Company LOGO Longer Life, Better Life Presenter: 陈陈 Representing The third group ——Current research progress on Alzheimer Disease
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LOGO Longer Life, Better Life
Presenter:陈昊Representing The third group
——Current research progress on Alzheimer Disease
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21st century--time for the aged
Number of the aged is so huge!
October 31st, 2011
7 billion people on the world?
0.7 billion is the old!Almost 1 in 10 on the world
is over 60!
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Aging is everywhere!
Number of the aged (current and predicted) of some continents
4-5 times increasing in 50 years, just like a
rocket!
What about China?
The pace is faster.
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The Result of aging: Enjoy a longer life
Life expectancy worldwide on 2007
From Wikipedia
CIA World Fact book 2007 :Over 100 nations or regions enjoy the life expectancy over 70!
Quality
of life?
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Living quality---A better life as well?
Economic influence
Social problems
Health and diseases
Aging is good Aging is good or not? This is or not? This is
a question.a question.
The tragedy of aging:
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The position of Alzheimer
diabetes
CHF Stroke
Neurodegenerativedisease hypertension
Aged diseases
When we become old……
Cancer
Alzheimer
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Contents
1 The characters of Alzheimer
2 Alzheimer----the killer of life quality
3 Research on Mechanism of Alzheimer
4 Current drug and therapy
5 Can Alzheimer be prevented?
Fight against
Alzheimer!
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1 Alzheimer--- four stages characters
Early Middle Severe Final
1. slow, progressive loss of intellectual ability
2. difficulty learning
3. mild depression
1. an increase in memory loss
2. Decrease losing of daily living ability
1. unable to recognize objects and family members
1. cannot speak or walk, even breathe
2. has profound memory loss
Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30
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Epidemiology: the high rate of AD in the aged
60-6565-70
70-75over 80
over 90
2 4
8
20
40
0
5
10
15
20
25
30
35
40
Age
The percentage of AD (%)
The older one is, the more risky on getting AD!
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2. Alzheimer destroys the quality of life
Danger of the patients
Remember lossRemember loss
Ability lossAbility loss
cognition losscognition loss
15-20 years!
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Alzheimer destroys the quality of life
Social problems
TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661
Have you remembered or not? !
Mercy killing!
Living without quality or die at once, this is a question!
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3.The mechanism of Alzheimer—so many hypothesis
Cholinergic hypothesis
The mechanismOf Alzheimer
Amyloid hypothesis
Acetylcholine (ACh)
production elimination
imbalance
11C-PIB PET images characteristic
Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011)
Rubbish in brain!
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New research: The interaction between these hypothesis
MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111
Amyloid hypothesis to Cholinergic one:The more rubbish, the less Ach is!
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New research: The interaction between these hypothesis
MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111
Cholinergic hypothesis to Amyloid one:Ach inhibits the rubbish’s producing!
amyloid
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4.Current Drug and therapy
CurrentDrug for AD H3
antagonist
5-HTreceptor
ACEIs
NewACEIs
Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210
Donepezil
Rivastigmine
Galantamine
……
Huperzine AMianserin 5-HT2A antagonist
Effect in cognition loss 2004
Ciproxifan 2009
Thioperamide 2006
Anti-depre
ssant o
nly?
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A large market in AD drug and therapy
•Drugs for AD have a large
market.
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The mechanism of ACEIs
The Cholinergic pass way
decompose Ach
Re-uptake
X
AChE: Acetylcholinesterase
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5. Can Alzheimer be prevented?
EmotionalTherapy?
anti-amyloidTherapy?
DietTherapy?
ChineseTraditionalmedicine?
Virus-likeVaccine?
PreventionOf AD
Biotech therapy
Self
therapy
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Current research: Biotech vaccine
Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease.
Human Vaccines.2010 Volume 6, Issue 11
Virus-like particle based vaccines for AD
2010
Virus-like particle based antigen
High-affinity antibody anti- amyloid!
currently in human clinical trials
virus
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---Live longer, live better!Conclusion
Our loveTo the old?
Better prevention
More drugs
Mechanismclearer
live longer, live better.
It’s not only for the old, but also for our
future!
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Reference and acknowledgements
1 Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30
2 TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661
3 Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011)
4 MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111
5 Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210
6 Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease. Human Vaccines.2010 Volume 6, Issue 11
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