only be applicable on a mutual agreement between the Service Provider and the Generator. The rates for co-processing services provided by the Service Provider have been duly approved and agreed by the Generator and the Generator undertakes and agrees to pay as .
per the rate prescribed in commercial offer. The Generator will submit 50% amount of annual Co- processing fees with service provider before commencement of actual Co-processing. The said amount will be considered as sec~~r i ty deposit and the same is refundable or adjustable against any dues pending with Generator. However Service Provider will not pay any interest for such Security Deposit amount lying with it during tenure of this agreement. Ambiguity or dispute about any irlvoice amount, the Generator shall be entitled to dispute the invoice amount within 3 business days after receipt of the invoice. I f the Generator does not raise any dispute, it is presumed that the same is acceptable and the Generator sl~all be liable to make the payment in respect of the same within a period of 30 days from the date of the invoice.
S eal & Signature '
(First Partyl
A-68
The Service Provider will carry out Finger Print analysis atbits own cost for every consignment of the waste received from the Generator to confirm the basic parameters in corrlparison to the Corliprehensive analysis. I n case of the discrepancy between Finger Print and Comprehensive analysis, the Service Provider will have the right to carry out a Compreliensive analysis for that consignment; charges of the same shall be borne by the Generator. If the Generator wishes to cross check the results of the analysis, the sample can be sent to a third party lab for analysis mutually agreed by both the parties. However, the cost for the same shall be borne by the Generator. I n case a discrepancy is found between the two analysis, tlie Service Provider will have the right either refuse the waste or revise the charges for the co processing based 011 the characteristics of the waste as per the latest comprehensive analysis, in this case the Generator shall be liable, as per the estimates provided by the ~erGice Provider and agreed to by the Generator to pay the revised charges for co-processing. However, the Generator shall always be liable for any injury to persons or damage to properties arising from any accident or exposure till the time both the parties arrive at some solution for safe disposal through Co-processing. 'The Service Provider shall charge the Generator on the basis of Weight (as per the weight slip of the weight bridge a t the Service Provider's Site) at the rates as per agreed commercial offer annexed as Annexure-B and Annexure - C to this Agreement. I f the Weigh Bridge at Co-processing site is not working, it will be weighed at outside Weigh Bridge approved by both parties l1
The Generator covenants that the charges for the Co- processing of its Hazardous Waste as notified by the Service Provider shall be subject to revision during the validity of this Agreement and as and when the revision is called for on the grounds of escalation of Fuel cost, on other major price escalation namely Power tariff, Change in the disposal/ Co- processing technology/ pre-processing requirements, Hike in wages etc. The Service Provider shall inform the Generator in advance the revised charges for the service and the same will orrly be applicable on a mutual agreement between the Service Provider and Generator. The Generator shall immediately, upon the receipt of the bill from the Service Provider, make the payment on or before the due date i.e. 7 days from the date of receipt of invoice.
s c
Seal & Signature (First ~ a r t y l (Second Partyl Z
A-69
6.12 It is hereby agreed by and between the parties hereto that delayed payment means any payment not received within the stipulated due date of any invoice raised on the Generator by the Service Provider. The Service Provider reserves its right to discontinue the arrangement under this Agreement on account of non-payment of an.y of its outstanding amounts in due course and the Service Provider shall have a right to refuse to accept any Material sent by the Generator
6.13 I n case of default / dishonor in payment and subsequent settlement of outstanding dues, the Service Provider shall restart the performance of the facilities under this Agreement to the Generator only on receipt of Undisputed outstanding dues/ DEMAND DRAFT of the said amount within 24 hours
7. TOTALFEE.
The Total Waste Fee charged by the Service Provider shall include any amount that the Service Provider is required to pay to any government or agency by virtue of tax, tariff. fee or other charge. whether presently or future. Any such increase will be included as a separate item on invoices su brnitted to the Generator.
8.
8.1 The Service Provider reserves the right: to accept or refuse waste, in the event of the Generator committing any breach/violation of the condition of the present Agreement or any provision of Law/Act/Rules for the time being in force. -the Service Provider reserves its right to suspend/terminate this Agreement for such period with an intimation of the breach to the Generator.
8.2 The suspension / termination shall be revbked only a t the sole ,, discretion of the Service provider after it is satisfied that breach of the terms have been rectified by the Generator.
9. SUPPLY SCHEDULE
9.1 The Generator will deliver Material as specifled in Annexure-A to a storage location designated by the Service Provider at no cost t o the Service Provider. The Generator shall be responsible for all costs and risk related t o the preparation, loading, delivery, handling and transportation of the Conforming Materials as specified in Annexure-A
9.2 The Generator shall pay to the Service Provider the charges calculated according t o the rates listed in Annexure-B. for all hazardous Waste, the Generator shall arrange for delivery of the waste t o the location designated by the Service Provider as per Hazardous and Other Wastes (Management & Transboundary Movement) Rules 2016. It shall undertake this activity under its own risk and responsibility. 48 hours prior notice shall be given by the Generator subject to the Service Provider cif the intention to transport the ~aza rdous Wastes and shall always availability of storage space at the designated location
.'P :, ,5 ! (Fzrst Party)
(3 9, t . . A-70
The Service Provider may provide Dumpers, Trucks or other form of transport duly authorized by 'SPCB' to the Generator for transporting its Hazardous Waste to the co-processing site of the Service Provider at the cost of the Generator. The Generator will provide details of all hazardous waste to the Service Provider by filling Form 8 as may be prescribed as per Hazardous and other Wastes (Management and Trans- boundary Movement) Rules 2016 and amended thereafter. The Generator will provide details of the Hazardous Waste in the manifest Form 10 as may be prescribed as per the Hazardous and other Wastes (Management and Trans- bol-~ndary Movement) Rules 2016 & Guidelines on Co- processing in Cement industry and amended thereafter. The Generator shall not in any case send waste specified in negative list for Co-processing as per the Annexure E attached herewith. 'The Generator will provide the TREM Card i.e. Form 6 - Contents as per the ~azardous and other Wastes (Management and Trans-boundary Movement) Rules 2016 and Guidelines on Co-processing in Cement industry and amended thereafter to be duly filled and handed over to the Transporter. I n case of any false information provided by the Generator, liabilities will lie on them as per the Hazardous and other Wastes (Management and Tran boundary Movement) Rules 2016 and Guidelines on Co-processing in Cement industry and amendments thereafter. I f the ~ e n e r a t & wishes to use transportation facilities of the Service Provider, the Generator will be required to intimate the Service Provider with a t least 48 hours prior notice. Due to the extensive a~ialytical requirements to comply with internal accepta~ice criteria, the Service Provider may require an unloading time of eight hours. The Service Provider assumes no responsibility for transportation demurrage or the time required for resolving analytical or manifest discrepancies and such costs will be the sole responsibility of the Generator OBLIGATION OF THE GENERATORS
The Generator shall provide the Service Provider the different categories of Hazardous Waste that it desires to dispose. These categories of Waste shall be as per the parameters specified in the Schedule of Hazardous and other Wastes (Management and Tran boundary Movement) Rules 2016, as amended from time to time. The Generator shall also give true and correct information related to the 'description, amount, nature and toxicitv of Hazardous Waste Substance.
Seal & Signature (First Party)
Seal & Signature \vJ &/' (Second Par@)
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10.2 The Generator shall take all Primary Treatment arrangement at its premises prior to transportation to the Service Provider of any waste material that may be notified by the Service Provider or SPCB or any other Authority prescribed under the relevant provisions of law in this behalf for the time being in force
10.3 The Generator shall comply with the provisions of Environment (Protection) Act, 1986 and the Rules and all other applicable laws as amended from time to time as also with the condition of the present agreement and that any breach of this Agreement committed by the Generator will allow the Service Provider to terminate this Agreement.
10.4 Packaging, Labeling and Loading:- 10.4.1 Before Hazardous Waste is loaded in the transportation
facilities, the Generator shall ensure that the said waste is packed in a manner suitable for transportation (so that no leakage/Seepage shall occur during the transit and after reaching the Service Provideras Site). The packing cost will be borne by the Generator.
I INSURANCE, TAXES
The Generator and the Service Provider sliall maintain all insurances as per the applicable laws and regulations. Upon req~~est , a party shall provide certificates or other documentary evidence of the above insurance. These policies will remain in effect during the initial term and any renewal terms of this Agreement.
12. INSPECTIONS
The Generator shall allow the Service provider to conduct inspections of any delivery of Material tendered to the Service Provider prior to loading at the Generator site or unloading at the Service Provider's site.
13. TRANSFER OF RIGHTS
The Service Provider may at any time transfer or assign its rights and obligations under this Agreement to any other company or business concern by giving intimation in writing to the Generator. Upon such transfer or assignment, only the transferee or assignee shall be liable for the obligations herein contained.
14. GOVERNING LAW AND DISPUTE RESOLUTION
a. Governing Law: This Agreement shall be governed by and interpreted under the laws of India and both the parties hereby submit to the Jurisdiction of the court in Ahmedabad, Gujarat State subject to the clause no.14.b mentioned below.
% ' Seal & Signature
. . ~jsd.: (First Party) .I
(Second Party)
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b. Dispute Resolution: All disputes in connection with this agreement or the execution thereof shall be settled by friendly negotiation between the parties. Should the parties fail to resolve any controversy or claim within 30 days, arising out of or relating to the interpretation or application of any term or provision set forth herein, or the alleged breach thereof, such controversy or claim shall be resolved by arbitration of law in accordance with the Rules of Conciliation and Arbitration under the Arbitration and Conciliation Act, 1996. Any award rendered pursuant to the terms and conditions set forth herein shall be final and binding. 'The Parties expressly agree to abide by the arbitration award. Any arbitration held pursuant to this Agreement shall be held in Ahmedabad, Gyjarat State, IIVDIA. The language for conducting the arbitration proceedings shall be English.
AMENDMENTS:
Both the parties can a t any point of t ime make suitable changes in the present Agreement after serving a notice to the other party and after mutually agreeing to the amendments. The modification, amendment, or waiver of any provision of this Agreement shall be effective only i f it is in writing and signed in person or by an authorized representative of each Party.
16. TERMINATION OF AGREEMENT
16.1 Either party hereto may terrr~inate this Agreement forthwith in the event of: (1) the other Party committing a breach of any of the terms and
conditions of this Agreement, including non-payment of dues. (2) if a creditor takes possession of or a Receiver is appointed on the
whole or a substantial part of the undertaking or assets of the other party; or
(3) if the other party becomes insolvent or is taken into liquidation or an effective resolution for its winding up is passed by its shareholders;
(4) if either party commits any criminal offence with respect to the business connected with this Agreement and cognizance of the same is taken by any statutory authority.
(5) the other party, for any reason whatsoever, prevented or prohibited by virtue of any law from performing its part of obligations as mentioned herein.
(6) Expiration or termination of this Agreement shall be without prejudice to any right which has accrued to the Parties hereto with respect of any antecedent breach of any provision of this Agreement or any obligation undertaken by any Party hereto before termination.
3 t A . - - 8 I ' Seal & Signature 2' uM'+ - (First Party) 3 q 1 . r
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16.2 Both the Parties hereto agree that the present Agreement shall automatically come to an end if the Authorization for Co- processing given t o the Service Provider by relevant authorities is cancelled/refused or not granted by SPCB. I n such case the Service Provider will inform the Generator immediately and then this Agreement will come to end.
16.3 l lotwithstanding anything contained in this Agreement, either of the parties shall have the right to terminate this Agreement, with or without any reason by serving the other party a prior notice o f 30 days RELATIONSHIP
Nothing contained herein shall be deemed to constitute a partnership, joint venture or agency by and between the Parties hereto. Accordingly the parties herein shall have and maintain exclusive control and direction over all of its employees, agents and contractors and assumes full and exclusive responsibility for payment of all compensation, ,benefits, premiums, contributions, payroll taxes and other taxes now or hereafter imposed by any law or regulation as to its employees, agents and contractors.
'
18. CONFIDENTIALITY The Parties hereto agrees that he/they/it shall not, at any time or in any manner, either directly or indirectly, divulge, disclose or communicate to any third party, any information concerning the business affairs of the other Party without prior written permission of the other Partv.
The OH&S Policy of the Service Provider Company relating tp safety measures and-occupational health to be obsetved by the Generator Company and his/their/its employees / workers / agents / representatives during the subsistence of this Agreement is attached herewith as Annexure-D (OH&S Policy). 'The Generator Company shall regularly provide necessary training on safety to all his/their/its employees/ workers/ agents/ representatives engaged for performing the work covered under this Agreement.
20. Ethical View Reporting Policy and Anti-Briberv & Corruption
Directives (ABCD) of the Company
The Generator Company is aware that the Service provider Company has instituted a ~histleblower policy viz. Ethical View Reporting Policy and an Anti-Bribery & Corruption Directives (ABCD), which is a part of the Code of Conduct initiated by the Company to promote the highest standards of professionalism, honesty, integrity and ethical behavior within its organization. 'The Generator Company declare(s) that he/they/it haslhave not paid or agreed to pay any favour either in cash or kind to any of the officials of the Service Provider Company either directly or indirectly to secure this Contract and further undertake(s) to promptly inform the Service Provider Company if any such demand'is made in future by any officials of the Service Provider Company either directly or&F-1 indirectly.
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The Generator Company is also aware that if it is found indulged in any of fraudulent, unfair or unethical practices, the Generator Company shall be liable for such action at the sole discretion of the Service Provider Company including termination of this Agreement by concurrent notice and the decision of the Service Provider Company in this regard shall be final and binding on the Generator Company. The Generator Compa~iy further undertakes not to directly or indirectly indulge in any corruption with Government officials or otherwise in any manner at any time and in case of such breach, violation, the Generator themselves shall wholly liable for all consequences.
The Generator represents and warrants that any Materials provided to the Service provider will be Conforming Material, unless otherwise agreed to by The Service provider in writing.
22. COMPLIANCE WITH LAWS
The Generator and the Service provider shall comply with all applicable laws, rules, rulings, brders, ordinances, permits and regulations affecting or related to their respective obligations under this Agreement.
23. INDEMNITY
23.1 First Party shall indemnify, defend and hold harmless Second Party and its directors, employees and agents from and against any and all ~claims, demands, fines, losses, damages, costs, penalties, expenses, actions, suits or proceedings, injuries, monetary liability on account of death of any person, costs 6f response to any governmental inquiry, liability for loss of or damage to property or for loss or damage arising from attachments, liens or claims of materials, men or laborers, and reasonable attorney and consulting fees and costs relating to any of the foregoing ("Claims"), arising
r.
from First Party's performance of the Agreement or resulting from First Party's negligence, acts or omissions or from First Party's tender of Waste Material or from First Party 's breach of the terms and conditions of this Agreement. The foregoing indemnification shall not apply to the extent such Claims are the result of Second Party's gross negligence or willful default.
23.2 Second Party shall indemnify, defend and hold harmless First Party and its directors, employees and agents from and against any and all claims, demands, fines, losses, damages, costs, penalties, expenses, actions, suits or proceedings, injuries, monetary liability on account of death of any person, costs of response to any governmental inquiry, liability for loss of or damage to property or for loss or damage arising from attachments, liens or claims of materials, men or laborers, and reasonable attorney and consulting fees and costs relating to any of the foregoing ("Claims"), arising from Second Party's performance of the Agreement or resulting from Second Party's negligence, acts or omissions or from Second Party's breach of the terms and conditions of this A'greement. The foregoing indemnification shall not apply to the extent such Claims are the result of First Party's gross negligence or willful default.
s- , h t i i> 'r t , r uf,? @ Seal & Signature 5' . ,f-)zi (First Party) ! h
' . \. : '. :yt :.: \ . A-75
24. FORCE MAJURE
24.1 Any failure or omission by either Party to perform its obligations shall not be deemed to be a breach of this Agreement, if the same is caused by reasons or circumstances constituting Force Majeure which shall include acts of God, acts of any Government or any agency thereof, law, order, decree or regulation, both present and future, of any Government or any agency thereof, fire, war, riots, civil, commotion, strikes, lockouts, embargoes, disasters or any other cause beyond the control of the party affected.
24.2 The Party claiming Force Majeure shall, as soon as possible, notify the other Party by post, courier, registered letter or fax of the conditions constituting Force Majeure which affect the execution of the Agreement together with expected duration thereof, and send at the earljest by registered mall a detailed report of the Force IYajeure circumstances.
24.3 When the cause of Force Majeure has ceased to exist, the Party affected thereby shall immediately inform the other Party by post, courier or fax about the same and confirm it by registered mail. Further, the performance of obligations of the Party invoking Force Majeure shall, to the extent affected by it, remain suspended during the subsistence of such Force Majeure and the period for the performance thereof shall stand extended by the period(s) of delay on account of it.
24.4 I f the Force-Majeure condition continues for a period of three months, both the parties shall meet and decide the future course of action, including termination of.this Agreement.
25. SEVERABILITY.
I n case any one or more of the provisions contained .in this Agreement shall for any reason be held invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provision hereof, and this Agreement shall be construed as if such invalid, illegal, unenforceable provision had never been contained.
26. INTEGRATION, MODIFICATION.
This Agreement constitutes the entire agreement between the parties and supersedes all other agreements and understandings between the parties. No modification or any claimed waiver of any of the provisions of this Agreement shall be binding
Seal & Signature '
(First Party)
. . . unless in writing- and signed . by all parties.
. Seal & Signature :,,.. ,... - : .,. ;. .. ,:
(Second Parv) >...
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NOTICE
Any notice, demand, request or report to be given or made under this Agreement shall be given or made in the English language in writing by letter or facsirr~ile transceiver and shall be deemed to have been given, in the case of a letter ten [ l o ] days after posting and in the case of a facsimile transceiver, twenty four [24] hours after dispatch, provided always that if the deemed delivery date is not a normal business day at the address of the address then the delivery shall be deemed to take place on the first normal business day then following. The notice, demand, request or report shall be given or made to Mr R 3 Modi, at the address stated at the commencement of this agreement or at such other address as such Party shall have designated by notice in writing to the other Party hereto. Notices to be given he,reunder shall be in writing and except where provided otherwise herein shall be deemed delivered in case of registered mail or personal delivery on receipt and in case of fax 12 hours after confirmed transmission. Any notice communication or invoice to be given under this agreement shall be in writing and deemed to have sufficiently given when delivered in person or by registered post or confirmed facsimile transmission to the address of the respective party set out in this agreement. BINDING EFFECT The agreement shall be binding upon the successor in title, legal representatives and permitted assigns of the parties hereto. NON EXCLUSIVE ENGAGEMENT
The Generator -hereby grants to the Service Provider a non- exclusive right, on the terms and conditions contained herein, to provide the Services. Nothing herein contained shall prevent or prohibit the Generator from engaging other Parties for the provision of the Services once the committed quantities are sent for co-processing to the Service Provider in this Agreement. It is clearly agreed and understood between the parties heretothat the Service Provider shall also on their part be at liberty to be engaged by other Industries who generate waste material for the provision of the Services. The Parties hereby agree t o procure all the required permissions and sanctions to deal with the material and to dispose off the same in accordance with the Laws. The Signatories of the parties here are competent and authorized to agree to the terms and execute this presents. This Agreement may be executed in two counter parts each of which when so executed will be deemed an original and such counter parts together shall constitute one and the same instrument. fl . .
