CombiFlash Rf Torrent For Large Scale Purification
Mar 31, 2015
CombiFlash Rf Torrent
For Large Scale
Purification
CombiFlash Rf Torrent Capabilities
■ Up to 1 L/min at 100 psi
■ 300g purifications in an hour unattended
■ Automatic solvent level sensing
■ Customize for different laboratory needs
■ All external tubing for easy loading
■ Collect known compounds using Time Windows
■ Compact design
Pumping System■ Level sensing on inlet and waste
■ Makes it a walk away large scale system
■ Pumps precisely from 0 to 100%■ Up to 1L/min accurately
■ Up to 100psi consistently
■ Accurately delivers DCM and MeOH
■ Solvent can be located on the floor
■ Up to 100 psi■ Large tubing creates minimal system backpressure
■ Custom inlets for variety of sources
Binary Gradient■ 2 Solvent inlet
■ B solvent auto prime for accurate gradients
■ 50ml/min to 1 L/min
■ 80 grams up to 3 kg columns purification■ 80 gram useful for method development and scale up
■ Rapid equilibration function
■ Fast air purge for column disposal
Customizable to Meet any Purification Need
Solvent Inlet Options
■ Stainless steel braided*
■ 5 (standard), 9 ft length
■ Grounded flow path
■ Pressurized solvent reservoirs*
■ Custom connection
■ Quick Connects
*Ability to have level sensing
Stainless Steel Braided
Remote Solvent Source
Pressurized Solvent Reservoirs
With Solvent Level Sensing
Optional Solvent Caps
■ 100 mm
■ 83B
■ Available for both inlet and outlet
■ Customize for your container
Injection Option 1■ Solid load cartridges
■ Cartridges available in 4 sizes■ 25, 65, 260, and 750 gram
■ Available empty and prepacked
■ Prepacked with silica, Celite or C18
■ Bulk silicas also available
■ Use cartridges as a guard column to extend the life of reusable columns
Injection Option 2■ Liquid Load pump
■ Pull directly from a sample container
■ Utilize an empty cartridge as a funnel, pull from the cartridge and load onto the column
■ Load manually with a syringe
Automatic Operation■ Injection valve enables true walk-
away automation
■ Automatically equilibrates, loads the sample and purifies
■ Post run - air purge, and clean the valve to ensure no cross contamination
Automatic Self Cleaning Injection Valve■ All external tubing
■ Easy to access and clean
■ Automatic wash sequence■ Wash injection valve with strong solvent after run
■ Prevents buildup in valve
■ Automatic operation■ “Start and walk away”
■ Rapid auto air purge
Detector Options■ Select from either internal UV or UV-Vis PDA detector
■ Peak collection via slope, threshold or time windows
■ Perform All-Wavelength Collection
■ Ability to detect small impurities in the sample
■ Alternatively, connect to an external detector
■ Teledyne Isco Model 340CF ELSD available
■ December software release will add Spectral Capabilities
■ December software release will add MS support/control
Torrent Collection Option 1■ Foxy R2 High Flow Fraction Collector
with RFID rack identification technology
■ Chain up to 4 collectors together
■ Collect in 16-25 mm test tubes or 450 ml bottles
■ Use funnel rack to collect unlimited quantities in any container
■ Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows
RFID Test Tubes Racks■ Greatest Collection Capacity – can be hot swapped
■ (150) 16x125 mm
■ (150) 16x150 mm
■ (140) 18x150 mm
■ (60) 25x150 mm
■ Bottle Racks – 480 ml■ 480 ml bottles available
■ Funnel Rack (36)■ RFID Rack Identification
■ Identifies rack sizes
■ Prevents overfilling or incorrect tube selection
Torrent Collection Option 2■ Torrent Fraction Valve
■ Collect up to 6 large volume fractions and a separate waste for defined protocols
■ Collect based on Volume with triggers from detected Threshold, Slope and/or Time Windows
■ Collect a given volume per container – up to 99 L
Torrent Collection Option 3
■ Manual collection – no collector necessary
■ Collect by hand
RediSep Rf and RediSep Rf Gold Columns■ RFID sensors for fast setup
■ Run 80 gram up to 3 kg columns
■ Scale up from an 80 gram
■ Scale up from the CombiFlash Rf+
■ 750g, 1.5 kg and 3 kg columns have large inlets and outlets to prevent flow restriction and crystallization
■ GOLD Speed and GOLD Resolution methods on RediSep Rf Gold silica columns
■ Save half the solvent
Teledyne Isco Confidential
21
The Real Driver to Sell a Torrent
■ Post Sales Revenue■ At the end of 2012 there were 70 Torrents in the field
■ Annually each Torrent used an average of:■ 750G RediSep 5■ 1500G RediSep 4■ 3000G RediSep 3■ 750G Gold 1■ 1500G Gold 2■ 3000G Gold 2
■ Over $9K in columns/instrument/year
Safety Features■ Vapor Sensors
■ Pressure Sensors
■ Air purge for easy disposal of columns
■ Audible alarm when user intervention is required
■ Removable, washable drain tray
■ Static-dissipative tubing throughout
■ Patented level sensing ensures adequate solvent for purification and prevents waste flow
■ Ability to network the system, watch progress, and make run adjustments from any location through either a PC or iPad
Teledyne Isco Confidential
23
Key Markets
PharmaceuticalDrug Discovery Natural
Products
AgriculturalChemistry Foods
and Flavors
Petrochemicals