COMPLETE, INTEGRATED, AND ROBUST - The LTG...Xevo TQ-S micro uw For more information, reference application note 720006097EN QUANTITATIVE ANALYSIS FOR THE MOST CHALLENGING APPLICATIONS

COMPLETE, INTEGRATED, AND ROBUST Solutions for Forensic Laboratories

[ FORENSIC SOLUTIONS ]

APPLICATION AREAS

Drug Testing Laboratory

State Crime Laboratory Homeland Security

Forensic Toxicology Laboratory

Medical Examiner Institute of Legal Medicine

Sports Doping

SPEND MORE TIME ANALYZING SAMPLESWaters forensic screening and confirmatory analysis solutions based on both high resolution time-of-flight (Tof) and quadrupole mass spectrometry (MS) technology offer unmatched ease-of-use, accuracy, and sensitivity.

■■ Pre-configured methods and workflows so that you can spend more of your time analyzing samples rather than on developing methods

■■ Industry leading UltraPerformance Liquid Chromatography® (UPLC®), MS, informatics, and chemistries

■■ A team of dedicated scientists with extensive experience and understanding of forensic applications

We offer a portfolio of complete solutions specifically designed for forensic laboratories whether you need to:

■■ Identify seized drugs

■■ Perform a comprehensive screen for DUID and post-mortem forensic toxicology investigations

■■ Analyze prohibited substances in a sports doping investigation

■■ Monitor illicit drug use

■■ Keep up with the demand to detect and identify novel psychoactive substances (NPS)

uw For more information, reference application note 720006004EN

RAPID IDENTIFICATION OF SEIZED DRUGS

With the increased prevalence of NPS, alternatives to traditional GC-MS methods are required to rapidly analyze seized drug material. The ACQUITY® QDa® Mass Detector enables seized drug analysis using either a UPLC inlet or by direct analysis using a DART® ionization source and allows for:

■■ Compact space saving design

■■ Increased turnaround and productivity using either LC or DART source

■■ No need to derivatize drug samples prior to analysis

■■ Direct analysis of solids and liquids using direct ionization DART source

ACQUITY QDa Mass Detector


ROBUST HIGH PERFORMANCE FOR ROUTINE ANALYSIS

When combined with the ACQUITY UPLC® I-Class System, the Xevo® TQD or Xevo TQ-S micro provide exceptional performance, delivering ease-of-use and robust high-quality data in a small footprint. Whether you need to identify seized drugs, detect and identify toxicants in physiological fluids, or perform quantitative analysis for drug panels these systems provide:

■■ MRM and full scan MS screening methods with automated data processing and library searching

■■ Fast scanning, high sensitivity, ease-of-use, and robustness

■■ Quantitative methods including sample pre-treatment and optimized LC-MS methods

■■ Confident quantitative analysis for alternative matrices such as oral fluid and hair

FOR ROUTINE FORENSIC TOXICOLOGY LABORATORIESScreen and confirm for common illicit and prescription drugs, confirmation assays for opiates, amphetamines, cocaine, benzodiazepines, and psychoactive drugs.

Xevo TQD Xevo TQ-S microRoutine screening ü ü

Confirmation panels for common illicit and prescription drugs

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High sensitivity assays in oral fluid and hair ü

Xevo TQ-S micro


QUANTITATIVE ANALYSIS FOR THE MOST CHALLENGING APPLICATIONS

When you need the ultimate in analytical sensitivity, the ACQUITY UPLC I-Class/Xevo TQ-XS offers unmatched performance, ease-of-use, and robustness. Whether you are analyzing small or large molecules, single analytes, or panels of multiple compounds, this system will provide the data that you can rely upon and features:

■■ StepWave XS™ ion guide that provides increased sensitivity for challenging compounds

■■ Enhanced detection system to ensure routine high sensitivity is always accessible

■■ Tool-free probe design reduces the time taken for routine maintenance and provides improved reproducibility between users

■■ UniSpray™ ionization for wider compound coverage

Xevo TQ-XS


THE ULTIMATE SOLUTION TO MEET THE NPS CHALLENGE AND UNKNOWN COMPOUND IDENTIFICATION

When you need to screen for a large number of compounds and keep up with the challenge of constantly changing NPS, Waters Forensic Toxicology Screening Application Solution with UNIFI® brings the power and versatility of high resolution MS to the forensic toxicology laboratory providing:

■■ A comprehensive Scientific Library of 1500 relevant compounds

■■ Library search using retention time and accurate mass of precursor and fragment ions

■■ Workflows for targeted and non-targeted screening

■■ Retrospective data analysis

■■ Common fragment and neutral loss search functions to identify NPS

■■ Automated discovery workflows for elemental composition derivation and structural elucidation

Xevo G2-XS QTof

[ FORENSIC SOLUTIONS ]


In addition to performance leading UPLC-MS systems, Waters also provides a comprehensive range of SPE sample preparation and UPLC column chemistry products to ensure method robustness and accurate results.