. :
. . . ,
(Second Party) . .. .< ., . .
. . .- > . -<.
,;, h! Lh>'), , , Seal & Signature ..,. i ; d 4 ~ . . , ~ , - . ,\ , -3i, !%,,,," .? !; (First Partyl
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The addressees of the, parties hereto unless changed by written
notification to be given at least 15 days in advance by registered
letter prior to proposed date of change, shall be as follows:
I I Site/Unit Address I
Concord Biotech Ltd
Service Provider
Ambuja Cements Ltd
Second Party
Plot No. 1482-1486,Village- Trasad Rd, Tal-
Dholka, Dist.- Ahmedabad, PIN-382225
Gujarat .
First Party
Post-Ambujanagar, Tal- Kodinar, Dist- Gi
Sonmath- 3627i5, Gujarat
Second Party
Sea2 & Signature .. .. (Second Partyl
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IN WI'TIVESS WHEREOF the parties hereto acting through their properly constituted representatives have set their hands to cause this AGREEMENT signed and executed in their respective names and on their behalf.
SIGNED AND DELIVERED by the
Within named Service Provider,
AMBUJA CEMENTS LIMITED
through its Authorised Signatory )
Mr. S Ramarao- Unit Head 1 in the presence of
SIGNED AND DELIVERED by the . . Within named Generator For, Corrcnrd Biotech Limited
i l 1
Concord Biotech Ltd ) 'F. through its Authorised Signatory . . . ,. ..
Mr R J Modi- Factory Manager
in the presence of 1
Seal & Signature (First Party)
seal & Signature (Second Party)
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Charges (Per Ton'). Spent Carbon
No.
1
I
Co-processing Charges Rs. . Rs. 55001MT + Taxes '
To be borne by Concord Transportation Charges Rs.
HDPE bags or Non PVC 1
PARAMETERS
Moisture O/O
Packaging Mode
Limits
< 20%
3
4
5
material bags-
(preferably jumbo type) ~
CI O/o
S O/o
PH
, " . LG': . % ,.. Seal & Signature
! I I (First Par&)
1.5O/o
1.5OIo
4 - 8
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ACL (Service Provider's) OCCUPATIONAL HEALTH & SAFETY V IS ION
'NO HARM ANYWHERE TO ANYONE ASSOCIATED W I T H ACL"
'NO HARM" means:
IVo fatalities
IVo disabling Injuries
IVo Lost Time Injuries
IVo Medical treatment Injuries
No First Aid Injuries
No Occupational Illness
"ANYONE" means:
Employees, Contractors personnel on site, Ready-mix drivers on
job, Third party contractors on site, Visitors to ACL site
ACL OCCUPATIONAL HEALTH & SAFETY POLICY
We manage our activities in a responsible manner to avoid causing any harm to the health and safety of our employees, contract personnel and visitors. We apply OH&S standards and guidelines; provide the necessary resources, training and education and measure performance for continuous improvement.
ACL OH&S PRINCIPLES
All injuries, occupational illnesses a ~ d diseases are preventable. It is good business to prevent injuries and illness. Working safely is a condition of en-~ployment. Everyone is responsible for health & Safety performance. Line Managers / Supervisors are accountable. All Line Managers / Supervisors must do safety observations and they must ensure all problenis are noted and corrected. All unsafe practices / incidents must be recorded. Unsafe practices must be corrected; incidents must be investigated, root causes found & corrected.
Training is essential to have a healthy and safe working environment. promote off the job safety for employees. . ,
8
r Seal & Signature
(Second Partyl
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FIVE CARDINAL RULES FOR SAFETY
I. I assess and control risks before starting any task.
2. I only perform activities for which I am authorized.
3. I never override or misuse health & safety devices.
4. I do not work under the influence of alcohol or
drugs.
5. I report all incidents. . .
CORPORATE SOCIAL RESPONSIBILITY . .
a. Labor conditions
Without prejudice to the Warranties, Representations and Covenants on the part of Generator in this Agreement, Generator represents and warrants. to Service Provider that Generator comply with the Standard of Social Accountability SA8000. i.e. I. No child labor. 2. No forced labor. 3. Respect local occupational health and safety regulations. 4. Freedom of Association and collective bargaining. 5. No Discrimination 6. No corporal punishment, mental or physical coercion or verbal abuse. 7. Respect legally mandated work hours. 8. Guarantee of a fair compensation to its employees. (This standard is available at: http://www.sa-intl.org) Service Provider makes the same representations'and warranties to ., Generator under these Clauses.
b. Occupational Health & Safety
Generator represents warrants and agrees with the Service Provider that:
1. It is the policy of the Service Provider to secure the health and safety of all personnel (own, and Generator s') as well as the integrity and reliability of all property and equipment. Hence, the Generator also recognizes its responsibility and accountability for the protection of all employees and preservation of the Service Provider's property and equipment.
2. To comply with this policy, the Generator will use properly qualified personnel and incorporate safeguards, rules and procedures which will rr~inin~ize the risk of any personal injury to Service Provider's people and loss of, or damage to, Service Provider's property and equipmgnt during the performance of the service provided.
$1 Seal [,J di Signature \ 0 ii ' (Second Parlyl
$ L _ ; I - '
' r
($3 A-82
3. Generator's persohnel must comply with Service Provider3 established OH&S rules, practices and procedures, use OH&S equipment, Personal Protective equipment (PPE), tools and any devices that are required / provided, and conduct themselves in a way which assures the health and safety of themselves, their fellow employees and/or any other persons.
4. Generator's personnel are responsible for providing and maintaining a safe and healthy workplace where all hazards, unsafe acts and/or conditions are identified and analysed before being controlled o r eliminated. Generator must document this in a (mandatory) health and safety program.
5. When working, all Generator's personnel will conduct themselves in accordance with Service Provider's OH&S standards, including having a proper OH&S plan for the work, work instructions, training and testing as needed, inspection and audit programs as well as recording and reporting of all accidents, unsafe actions and/or conditions.
6. Generator represents and warrants to Service Provider, that they have accident/workers compensation insurance.
7. Service Provider is entitled to inspect and audit the corrrpliance of Generator with Clauses 1 to 6.
8. Non-compliance with Clauses 1 - 6 is a serious offence and may result in immediate termination of the contract with ACL. Any direct o r consequential damage resulting out of non-compliance is in the full liability of the Generator.
Annexure-E
The wastes listed below are not recommended f& Co-processing
till otherwise provided for:
a) Radioactive waste b) Asbestos-containing waste c) Explosives and ammunition / weapons d) Anatomical medical waste e) Electronic fraction of electrical and electronic waste (e-waste) f) Whole batteries as a targeted material stream g) Waste of unknown or unpredictable composition, including unsorted m~~nicipal waste
Seal & Signature (First Partyl
f.. Seal & Signature
(Second Par@)
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Annexure-III
Membership certificate for disposal of hazardous waste
at TSDF & CHWIF
Snunlshrnn Envino Pnojtcrs Pvr. Lrd.Integrated Common Hazardous Waste Management Facility
Site : R S No. 415 417 & 418, Village : Juna Kataliya. B/h. Gail Pump Sialion,
Ph.r+91.261-2351248 2346181,6452205 Fax:+91-26t2354068 E.mai r [email protected] Websiie : vvvl]\'.seppllndia.com
DT - 11,04'2014
TO WIIOMSOEVER CONCENRED
CERTIFICATE
This is to certify that M/s Concord Biotech Ltd situated at 1482'1486' T€sad Road Dholka'' Disl
Ahmedabad is valid member of our Integrated Common Hazardous Waste Management Facility
(ICHWMF) though membership No CSC032.
Details of$aste type along with quantity proposed by the member unit are as follows:-
SrNo.
1
Ilazardous waste
ETP Sludge
Distillation Residue
Spent Catalyst
Cat. No.
34.3
20.3
28.2
9!s4!!
100 MVMonth
15 Kl^r'ear
7 Mvlronth
N4/s Saurashtra Enviro Projects P!'t.Ltd Sho\ts its readiness to accept thg above waste proposed by
th" .".b"r unit after successful completion of all rnembership fomalities and undefaking
comprehensit e analysis of the *ast" confitmittg disposal pathway for safe disposal of Hazardous
waste.
For Saurashtra Enviro Projects Pvt. Ltd.
vY,,/
Amit Renose(Sr. Mgr - Business Developmeut)
Resd.off.€ |3rd Floor, K.G. chamb€6, Udhna Da /aja, Rlnt Road, Sunt - 395 002.
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Annexure-IV
Material Safety Data Sheet of Hazardous chemicals
SIGMA-ALDRICH MATERIAL SAFETY DATA SHEET Date Printed: 10/01/2009 Date Updated: 01/31/2006 Version 1.4 Section 1 - Product and Company Information Product Name ACETONE-1,3-13C2, 99 ATOM % 13C Product Number 299189 Brand ALDRICH Company Sigma-Aldrich Address 3050 Spruce Street SAINT LOUIS MO 63103 US Technical Phone: 800-325-5832 Fax: 800-325-5052 Emergency Phone: 314-776-6555 Section 2 - Composition/Information on Ingredient Substance Name CAS # SARA 313 ACETONE-1,3-13C2, 98 ATOM % 13C 7217-25-6 No Formula C3H6O Section 3 - Hazards Identification EMERGENCY OVERVIEW Flammable (USA) Highly Flammable (EU). Irritant. Irritating to respiratory system and skin. Risk of serious damage to eyes. Target organ(s): Liver. Kidneys. HMIS RATING HEALTH: 1 FLAMMABILITY: 4 REACTIVITY: 1 NFPA RATING HEALTH: 1 FLAMMABILITY: 4 REACTIVITY: 1 For additional information on toxicity, please refer to Section 11. Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician. INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water.
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EYE EXPOSURE In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes. Section 5 - Fire Fighting Measures FLAMMABLE HAZARDS Flammable Hazards: Yes EXPLOSION HAZARDS Vapor may travel considerable distance to source of ignition and flash back. Container explosion may occur under fire conditions. FLASH POINT 1 °F - 17.0 °C Method: closed cup EXPLOSION LIMITS Lower: 2.15 % Upper: 13.2 % AUTOIGNITION TEMP N/A FLAMMABILITY N/A EXTINGUISHING MEDIA Suitable: For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Extremely flammable. Vapor may travel considerable distance to source of ignition and flash back. Emits toxic fumes under fire conditions. Section 6 - Accidental Release Measures PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area. Shut off all sources of ignition. PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear respirator, chemical safety goggles, rubber boots, and heavy rubber gloves. METHODS FOR CLEANING UP Cover with dry-lime, sand, or soda ash. Place in covered containers using non-sparking tools and transport outdoors. Ventilate area and wash spill site after material pickup is complete. Section 7 - Handling and Storage HANDLING User Exposure: Avoid breathing vapor. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure. ALDRICH - 299189 www.sigma-aldrich.com Page 2
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STORAGE Suitable: Keep container closed. Keep away from heat, sparks, and open flame. Section 8 - Exposure Controls / PPE ENGINEERING CONTROLS Safety shower and eye bath. Use nonsparking tools. Mechanical exhaust required. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles. GENERAL HYGIENE MEASURES Wash thoroughly after handling. Wash contaminated clothing before reuse. SPECIAL PRECAUTIONS The material may slowly penetrate protective gloves; therefore in case of spills, discard gloves after use. Section 9 - Physical/Chemical Properties Appearance Physical State: Liquid Property Value At Temperature or Pressure Molecular Weight 60.06 AMU pH N/A BP/BP Range 56.5 °C 760 mmHg MP/MP Range - 94.0 °C Freezing Point N/A Vapor Pressure 184 mmHg 20 °C Vapor Density 2 g/l Saturated Vapor Conc. N/A SG/Density 0.818 g/cm3 Bulk Density N/A Odor Threshold N/A Volatile% N/A VOC Content N/A Water Content N/A Solvent Content N/A Evaporation Rate N/A Viscosity N/A Surface Tension N/A Partition Coefficient N/A Decomposition Temp. N/A Flash Point 1 °F - 17.0 °C Method: closed cup Explosion Limits Lower: 2.15 % Upper: 13.2 % Flammability N/A Autoignition Temp N/A Refractive Index 1.359 Optical Rotation N/A ALDRICH - 299189 www.sigma-aldrich.com Page 3
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Miscellaneous Data N/A Solubility N/A N/A = not available Section 10 - Stability and Reactivity STABILITY Conditions of Instability: Moisture. Conditions to Avoid: Moisture. Materials to Avoid: Bases, Oxidizing agents, Reducing agents. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide. HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information ROUTE OF EXPOSURE Skin Contact: Causes skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: Causes severe eye irritation. Inhalation: Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: May be harmful if swallowed. SENSITIZATION Sensitization: Causes dermatitis. TARGET ORGAN(S) OR SYSTEM(S) Liver. Kidneys. SIGNS AND SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Section 12 - Ecological Information No data available. Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Observe all federal, state, and local environmental regulations. Section 14 - Transport Information DOT Proper Shipping Name: Acetone UN#: 1090 Class: 3 Packing Group: Packing Group II Hazard Label: Flammable liquid PIH: Not PIH IATA ALDRICH - 299189 www.sigma-aldrich.com Page 4
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Proper Shipping Name: Acetone IATA UN Number: 1090 Hazard Class: 3 Packing Group: II Section 15 - Regulatory Information EU ADDITIONAL CLASSIFICATION Symbol of Danger: F Indication of Danger: Highly Flammable. R: 11 Risk Statements: Highly flammable. S: 9-16-23-33 Safety Statements: Keep container in a well-ventilated place. Keep away from sources of ignition - no smoking. Do not breathe vapor. Take precautionary measures against static discharges. US CLASSIFICATION AND LABEL TEXT Indication of Danger: Flammable (USA) Highly Flammable (EU). Irritant. Risk Statements: Irritating to respiratory system and skin. Risk of serious damage to eyes. Safety Statements: Keep container tightly closed in a cool place. Keep away from sources of ignition - no smoking. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. US Statements: Target organ(s): Liver. Kidneys. UNITED STATES REGULATORY INFORMATION SARA LISTED: No CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. DSL: No NDSL: No Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses. WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2009 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. ALDRICH - 299189 www.sigma-aldrich.com Page 5
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ACETONITRILE MSDS
ACETONITRILE
1 IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY/UNDERTAKING
PRODUCT NAME ACETONITRILE
PRODUCT NO. A007
Abbey ChemicalsSUPPLIER
27-30 North River Road
Great Yarmouth, Norfolk, NR30 1SH
Tel: +44 1493 850303
Fax: +44 1493 330909
www.abbey-chemicals.co.uk
EMERGENCY TELEPHONE +44 (0) 1493 850303
2 COMPOSITION/INFORMATION ON INGREDIENTS
EU INDEX NO. 608-001-00-3
EC (EINECS) NO. 200-835-2
CAS-NO. 75-05-8
3 HAZARDS IDENTIFICATION
Highly flammable. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes.
CLASSIFICATION Xn;R20/21/22. Xi;R36. F;R11.
4 FIRST-AID MEASURES
GENERAL INFORMATION
In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
INHALATION
Move the exposed person to fresh air at once. Keep the affected person warm and at rest. Get prompt medical attention.
INGESTION
Immediately rinse mouth and provide fresh air. Drink plenty of water. Do not induce vomiting. NEVER MAKE AN UNCONSCIOUS PERSON
VOMIT OR DRINK FLUIDS! Get medical attention if any discomfort continues.
SKIN CONTACT
Remove affected person from source of contamination. Promptly wash contaminated skin with soap or mild detergent and water. Promptly remove
clothing if soaked through and wash as above. Contact physician if irritation persists.
EYE CONTACT
Remove victim immediately from source of exposure. Promptly wash eyes with plenty of water while lifting the eye lids. Continue to rinse for at least
15 minutes. Get medical attention promptly if symptoms occur after washing.
5 FIRE-FIGHTING MEASURES
EXTINGUISHING MEDIA
Fire can be extinguished using: Do not use water as an extinguisher. Water spray, fog or mist. Foam, carbon dioxide or dry powder.
SPECIAL FIRE FIGHTING PROCEDURES
Standard procedure for chemical fires Cool containers exposed to flames with water until well after the fire is out.
SPECIFIC HAZARDS
In case of fire, toxic gases may be formed.
PROTECTIVE MEASURES IN FIRE
Self contained breathing apparatus and full protective clothing must be worn in case of fire.
6 ACCIDENTAL RELEASE MEASURES
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ACETONITRILE
PERSONAL PRECAUTIONS
Warn everybody of potential hazards and evacuate if necessary. Extinguish all ignition sources. Avoid sparks, flames, heat and smoking.
Ventilate. In case of inadequate ventilation, use respiratory protection. Wear protective clothing as described in Section 8 of this safety data sheet.
ENVIRONMENTAL PRECAUTIONS
Collect and dispose of spillage as indicated in section 13. Do not discharge into drains, water courses or onto the ground. Spillages or
uncontrolled discharges into watercourses must be IMMEDIATELY alerted to the Environmental Agency or other appropriate regulatory body.
SPILL CLEAN UP METHODS
Absorb with sand or other inert absorbent. Collect in containers and seal securely. Remove containers and flush area with water. Ensure that
waste and contaminated materials are collected and removed from the work area as soon as possible in a suitably labelled container
7 HANDLING AND STORAGE
USAGE PRECAUTIONS
Keep away from sources of ignition - No smoking. Take precautionary measures against static discharges. Avoid contact with skin and eyes. Wear
full protective clothing for prolonged exposure and/or high concentrations. Provide adequate ventilation, including appropriate local extraction,
to ensure that the defined occupational exposure limit is not exceeded. If ventilation is insufficient, suitable respiratory protection must be
provided. Good personal hygiene is necessary. Wash hands and contaminated areas with water and soap before leaving the work site.
