Comparative study of sildenafil, Chlorophytum borivilianum leaf and root aqueous extracts on aphrodisiac activity and its influence on cardiac profile.” By Pankaj B. Magadum. B Pharm Dissertation Protocol Submitted to the Rajiv Gandhi University of Health Sciences, Bangalore – 560040, Karnataka. In partial fulfillment Of the requirement for the degree of MASTER OF PHARMACY IN PHARMACOLOGY Under the Guidance of Dr. Benson Mathai K, M.Pharm,Ph.D. Professor
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“COMPARATIVE STUDY OF EFFECT OF … · Web viewErectile dysfunction may affect 30-50% of men aged 40-70 years. [2] Presently, pharmaceutical compound sildenafil citrate (Viagra®)
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Comparative study of sildenafil, Chlorophytum borivilianum leaf and root aqueous extracts on aphrodisiac activity and its influence on
cardiac profile.”
ByPankaj B. Magadum. B Pharm
Dissertation Protocol Submitted to the
Rajiv Gandhi University of Health Sciences,Bangalore – 560040, Karnataka.
In partial fulfillmentOf the requirement for the degree of
MASTER OF PHARMACYIN
PHARMACOLOGY
Under the Guidance ofDr. Benson Mathai K, M.Pharm,Ph.D.
Professor
Dept. of Advanced Pharmacology and ToxicologySt. John’s Pharmacy College.
(2010-12)
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,KARNATAKA, BANGALORE.
ANNEXURE-II
PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION
1 Name of the candidate and addressMR.PANKAJ B. MAGADUMPOST GRADUATE STUDENT,DEPT OF PHARMACOLOGY AND TOXICOLOsGY,ST. JOHN’S PHARMACY COLLEGE,BANGALORE- 560040
3 Course of study and subject MASTER OF PHARMACY (PHARMACOLOGY)
4 Date of the admission 22th JUNE 2010
5 Title of the topic:
“Comparative study of sildenafil, Chlorophytum borivilianum leaf and root aqueous extracts on aphrodisiac activity and its influence on cardiac profile.”
Sexual activity is an important component of a human well being and quality of life, Sexual
dysfunction (impotence) and other related problems is eluding scientific community and medical
practitioners since time immemorial.[1] Erectile dysfunction may affect 30-50% of men aged 40-70
years. [2]
Presently, pharmaceutical compound sildenafil citrate (Viagra®) is looked upon as a reliable drug to
treat sexual dysfunction. But due to venodilator effects on the peripheral vasculature it has got
undesirable side effects specially on cardiac activity in patients having history of cardiac problems.[3] The risk association between erectile dysfunction (ED) and new onset of coronary artery disease
(CAD) has been documented in a recent study, which strongly suggested that ED is a surrogate
marker for future CAD.[4] There has been a constant exploration for newer herbal and chemical
agents to overcome these age-old problems of sexual dysfunction with less side effects.[1]
The present study is designed to validate on scientific basis for traditional use of the plant
Chlorophytum borivilianum (CB) for treating sexual dysfunction and also will check for its action
on cardiac profile as compared to sildenafil citrate.
6.2 Review of the Literature:
The Chlorophytum has 256 varieties in the world, 17 of them are found in India, amongst
which C. borivilianum (CB) belonging to the family Liliaceae is indogenous medicinal plant which
is cultivated in eastern parts of India and has good market demand. The common name of this herb
is SAFED MUSLI. [5] It possess unique healing and health giving properties which makes it useful
as a tonic and an important ingredient in around 20 ayurvedic and unani medicines of which
CHYAWANPRASH is the best example. [6]
Extracts of tubers has been studied for its antidiabetic, antistress, immunomodulatory,anti
inflammatory, antioxidant, anti microbial and anthelmintic activity.[7] Fasiculated roots of
C.borivilianum are used in preparation of medicines.