Aristotle Voineskos MD, PhD, FRCP(C) Head, Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health Assistant Professor, Department of Psychiatry and Institute of Medical Science, University of Toronto Conceptualizing the Schizophrenias As Circuit Disorders
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Conceptualizing the Schizophrenias As Circuit Disorders · Head, Kimel Family Translational Imaging -Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental
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Aristotle Voineskos MD, PhD, FRCP(C)
Head, Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health
Assistant Professor, Department of Psychiatry and Institute of Medical Science, University of Toronto
Conceptualizing the Schizophrenias As Circuit Disorders
MicroCircuit Disruption in the DLPFC in Schizophrenia
Meyer-Lindenberg, Nature, 2010 (adapted from Lewis et al, JCI, 2009)
www.neuralcircuits.uwm.edu
Hippocampal MicroCircuits
Winterburn et al, Neuroimage in press
Toward Measuring Microcircuit Structure in vivo
MacroCircuits
Analysis of gray matter morphology.
Analysis of white matter connectivity. [Images from Gray’s Anatomy]
• Genetic Heterogeneity is an important consideration • Circuit disruption can be targeted for treatment
Kimel Family Translational Imaging-Genetics Laboratory Mallar Chakravarty Anne Wheeler Tris Lett Dan Felsky Arash Nazeri Jon Pipitone Julie Winterburn Aysah Amath
Geriatric Division Benoit Mulsant Bruce Pollock Tarek Rajji Dielle Miranda
Neuroscience Program Jim Kennedy Arun Tiwari Natalie Freeman Clement Zai
Kimel Family, Michael and Sonja Koerner, and Paul Garfinkel New Investigator Award