STORAGE PRECAUTIONS
Keep away from food, drink and animal feeding stuffs. Keep away from sources of ignition - No smoking. Store in tightly closed original
container in a cool, dry well-ventilated place. Do not store near heat sources or expose to high temperatures. Protect from freezing and direct
sunlight.
8 EXPOSURE CONTROLS/PERSONAL PROTECTION
Std ST - ppmLT - ppm LT - mg/m3 ST - mg/m3Name
40 ppm 68 mg/m3OES 60 ppm 102 mg/m3ACETONITRILE
40 ppm 68 mg/m3OES 60 ppm 102 mg/m3ACETONITRILE
PROTECTIVE EQUIPMENT
ENGINEERING MEASURES
No specific ventilation requirements noted, except this product must not be used in a confined space without good ventilation.
RESPIRATORY EQUIPMENT
If ventilation is insufficient, suitable respiratory protection must be provided.
HAND PROTECTION
Chemical resistant gloves required for prolonged or repeated contact.
EYE PROTECTION
If risk of splashing, wear safety goggles or face shield.
OTHER PROTECTION
Chemical resistant apron, lightweight protective clothing or suit & heavy duty work shoes.
HYGIENE MEASURES
When using do not eat, drink or smoke. Wash promptly if skin becomes wet or contaminated. Wash at the end of each work shift and before
eating, smoking and using the toilet.
9 PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE Liquid
COLOUR Colourless
ODOUR Pungent
BOILING POINT (°C) 81.6 @ 760 mm Hg MELTING POINT (°C) -45.7
RELATIVE DENSITY 0.782 20 FLASH POINT (°C) 2
AUTO IGNITION TEMPERATURE
(°C)
524 FLAMMABILITY LIMIT - LOWER(%) 4.4
FLAMMABILITY LIMIT - UPPER(%) 16
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ACETONITRILE
10 STABILITY AND REACTIVITY
STABILITY
Stable under normal temperature conditions and recommended use.
MATERIALS TO AVOID
Oxidising materials. Strong acids. Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Fire or high temperatures create: Vapours/gases/fumes of: Carbon monoxide (CO). Carbon dioxide (CO2). Sulphurous gases (SOx). Nitrous
gases (NOx).
11 TOXICOLOGICAL INFORMATION
INHALATION
Harmful by inhalation.
EYE CONTACT
Irritating to eyes.
12 ECOLOGICAL INFORMATION
13 DISPOSAL CONSIDERATIONS
GENERAL INFORMATION
Do not reuse empty containers. Dispose of contaminated packaging in accordance with local Environmental Protection Agency requirements.
DISPOSAL METHODS
Dispose of waste and residues in accordance with local authority requirements. Incinerate with provision for removal of effluent gases by scrubber.
14 TRANSPORT INFORMATION
UK ROAD CLASS 3
PROPER SHIPPING NAME ACETONITRILE
1648UN NO. ROAD UK ROAD PACK GR.
3ADR CLASS NO. Class 3: Flammable liquids.ADR CLASS
IIADR PACK GROUP 3ADR LABEL NO.
2YEHAZCHEM CODE 30GF1-I+IICEFIC TEC(R) NO.
3RID CLASS NO. RID PACK GROUP
1648UN NO. SEA 3IMDG CLASS
IIIMDG PACK GR. F-E, S-DEMS
See GuideMFAG No.MARINE POLLUTANT
1648UN NO. AIR 3ICAO CLASS
IIAIR PACK GR.
15 REGULATORY INFORMATION
LABELLING
Highly Flammable Harmful
RISK PHRASES
R11 Highly flammable.
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed. 4
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R36 Irritating to eyes.
SAFETY PHRASES
S1/2 Keep locked up and out of the reach of children.
S16 Keep away from sources of ignition - No smoking.
S36/37 Wear suitable protective clothing and gloves.
STATUTORY INSTRUMENTS
Chemicals (Hazard Information and Packaging) Regulations.
16 OTHER INFORMATION
REVISION DATE 04/04/2005
REV. NO./REPL. SDS GENERATED 5
DATE 28/03/2002
DISCLAIMER
This information relates only to the specific material designated and may not be valid for such material used in combination with any
other materials or in any process. Such information is, to the best of the company's knowledge and belief, accurate and reliable as of
the date indicated. However, no warranty guarantee or representation is made to its accuracy, reliability or completeness. It is the
user's responsibility to satisfy himself as to the suitability of such information for his own particular use.
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Material Safety Data SheetAmmonium hydroxide MSDS
Section 1: Chemical Product and Company Identification
Product Name: Ammonium hydroxide
Catalog Codes: SLA3667, SLA3490, SLA1144
CAS#: 1336-21-6
RTECS: BQ9625000
TSCA: TSCA 8(b) inventory: Ammonium hydroxide
CI#: Not applicable.
Synonym: Aqueous Ammonia; Strong Ammonia Solution;Stronger Ammonia Water
Chemical Name: Not applicable.
Chemical Formula: Not applicable.
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Ammonia, anhydrous 7664-41-7 27-31
Water 7732-18-5 69-73
Toxicological Data on Ingredients: Ammonia, anhydrous: GAS (LC50): Acute: 2000 ppm 4 hours [Rat]. 4230 ppm 1 hours[Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:Very hazardous in case of skin contact (corrosive, irritant, permeator), of eye contact (irritant), of ingestion, . Non-corrosiveto the eyes. Non-corrosive for lungs. Liquid or spray mist may produce tissue damage particularly on mucous membranes ofeyes, mouth and respiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritationof respiratory tract, characterized by coughing, choking, or shortness of breath. Severe over-exposure can result in death.Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching,scaling, reddening, or, occasionally, blistering.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. [Ammonia,anhydrous]. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic
to upper respiratory tract, skin, eyes. Repeated or prolonged exposure to the substance can produce target organs damage.Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated orprolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or manyhuman organs.
Section 4: First Aid Measures
Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention immediately. Finish by rinsing thoroughly with running water to avoid apossible infection.
Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly cleanshoes before reuse. Get medical attention immediately.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention immediately.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek medical attention.
Ingestion:If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Non-flammable.
Auto-Ignition Temperature: Not applicable.
Flash Points: Not applicable.
Flammable Limits: Not applicable.
Products of Combustion: Hazardous decomposition include Nitric oxide, and ammonia fumes
Fire Hazards in Presence of Various Substances: Not applicable.
Explosion Hazards in Presence of Various Substances: Non-explosive in presence of open flames and sparks, of shocks.
Fire Fighting Media and Instructions: Not applicable.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards:Forms explosive compounds with many heavy metals such as silver, lead, zinc and their halide salts. It can form shocksensitive compounds with halogens, mercury oxide, and siliver oxide.
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Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Ifnecessary: Neutralize the residue with a dilute solution of acetic acid.
Large Spill:Corrosive liquid. Poisonous liquid. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material.Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Use water sprayto reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal.Neutralize the residue with a dilute solution of acetic acid. Be careful that the product is not present at a concentration levelabove TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
Precautions:Keep locked up.. Keep container dry. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product.In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and showthe container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as metals, acids.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 25°C (77°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits:TWA: 25 (ppm) from ACGIH (TLV) [United States] TWA: 50 STEL: 35 (ppm) from OSHA (PEL) [United States] TWA: 25 STEL:35 from NIOSH Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Ammonia-like (Strong.)
Taste: Acrid.
Molecular Weight: 35.05
Color: Colorless.
pH (1% soln/water): 11.6 [Basic.] This is the actual pH in a 1 N solution.
Boiling Point: Not available
Melting Point: -69.2°C (-92.6°F)
Critical Temperature: Not available.
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Specific Gravity: 0.898 (Water = 1)
Vapor Pressure: 287.9 kPa (@ 20°C)
Vapor Density: Not available
Volatility: Not available.
Odor Threshold: 5 - 50 ppm as ammonia
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water
Solubility: Easily soluble in cold water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Incompatible materials, high temperatures
Incompatibility with various substances:Highly reactive with metals. Reactive with acids. Slightly reactive to reactive with oxidizing agents.
Corrosivity:Extremely corrosive in presence of zinc, of copper. Corrosive in presence of aluminum. Non-corrosive in presence of glass, ofstainless steel(304), of stainless steel(316).
Special Remarks on Reactivity:Incompatible with the following: Organic acids, amides, organic anhydrides, isocyanates, vinyl acetate, epichlorhydrin,aldehydes, Acrolein, Acrylic acid, chlorosulfonic acid, dimethyl sulfate, fluorine, gold + aqua regia, hydrochloric acid,hydrofluoric acid, hydrogen peroxide, iodine, nitric acid, olelum, propiolactone, propylene oxide, silver nitrate, silver oxide,silver oxide + ethyl alcohol, nitromethane, silver permanganate, sulfuric acid, halogens. Forms explosive compounds withmany heavy metals (silver, lead, zinc) and halide salts.
Special Remarks on Corrosivity:Dissolves copper and zinc. Corrosive to aluminum and its alloys. Corrosive to galvanized surfaces. Severe corrosive effect onbrass and bronze
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 350 mg/kg [Rat].
Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. [Ammonium hydroxide]. May cause damage to the followingorgans: mucous membranes, skin, eyes.
Other Toxic Effects on Humans:Very hazardous in case of skin contact (corrosive, irritant, permeator), of ingestion, . Hazardous in case of eye contact(corrosive), of inhalation (lung corrosive).
Special Remarks on Toxicity to Animals: Highly toxic to aquatic organisms
Special Remarks on Chronic Effects on Humans:May affect genetic material based on tests with microorganisms and animals. May cause cancer (tumorigenic) based onanimal data. No human data found at this time. (Ammonia, anhydrous)
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Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes severe irritation. Causes skin burns. May cause deep, penetrating ulcers of theskin. Contact with skin may cause staining, inflammation, and thickening of the skin. Eye: Contact with liquid or vapor causessevere burns and possible irreversible eye damage including corneal injury and cataracts. Inhalation: Causes severe irritationof the upper respiratory tract with coughing, burns, breathing difficulty. May cause acute pulmonary edema, pneumoconiosis,fibrosis, and even coma. It is a respiratory stimulant when inhaled at lower concentrations. It may also affect behavior/central nervous system (convulsions, seizures, ataxia, tremor), cardiovascular system (increase in blood pressure and pulserate). Ingestion: Harmful if swallowed. Affects the Gastrointestinal tract (burns, swelling of the lips, mouth, and larynx, throatconstriction, nausea, vomiting, convulsions, shock, and may cause severe and permanent damage), liver, and urinary system(kidneys) May affect behavior (convulsions, seizures, ataxia, excitement). Chronic Potential Health Effects: Ingestion: Maycause effects similar to those of acute ingestion. Inhalation: Repeated exposure to low concentrations may cause bronchitiswith cough, phlegm, and/or shortness of breath. May also cause liver and kidney damage, and affect the brain, and blood.Eye: May cause corneal damage and the development of cataracts and glaucoma. Skin: Repeated skin contact to lowconcentrations may cause dryness, itching, and redness (dermatitis)
Section 12: Ecological Information
Ecotoxicity:Ecotoxicity in water (LC50): 0.1 ppm 24 hours [Rainbow trout]. 8.2mg/l 96 hours [Fathead minnow]. 0.1 ppm 48 hours[Bluegill].
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: Class 8: Corrosive material
Identification: : Ammonia Solution UNNA: 2672 PG: III
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Connecticut hazardous material survey.: Ammonium hydroxide Illinois toxic substances disclosure to employee act:Ammonium hydroxide Illinois chemical safety act: Ammonium hydroxide New York release reporting list: Ammoniumhydroxide Pennsylvania RTK: Ammonium hydroxide Massachusetts RTK: Ammonium hydroxide Massachusetts spill list:Ammonium hydroxide New Jersey: Ammonium hydroxide New Jersey spill list: Ammonium hydroxide New Jersey toxiccatastrophe prevention act: Ammonium hydroxide Louisiana spill reporting: Ammonium hydroxide California Director's List ofHazardous Substances (8 CCR 339): Ammonium hydroxide TSCA 8(b) inventory: Ammonium hydroxide CERCLA: Hazardoussubstances.: Ammonium hydroxide: 1000 lbs. (453.6 kg)
Other Regulations:
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OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS E: Corrosive liquid.
DSCL (EEC):
HMIS (U.S.A.):
Health Hazard: 3
Fire Hazard: 0
Reactivity: 0
Personal Protection:
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 0
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Face shield.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 03:55 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetCyclohexane MSDS
Section 1: Chemical Product and Company Identification
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Cyclohexane 110-82-7 100
Toxicological Data on Ingredients: Cyclohexane: ORAL (LD50): Acute: 12705 mg/kg [Rat]. 813 mg/kg [Mouse]. DERMAL(LD): Acute: >18000 mg/kg [Rabbit].
Section 3: Hazards Identification
Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), ofingestion, of inhalation.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, liver, cardiovascular system, centralnervous system (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.
Ingestion:If swallowed, do NOT induce vomiting. Do NOT induce vomiting unless directed to do so by medical personnel. Never giveanything by mouth to an unconscious person. Aspiration hazard if swallowed- can enter lungs and cause damage. Loosentight clothing such as a collar, tie, belt or waistband. Get medical attention. Get medical attention if symptoms appear.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of openflames and sparks.
Fire Fighting Media and Instructions:Flammable liquid, insoluble in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog.
Special Remarks on Fire Hazards: Vapor may travel considerable distance to source of ignition and flash back.
Special Remarks on Explosion Hazards: When mixed hot with liquid dinitrogen tetraoxide an explosion can result.
Section 6: Accidental Release Measures
Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.
Large Spill:Flammable liquid, insoluble in water. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk.Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilledmaterial. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be carefulthat the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
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Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin andeyes. Keep away from incompatibles such as oxidizing agents.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 3.4
Ionicity (in Water): Not available.
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Dispersion Properties: See solubility in water, methanol.
Solubility:Soluble in methanol. Insoluble in cold water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, ignition sources, incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents.
Corrosivity: Not considered to be corrosive for metals and glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 813 mg/kg [Mouse].
Chronic Effects on Humans: May cause damage to the following organs: kidneys, liver, cardiovascular system, centralnervous system (CNS).
Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals:Lowest Published Lethal Dose: LCL[Mouse] - Route: Inhalation; Dose: 70000 mg/m3/2H LCL[Rabbit] - 89600 mg/m3/1H
Special Remarks on Chronic Effects on Humans:Human: passes the placental barrier, detected in maternal milk. May affect genetic material (mutagenic)
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: It may cause skin irritation. It may be absorbed through the skin. Eyes: It may causeeye irritation. Inhalation: It may cause respiratory tract (nose, throat) irritation. Exposure to high concentrations of vapormay cause nausea, increased respiration rate. It may also affect behavior/central nervous system(dizziness, lethargy,somnolence, lightheadedness, seizures/convulsions, weakness, loss of coordination and judgement, trembling, drowsiness).Unconsciousness and death may occur at high exposures. In experimental animals there is a narrow margin between dosescausing narcosis, loss of reflexes and death. Generalized vascular damage/collapse and degenerative changes were seenin the heart, lung, liver kidneys and brain of experimental animals exposed to lethal concentrations by inhalation or ingestion.Ingestion: May cause gastrointestinal irritation and diarrhea. May affect behavior/central nervous system with symptomssimilar that that of inhalation. May cause liver and kidney damage. Aspiration of cyclohexane into the lungs may causechemical pneumonitis. Chronic Potential Health Effects: Skin: Prolonged or repeated skin contact may cause drying, crackingand chapping of exposed areas. Ingestion and Ingestion: Prolonged or repeated inhalation or ingestion may causeliver andkidney damage. It may also affect behavior/central nevous system with symtoms similar to that of acute ingestion or inhalation.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:
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Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Cyclohexane UNNA: 1145 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Connecticut hazardous material survey.: Cyclohexane Illinois toxic substances disclosure to employee act: CyclohexaneIllinois chemical safety act: Cyclohexane New York release reporting list: Cyclohexane Rhode Island RTK hazardoussubstances: Cyclohexane Pennsylvania RTK: Cyclohexane Minnesota: Cyclohexane Massachusetts RTK: CyclohexaneMassachusetts spill list: Cyclohexane New Jersey: Cyclohexane New Jersey spill list: Cyclohexane Louisiana spill reporting:Cyclohexane TSCA 8(b) inventory: Cyclohexane SARA 313 toxic chemical notification and release reporting: CyclohexaneCERCLA: Hazardous substances.: Cyclohexane: 1000 lbs. (453.6 kg)
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
DSCL (EEC):
HMIS (U.S.A.):
Health Hazard: 1
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
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Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 08:17 PM
Last Updated: 11/06/2008 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetN,N-Dimethylformamide MSDS
Section 1: Chemical Product and Company Identification
Product Name: N,N-Dimethylformamide
Catalog Codes: SLD4261, SLD3331
CAS#: 68-12-2
RTECS: LQ2100000
TSCA: TSCA 8(b) inventory: N,N-Dimethylformamide
CI#: Not applicable.
Synonym: DMF; Dimethyl Formamide
Chemical Name: N,N-Dimethylformamide
Chemical Formula: HCON(CH3)2
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion,of inhalation.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for mammaliansomatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Classified POSSIBLE for human.DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE].The substance is toxic to kidneys, liver, central nervous system (CNS). The substance may be toxic to blood, the nervoussystem. Repeated or prolonged exposure to the substance can produce target organs damage.
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medicalattention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek medical attention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Various Substances:Flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards:A mixture of triethylaluminum and DMF explodes when heated. DMF + potassium permanganate may explode.
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:
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Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.
Section 7: Handling and Storage
Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits:TWA: 10 (ppm) from ACGIH (TLV) [United States] TWA: 30 (mg/m3) from ACGIH (TLV) [United States] Consult localauthorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Amine like. (Slight.)
Taste: Not available.
Molecular Weight: 73.09 g/mole
Color: Colorless to light yellow.
pH (1% soln/water): Not available.
Boiling Point: 153°C (307.4°F)
Melting Point: -61°C (-77.8°F)
Critical Temperature: 374°C (705.2°F)
Specific Gravity: 0.949 (Water = 1)
Vapor Pressure: 0.3 kPa (@ 20°C)
Vapor Density: 2.51 (Air = 1)
Volatility: Not available.
