Combating the Opioid Abuse Epidemic with Evzio ® (naloxone) Baely Crockett, PharmD Eskenazi Health Internal Medicine PGY2 This speaker has no actual or.

Combating the Opioid Abuse Epidemicwith Evzio® (naloxone)

Baely Crockett, PharmDEskenazi Health Internal Medicine PGY2

This speaker has no actual or potential conflicts of interest to disclose in relation to this presentation.

43,982 Drug Overdose Deaths in 2013

Centers for Disease Control and Prevention. CDC’s top ten: 5 health threats in 2014.Centers for Disease Control and Prevention. Injury prevention & control: prescription drug overdose.

Non-Prescrip-

tion 21,215

Opioid 16,235

Other6,532

Drug Overdose Deaths in Indiana

Indiana State Department of Health. Special emphasis report: drug overdose deaths. 2014.

206 Opioids

98 BZD30 Cocaine

110

Heroin

690Other

unspeci-fied

drugs

999 Deaths

Opioid Mechanism of Action and Abuse

University Of Florida. Opioids: mechanism of action.

Treatment of Opioid Overdose

Naloxone and overdose prevention education program of Rhode Island.

Naloxone

• Routes of administration• Intravenously • Intramuscularly • Subcutaneously• Intranasally• Nebulizer

Naloxone. LexiComp. 2015Kaleo, Evzio. 2015.

What is Evzio®?

• Hand-held, single-use naloxone auto-injector• Intramuscularly or subcutaneously • Outer thigh

• Holds 0.4 mg of naloxone• User-friendly with audio instruction on appropriate

administration• Does not replace need for emergency medical

assistance

Kaleo, Evzio. 2015.

Audience Participation

Who can administer Evzio?

A. Patients prescribed high doses of opiatesB. Family members of patients who are

prescribed high doses of opiatesC. Health care professionals working at a pain

management clinicD. All of the above

Kaleo, Evzio. 2015.

How to use Evzio®

1. Remove cap2. If ready to use, pull off

red safety guard3. To inject, place black

end against outer thigh then press firmly and hold in place for five seconds

4. Counts down from five to one

Kaleo, Evzio. 2015.

How to use Evzio®(cont’d)

5. Injection complete6. Seek emergency

medical attention 7. This device has been

used and should be taken to your physician for proper disposal and a prescription refill

Kaleo, Evzio. 2015.

Increased Access to Naloxone

Kaleo, Evzio. 2015.

Pros Cons

Frontline personnel would be able to treat patients faster to save

lives

Abusers may try higher doses, knowing reversal is at their fingertips

Combating the Opioid Abuse Epidemicwith Evzio® (naloxone)

Baely Crockett, PharmDEskenazi Health Internal Medicine PGY2

This speaker has no actual or potential conflicts of interest to disclose in relation to this presentation