Commonly Used EPA Registered Canine Topical Flea and Tick Control Products External parasites pose a threat to your patients year round, so clients deserve your very best advice when developing a strategy for controlling infestations. This chart represents the most commonly used EPA-regulated canine topical flea & tick control products as of April 1, 2016. All products are applied monthly unless otherwise indicated. Please refer to individual product labels and package information for more details on target parasites, contraindications, and safety information. Products listed here are not for use on cats. *Refer to product label for specific tick, mosquito, fly, and mite species affected. † Indicates that the product repels the selected parasite. The trademarks and trade names listed above are the property of their respective owners. This poster is an independent publication and has not been authorized, sponsored, or otherwise approved by any of the companies who own the products listed. Jorge Guerrero, DiplEVPC (ret), DVM, MSc, PhD, is an internation- ally recognized veterinary para- sitologist, with a unique blend of experience in the animal health in- dustry and academia. He has been Adjunct Professor of Parasitology at the University of Pennsylvania since 1983. Dr. Guerrero is Past President of the North American Veterinary Conference (NAVC) and a recipient of the Distinguished Veterinary Parasitologists Award for 2005, granted by the American Association of Veterinary Parasitolo- gists. Dr. Guerrero has authored or co-authored more than 170 refereed original research articles and book chapters, and in 2010 he co-authored a book on helminth parasite infections of dogs and cats. Activyl ® Merck 773-94 8 weeks 19.53% Indoxacarb Activyl ® Tick Plus Merck 773-95 8 weeks 13.01% Indoxacarb + 42.5% Permethrin Adams ™ Spot-On ® Farnam 2724-811270 6 months 30% Etofenprox 5% PBO 3.6% (S)-Methoprene Advantage ® II Bayer 11556-125 (127,128,130) 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen Advecta ™ II CapInnoVet 2596-180-91384 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen Adventure ™ Plus Promika 91300-2 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen Barricade ™ Spot On ® Farnam 88052-8-89459 8 weeks 9.7% Fipronil Bio Spot ® Spot On ® Farnam 2724-497-270 6 months 45% Permethrin 3% (S)-Methoprene Bio Spot ® Defense ™ Farnam 2724-796-270 6 months 30% Etofenprox 5% PBO 3.6% (S)-Methoprene Certifect ® Merial 65331-7 8 weeks 9.8% Fipronil + 22.1% Amitraz 8.8% (S)-Methoprene Defense Care ™ Bayer 1156-135 7 weeks 8.8% Imidacloprid + 44% Permethrin Effitix ® Virbac 2382-187 12 week 6.01% Fipronil + 44.8% Permethrin Flea 5X Plus ™ 1800 PetMeds 2517-134-88832 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene Fortress ™ Spot On ® Farnam 88052-8-89459 8 weeks 9.7% Fipronil Frontline ® Gold Merial 2596-178-65331 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene + 0.25% Pyriproxyfen Frontline ® TriTak ® Merial 2517-142-65331 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin 8.8% (S)-Methoprene Frontline ® Plus Merial 65331-5 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene Happy Jack ® DuraSpot ™ Happy Jack Inc. 67505-3-2781 12 weeks 45% Permethrin 5.0% Pyriproxyfen Hartz ® UltraGuard ® Hartz 2596-167 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264 Hartz ® UltraGuard Plus ® Hartz 2596-168 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264 0.5% Pyriproxyfen Hartz ® UltraGuard Pro ® Hartz 2596-169 12 weeks 55% Etofenprox 10% PBO + 1% MGK-264 0.5% Pyriproxyfen + 0.25% (S)-Methoprene Hartz First Defense ® Hartz 2596-163 8 weeks 9.7% Fipronil K9 Advantix ® Bayer 11556-132 (133,134,135) 7 weeks 8.8% Imidacloprid + 44% Permethrin K9 Advantix ® II Bayer 11556-141 (142,143,144) 7 weeks 8.8% Imidacloprid + 44% Permethrin 0.44% Pyriproxyfen Liberty ® 50 Plus IGR Spot-On Star Horse Products 75844-8-81021 12 weeks 50% Permethrin 1.2% Pyriproxyfen Para / Defense ™ CapInnoVet 2596-180-91384 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen ParaStar ® Novartis 70585-12 8 weeks 9.7% Fipronil ParaStar ® Plus Novartis 70585-13 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin PetAction ™ Plus TruRX, LLC 91019-1 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene Pet Armor ® Perrigo 86230-2-85495 8 weeks 9.7% Fipronil Pet Armor ® Advanced 2 Perrigo 2517-176 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen Pet Armor ® Plus Perrigo 2517-134 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene PetLock ™ Plus TruRX, LLC 88052-13-89609 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene Pet Lock ™ II CapInnoVet 2596-180-91384 7 weeks 9.1% Imidacloprid 0.46% Pyriproxyfen Sentry ® FiproGuard ® Perrigo 2517-136 8 weeks 9.7% Fipronil Sentry ® FiproGuard ® Max Perrigo 2517-140 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin Sentry ® FiproGuard ® Plus Perrigo 2517-134 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene Sentry ® Pro Squeeze-On Perrigo 2517-87 12 weeks 45% Permethrin 1.9% Pyriproxyfen Sentry ® Pro XFT Large Dog Perrigo 2517-130 12 weeks 30% Cyphenothrin 2% Pyriproxyfen Sentry Pro ® XFT Small/Medium Dog Perrigo 2517-129 12 weeks 20% Cyphenothrin 2% Pyriproxyfen Sentry Pro ® Toy Dog Perrigo 2517-133 12 weeks 55% Etofenprox 2.2% Pyriproxyfen Sergeant's ® Pronyl OTC ™ Perrigo 2517-136 8 weeks 9.7% Fipronil Sergeant's ® Pronyl OTC ™ Max Perrigo 2517-140 12 weeks 9.8% Fipronil + 5.2% Cyphenothrin Sergeant's ® Squeeze-On Perrigo 2517-126 12 weeks 45% Permethrin 1.2% (S)-Methoprene ShieldTec ™ Plus Promika 91300-1 12 weeks 45% Permethrin 5.0% Pyriproxyfen SpectraSure ® Plus IGR Durvet 53883-351-89400 12 weeks 9.8% Fipronil 8.8% (S)-Methoprene TripleGuard ™ PetBalance 67505-3-88966 T 12 weeks 45% Permethrin 5% Pyriproxyfen Vectra ® Ceva 83399-10 8 weeks 22% Dinotefuran 3% Pyriproxyfen Vectra 3D ® Ceva 83399-6 7 weeks 4.95% Dinotefuran + 36.08% Permethrin 0.44% Pyriproxyfen Vet Guard ® Plus Pet IQ 67505-3-88966l 12 weeks 45% Permethrin 5% Pyriproxyfen Zodiac ® Spot On ® Farnam 2724-497 6 months 45% Permethrin 3% (S)-Methoprene ZoGuard ™ Plus Promika 53883-351-91300 8 weeks 9.8% Fipronil 8.8% (S)-Methoprene Updated: April, 2016. Information presented is believed to be accurate, but not guaranteed. Canine Products Manufacturer EPA Reg Number Earliest Age for Use Killing Ingredients Synergist Ingredients Insect Growth Regulators (IGRs) (Only Control Pre-adult Fleas) Kills Adult Fleas Kills Pre-adult Fleas (Eggs/Larvae) Kills Ticks* Controls Mites* Kills Tick Nymphs & Larvae Kills/Repels Mosquitoes* Kills Lice Kills Flies* Active Ingredients † †