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Odor Threshold: 100 ppm
Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -1
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, diethyl ether, acetone.
Solubility:Easily soluble in cold water, hot water. Soluble in diethyl ether, acetone. Miscible organic solvents. Soluble in benzene, andchloroform.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, ignition sources (sparks, flames), incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents, acids.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:Can react vigorously with oxidizing agents, halogenated hydrocarbons, and inorganic nitrates. Incompatible with carbontetrachloride, alkyl aluminums, sodium tetrahydroborate, nitrates, chromic acid, diisocyanatomethane, triethylaluminum,sodium hydride, lithium azide, metallic sodium, bromine, magnesium nitrate, potassium permanganate, nitric acid, chromiumtrioxide, borohydrides, phosphorus trioxide, diborane, octafluoroisobutyrate, sodium nitrite, perchloryl fluoride, postassiummethyl 4,4'-dinitrobutyrate. Reaction with inorganic acid chlorides, such as phosphorous oxychloride and thionyl chloride, mayform dimethylcarbamoyl, a suspect carcinogen. May release dimethylamine and carbon monoixde if heated above 350 C (662F).
Special Remarks on Corrosivity:Pure dimethylformamide is essentially non-corrosive to metals. However copper, tin and their alloys should be avoided.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 2800 mg/kg [Rat]. Acute dermal toxicity (LD50): 4720 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 94001 hours [Mouse].
Chronic Effects on Humans:CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic for mammaliansomatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Classified POSSIBLE for human.DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE].Causes damage to the following organs: kidneys, liver, central nervous system (CNS). May cause damage to the followingorgans: blood, the nervous system.
Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals:Lowest Published Lethal Dose: LCL[Rat] - Route: Inhalation; Dose: 5000 ppm/6H
Special Remarks on Chronic Effects on Humans:May affect genetic material. May cause adverse reproductive effects(paternal and maternal) and birth defects. Embryotoxicand/or foetotoxic in animal. Passes through the placental barrier in animal. May cause cancer although IARC evidence forcancer in humans shows inadequate data.
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Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation with itching, burning, redness, swelling, or rash. It may be absorbedthrough the skin in toxic amounts and cause systemic effects similar to that of ingestion. It may facilitate the absorptionof other chemical substances through the skin. If there is significant potential for skin contact, monitoring should be doneto measure the level of DMF metabolites in urine specimans at the end of the shift. It is common practice to limit end-of-shift metabolites at or below 40 ppm expressed as n-monomethylformamide or a single individual or at or below 20 ppmMMF for several workers doing the same job. Eyes: Causes eye irritation (possibly severe) with tearing pain or blurredvision. Inhalation: May cause respiratory tract irritation. Short-term overexposure by inhalation may affect behavior/centralnervous system (convulsions, muscle weakness and other symptoms similar to that of acute ingestion), respiration (dyspnea).Ingestion: It can cause gastrointestinal tract irritation with heartburn, abdominal pain, nausea, vomiting or diarrhea. It may alsoaffect the cardiovascular system (hypertension, tachycardia, ECG abnormalities), blood (elevated white blood cell counts), andliver damage (hepatomegaly, jaundice, altered liver enzymes, fatty liver
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : N,N-Dimethylformamide UNNA: 2265 PG: III
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Illinois toxic substances disclosure to employee act: N,N-Dimethylformamide Illinois chemical safety act: N,N-Dimethylformamide New York release reporting list: N,N-Dimethylformamide Rhode Island RTK hazardous substances: N,N-Dimethylformamide Pennsylvania RTK: N,N-Dimethylformamide Minnesota: N,N-Dimethylformamide Massachusetts RTK:N,N-Dimethylformamide Massachusetts spill list: N,N-Dimethylformamide New Jersey: N,N-Dimethylformamide New Jerseyspill list: N,N-Dimethylformamide Louisiana spill reporting: N,N-Dimethylformamide California Director's List of HazardousSubstances: N,N-Dimethylformamide TSCA 8(b) inventory: N,N-Dimethylformamide TSCA 8(d) H and S data reporting: N,N-Dimethylformamide: 12/19/95 SARA 313 toxic chemical notification and release reporting: N,N-Dimethylformamide CERCLA:Hazardous substances.: N,N-Dimethylformamide: 100 lbs. (45.36 kg)
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
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WHMIS (Canada):CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS D-2A: Material causingother toxic effects (VERY TOXIC).
DSCL (EEC):R20/21- Harmful by inhalation and in contact with skin. R36- Irritating to eyes. R61- May cause harm to the unborn child.S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S53- Avoidexposure - obtain special instructions before use.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 2
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 2
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 05:12 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetEthyl Alcohol 190 Proof MSDS
Section 1: Chemical Product and Company Identification
Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), . Slightly hazardous in case of skin contact (permeator), ofingestion. Non-corrosive for skin. Non-corrosive to the eyes. Non-corrosive for lungs.
Potential Chronic Health Effects:Slightly hazardous in case of skin contact (sensitizer) CARCINOGENIC EFFECTS: Classified PROVEN by State of CaliforniaProposition 65 [Ethyl alcohol 200 Proof]. Classified A4 (Not classifiable for human or animal.) by ACGIH [Ethyl alcohol 200Proof]. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. [Ethyl alcohol 200 Proof]. Mutagenic for bacteriaand/or yeast. [Ethyl alcohol 200 Proof]. TERATOGENIC EFFECTS: Classified PROVEN for human [Ethyl alcohol 200 Proof].DEVELOPMENTAL TOXICITY: Classified Development toxin [PROVEN] [Ethyl alcohol 200 Proof]. Classified Reproductivesystem/toxin/female, Reproductive system/toxin/male [POSSIBLE] [Ethyl alcohol 200 Proof]. The substance is toxic to blood,the reproductive system, liver, upper respiratory tract, skin, central nervous
Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medicalattention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention if symptoms appear.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: The lowest known value is 363°C (685.4°F) (Ethyl alcohol 200 Proof).
Flammable Limits: The greatest known range is LOWER: 3.3% UPPER: 19% (Ethyl alcohol 200 Proof)
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizingmaterials. Non-flammable in presence of shocks, of reducing materials, of combustible materials, of organic materials, ofmetals, of acids, of alkalis.
Explosion Hazards in Presence of Various Substances:Slightly explosive in presence of open flames and sparks, of heat, of oxidizing materials, of acids. Non-explosive in presenceof shocks.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog.
Special Remarks on Fire Hazards:Containers should be grounded. CAUTION: MAY BURN WITH NEAR INVISIBLE FLAME Vapor may travel considerabledistance to source of ignition and flash back. May form explosive mixtures with air. Contact with Bromine pentafluoride is likelyto cause fire or explosion. Ethanol ignites on contact with chromyl chloride. Ethanol ignites on contact with iodine heptafluoridegas. It ignites than explodes upon contact with nitrosyl perchlorate. Additon of platinum black catalyst caused ignition. (Ethylalcohol 200 Proof)
Special Remarks on Explosion Hazards:Ethanol has an explosive reaction with the oxidized coating around potassium metal. Ethanol ignites and then explodes oncontact with acetic anhydride + sodium hydrosulfate (ignites and may explode), disulfuric acid + nitric acid, phosphorous(III)
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oxide platinum, potassium-tert-butoxide+ acids. Ethanol forms explosive products in reaction with the following compound :ammonia + silver nitrate (forms silver nitride and silver fulminate), iodine + phosphorus (forms ethane iodide), magnesiumperchlorate (forms ethyl perchlorate), mercuric nitrate, nitric acid + silver (forms silver fulminate) silver nitrate (forms ethylnitrate) silver(I) oxide + ammonia or hydrazine (forms silver nitride and silver fulminate), sodium (evolves hydrogen gas).Sodium Hydrazide + alcohol can produce an explosion. Alcohols should not be mixed with mercuric nitrate, as explosivemercuric fulminate may be formed. May form explosive mixture with manganese perchlorate + 2,2-dimethoxypropane. Additionof alcohols to highly concentrate hydrogen peroxide forms powerful explosives. Explodes on contact with calcium hypochloriteVapor may explode if ignited in an enclosed area. Containers may explode when heated or involved in a fire. (Ethyl alcohol200 Proof)
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.
Section 7: Handling and Storage
Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids, alkalis, moisture.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame). Do not store above 23°C (73.4°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Odor:Alcohol like. Mild to strong. Like wine or whiskey; Ethereal, vinous. Pleasant.
Taste: Burning. Pungent.
Molecular Weight: Not applicable.
Color: Clear Colorless.
pH (1% soln/water): Neutral.
Boiling Point: The lowest known value is 78.5°C (173.3°F) (Ethyl alcohol 200 Proof). Weighted average: 79.58°C (175.2°F)
Melting Point: May start to solidify at -114.1°C (-173.4°F) based on data for: Ethyl alcohol 200 Proof.
Critical Temperature: The lowest known value is 243°C (469.4°F) (Ethyl alcohol 200 Proof).
Specific Gravity: Weighted average: 0.8 (Water = 1)
Vapor Pressure: The highest known value is 5.7 kPa (@ 20°C) (Ethyl alcohol 200 Proof). Weighted average: 5.53 kPa (@20°C)
Vapor Density: The highest known value is 1.59 (Air = 1) (Ethyl alcohol 200 Proof). Weighted average: 1.54 (Air = 1)
Volatility: Not available.
Odor Threshold: 100 ppm
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, methanol, diethyl ether, acetone.
Solubility:Easily soluble in cold water, hot water, methanol, diethyl ether. Soluble in acetone.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Incompatible materials, heat, sources of ignition.
Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:Ethanol rapidly absorbs moisture from the air. Can react vigorously with oxiders. The following oxidants have beendemonstrated to undergo vigorous/explosive reaction with ethanol: barium perchlorate, bromine pentafluoride, calciumhypochlorite, chloryl perchlorate, chromium trioxide, chromyl chloride, dioxygen difluoride, disulfuryl difluoride, fluorine nitrate,hydrogen peroxide, iodine heptafluoride, nitric acid nitrosyl perchlorate, perchloric acid permanganic acid, peroxodisulfuricacid, potassium dioxide, potassium perchlorate, potassium permanganate, ruthenium(VIII) oxide, silver perchlorate, silverperoxide, uranium hexafluoride, uranyl perchlorate. Ethanol reacts violently/expodes with the following compounds: acetylbromide (evolves hydrogen bromide) acetyl chloride, aluminum, sesquibromide ethylate, ammonium hydroxide & silveroxide, chlorate, chromic anhydride, cyanuric acid + water, dichloromethane + sulfuric acid + nitrate (or) nitrite, hydrogenperoxide + sulfuric acid, iodine + methanol + mercuric oxide, manganese perchlorate + 2,2-dimethoxy propane, perchlorates,permanganates + sulfuric acid, potassium superoxide, potassium tert-butoxide, silver & nitric acid, silver perchlorate, sodiumhydrazide, sulfuric acid + sodium dichromate, tetrachlorisilane + water. Ethanol is also incompatible with platinium, andsodium. No really safe conditions exist under which ethyl alcohol and chlorine oxides can be handled. Reacts vigorously withacetyl chloride (Ethyl alcohol 200 Proof)
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
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Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): 3632 mg/kg (Mouse) (Calculated value for the mixture).
Chronic Effects on Humans:CARCINOGENIC EFFECTS: Classified PROVEN by State of California Proposition 65 [Ethyl alcohol 200 Proof]. ClassifiedA4 (Not classifiable for human or animal.) by ACGIH [Ethyl alcohol 200 Proof]. MUTAGENIC EFFECTS: Mutagenicfor mammalian somatic cells. [Ethyl alcohol 200 Proof]. Mutagenic for bacteria and/or yeast. [Ethyl alcohol 200 Proof].TERATOGENIC EFFECTS: Classified PROVEN for human [Ethyl alcohol 200 Proof]. DEVELOPMENTAL TOXICITY:Classified Development toxin [PROVEN] [Ethyl alcohol 200 Proof]. Classified Reproductive system/toxin/female, Reproductivesystem/toxin/male [POSSIBLE] [Ethyl alcohol 200 Proof].
Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous in case of skin contact (permeator), of ingestion.
Special Remarks on Toxicity to Animals:Lowest Published Dose/Conc: LDL[Human] - Route: Oral; Dose: 1400 mg/kg LDL[Human child] - Route: Oral; Dose: 2000 mg/kg LDL[Rabbit] - Route: Skin; Dose: 20000 mg/kg (Ethyl alcohol 200 Proof)
Special Remarks on Chronic Effects on Humans:May affect genetic material (mutagenic) Causes adverse reproductive effects and birth defects (teratogenic) , based onmoderate to heavy consumption. May cause cancer based on animal data. Human: passes through the placenta, excreted inmaternal milk. (Ethyl alcohol 200 Proof)
Special Remarks on other Toxic Effects on Humans:Acute potential health effects: Skin: causes skin irritation Eyes: causes eye irritation Ingestion: May cause gastrointestinal tractirritation with nausea, vomiting, diarrhea, and alterations in gastric secretions. May affect behavior/central nervous system(central nervous system depression - amnesia, headache, muscular incoordination, excitation, mild euphoria, slurred speech,drowsiness, staggaring gait, fatigue, changes in mood/personality, excessive talking, dizziness, ataxia, somnolence, coma/narcosis, hallucinations, distorted perceptions, general anesthetic), peripherial nervous system (spastic paralysis)vision(diplopia). Moderately toxic and narcotic in high concentrations. May also affect metabolism, blood, liver, respiration (dyspnea),and endocrine system. May affect respiratory tract, cardiovascular(cardiac arrhythmias, hypotension), and urinary systems.Inhalation: May cause irritation of the respiratory tract and affect behavior/central nervous system with symptoms similarto ingestion. Chronic Potential Health Effects: Skin: Prolonged or repeated skin contact may casue dermatitis, an allergicreaction. Ingestion: Prolonged or repeated ingestion will have similiar effects as acute ingestion. It may also affect the brain.(Ethyl alcohol 200 Proof)
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Federal and State Regulations:California prop. 65: This product contains the following ingredients for which the State of California has found to causecancer, birth defects or other reproductive harm, which would require a warning under the statute: Ethyl alcohol 200 Proof (inalcoholic beverage) California prop. 65: This product contains the following ingredients for which the State of California hasfound to cause birth defects which would require a warning under the statute: Ethyl alcohol 200 Proof (in alcoholic beverage)Connecticut hazardous material survey.: Ethyl alcohol 200 Proof Illinois toxic substances disclosure to employee act: Ethylalcohol 200 Proof Rhode Island RTK hazardous substances: Ethyl alcohol 200 Proof Pennsylvania RTK: Ethyl alcohol 200Proof Florida: Ethyl alcohol 200 Proof Minnesota: Ethyl alcohol 200 Proof Massachusetts RTK: Ethyl alcohol 200 ProofMassachusetts spill list: Ethyl alcohol 200 Proof New Jersey: Ethyl alcohol 200 Proof TSCA 8(b) inventory: Water; Ethylalcohol 200 Proof
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects(TOXIC).
DSCL (EEC):R11- Highly flammable. S7- Keep container tightly closed. S16- Keep away from sources of ignition - No smoking.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 05:28 PM
Last Updated: 05/21/2013 12:00 PM
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The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetEthyl acetate MSDS
Section 1: Chemical Product and Company Identification
Product Name: Ethyl acetate
Catalog Codes: SLE2452, SLE2317
CAS#: 141-78-6
RTECS: AH5425000
TSCA: TSCA 8(b) inventory: Ethyl acetate
CI#: Not available.
Synonym: Acetic Acid, Ethyl Ester Acetic Ether
Chemical Name: Ethyl Acetate
Chemical Formula: C4-H8-O2
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
Potential Acute Health Effects:Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator), of eye contact(irritant).
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to mucousmembranes, upper respiratory tract. The substance may be toxic to blood, kidneys, liver, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.
Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention.
Skin Contact:Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold watermay be used.
Serious Skin Contact: Not available.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention if symptoms appear.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizingmaterials, of acids, of alkalis. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of static discharge: Not available. Slightly explosive in presence of heat. Non-explosive in presence of shocks.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog.
Special Remarks on Fire Hazards:Vapor may travel considerable distance to source of ignition and flash back. When heated to decomposition it emits acridsmoke and irritating fumes.
Special Remarks on Explosion Hazards:The liquid produces a vapor that forms explosive mixtures with air at normal temperatures. Explosive reaction with lithiumtetrahydroaluminate.
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
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Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.
Section 7: Handling and Storage
Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatiblessuch as oxidizing agents, acids, alkalis.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame). Moisture sensitive.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits:TWA: 400 (ppm) from OSHA (PEL) [United States] TWA: 400 from ACGIH (TLV) [United States] TWA: 1400 (mg/m3) fromNIOSH [United States] TWA: 400 (ppm) from NIOSH [United States] TWA: 400 (ppm) [Canada] TWA: 1440 (mg/m3) [Canada]TWA: 1400 (mg/m3) from OSHA (PEL) [United States]3 Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Ethereal. Fruity. (Slight.)
Taste: Bittersweet, wine-like burning taste
Molecular Weight: 88.11 g/mole
Color: Colorless.
pH (1% soln/water): Not available.
Boiling Point: 77°C (170.6°F)
Melting Point: -83°C (-117.4°F)
Critical Temperature: 250°C (482°F)
Specific Gravity: 0.902 (Water = 1)
Vapor Pressure: 12.4 kPa (@ 20°C)
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Vapor Density: 3.04 (Air = 1)
Volatility: Not available.
Odor Threshold: 3.9 ppm
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 0.7
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, diethyl ether, acetone.
Solubility: Soluble in cold water, hot water, diethyl ether, acetone, alcohol, benzene.
Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:Also incompatible with nitrates, chlorosulfonic acid, oleum, potassium-tert-butoxide, and lithium tetrahydroaluminate. Moisturesensitive. On storage, it is slowly decomposed by water.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 4100 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 45000 mg/m3 3 hours [Mouse].
Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. Causes damage to the following organs:mucous membranes, upper respiratory tract. May cause damage to the following organs: blood, kidneys, liver, central nervoussystem (CNS).
Other Toxic Effects on Humans:Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator).
Special Remarks on Toxicity to Animals: LD50 [Rabbit] - Route: skin; Dose >20,000 ml/kg
Special Remarks on Chronic Effects on Humans:May affect genetic material (mutagenic). May cause adverse reproductive effects. based on animal test data. No human datafound at this time.
