Pharmacology & Pharmacy, 2011, 2, 146-150 doi:10.4236/pp.2011.23020 Published Online July 2011 (http://www.scirp.org/journal/pp) Copyright © 2011 SciRes. PP Comparison of the Anthelmintic Efficacy of Three Commercial Products against Ascarids and Capillaria SPP. in Fighting Cocks Froylán Ibarra-Velarde, Cristina Guerrero-Molina, Yolanda Vera-Montenegro, Yazmín Alcalá-Canto, Evangelina Romero-Callejas Departamento de Parasitología, Facultad de Medicina Veterinaria y Zootecnia de la, Universidad Nacional Autónoma de Mexico, Coyoacán, México City, Mexico. Email: [email protected] Received February 9 th , 2011; March 20 th , 2011; April 20 th , 2011. ABSTRACT The aim of the present study was to evaluate the anthelmintic efficacy of three commercial compounds against ascarids and Capillaria spp. in naturally infected fighting cocks from Mexico. First experiment—Forty cocks were selected on the basis of eggs per gram (EPG) counts quantified by the McMaster method. On day 0 the birds were divided into four groups of 10 cocks, each subjected to the treatments. Group 1 received a single oral dose of 1 mg of ivermectin, 25 mg of praziquantel and 40 mg of fenbendazole given in tablets according to body weight (b.w). Group 2 was treated with a single oral dose of 1 mg of ivermectin, 25 mg of praziquantel and 40 mg of fenbendazole given in tablets/b.w. but formulated with a different excipient. Group 3 received a single tablet containing 0.2 mg of abamectin and 30 mg of albendazole. Group 4 served as a non-treated control. Fecal analyses were carried out on days 0 (day of treatment), 7, 14, 21 and 28, being collected from the floor where the cocks were individually caged. Efficacy was measured on the percentage of egg reduction from day 0 with respect the EPG counts from the control group. In a second experiment the study was similarly performed using another cock-farm located at approximately 300 km away from the first one. Results indicated an overall efficacy of 100%, 94.0% and 100% for groups 1, 2 and 3 in the first experiment and 100%, 100%, 100% for groups 1, 2 and 3 of the 2nd experiment, respectively. It is concluded that all drugs used exerted high efficacy in fighting cocks naturally infected with helminths. Keywords: Anthelmintic Efficacy, Commercial Drugs, Fighting Cocks 1. Introduction In Mexico the cockfight is a popular activity frequently carried out in places for combat called “palenques”. The fights generally take place on holidays, national festivities or week-ends throughout the country. Important to note is the fact that the cockfight is also a growing industry which provides employment and involves thousands of people engaged in the gambling on the outcome of of this festive activity. However, one of the important factors which hampers the aggressive performance of fighting cocks at the time of combat is the decrease of energy commonly caused by different parasitic infections. On the other hand, there is very limited information on the use of drugs that can remove helminths from the cocks. The present study was aimed at the evaluation of the antelmintic efficacy of three commercial compounds against Ascarids and Capi- llaria spp. in fighting cocks from two different farms. 2. Material and Methods 2.1. First Experiment 2.1.1. Location of the Study This study was carried out at the farm “El Colorado”, located in the municipality of Tulancingo, in the state of Hidalgo, Mexico, (central part of Mexico). 2.1.2. Study Animals Forty adult and young fighting cocks with no deworming background of at least 6 months were selected for inclu- sion in the trial. They were chosen on the basis of egg counts per gram (EPG) by using the quantitative Mc- Master method. All animals were individually caged,
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