Comparative genomics confirms a rare melioidosis human‐to‐human transmission event and reveals incorrect phylogenomic reconstruction due to polyclonality

1 Comparative genomics confirms a rare melioidosis human‐to‐human transmission 1 event and reveals incorrect phylogenomic reconstruction due to polyclonality 2 Ammar Aziz 1 , Bart J. Currie 1,2 , Mark Mayo 1 , Derek S. Sarovich 1,3,4^* and Erin P. Price 1,3,4^* 3 4 Affiliations: 5 1 Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, 6 Darwin, NT, Australia 7 2 Infectious Diseases Department, Royal Darwin Hospital, Darwin, NT, Australia 8 3 GeneCology Research Centre, University of the Sunshine Coast, Sippy Downs, QLD, Australia 9 4 Sunshine Coast Health Institute, Birtinya, QLD, Australia 10 ^ Authors contributed equally 11 12 *Correspondence: 13 Dr Derek S. Sarovich; [email protected] 14 Dr Erin P. Price; [email protected] 15 16 Keywords: human‐to‐human transmission, Burkholderia pseudomallei, Melioidosis, phylogenomics, 17 comparative genomics, strain mixtures, bioinformatics 18 Repositories: All sequencing data generated as part of this study can be found under the NCBI BioProject 19 PRJNA559002 with accession numbers listed in Table 1. 20 . CC-BY-NC-ND 4.0 International license available under a was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint (which this version posted October 15, 2019. ; https://doi.org/10.1101/804344 doi: bioRxiv preprint

Comparative genomics confirms a rare melioidosis human‐to‐human transmission event and reveals incorrect phylogenomic reconstruction due to polyclonality

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