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: Causes eye irritation. May cause irritation of theconjunctivia. Inhalation: May cause respiratory tract and mucous membrane irritation. May affect respiration and may causeacute pulmonary edema. May affect gastrointestinal tract (nausea, vomiting). May affect behavior/central nervous system(mild central nervous system depression - exhilaration, talkativeness, boastfulness, belligerancy, vertigo, diplopia, drowsiness,slurred speech, slowed reaction time, dizziness, lightheadedness, somnolence, ataxia, unconciousness, irritability, fatigue,sleep disturbances, reduced memory and concentration, stupor, coma), cardiovascular system (peripheral vascular collapse(shock) - rapid pulse, hypotension, cold pale skin, hypothermia). Other symptoms may include: flushing of face and sweating.
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Ingestion: May cause gastrointestinal tract irritation with nausea and vomiting. May affect blood, behavior/central nervoussystem (CNS depression - effects may be similar to that of inhalation). Chronic Potential Health Effects: Skin: Repeated orprolonged skin contact may cause drying and cracking of the skin. IngestIon: Prolonged or repeated ingestion may affectthe liver. Inhalation: Prolonged inhalation may affect behavior/central nervous system (symptoms similar to those of acuteinhalation), and cause liver, kidney, lung, and heart damage. It may also affect metabolism, and blood (anemia, leukocytosis).
Section 12: Ecological Information
Ecotoxicity:Ecotoxicity in water (LC50): 220 mg/l 96 hours [Fish (Fathead minnow)]. 212.5 ppm 96 hours [Fish (Indian catfish)].
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Ethyl Acetate UNNA: 1173 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Connecticut hazardous material survey.: Ethyl acetate Illinois toxic substances disclosure to employee act: Ethyl acetateIllinois chemical safety act: Ethyl acetate New York release reporting list: Ethyl acetate Rhode Island RTK hazardoussubstances: Ethyl acetate Pennsylvania RTK: Ethyl acetate Florida: Ethyl acetate Minnesota: Ethyl acetate MassachusettsRTK: Ethyl acetate Massachusetts spill list: Ethyl acetate New Jersey: Ethyl acetate New Jersey spill list: Ethyl acetateLouisiana spill reporting: Ethyl acetate California Director's list of Hazardous Substances: Ethyl acetate TSCA 8(b) inventory:Ethyl acetate TSCA 4(a) final test rules: Ethyl acetate TSCA 8(a) IUR: Ethyl acetate TSCA 12(b) annual export notification:Ethyl acetate CERCLA: Hazardous substances.: Ethyl acetate: 5000 lbs. (2268 kg)
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
DSCL (EEC):R11- Highly flammable. R36- Irritating to eyes. S2- Keep out of the reach of children. S16- Keep away from sources of ignition- No smoking. S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33-Take precautionary measures against static discharges. S46- If swallowed, seek medical advice immediately and show thiscontainer or label.
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HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: g
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Safety glasses.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 08:18 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetIsobutyl acetate MSDS
Section 1: Chemical Product and Company Identification
Product Name: Isobutyl acetate
Catalog Codes: SLB3337
CAS#: 110-19-0
RTECS: AI4025000
TSCA: TSCA 8(b) inventory: Isobutyl acetate
CI#: Not available.
Synonym: 2-Methyl-1-propyl acetate
Chemical Name: Isobutyl acetate
Chemical Formula: C6-H12-O2
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Isobutyl acetate 110-19-0 100
Toxicological Data on Ingredients: Isobutyl acetate: ORAL (LD50): Acute: 13400 mg/kg [Rat]. 4763 mg/kg [Rabbit].DERMAL (LD50): Acute: 17400 mg/kg [Rabbit].
Section 3: Hazards Identification
Potential Acute Health Effects:Very hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of inhalation (lung irritant). Inflammation ofthe eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,or, occasionally, blistering.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Classified None. by NTP, None. by OSHA. A4 (Not classifiable for human or animal.) byACGIH. MUTAGENIC EFFECTS: Classified None. for human. TERATOGENIC EFFECTS: Classified None. for human.DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, upper respiratory tract, eyes, eye, lens orcornea. Repeated or prolonged exposure to the substance can produce target organs damage.
Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Skin Contact:After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with runningwater and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing beforereusing.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.
Ingestion:Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, performmouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: 421°C (789.8°F)
Flash Points: CLOSED CUP: 17.8°C (64°F). OPEN CUP: 85°C (185°F).
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Highly explosive in presence of oxidizing materials, of metals, of acids.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: May explode if ignited in an enclosed area.
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Eliminate all ignition sources. Be careful that the product is not present at a concentration level aboveTLV. Check TLV on the MSDS and with local authorities.
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Section 7: Handling and Storage
Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Donot breathe gas/fumes/ vapour/spray. In case of insufficient ventilation, wear suitable respiratory equipment If ingested,seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes Keep away fromincompatibles such as oxidizing agents, metals, acids.
Storage:Flammable materials should be stored in a separate safety storage cabinet or room. Keep away from heat. Keep away fromsources of ignition. Keep container tightly closed. Keep in a cool, well-ventilated place. Ground all equipment containingmaterial. A refrigerated room would be preferable for materials with a flash point lower than 37.8°C (100°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Chronic Effects on Humans:CARCINOGENIC EFFECTS: Classified None. by NTP, None. by OSHA. A4 (Not classifiable for human or animal.) by ACGIH.MUTAGENIC EFFECTS: Classified None. for human. TERATOGENIC EFFECTS: Classified None. for human. The substanceis toxic to lungs, upper respiratory tract, eyes, eye, lens or cornea.
Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant, permeator), of inhalation (lung irritant).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
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Section 14: Transport Information
DOT Classification: Class 3: Flammable liquid.
Identification: : Isobutyl Acetate : UN1213 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Rhode Island RTK hazardous substances: Isobutyl acetate Pennsylvania RTK: Isobutyl acetate Florida: Isobutyl acetateMassachusetts RTK: Isobutyl acetate New Jersey: Isobutyl acetate TSCA 8(b) inventory: Isobutyl acetate SARA 311/312MSDS distribution - chemical inventory - hazard identification: Isobutyl acetate: immediate health hazard CERCLA: Hazardoussubstances.: Isobutyl acetate
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada): CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
DSCL (EEC): R11- Highly flammable.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 04:27 PM
Last Updated: 11/06/2008 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetIsopropyl alcohol MSDS
Section 1: Chemical Product and Company Identification
Potential Acute Health Effects:Hazardous in case of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant,sensitizer, permeator).
Potential Chronic Health Effects:Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.)by ACGIH, 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Notavailable. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE].The substance may be toxic to kidneys, liver, skin, central nervous system (CNS). Repeated or prolonged exposure to thesubstance can produce target organs damage.
Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention.
Skin Contact:Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold watermay be used.
Serious Skin Contact: Not available.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention if symptoms appear.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Flammable in presence of oxidizing materials. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Explosive in presence of open flames andsparks, of heat.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog.
Special Remarks on Fire Hazards:Vapor may travel considerable distance to source of ignition and flash back. CAUTION: MAY BURN WITH NEAR INVISIBLEFLAME. Hydrogen peroxide sharply reduces the autoignition temperature of Isopropyl alcohol. After a delay, Isopropylalcohol ignites on contact with dioxgenyl tetrafluorborate, chromium trioxide, and potassium tert-butoxide. When heated todecomposition it emits acrid smoke and fumes.
Special Remarks on Explosion Hazards:Secondary alcohols are readily autooxidized in contact with oxygen or air, forming ketones and hydrogen peroxide. It canbecome potentially explosive. It reacts with oxygen to form dangerously unstable peroxides which can concentrate andexplode during distillation or evaporation. The presence of 2-butanone increases the reaction rate for peroxide formation.Explosive in the form of vapor when exposed to heat or flame. May form explosive mixtures with air. Isopropyl alcohol +phosgene forms isopropyl chloroformate and hydrogen chloride. In the presence of iron salts, thermal decompositon canoccur, whicn in some cases can become explosive. A homogeneous mixture of concentrated peroxides + isopropyl alcohol arecapable of detonation by shock or heat. Barium perchlorate + isopropyl alcohol gives the highly explosive alkyl perchlorates.
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It forms explosive mixtures with trinitormethane and hydrogen peroxide. It produces a violent explosive reaction when heatedwith aluminum isopropoxide + crotonaldehyde. Mixtures of isopropyl alcohol + nitroform are explosive.
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confinedareas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.
Section 7: Handling and Storage
Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Avoid contact with eyes. Wear suitable protective clothing. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keepaway from incompatibles such as oxidizing agents, acids.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Water/Oil Dist. Coeff.: The product is equally soluble in oil and water; log(oil/water) = 0.1
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, methanol, diethyl ether, n-octanol, acetone.
Solubility:Easily soluble in cold water, hot water, methanol, diethyl ether, n-octanol, acetone. Insoluble in salt solution. Soluble inbenzene. Miscible with most organic solvents including alcohol, ethyl alcohol, chloroform.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, Ignition sources, incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:Reacts violently with hydrogen + palladium combination, nitroform, oleum, COCl2, aluminum triisopropoxide, oxidantsIncompatible with acetaldehyde, chlorine, ethylene oxide, isocyanates, acids, alkaline earth, alkali metals, caustics, amines,crotonaldehyde, phosgene, ammonia. Isopropyl alcohol reacts with metallic aluminum at high temperatures. Isopropyl alcoholattacks some plastics, rubber, and coatings. Vigorous reaction with sodium dichromate + sulfuric acid.
Special Remarks on Corrosivity: May attack some forms of plastic, rubber and coating
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 3600 mg/kg [Mouse]. Acute dermal toxicity (LD50): 12800 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50):16000 8 hours [Rat].
Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. May causedamage to the following organs: kidneys, liver, skin, central nervous system (CNS).
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Other Toxic Effects on Humans:Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer, permeator).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans:M a y c a u s e a d v e r s e r e p r o d u c t i v e / t e r a t o g e n i c e f f e c t s ( f e r t i l i t y , f e t o x i c i t y , d e v e l o p m en t a l abnormalities(developmental toxin)) based on animal studies. Detected in maternal milk in human.
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause mild skin irritation, and sensitization. Eyes: Can cause eye irritation.Inhalation: Breathing in small amounts of this material during normal handling is not likely to cause harmful effects. However,breathing large amounts may be harmful and may affect the respiratory system and mucous membranes (irritation), behaviorand brain (Central nervous system depression - headache, dizziness, drowsiness, stupor, incoordination, unconciousness,coma and possible death), peripheral nerve and senstation, blood, urinary system, and liver. Ingestion: Swallowing smallamouts during normal handling is not likely to cause harmful effects. Swallowing large amounts may be harmful. Swallowinglarge amounts may cause gastrointestinal tract irritation with nausea, vomiting and diarrhea, abdominal pain. It also mayaffect the urinary system, cardiovascular system, sense organs, behavior or central nervous system (somnolence, generallydepressed activity, irritability, headache, dizziness, drowsiness), liver, and respiratory system (breathing difficulty). ChronicPotential Health Effects: May cause defatting of the skin and dermatitis and allergic reaction. May cause adverse reproductiveeffects based on animal data (studies).
Section 12: Ecological Information
Ecotoxicity: Ecotoxicity in water (LC50): 100000 mg/l 96 hours [Fathead Minnow]. 64000 mg/l 96 hours [Fathead Minnow].
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Isopropyl Alcohol UNNA: 1219 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Connecticut hazardous material survey.: Isopropyl alcohol Illinois toxic substances disclosure to employee act: Isopropylalcohol Rhode Island RTK hazardous substances: Isopropyl alcohol Pennsylvania RTK: Isopropyl alcohol Florida: Isopropylalcohol Minnesota: Isopropyl alcohol Massachusetts RTK: Isopropyl alcohol New Jersey: Isopropyl alcohol New Jersey spilllist: Isopropyl alcohol Director's list of Hazardous Substances: Isopropyl alcohol Tennesee: Isopropyl alcohol TSCA 8(b)inventory: Isopropyl alcohol TSCA 4(a) final testing order: Isopropyl alcohol TSCA 8(a) IUR: Isopropyl alcohol TSCA 8(d) H
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and S data reporting: Isopropyl alcohol: Effective date: 12/15/86 Sunset Date: 12/15/96 TSCA 12(b) one time export: Isopropylalcohol SARA 313 toxic chemical notification and release reporting: Isopropyl alcohol
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects(TOXIC).
DSCL (EEC):R11- Highly flammable. R36- Irritating to eyes. S7- Keep container tightly closed. S16- Keep away from sources of ignition- No smoking. S24/25- Avoid contact with skin and eyes. S26- In case of contact with eyes, rinse immediately with plenty ofwater and seek medical advice.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 05:53 PM
Last Updated: 05/22/2009 09:11 AM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetMethyl alcohol MSDS
Section 1: Chemical Product and Company Identification
Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator). Severe over-exposure can result in death.
Potential Chronic Health Effects:Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS:Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: ClassifiedPOSSIBLE for human. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to eyes. The substance may betoxic to blood, kidneys, liver, brain, peripheral nervous system, upper respiratory tract, skin, central nervous system (CNS),optic nerve. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to ahighly toxic material may produce general deterioration of health by an accumulation in one or many human organs.
Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly cleanshoes before reuse. Get medical attention immediately.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention immediately.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.
Ingestion:If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: 464°C (867.2°F)
Flash Points: CLOSED CUP: 12°C (53.6°F). OPEN CUP: 16°C (60.8°F).
Flammable Limits: LOWER: 6% UPPER: 36.5%
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Explosive in presence of open flames andsparks, of heat.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog.
Special Remarks on Fire Hazards:Explosive in the form of vapor when exposed to heat or flame. Vapor may travel considerable distance to source of ignitionand flash back. When heated to decomposition, it emits acrid smoke and irritating fumes. CAUTION: MAY BURN WITH NEARINVISIBLE FLAME
Special Remarks on Explosion Hazards:Forms an explosive mixture with air due to its low flash point. Explosive when mixed with Choroform + sodium methoxide anddiethyl zinc. It boils violently and explodes.
Section 6: Accidental Release Measures
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Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:Flammable liquid. Poisonous liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk.Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilledmaterial. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Callfor assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on theMSDS and with local authorities.
Section 7: Handling and Storage
Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Donot ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wearsuitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as oxidizing agents, metals, acids.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.8
Ionicity (in Water): Non-ionic.
Dispersion Properties: See solubility in water.
Solubility: Easily soluble in cold water, hot water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, ingnition sources, incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents, metals, acids.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:Can react vigorously with oxidizers. Violent reaction with alkyl aluminum salts, acetyl bromide, chloroform + sodium methoxide,chromic anhydride, cyanuirc chlorite, lead perchlorate, phosphorous trioxide, nitric acid. Exothermic reaction with sodiumhydroxide + chloroform. Incompatible with beryllium dihydride, metals (potassium and magnesium), oxidants (bariumperchlorate, bromine, sodium hypochlorite, chlorine, hydrogen peroxide), potassium tert-butoxide, carbon tetrachloride, alkalimetals, metals (aluminum, potassium magnesium, zinc), and dichlormethane. Rapid autocatalytic dissolution of aluminum,magnesium or zinc in 9:1 methanol + carbon tetrachloride - sufficiently vigorous to be rated as potentially hazardous. Mayattack some plastics, rubber, and coatings.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 5628 mg/kg [Rat]. Acute dermal toxicity (LD50): 15800 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50):64000 4 hours [Rat].
Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Classified POSSIBLE for human. Causes damage to the following organs: eyes. May cause damage to thefollowing organs: blood, kidneys, liver, brain, peripheral nervous system, upper respiratory tract, skin, central nervous system(CNS), optic nerve.
Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans:
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Passes through the placental barrier. May affect genetic material. May cause birth defects and adverse reproductiveeffects(paternal and maternal effects and fetotoxicity ) based on animal studies.
Special Remarks on other Toxic Effects on Humans:
Section 12: Ecological Information
Ecotoxicity: Ecotoxicity in water (LC50): 29400 mg/l 96 hours [Fathead Minnow].
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation:Methanol in water is rapidly biodegraded and volatilized. Aquatic hydrolysis, oxidation, photolysis, adsorption to sediment, andbioconcentration are not significant fate processes. The half-life of methanol in surfact water ranges from 24 hrs. to 168 hrs.Based on its vapor pressure, methanol exists almost entirely in the vapor phase in the ambient atmosphere. It is degraded byreaction with photochemically produced hydroxyl radicals and has an estimated half-life of 17.8 days. Methanol is physicallyremoved from air by rain due to its solubility. Methanol can react with NO2 in pollulted to form methyl nitrate. The half-life ofmethanol in air ranges from 71 hrs. (3 days) to 713 hrs. (29.7 days) based on photooxidation half-life in air.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Methyl alcohol UNNA: 1230 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Connecticut hazardous material survey.: Methyl alcohol Illinois toxic substances disclosure to employee act: Methyl alcoholIllinois chemical safety act: Methyl alcohol New York release reporting list: Methyl alcohol Rhode Island RTK hazardoussubstances: Methyl alcohol Pennsylvania RTK: Methyl alcohol Minnesota: Methyl alcohol Massachusetts RTK: Methylalcohol Massachusetts spill list: Methyl alcohol New Jersey: Methyl alcohol New Jersey spill list: Methyl alcohol Louisianaspill reporting: Methyl alcohol California Directors List of Hazardous Substances (8CCR 339): Methyl alcohol TennesseHazardous Right to Know : Methyl alcohol TSCA 8(b) inventory: Methyl alcohol SARA 313 toxic chemical notification andrelease reporting: Methyl alcohol CERCLA: Hazardous substances.: Methyl alcohol: 5000 lbs. (2268 kg)
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-1B: Material causing immediate andserious toxic effects (TOXIC). CLASS D-2A: Material causing other toxic effects (VERY TOXIC). Class D-2B: Material causingother toxic effects (TOXIC).
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DSCL (EEC):R11- Highly flammable. R23/24/25- Toxic by inhalation, in contact with skin and if swallowed. R39- Danger of very seriousirreversible effects. R39/23/24/25- Toxic: danger of very serious irreversible effects through inhalation, in contact with skin andif swallowed. S7- Keep container tightly closed. S16- Keep away from sources of ignition - No smoking. S36/37- Wear suitableprotective clothing and gloves. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the labelwhere possible).