SAMPLE PREPARATIONSample preparation solutions for quantitative analysis make it easy to deliver a sample that is reproducible, yields high recovery, and is free of interferences.

Oasis® Sample Extraction products deliver unmatched purity, consistency, and quality for sample analysis. With a broad range of sorbents and an array of formats, Oasis products meet a wide variety of sample preparation needs, from simple and fast sample matrix cleanup to more complex sample preparation challenges.

COLUMN CHEMISTRIESWith more than 200 combinations of column configurations and chemistries, UPLC Columns combine faster separations with higher resolution and sensitivity.

All Waters UPLC Columns are designed, tested, and guaranteed for routine use in applications up to 18,000 psi (1241 bar).

FROM SAMPLE PREPARATION TO COLUMN CHEMISTRIES, WE’VE GOT IT COVERED

CHOOSE WATERS

Global ServicesWaters Service and Support offerings are tailored to optimize your laboratory’s productivity while addressing your budget realities. Our offerings help maintain peak system performance, minimize down time, address scientific application challenges, and support stringent compliance requirements. As your services and support provider, we are committed to the success of your laboratory and business.

Waters quality support and consultative services ensure your success wherever your laboratory is located in the world.

Waters, The Science of What’s Possible, ACQUITY, Oasis, QDa, UNIFI, UPLC, and Xevo are registered trademarks of Waters Corporation. StepWave XS and UniSpray are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

©2017 Waters Corporation. Printed in the U.S.A. 720006075EN October 2017 KP-SIG

Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 1 508 478 2000 F: 1 508 872 1990 www.waters.com

www.waters.com/forensics

Sales Offices:

Australia 61 2 9933 1777

Austria 43 1 877 18 07

Belgium and Luxembourg 32 2 726 1000

Brazil 55 11 4134 3788

Canada 1 800 252 4752

China 86 21 6156 2666

Czech Republic 420 2 617 11384

Denmark 45 46 59 8080

Finland 358 9 5659 6288

France 33 1 30 48 72 00

Germany 49 6196 400 600

Hong Kong 852 2964 1800

Hungary 36 1 350 5086

India 91 080 49292200 03

Ireland 353 1 448 1500

Israel 9723 3731391

Italy 39 02 265 0983

Japan 81 3 3471 7191

Korea 82 2 6300 9200

Malaysia 603 7841 1688

Mexico 52 55 52 00 1860

The Netherlands 31 76 508 7200

Norway 47 6 384 6050

Poland 48 22 101 5900

Portugal 351 21 893 61 77

Puerto Rico 1 787 747 8445

Singapore 65 6593 7100

Spain 34 93 600 9300

Sweden 46 8 555 115 00

Switzerland 41 56 676 7000

Taiwan 886 2 2508 5500

UAE 971 4 214 62 38

UK 44 208 238 6100

US 1 800 252 4752

Waters, The Science of What’s Possible, ACQUITY, UPLC, Xevo, MassLynx, QDa, and UNIFI are registered trademarks of Waters Corporation. ChromaLynx is a trademark of Waters Corporation. All other trademarks are property of their respective owners.


FORENSICS MASS SPECTROMETRY REFERENCE GUIDE

* Higher sensitivity may be achieved through the application of a higher amount of sample or more rigorous sample prep/sample concentration steps.+ Full scan/library searching solution on Xevo TQD or Xevo TQ-S micro requires ChromaLynx™ Application Manager.¥ Tof MRM panels.

With ACQUITY® UPLC® I-Class System

WATERS MS FORENSIC SOLUTIONS

ACQUITY QDa® Xevo® TQD Xevo TQ-S micro Xevo TQ-XS Xevo G2-XS QTof

Seized drug material, bulk chemical identification/forensic chemistry

Targeted screening solutions for systematic toxicological analysis

MRM screening solution available (180 drugs)

Full scan/library screening+ solution (>950 drugs)

Comprehensive screening with accurate mass library (>1500 compounds)

Non-targeted screening Discovery workflows for novel psychoactive substances (NPS)

Confirmatory assays

*Routine sensitivity confirmatory assays (e.g., urine, blood)

High sensitivity assays, alternative sample matrices (e.g., oral fluid, hair)

Informatics MassLynx® Software

MassLynx Software

MassLynx Software

MassLynx Software

UNIFI® Scientific Information System

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Waters, The Science of What’s Possible, ACQUITY, UPLC, Xevo, MassLynx, QDa, and UNIFI are registered trademarks of Waters Corporation. ChromaLynx is a trademark of Waters Corporation. All other trademarks are property of their respective owners.


FORENSICS MASS SPECTROMETRY REFERENCE GUIDE

COMPLETE, INTEGRATED, AND ROBUST - The LTG...Xevo TQ-S micro uw For more information, reference application note 720006097EN QUANTITATIVE ANALYSIS FOR THE MOST CHALLENGING APPLICATIONS

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