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data Sheetn-heptane MSDS
Section 1: Chemical Product and Company Identification
Product Name: n-heptane
Catalog Codes: SLH2152, SLH2998, SLH1675, SLH1948
CAS#: 142-82-5
RTECS: MI7700000
TSCA: TSCA 8(b) inventory: n-heptane
CI#: Not available.
Synonym: Dipropyl methane; Heptyl hydride
Chemical Name: Heptane
Chemical Formula: C7H16
Contact Information:
Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396
US Sales: 1-800-901-7247International Sales: 1-281-441-4400
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
{n-}heptane 142-82-5 100
Toxicological Data on Ingredients: n-heptane: VAPOR (LC50): Acute: 103000 mg/m 4 hours [Rat].
Section 3: Hazards Identification
Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, ofinhalation.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to lungs, peripheral nervous system, upperrespiratory tract, skin, central nervous system (CNS). Repeated or prolonged exposure to the substance can produce targetorgans damage.
Section 4: First Aid Measures
Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention if irritation occurs.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact: Not available.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention if symptoms appear.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.
Ingestion:If swallowed, do NOT induce vomiting. Never give anything by mouth to an unconscious person. Aspiration hazard ifswallowed- can enter lungs and cause damage. Loosen tight clothing such as a collar, tie, belt or waistband. Get medicalattention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Flammable.
Auto-Ignition Temperature: 203.89°C (399°F) - 223 C (433 F)
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances: Highly flammable in presence of open flames and sparks, of heat.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Slightly explosive in presence of heat.
Fire Fighting Media and Instructions:Flammable liquid, insoluble in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog.
Special Remarks on Fire Hazards:Flaming occurs when liquid chlorine in n-Heptane is added to added to red phosphorous. Vapors may form explosive mixtureswith air. Vapor may travel considerable distance to source of ignition and flash back.
Special Remarks on Explosion Hazards: Vapors may form explosive mixtures in air.
Section 6: Accidental Release Measures
Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.
Large Spill:Flammable liquid, insoluble in water. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk.Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilledmaterial. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be carefulthat the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
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Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. If ingested, seek medical advice immediately and show the container or the label. Keep awayfrom incompatibles such as oxidizing agents.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 4.7
Ionicity (in Water): Not available.
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Dispersion Properties: See solubility in water, diethyl ether, acetone.
Solubility:Soluble in diethyl ether, acetone. Insoluble in cold water. Soluble in alcohol. Solubility in Chloroform, Petroleum Ether, Ether,Acetone: >10% Floats on water.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, ignition sources (flames, sparks), incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents.
Corrosivity: Not considered to be corrosive for metals and glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Inhalation.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute toxicityof the vapor (LC50): 103000 mg/m3 4 hours [Rat].
Chronic Effects on Humans:May cause damage to the following organs: lungs, peripheral nervous system, upper respiratory tract, skin, central nervoussystem (CNS).
Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation. It can be absorbed through the skin. Eyes: Contact with liquid maycause eye irritation. Contact with vapors is not expected to cause eye irritation. Inhalation: Inhalation of vapor or mist causesrespiratory tract and mucous membrane irritation. It can affect behavior/central nervous system and cause central nervoussystem effects (mild excitement followed CNS depression which is characterized by headache, nausea, dizziness, hilarity,hallucinations, lightheadness, distorted perceptions, convulsions, weakness, loss of judgement and coordination, narcosis,semi-conciousness, coma and death at higher doses). It may cause cardiac effects (irregular heartbeat/cardiac arrhythmias, orheart to stop beating), and pulmonary edema. It is readily absorbed by the inhalation route. Ingestion: Causes gastrointestinaltract irritation with nausea, vomiting, swelling of the abdomen. Aspiration into the lungs can produce chemical pneumonitis.It can also affect behavior/central nervous system with symptoms paralleling those of inhalation. Chronic Potential HealthEffects: Skin: Prolonged or repeated skin contact can defat the skin and product irritation and dermatitis. Inhalation: Repeatedor prolonged inhalation may affect behavior/central nervous system (symptoms similar to acute inhalation) and may produceminimal peripheral nerve damage (polyneuropathy) with numbness and tingling of the extremities in a stocking-and -glovepattern. Reversible of polyneuropathy as been reversible by a year following removal from exposure. It may also affect thebrain, blood (anemia), and hearing (mild change in auditory threshold), and may also cause weight loss, Ingestion: Prolongedor repeated ingestion may affect the liver, urinary system, blood (changes in blood serum compostion).
Section 12: Ecological Information
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Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Heptane UNNA: 1206 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Connecticut hazardous material survey.: n-heptane Illinois toxic substances disclosure to employee act: n-heptane RhodeIsland RTK hazardous substances: n-heptane Pennsylvania RTK: n-heptane Minnesota: n-heptane Massachusetts RTK: n-heptane Massachusetts spill list: n-heptane New Jersey: n-heptane California Director's List of Hazardous Substances: n-heptane TSCA 8(b) inventory: n-heptane TSCA 4(a) proposed test rules: n-heptane TSCA 8(d) H and S data reporting: n-heptane: Effective date: 1/26/94; Sunset date: 6/30/98
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2B: Material causing other toxic effects(TOXIC).
DSCL (EEC):
HMIS (U.S.A.):
Health Hazard: 1
Fire Hazard: 3
Reactivity: 0
Personal Protection: g
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 3
Reactivity: 0
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Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Safety glasses.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/09/2005 05:42 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetSulfuric acid MSDS
Section 1: Chemical Product and Company Identification
Potential Acute Health Effects:Very hazardous in case of skin contact (corrosive, irritant, permeator), of eye contact (irritant, corrosive), of ingestion,of inhalation. Liquid or spray mist may produce tissue damage particularly on mucous membranes of eyes, mouth andrespiratory tract. Skin contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratorytract, characterized by coughing, choking, or shortness of breath. Severe over-exposure can result in death. Inflammation ofthe eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,or, occasionally, blistering.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Classified 1 (Proven for human.) by IARC, + (Proven.) by OSHA. Classified A2 (Suspected forhuman.) by ACGIH. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTALTOXICITY: Not available. The substance may be toxic to kidneys, lungs, heart, cardiovascular system, upper respiratory tract,eyes, teeth. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged
contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spraymist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. Repeated exposure to a highlytoxic material may produce general deterioration of health by an accumulation in one or many human organs.
Section 4: First Aid Measures
Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention immediately.
Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly cleanshoes before reuse. Get medical attention immediately.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention immediately.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: Non-flammable.
Auto-Ignition Temperature: Not applicable.
Flash Points: Not applicable.
Flammable Limits: Not applicable.
Products of Combustion:Products of combustion are not available since material is non-flammable. However, products of decompostion include fumesof oxides of sulfur. Will react with water or steam to produce toxic and corrosive fumes. Reacts with carbonates to generatecarbon dioxide gas. Reacts with cyanides and sulfides to form poisonous hydrogen cyanide and hydrogen sulfide respectively.
Fire Hazards in Presence of Various Substances: Combustible materials
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available. Slightly explosive in presence of oxidizing materials.
Fire Fighting Media and Instructions: Not applicable.
Special Remarks on Fire Hazards:Metal acetylides (Monocesium and Monorubidium), and carbides ignite with concentrated sulfuric acid. White Phosphorous +boiling Sulfuric acid or its vapor ignites on contact. May ignite other combustible materials. May cause fire when sulfuric acidis mixed with Cyclopentadiene, cyclopentanone oxime, nitroaryl amines, hexalithium disilicide, phorphorous (III) oxide, andoxidizing agents such as chlorates, halogens, permanganates.
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Special Remarks on Explosion Hazards:M i x t u r e s o f s u l f u r i c a c i d a n d a n y o f t h e f o l l o w i n g c a n e x p l o d e : p - n i t r o t o l u e n e , p e n t a s il v e r trihydroxydiaminophosphate, perchlorates, alcohols with strong hydrogen peroxide, ammonium tetraperoxychromate,mercuric nitrite, potassium chlorate, potassium permanganate with potassium chloride, carbides, nitro compounds, nitrates,carbides, phosphorous, iodides, picratres, fulminats, dienes, alcohols (when heated) Nitramide decomposes explosivelyon contact with concentrated sulfuric acid. 1,3,5-Trinitrosohexahydro-1,3,5-triazine + sulfuric acid causes explosivedecompositon.
Section 6: Accidental Release Measures
Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Ifnecessary: Neutralize the residue with a dilute solution of sodium carbonate.
Large Spill:Corrosive liquid. Poisonous liquid. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material.Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Use water sprayto reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal.Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at a concentrationlevel above TLV. Check TLV on the MSDS and with local authorities.
Section 7: Handling and Storage
Precautions:Keep locked up.. Keep container dry. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product.In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and showthe container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducingagents, combustible materials, organic materials, metals, acids, alkalis, moisture. May corrode metallic surfaces. Store in ametallic or coated fiberboard drum using a strong polyethylene inner package.
Storage:Hygroscopic. Reacts. violently with water. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do notstore above 23°C (73.4°F).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits:TWA: 1 STEL: 3 (mg/m3) [Australia] Inhalation TWA: 1 (mg/m3) from OSHA (PEL) [United States] Inhalation TWA: 1 STEL: 3(mg/m3) from ACGIH (TLV) [United States] [1999] Inhalation TWA: 1 (mg/m3) from NIOSH [United States] Inhalation TWA: 1(mg/m3) [United Kingdom (UK)]Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
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Physical state and appearance: Liquid. (Thick oily liquid.)
Odor: Odorless, but has a choking odor when hot.
Taste: Marked acid taste. (Strong.)
Molecular Weight: 98.08 g/mole
Color: Colorless.
pH (1% soln/water): Acidic.
Boiling Point:270°C (518°F) - 340 deg. C Decomposes at 340 deg. C
Melting Point: -35°C (-31°F) to 10.36 deg. C (93% to 100% purity)
Critical Temperature: Not available.
Specific Gravity: 1.84 (Water = 1)
Vapor Pressure: Not available.
Vapor Density: 3.4 (Air = 1)
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility:Easily soluble in cold water. Sulfuric is soluble in water with liberation of much heat. Soluble in ethyl alcohol.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability:Conditions to Avoid: Incompatible materials, excess heat, combustible material materials, organic materials, exposure to moistair or water, oxidizers, amines, bases. Always add the acid to water, never the reverse.
Incompatibility with various substances:Reactive with oxidizing agents, reducing agents, combustible materials, organic materials, metals, acids, alkalis, moisture.
Corrosivity:Extremely corrosive in presence of aluminum, of copper, of stainless steel(316). Highly corrosive in presence of stainlesssteel(304). Non-corrosive in presence of glass.
Special Remarks on Reactivity:Hygroscopic. Strong oxidizer. Reacts violently with water and alcohol especially when water is added to the product.Incompatible (can react explosively or dangerously) with the following: ACETIC ACID, ACRYLIC ACID, AMMONIUMHYDROXIDE, CRESOL, CUMENE, DICHLOROETHYL ETHER, ETHYLENE CYANOHYDRIN, ETHYLENEIMINE, NITRICACID, 2-NITROPROPANE, PROPYLENE OXIDE, SULFOLANE, VINYLIDENE CHLORIDE, DIETHYLENE GLYCOLMONOMETHYL ETHER, ETHYL ACETATE, ETHYLENE CYANOHYDRIN, ETHYLENE GLYCOL MONOETHYL ETHERACETATE, GLYOXAL, METHYL ETHYL KETONE, dehydrating agents, organic materials, moisture (water), Acetic anhydride,Acetone, cyanohydrin, Acetone+nitric acid, Acetone + potassium dichromate, Acetonitrile, Acrolein, Acrylonitrile, Acrylonitrile+water, Alcohols + hydrogen peroxide, ally compounds such as Allyl alcohol, and Allyl Chloride, 2-Aminoethanol, Ammoniumhydroxide, Ammonium triperchromate, Aniline, Bromate + metals, Bromine pentafluoride, n-Butyraldehyde, Carbides, Cesiumacetylene carbide, Chlorates, Cyclopentanone oxime, chlorinates, Chlorates + metals, Chlorine trifluoride, Chlorosulfonicacid, 2-cyano-4-nitrobenzenediazonium hydrogen sulfate, Cuprous nitride, p-chloronitrobenzene, 1,5-Dinitronaphthlene +
Special Remarks on Corrosivity:Non-corrosive to lead and mild steel, but dillute acid attacks most metals. Attacks many metals releasing hydrogen. Minorcorrosive effect on bronze. No corrosion data on brass or zinc.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 2140 mg/kg [Rat.]. Acute toxicity of the vapor (LC50): 320 mg/m3 2 hours [Mouse].
Chronic Effects on Humans:CARCINOGENIC EFFECTS: Classified 1 (Proven for human.) by IARC, + (Proven.) by OSHA. Classified A2 (Suspectedfor human.) by ACGIH. May cause damage to the following organs: kidneys, lungs, heart, cardiovascular system, upperrespiratory tract, eyes, teeth.
Other Toxic Effects on Humans:Extremely hazardous in case of inhalation (lung corrosive). Very hazardous in case of skin contact (corrosive, irritant,permeator), of eye contact (corrosive), of ingestion, .
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans:Mutagenicity: Cytogenetic Analysis: Hamster, ovary = 4mmol/L Reproductive effects: May cause adverse reproductive effectsbased on animal data. Developmental abnormalities (musculoskeletal) in rabbits at a dose of 20 mg/m3 for 7 hrs.(RTECS)Teratogenecity: neither embryotoxic, fetoxic, nor teratogenetic in mice or rabbits at inhaled doses producing some maternaltoxicity
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes severe skin irritation and burns. Continued contact can cause tissue necrosis.Eye: Causes severe eye irritation and burns. May cause irreversible eye injury. Ingestion: Harmful if swallowed. May causepermanent damage to the digestive tract. Causes gastrointestial tract burns. May cause perforation of the stomach, GIbleeding, edema of the glottis, necrosis and scarring, and sudden circulatory collapse(similar to acute inhalation). It mayalso cause systemic toxicity with acidosis. Inhalation: May cause severe irritation of the respiratory tract and mucousmembranes with sore throat, coughing, shortness of breath, and delayed lung edema. Causes chemical burns to the repiratorytract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis,and pulmonary edema. Cause corrosive action on mucous membranes. May affect cardiovascular system (hypotension,depressed cardiac output, bradycardia). Circulatory collapse with clammy skin, weak and rapid pulse, shallow respiration, andscanty urine may follow. Circulatory shock is often the immediate cause of death. May also affect teeth(changes in teeth andsupporting structures - erosion, discoloration). Chronic Potential Health Effects: Inhalation: Prolonged or repeated inhalationmay affect behavior (muscle contraction or spasticity), urinary system (kidney damage), and cardiovascular system, heart(ischemic heart leisons), and respiratory system/lungs(pulmonary edema, lung damage), teeth (dental discoloration, erosion).Skin: Prolonged or repeated skin contact may cause dermatitis, an allergic skin reaction.
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Section 12: Ecological Information
Ecotoxicity: Ecotoxicity in water (LC50): 49 mg/l 48 hours [bluegill/sunfish].
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Sulfuric acid may be placed in sealed container or absorbed in vermiculite, dry sand, earth, or a similar material. It may alsobe diluted and neutralized. Be sure to consult with local or regional authorities (waste regulators) prior to any disposal. Wastemust be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: Class 8: Corrosive material
Identification: : Sulfuric acid UNNA: 1830 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Illinois toxic substances disclosure to employee act: Sulfuric acid New York release reporting list: Sulfuric acid RhodeIsland RTK hazardous substances: Sulfuric acid Pennsylvania RTK: Sulfuric acid Minnesota: Sulfuric acid MassachusettsRTK: Sulfuric acid New Jersey: Sulfuric acid California Director's List of Hazardous Substances (8 CCR 339): Sulfuric acidTennessee RTK: Sulfuric acid TSCA 8(b) inventory: Sulfuric acid SARA 302/304/311/312 extremely hazardous substances:Sulfuric acid SARA 313 toxic chemical notification and release reporting: Sulfuric acid CERCLA: Hazardous substances.:Sulfuric acid: 1000 lbs. (453.6 kg)
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). CLASS E: Corrosive liquid.
DSCL (EEC):R35- Causes severe burns. S2- Keep out of the reach of children. S26- In case of contact with eyes, rinse immediately withplenty of water and seek medical advice. S30- Never add water to this product. S45- In case of accident or if you feel unwell,seek medical advice immediately (show the label where possible).
HMIS (U.S.A.):
Health Hazard: 3
Fire Hazard: 0
Reactivity: 2
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Personal Protection:
National Fire Protection Association (U.S.A.):
Health: 3
Flammability: 0
Reactivity: 2
Specific hazard:
Protective Equipment:Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Face shield.
Section 16: Other Information
References:-Material safety data sheet emitted by: la Commission de la Santé et de la Sécurité du Travail du Québec. -The Sigma-AldrichLibrary of Chemical Safety Data, Edition II. -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., VanNostrand Reinold, 1987.
Other Special Considerations: Not available.
Created: 10/09/2005 11:58 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Material Safety Data SheetToluene MSDS
Section 1: Chemical Product and Company Identification
Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator).
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Notavailable. The substance may be toxic to blood, kidneys, the nervous system, liver, brain, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.
Eye Contact:Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek medical attention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:Flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.
Fire Fighting Media and Instructions:Flammable liquid, insoluble in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray or fog.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards:Toluene forms explosive reaction with 1,3-dichloro-5,5-dimethyl-2,4-imidazolididione; dinitrogen tetraoxide; concentrated nitricacid, sulfuric acid + nitric acid; N2O4; AgClO4; BrF3; Uranium hexafluoride; sulfur dichloride. Also forms an explosive mixturewith tetranitromethane.
Section 6: Accidental Release Measures
Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.
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Large Spill:Toxic flammable liquid, insoluble or very slightly soluble in water. Keep away from heat. Keep away from sources of ignition.Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container.Do not touch spilled material. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance ondisposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with localauthorities.
Section 7: Handling and Storage
Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin andeyes. Keep away from incompatibles such as oxidizing agents.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits:TWA: 200 STEL: 500 CEIL: 300 (ppm) from OSHA (PEL) [United States] TWA: 50 (ppm) from ACGIH (TLV) [United States]SKIN TWA: 100 STEL: 150 from NIOSH [United States] TWA: 375 STEL: 560 (mg/m3) from NIOSH [United States] Consultlocal authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Sweet, pungent, Benzene-like.
Taste: Not available.
Molecular Weight: 92.14 g/mole
Color: Colorless.
pH (1% soln/water): Not applicable.
Boiling Point: 110.6°C (231.1°F)
Melting Point: -95°C (-139°F)
Critical Temperature: 318.6°C (605.5°F)
Specific Gravity: 0.8636 (Water = 1)
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Vapor Pressure: 3.8 kPa (@ 25°C)
Vapor Density: 3.1 (Air = 1)
Volatility: Not available.
Odor Threshold: 1.6 ppm
Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 2.7
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, diethyl ether, acetone.
Solubility:Soluble in diethyl ether, acetone. Practically insoluble in cold water. Soluble in ethanol, benzene, chloroform, glacial aceticacid, carbon disulfide. Solubility in water: 0.561 g/l @ 25 deg. C.
Incompatibility with various substances: Reactive with oxidizing agents.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:Incompatible with strong oxidizers, silver perchlorate, sodium difluoride, Tetranitromethane, Uranium Hexafluoride. FrozenBromine Trifluoride reacts violently with Toluene at -80 deg. C. Reacts chemically with nitrogen oxides, or halogens to formnitrotoluene, nitrobenzene, and nitrophenol and halogenated products, respectively.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 636 mg/kg [Rat]. Acute dermal toxicity (LD50): 14100 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50): 44024 hours [Mouse].
Chronic Effects on Humans:CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH, 3 (Not classifiable for human.) by IARC.May cause damage to the following organs: blood, kidneys, the nervous system, liver, brain, central nervous system (CNS).
Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).
Special Remarks on Toxicity to Animals:Lowest Published Lethal Dose: LDL [Human] - Route: Oral; Dose: 50 mg/kg LCL [Rabbit] - Route: Inhalation; Dose: 55000ppm/40min
Special Remarks on Chronic Effects on Humans:Detected in maternal milk in human. Passes through the placental barrier in human. Embryotoxic and/or foetotoxic in animal.May cause adverse reproductive effects and birth defects (teratogenic). May affect genetic material (mutagenic)
Special Remarks on other Toxic Effects on Humans:
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Acute Potential Health Effects: Skin: Causes mild to moderate skin irritation. It can be absorbed to some extent throughthe skin. Eyes: Cauess mild to moderate eye irritation with a burning sensation. Splash contact with eyes also causesconjunctivitis, blepharospasm, corneal edema, corneal abraisons. This usually resolves in 2 days. Inhalation: Inhalationof vapor may cause respiratory tract irritation causing coughing and wheezing, and nasal discharge. Inhalation of highconcentrations may affect behavior and cause central nervous system effects characterized by nausea, headache, dizziness,tremors, restlessness, lightheadedness, exhilaration, memory loss, insomnia, impaired reaction time, drowsiness, ataxia,hallucinations, somnolence, muscle contraction or spasticity, unconsciousness and coma. Inhalation of high concentration ofvapor may also affect the cardiovascular system (rapid heart beat, heart palpitations, increased or decreased blood pressure,dysrhythmia, ), respiration (acute pulmonary edema, respiratory depression, apnea, asphyxia), cause vision disturbancesand dilated pupils, and cause loss of appetite. Ingestion: Aspiration hazard. Aspiration of Toluene into the lungs may causechemical pneumonitis. May cause irritation of the digestive tract with nausea, vomiting, pain. May have effects similar to thatof acute inhalation. Chronic Potential Health Effects: Inhalation and Ingestion: Prolonged or repeated exposure via inhalationmay cause central nervous system and cardiovascular symptoms similar to that of acute inhalation and ingestion as well liverdamage/failure, kidney damage/failure (with hematuria, proteinuria, oliguria, renal tubular acidosis), brain damage, weightloss, blood (pigmented or nucleated red blood cells, changes in white blood cell count), bone marrow changes, electrolyteimbalances (Hypokalemia, Hypophostatemia), severe, muscle weakness and Rhabdomyolysis. Skin: Repeated or prolongedskin contact may cause defatting dermatitis.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Toluene UNNA: 1294 PG: II
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,birth defects or other reproductive harm, which would require a warning under the statute: Toluene California prop. 65 (nosignificant risk level): Toluene: 7 mg/day (value) California prop. 65 (acceptable daily intake level): Toluene: 7 mg/day (value)California prop. 65: This product contains the following ingredients for which the State of California has found to cause birthdefects which would require a warning under the statute: Toluene Connecticut hazardous material survey.: Toluene Illinois
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toxic substances disclosure to employee act: Toluene Illinois chemical safety act: Toluene New York release reporting list:Toluene Rhode Island RTK hazardous substances: Toluene Pennsylvania RTK: Toluene Florida: Toluene Minnesota: TolueneMichigan critical material: Toluene Massachusetts RTK: Toluene Massachusetts spill list: Toluene New Jersey: Toluene NewJersey spill list: Toluene Louisiana spill reporting: Toluene California Director's List of Hazardous Substances.: Toluene TSCA8(b) inventory: Toluene TSCA 8(d) H and S data reporting: Toluene: Effective date: 10/04/82; Sunset Date: 10/0/92 SARA 313toxic chemical notification and release reporting: Toluene CERCLA: Hazardous substances.: Toluene: 1000 lbs. (453.6 kg)
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects(VERY TOXIC).
DSCL (EEC):R11- Highly flammable. R20- Harmful by inhalation. S16- Keep away from sources of ignition - No smoking. S25- Avoidcontact with eyes. S29- Do not empty into drains. S33- Take precautionary measures against static discharges.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 08:30 PM
Last Updated: 11/06/2008 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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3 2 0
He a lt h
Fire
Re a c t iv it y
Pe rs o n a lPro t e c t io n
2
3
0
H
Material Safety Data SheetXylenes MSDS
Section 1: Chemical Product and Company Identification
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients
Composition:
Name CAS # % by Weight
Xylenes 1330-20-7 100
Toxicological Data on Ingredients: Xylenes: ORAL (LD50): Acute: 4300 mg/kg [Rat]. 2119 mg/kg [Mouse]. DERMAL(LD50): Acute: >1700 mg/kg [Rabbit].
Section 3: Hazards Identification
Potential Acute Health Effects: Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion,of inhalation.
Potential Chronic Health Effects:CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Not available. TERATOGENICEFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to blood, kidneys, liver,mucous membranes, bone marrow, central nervous system (CNS). Repeated or prolonged exposure to the substance canproduce target organs damage.
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention.
Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.
Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention if symptoms appear.
Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medicalattention.
Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of openflames and sparks, of heat.
Fire Fighting Media and Instructions:Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion.
Special Remarks on Fire Hazards: Vapors may travel to source of ignition and flash back.
Special Remarks on Explosion Hazards:Vapors may form explosive mixtures with air. Containers may explode when heated. May polymerize explosively when heated.An attempt to chlorinate xylene with 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidindione (dichlorohydrantoin) caused a violentexplosion
Section 6: Accidental Release Measures
Small Spill: Absorb with an inert material and put the spilled material in an appropriate waste disposal.
Large Spill:Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined
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areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDSand with local authorities.
Section 7: Handling and Storage
Precautions:Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do notbreathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratoryequipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin andeyes. Keep away from incompatibles such as oxidizing agents, acids.
Storage:Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed andsealed until ready for use. Avoid all possible sources of ignition (spark or flame).
Section 8: Exposure Controls/Personal Protection
Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Personal Protection:Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.
Exposure Limits:TWA: 100 (ppm) [Canada] TWA: 435 (mg/m3) [Canada] TWA: 434 STEL: 651 (mg/m3) from ACGIH (TLV) [United States]TWA: 100 STEL: 150 (ppm) from ACGIH (TLV) [United States] Consult local authorities for acceptable exposure limits.
Section 9: Physical and Chemical Properties
Physical state and appearance: Liquid.
Odor: Sweetish.
Taste: Not available.
Molecular Weight: 106.17 g/mole
Color: Colorless. Clear
pH (1% soln/water): Not available.
Boiling Point: 138.5°C (281.3°F)
Melting Point: -47.4°C (-53.3°F)
Critical Temperature: Not available.
Specific Gravity: 0.864 (Water = 1)
Vapor Pressure: 0.9 kPa (@ 20°C)
Vapor Density: 3.7 (Air = 1)
Volatility: Not available.
Odor Threshold: 1 ppm
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Water/Oil Dist. Coeff.: The product is more soluble in oil; log(oil/water) = 3.1
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility:Insoluble in cold water, hot water. Miscible with absolute alcohol, ether, and many other organic liquids.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Heat, ignition sources, incompatibles
Incompatibility with various substances: Reactive with oxidizing agents, acids.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Store away from acetic acid, nitric acid, chlorine, bromine, and fluorine.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.
Toxicity to Animals:WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oraltoxicity (LD50): 2119 mg/kg [Mouse]. Acute dermal toxicity (LD50): >1700 mg/kg [Rabbit]. Acute toxicity of the vapor (LC50):5000 4 hours [Rat].
Chronic Effects on Humans:CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. May cause damage to the following organs: blood,kidneys, liver, mucous membranes, bone marrow, central nervous system (CNS).
Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals:Lowest Lethal Dose: LDL [Human] - Route: Oral; Dose: 50 mg/kg LCL [Man] - Route: Oral; Dose: 10000 ppm/6H
Special Remarks on Chronic Effects on Humans:Detected in maternal milk in human. Passes through the placental barrier in animal. Embryotoxic and/or foetotoxic in animal.May cause adverse reproductive effects (male and femael fertility (spontaneous abortion and fetotoxicity)) and birth defectsbased animal data.
Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation. Can be absorbed through skin. Eyes: Causes eye irritation.Inhalation: Vapor causes respiratory tract and mucous membrane irritation. May affect central nervous system and behavior(General anesthetic/CNS depressant with effects including headache, weakness, memory loss, irritability, dizziness, giddiness,loss of coordination and judgement, respiratory depression/arrest or difficulty breathing, loss of appetite, nausea, vomiting,shivering, and possible coma and death). May also affects blood, sense organs, liver, and peripheral nerves. Ingestion: Maycause gastrointestinal irritation including abdominal pain, vomiting, and nausea. May also affect liver and urinary system/kidneys. May cause effects similar to those of acute inhalation. Chronic Potential Health Effects: Chronic inhalation may affectthe urinary system (kidneys) blood (anemia), bone marrow (hyperplasia of bone marrow) brain/behavior/Central Nervoussystem. Chronic inhalation may alsocause mucosal bleeding. Chronic ingestion may affect the liver and metabolism (loss ofappetite) and may affect urinary system (kidney damage)
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Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: CLASS 3: Flammable liquid.
Identification: : Xylenes UNNA: 1307 PG: III
Special Provisions for Transport: Not available.
Section 15: Other Regulatory Information
Federal and State Regulations:Connecticut hazardous material survey.: Xylenes Illinois chemical safety act: Xylenes New York acutely hazardoussubstances: Xylenes Rhode Island RTK hazardous substances: Xylenes Pennsylvania RTK: Xylenes Minnesota: XylenesMichigan critical material: Xylenes Massachusetts RTK: Xylenes Massachusetts spill list: Xylenes New Jersey: Xylenes NewJersey spill list: Xylenes Louisiana spill reporting: Xylenes California Director's List of Hazardous Substances: Xylenes TSCA8(b) inventory: Xylenes SARA 302/304/311/312 hazardous chemicals: Xylenes SARA 313 toxic chemical notification andrelease reporting: Xylenes CERCLA: Hazardous substances.: Xylenes: 100 lbs. (45.36 kg)
Other Regulations:OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on theEuropean Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects(VERY TOXIC).
DSCL (EEC):R10- Flammable. R21- Harmful in contact with skin. R36/38- Irritating to eyes and skin. S2- Keep out of the reach of children.S36/37- Wear suitable protective clothing and gloves. S46- If swallowed, seek medical advice immediately and show thiscontainer or label.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: h
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National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 3
Reactivity: 0
Specific hazard:
Protective Equipment:Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/11/2005 12:54 PM
Last Updated: 05/21/2013 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.
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Annexure-V
Certified Compliance report of existing EC by
RO, MoEF&CC
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Annexure-VI
NABET/QCI Certificate
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Annexure-VII
Copy of Environmental Clearance
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Annexure-VIII
Photographs of existing site, proposed expansion area &
Plantation/Greenbelt
Photographs of Existing plant
Main gate of the company
Overview of the plant
Overview of the plant
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Tank farm Existing ETP
Solvent recovery system Utility area with stack of D G Set
-- STANDARD OPEIWTING PROCEDURE SOP No. 1 HR/SOP/002 I Effective Date / 15.04.201 6 I Page I of 1
Identi,fication Marlts: ~ o i s e : QW& hi%.
Revision No. Title
I I I
05 I ReviewDate 14.04.2019 I Copy No. I EMPLOYEE MEDICAL CEIECICUP
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PERSONAL HABIT: ,(Tick d whichever is applicable)
Education: (Tick d whichever is applicable) I
MEDICAL EXAMINATION FORM Format No : HR / F / 007 Date:-01, 10% /do 1 t
Under Graduate
GENEIRAE EXAMINATION:
Diet :
Tobacco:
( Particulars 1 Remarks 1 Particulars I Remarks I Particulars
Name of Employee
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FBMI[LY MEDICAL HISTORY :- (write N.A. if not applicable)
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and foynd l l i~~ lhe r (tick the box) FITfor duty U FIT . r duty . <: Pencling
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A-202
Dr. Palak Shah Diagnostic centre Computerised Pathology Laboratory
Dr. Palak Shah .." ---.-------------- ------- ----- -- M.D. (Pathology), D.C.P.
S' Complex, First Floor, Near H.D.F.C Bank, Opp S.T. Workshop, . University First - Lunawada - 389 230. Ph.: (02674) 250958, M.: 98256 38041,98256 70841 Reg. NO. : G-14783 . - -- - . -
Patient Name : Nikunj Patel Reffered by : Concord Biotech Ltd.
Ref. No : 6734 Address : Lunawada
Date . : 30/06/2016
Parameter
Haemogram Report
Result - Unit Normal Ranae
Haemoglobin G% : 13.4 gm"/o New Born : 15.0 - 24.0 I ABOVE 10 YRS : 1 -2 YRS : 10.5 - 14.0 1 (M) : 13.0 - 18.0
Erythrocyte Sedimentation Rate (E.S.R.) (Westergren method) After one hour : 08 mm M[Q2-09 ]mmF[04-11 ]mm
Blood Group & Rh Type Blood Group : "0 Rh (D) Factor : Positive
Peripheral Smear R. B. C. : Macrocytic , Normochromic W. 8. C : No Premature or abnormal WBC seen. Platelate : Adequet & Normal Parasites : M.P. Not Detected #
Total Platelet count : 2,06,000 1c.rnm 1,50,000 - 4,50,000 3 .mm For, m. PaGz&9iah Dugmstic Centre 72Lwl&b gyZ4%.%..... .............................................................................................................
The Above Results Are Subject To Variations Due To Technical Limitations Hence Co-relations With Clinical Findings And Other Investigations Should Be Done.
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Dr. Palak Shah Diagnostic centre ~ o m ~ u t e r i s 2 Pathology Laboratory .--------------------- -----------..----.
S' Complex, First Floor, Near M.D.F.C Bank, Opp S.T. Workshop, Lunawada . . - - 389 - . 230. -- Ph.: (02674) 250958, M.: 98256 38041,98256 70841 -
DV. Palak Shah M.D. (Pathology), D.C.P.
University First Reg. No. : G-14783
Patient Name : Nikunj Patel Reffered by : Concord Biotech Ltd.
Ref. No : 6734 Address : Lunawada
Date : 30/06/2016
Test - Random Blood Sugar
Random Urine Sugar
Random Urine Acetone
Blood Glucose Estimation
GOD - PAP METHOD
Result
:85mg%
: Nil
: Absent
Normal Ranne
60 - 140 mg %
Remarks : Values -$ R checked
(N.A = Not Available)
Test - Blood Urea Method : Fix Time Kinetic
Result - : 29
Renal Function Tests
Units - ~orrilal Value
nlgldl 15 to 40 mgldl
F q Fa,ah. &G&~fuzh Diagftostic centre 72Lww4&fi ? $ j L 4 e . . .............................................................................................................. The Above Results Are Subject To Variations Due To Technical Limitations Hence Co-,relations With Clinical Findings And Other Investigations Should Be Done.
A-204
Dr. Palak Shah Diagnostic centre Computerised Pathology Laboratory
Dr. Pulak huh M.D. (Pathology), D.C.P.
S' ~oi~ i~?;~ i~Floor ,Nei~N.D.F.C~Ba~~O~~S.T. works hop, University First - Lunawada - 389 230. P h.: (02674) 250958, M.: 98256 38041,98256 70841 Reg. No. : G-14783 - - . - -- - -
Patient Name : Nikunj Patel ~effered by : Concord Biotech Ltd.
Ref. No : 6734 Address :Lunawada
AgeISex : 22 YearslMale
Date : 30/0612016
U RI NANALYSIS
Specimen: Random Phvsical Examination
Volume : 25ml Color : Yellow Transparency : Clear Deposits : Absent Reaction : Acidic Specific Gravity --
DiqnoStic Centre R-.k.b ciya%.w. .. ..................................... _. ...................................................................... The Above Results Are Subject To Variations Due To Technical Limitations Hence Co-relations With Clinical Findings And Other Investigations Should Be Done.
STANDARD OPERATING PROCEDURE SOP No. ( HRlSOP/002 ( Effective Date 1 15.04.2016 I Page 1 of 1
' MEDICAL EiAMlNATION FO& I
Format No : HR / F / 007 Date:- ih / 07 / 2 s l g
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Revision No. Title
- I I I
05 I Review Date 1 14.04.201 9 I Copy No. 1 EMPLOYEE MEDICAL CEIECKUP
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.Name of Employee
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GENERAL EXAMINATION:
w/ Non Veg. I Mixed
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. MBHOTRl MEDlCll liB@RIT@IlE$ PVT, SCO - 2425-26, First Floor, Sector 224, Chandigarh I Above Sony Showroom, Near Aroma Hotel
DIAGNOSTIC AND CANCER SCREENING CUM RESEARCH CENTRE Phone : 2700860,2721860,4644860 Fax : 0172-2703905
ernail : malhotra labs22~ahoo.com A Fully Automated Medical Diagnostic Laboratory
Dr. Vijay Malhotra M. D. (Pathology)
Patient's Name MR. ASHUTOSH UPADHYAY Reg. Date 07/07/2016 16:49:35 Patient ID 101616906 Sample Received 0710712016 1651 :34 F/H Name Reported On 07/07/2016 18:01:18 AgeISex 29 Yrs Male Printed On 07/07/2016 18:01:26 Address Panel Comp. --------------------
Ref by Doctor ------------------- Specimen :- BLOOD EDTA Ref.CentrelLab CITY HEALTH CARE DERABA,
lnvestigatioq - Value - Unit
M?J&%TOLOGY
TOTAL LEUKOCYTE COUNT 6800 " /cmm Tech - IMPEDANCE
BLOOD GROUP ABO Tech - MONOCi.ONAL AGGLIlNATING ANllCERA
"B" POSITIVE
** End of Report **
WISHING YOU GOOD HEALTH
Page No: I of I
1
Reviewed By: DR V U ~ Y M A L H O T ~ (MD Path) Director, Pathology S e r v i c e s .
Timings: 7.30A.M. to 8:OO P.M., Sunday 7.30 to 2.30 P.M. ! e $conditions of Reporting
%his report represents only an opinion. As such it is not valid for medico-lagal purposes. If clinical findings of the patient do not correlate with the opinion1 %indings givenlinferred in the report then the patientl referring doctor may please contact the lab immediately for re-confirmation by repeating the investigation.
The blood and other samples received from outside will be presumed to be of patients named on the samples. The blood samples and fluids for cytology are discarded after conducting the required tests unless otherwise informed earlier by the patients, referring doctor or hospital. The histopathological samples will be preserved for one month only whereas wax blocks and glass slides will be discarded after six months. A-207
MLLHOTRL MEDIGIIL LLBORITORIES PVT. LTU. SCO - 2425-26, First Floor, Sector 224, Chandigarh Above Sony Showroom, Near Aroma Hotel
DIAGNOSTIC AND CANCER SCREENING CUM RESEARCH CENTRE
A Fully Automated Medical Diagnostic Laboratory Dr. Vijay Malhotra M.D. (Pathdogy)
Patient's Name MR. ASHUTOSH UPADHYAY Patient ID 101616906 FIH Name Age/Sex 29 Yrs Male Address
Reg. Date 07/07/20 16 16:49:35 Sample Received 07/07/2016 1651 :34
Reported On 07/07/20 16 17: 19: 17 Printed On 07/07/2016 17:19:22 Panel Comp. ------------------ Refby Doctor ---------- ----------
Specimen :- URJNE Ref.Centre/Lab CITY HEALTH CARE DERABA:
Investigation
URINE R/E
PHYSICALICHEMICAL Appearance Colour Reaction Specific Gravity Albumin Glucose Bile Salts Bile Pigments Urobilinogen
CLEAR PALE YELLOW ACIDIC -- NIL NIL
Value - Unit Biolo~ical Ref Interval
Page No: 1 of 1
s
Pus cells RBC's Crystals Epithelial cells Casts Bacteria Any Other Remarks
00 - OlmF NIL NIL NIL NIL NIL
* * End of Report **
WISHING YOU GOOD HEALTH
Review . &: DR W A Y MALHO* (MD Path) DirectorfPathology Services.
Timinas: 7.30 A.M. t o 8:00 P.M.. Sundav 7.30 t o 2.30 P.M.
2 Fondltlons of Reporting
$his report represents only an opinion. As such it is not valid for medico-lagal purposes. If clinical findings of the patient do not correlate with the opinion1 findings givenlinferred in the report then the patient/ referring doctor may please contact the lab immediately for re-confirmation by repeating the Investigation. The blood and other samples received from outside will be pres'umed to be of patients named on the samples. The blood samples and fluids for cytology are discarded after conducting the required tests unless otherwise informed earlier by the patients, referring doctor or hospital. The histopathological samples will be preserved for one month only whereas wax blocks and glass slides will be discarded after six months.
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MILHOTRI MEDICIL lABORlTORlE$ PVT. LTR SCO - 2425-26, First Floor, Sector 224, Chandigarh Above Sonv Showroom. Near Aroma Hotel
DIAGNOSTIC AND CANCER SCREENING CUM RESEARCH CENTRE ,
DR VIJAY MALHOTL (MD Path) Director, Pathology Services.
2 Timings: 7.30A.M. to 8:00 P.M., Sunday 7.30 t o 2.30 P.M. L
gnditions of Reporting
%is report represents only an opinion. As such it is not valid for medico-lagal purposes. If clinical findings of the patient do not correlate with the opinion1 %dings givenlinferred in the report then the patient1 referring dbctor may please contact the lab immediately for re-confirmation by repeating the investigation. The blood and other samples received from outside will be presumed to be of patients named on the samples. The blood samples and fluids for cytology are discarded after conducting the required tests unless otherwise informed earlier by the patients, referridg doctor >r hospital. The histopathological samples will be preserved for one month only whereas wax blocks and alass slides wlll be discarded after cir mnn+h-
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Annexure-XI EHS policy
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Annexure-XII Copy of Terms of Reference (TOR)
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Annexure-I
GENERIC TERMS OF REFERENCE (TOR) IN RESPECT OF INDUSTRY SECTOR 1. Executive Summary 2. Introduction
i. Details of the EIA Consultant including NABET accreditation ii. Information about the project proponent iii. Importance and benefits of the project
3. Project Description i. Cost of project and time of completion. ii. Products with capacities for the proposed project. iii. If expansion project, details of existing products with capacities and whether
adequate land is available for expansion, reference of earlier EC if any. iv. List of raw materials required and their source along with mode of
transportation. v. Other chemicals and materials required with quantities and storage capacities vi. Details of Emission, effluents, hazardous waste generation and their
management. vii. Requirement of water, power, with source of supply, status of approval, water
balance diagram, man-power requirement (regular and contract) viii. Process description along with major equipments and machineries, process
flow sheet (quantities) from raw material to products to be provided ix. Hazard identification and details of proposed safety systems. x. Expansion/modernization proposals:
a. Copy of all the Environmental Clearance(s) including Amendments thereto obtained for the project from MOEF/SEIAA shall be attached as an Annexure. A certified copy of the latest Monitoring Report of the Regional Office of the Ministry of Environment and Forests as per circular dated 30th May, 2012 on the status of compliance of conditions stipulated in all the existing environmental clearances including Amendments shall be provided. In addition, status of compliance of Consent to Operate for the ongoing Iexisting operation of the project from SPCB shall be attached with the EIA-EMP report.
b. In case the existing project has not obtained environmental clearance, reasons for not taking EC under the provisions of the EIA Notification 1994 and/or EIA Notification 2006 shall be provided. Copies of Consent to Establish/No Objection Certificate and Consent to Operate (in case of units operating prior to EIA Notification 2006, CTE and CTO of FY 2005-2006) obtained from the SPCB shall be submitted. Further, compliance report to the conditions of consents from the SPCB shall be submitted.
4. Site Details
i. Location of the project site covering village, Taluka/Tehsil, District and State, Justification for selecting the site, whether other sites were considered.
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ii. A toposheet of the study area of radius of 10km and site location on 1:50,000/1:25,000 scale on an A3/A2 sheet. (including all eco-sensitive areas and environmentally sensitive places)
iii. Details w.r.t. option analysis for selection of site iv. Co-ordinates (lat-long) of all four corners of the site. v. Google map-Earth downloaded of the project site.
vi. Layout maps indicating existing unit as well as proposed unit indicating storage area, plant area, greenbelt area, utilities etc. If located within an Industrial area/Estate/Complex, layout of Industrial Area indicating location of unit within the Industrial area/Estate.
vii. Photographs of the proposed and existing (if applicable) plant site. If existing, show photographs of plantation/greenbelt, in particular.
viii. Landuse break-up of total land of the project site (identified and acquired), government/private - agricultural, forest, wasteland, water bodies, settlements, etc shall be included. (not required for industrial area)
ix. A list of major industries with name and type within study area (10km radius) shall be incorporated. Land use details of the study area
x. Geological features and Geo-hydrological status of the study area shall be included.
xi. Details of Drainage of the project upto 5km radius of study area. If the site is within 1 km radius of any major river, peak and lean season river discharge as well as flood occurrence frequency based on peak rainfall data of the past 30 years. Details of Flood Level of the project site and maximum Flood Level of the river shall also be provided. (mega green field projects)
xii. Status of acquisition of land. If acquisition is not complete, stage of the acquisition process and expected time of complete possession of the land.
xiii. R&R details in respect of land in line with state Government policy
5. Forest and wildlife related issues (if applicable):
i. Permission and approval for the use of forest land (forestry clearance), if any, and recommendations of the State Forest Department. (if applicable)
ii. Landuse map based on High resolution satellite imagery (GPS) of the proposed site delineating the forestland (in case of projects involving forest land more than 40 ha)
iii. Status of Application submitted for obtaining the stage I forestry clearance along with latest status shall be submitted.
iv. The projects to be located within 10 km of the National Parks, Sanctuaries, Biosphere Reserves, Migratory Corridors of Wild Animals, the project proponent shall submit the map duly authenticated by Chief Wildlife Warden showing these features vis-à-vis the project location and the recommendations or comments of the Chief Wildlife Warden-thereon
v. Wildlife Conservation Plan duly authenticated by the Chief Wildlife Warden of the State Government for conservation of Schedule I fauna, if any exists in the study area
vi. Copy of application submitted for clearance under the Wildlife (Protection) Act, 1972, to the Standing Committee of the National Board for Wildlife
6. Environmental Status
i. Determination of atmospheric inversion level at the project site and site-specific micro-meteorological data using temperature, relative humidity, hourly wind speed and direction and rainfall.
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ii. AAQ data (except monsoon) at 8 locations for PM10, PM2.5, SO2, NOX, CO and other parameters relevant to the project shall be collected. The monitoring stations shall be based CPCB guidelines and take into account the pre-dominant wind direction, population zone and sensitive receptors including reserved forests.
iii. Raw data of all AAQ measurement for 12 weeks of all stations as per frequency given in the NAQQM Notification of Nov. 2009 along with – min., max., average and 98% values for each of the AAQ parameters from data of all AAQ stations should be provided as an annexure to the EIA Report.
iv. Surface water quality of nearby River (100m upstream and downstream of discharge point) and other surface drains at eight locations as per CPCB/MoEF&CC guidelines.
v. Whether the site falls near to polluted stretch of river identified by the CPCB/MoEF&CC, if yes give details.
vi. Ground water monitoring at minimum at 8 locations shall be included. vii. Noise levels monitoring at 8 locations within the study area. viii. Soil Characteristic as per CPCB guidelines. ix. Traffic study of the area, type of vehicles, frequency of vehicles for
transportation of materials, additional traffic due to proposed project, parking arrangement etc.
x. Detailed description of flora and fauna (terrestrial and aquatic) existing in the study area shall be given with special reference to rare, endemic and endangered species. If Schedule-I fauna are found within the study area, a Wildlife Conservation Plan shall be prepared and furnished.
xi. Socio-economic status of the study area.
7. Impact and Environment Management Plan
i. Assessment of ground level concentration of pollutants from the stack emission based on site-specific meteorological features. In case the project is located on a hilly terrain, the AQIP Modelling shall be done using inputs of the specific terrain characteristics for determining the potential impacts of the project on the AAQ. Cumulative impact of all sources of emissions (including transportation) on the AAQ of the area shall be assessed. Details of the model used and the input data used for modelling shall also be provided. The air quality contours shall be plotted on a location map showing the location of project site, habitation nearby, sensitive receptors, if any.
ii. Water Quality modelling – in case of discharge in water body iii. Impact of the transport of the raw materials and end products on the
surrounding environment shall be assessed and provided. In this regard, options for transport of raw materials and finished products and wastes (large quantities) by rail or rail-cum road transport or conveyor-cum-rail transport shall be examined.
iv. A note on treatment of wastewater from different plant operations, extent recycled and reused for different purposes shall be included. Complete scheme of effluent treatment. Characteristics of untreated and treated effluent to meet the prescribed standards of discharge under E(P) Rules.
v. Details of stack emission and action plan for control of emissions to meet standards.
vi. Measures for fugitive emission control vii. Details of hazardous waste generation and their storage, utilization and
management. Copies of MOU regarding utilization of solid and hazardous waste in cement plant shall also be included. EMP shall include the concept of waste-minimization, recycle/reuse/recover techniques, Energy conservation, and natural resource conservation.
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viii. Proper utilization of fly ash shall be ensured as per Fly Ash Notification, 2009. A detailed plan of action shall be provided.
ix. Action plan for the green belt development plan in 33 % area i.e. land with not less than 1,500 trees per ha. Giving details of species, width of plantation, planning schedule etc. shall be included. The green belt shall be around the project boundary and a scheme for greening of the roads used for the project shall also be incorporated.
x. Action plan for rainwater harvesting measures at plant site shall be submitted to harvest rainwater from the roof tops and storm water drains to recharge the ground water and also to use for the various activities at the project site to conserve fresh water and reduce the water requirement from other sources.
xi. Total capital cost and recurring cost/annum for environmental pollution control measures shall be included.
xii. Action plan for post-project environmental monitoring shall be submitted.
xiii. Onsite and Offsite Disaster (natural and Man-made) Preparedness and Emergency Management Plan including Risk Assessment and damage control. Disaster management plan should be linked with District Disaster Management Plan.
8. Occupational health
i. Plan and fund allocation to ensure the occupational health & safety of all contract and casual workers
ii. Details of exposure specific health status evaluation of worker. If the workers’ health is being evaluated by pre designed format, chest x rays, Audiometry, Spirometry, Vision testing (Far & Near vision, colour vision and any other ocular defect) ECG, during pre placement and periodical examinations give the details of the same. Details regarding last month analyzed data of above mentioned parameters as per age, sex, duration of exposure and department wise.
iii. Details of existing Occupational & Safety Hazards. What are the exposure levels of hazards and whether they are within Permissible Exposure level (PEL). If these are not within PEL, what measures the company has adopted to keep them within PEL so that health of the workers can be preserved,
iv. Annual report of heath status of workers with special reference to Occupational Health and Safety.
9. Corporate Environment Policy
i. Does the company have a well laid down Environment Policy approved by its Board of Directors? If so, it may be detailed in the EIA report.
ii. Does the Environment Policy prescribe for standard operating process / procedures to bring into focus any infringement / deviation / violation of the environmental or forest norms / conditions? If so, it may be detailed in the EIA.
iii. What is the hierarchical system or Administrative order of the company to deal with the environmental issues and for ensuring compliance with
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the environmental clearance conditions? Details of this system may be given.
iv. Does the company have system of reporting of non compliances / violations of environmental norms to the Board of Directors of the company and / or shareholders or stakeholders at large? This reporting mechanism shall be detailed in the EIA report
10. Details regarding infrastructure facilities such as sanitation, fuel, restroom etc. to be
provided to the labour force during construction as well as to the casual workers including truck drivers during operation phase.
11. Enterprise Social Commitment (ESC)
i. Adequate funds (at least 2.5 % of the project cost) shall be earmarked towards the Enterprise Social Commitment based on Public Hearing issues and item-wise details along with time bound action plan shall be included. Socio-economic development activities need to be elaborated upon.
12. Any litigation pending against the project and/or any direction/order passed by any Court of Law against the project, if so, details thereof shall also be included. Has the unit received any notice under the Section 5 of Environment (Protection) Act, 1986 or relevant Sections of Air and Water Acts? If so, details thereof and compliance/ATR to the notice(s) and present status of the case.
13. ‘A tabular chart with index for point wise compliance of above TORs.
14. The TORs prescribed shall be valid for a period of three years for submission of the EIA-EMP reports.
The following general points shall be noted:
i. All documents shall be properly indexed, page numbered. ii. Period/date of data collection shall be clearly indicated. iii. Authenticated English translation of all material in Regional languages shall be
provided. iv. The letter/application for environmental clearance shall quote the MOEF file
No. and also attach a copy of the letter. v. The copy of the letter received from the Ministry shall be also attached as an
annexure to the final EIA-EMP Report. vi. The index of the final EIA-EMP report must indicate the specific chapter and
page no. of the EIA-EMP Report vii. While preparing the EIA report, the instructions for the proponents and
instructions for the consultants issued by MOEF vide O.M. No. J-11013/41/2006-IA.II (I) dated 4th August, 2009, which are available on the website of this Ministry shall also be followed.
viii. The consultants involved in the preparation of EIA-EMP report after accreditation with Quality Council of India (QCl) /National Accreditation Board of Education and Training (NABET) would need to include a certificate in this regard in the EIA-EMP reports prepared by them and data provided by other organization/Laboratories including their status of approvals etc. Name of the Consultant and the Accreditation details shall be posted on the EIA-EMP Report as well as on the cover of the Hard Copy of the Presentation material for EC presentation.
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TORs’ prescribed by the Expert Appraisal Committee (Industry) shall be considered for preparation of EIA-EMP report for the project in addition to all the relevant information as per the ‘Generic Structure of EIA’ given in Appendix III and IIIA in the EIA Notification, 2006. Where the documents provided are in a language other than English, an English translation shall be provided. The draft EIA-EMP report shall be submitted to the State Pollution Control Board of the concerned State for conduct of Public Hearing. The SPCB shall conduct the Public Hearing/public consultation, district-wise, as per the provisions of EIA notification, 2006. The Public Hearing shall be chaired by an Officer not below the rank of Additional District Magistrate. The issues raised in the Public Hearing and during the consultation process and the commitments made by the project proponent on the same shall be included separately in EIA-EMP Report in a separate chapter and summarised in a tabular chart with financial budget (capital and revenue) along with time-schedule of implementation for complying with the commitments made. The final EIA report shall be submitted to the Ministry for obtaining environmental clearance.
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Annexure-XIII Undertaking from Consultant & PP
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UNDERTAKING 8
I, Dr. Mahendra Sadaria, EIA Coordinator of San Envirotech P%. Ltd. 3
located at 424, Medicine Market, Paldi Cross Road, Paldi, Ah f a undertake that; cn . . .
N m t t t
0 0 2 I undertake that, prescribed TORS have been complied with and @I# d B 2
0 TI a * 0 ,, submitted is factually correct. - c 3 5
I 0 .< Y * 0
I hereby declare that, what is stated herein above is true to the b g t ofrfl"y s 'l: eGR
knowledge and same I believed to be true. ? c L, ? J " & . g N 9 3 !2 x m 2 P ;3 -i - 5) 9 * <
Date: 21/01/2017 Name: Dr. Mahendra ~ a d = ~ j & 8118q36 Place: Ahmedabad Designation: EIA Coordinator