Colchicine The Autumn Crocus
Jan 05, 2016
Colchicine
The Autumn Crocus
Structure
C22H25NO6C22H25NO6
Uses
Positive-Is an anti-inflammatory drugTreats goutPoisons cancer cells, but also poisons healthy cellsUsed “off-label” in Great Brittan and is used to
treat other things along with back painAlso treats familial Mediterranean fever and
Behçet’s disease.
Positive-Is an anti-inflammatory drugTreats goutPoisons cancer cells, but also poisons healthy cellsUsed “off-label” in Great Brittan and is used to
treat other things along with back painAlso treats familial Mediterranean fever and
Behçet’s disease.
UsesNegative-
Causes stomach upsetHigh doses can damage bone marrow, lead to hair
lose and anemiaCan cause peripheral nerve damage
Negative-Causes stomach upsetHigh doses can damage bone marrow, lead to hair
lose and anemiaCan cause peripheral nerve damage
Toxin-Poisoning is similar to arsenic poisoning. Symptoms begin 2-5 hours after toxic dose is
administered.There is no antidote but there are treatments.
Toxin-Poisoning is similar to arsenic poisoning. Symptoms begin 2-5 hours after toxic dose is
administered.There is no antidote but there are treatments.
Synthesis
Can be biosynthesized Involves the amino acids phenylalanine and
tyrosine In the end you have to add acetyl-Coenzyme A
to deacetylcolchicine to get colchicine
Can be biosynthesized Involves the amino acids phenylalanine and
tyrosine In the end you have to add acetyl-Coenzyme A
to deacetylcolchicine to get colchicine
Synthesis con’t.
Physical and Chemical Properties
Color Pale yellow but darkens with exposure to light
State Odorless powder or scales
Melting Point 153-157 C
pH In a .5% solution is 5.9
Solubility Soluble in alcohol or chloroform Slightly soluble in ether Insoluble in petroleum ether 1/25 soluble in water
Color Pale yellow but darkens with exposure to light
State Odorless powder or scales
Melting Point 153-157 C
pH In a .5% solution is 5.9
Solubility Soluble in alcohol or chloroform Slightly soluble in ether Insoluble in petroleum ether 1/25 soluble in water
Works Cited
http://upload.wikimedia.org/wikipedia/commons/2/2e/Colchicine_structure.png
http://upload.wikimedia.org/wikipedia/commons/3/3b/Colchicine_3D.png
http://en.wikipedia.org/wiki/Colchicine http://upload.wikimedia.org/wikipedia/commons/f/
f0/Colchicinebiogenesis.svg http://www.inchem.org/documents/pims/pharm/
colchic.htm http://healthmad.com/health/the-deadliest-flowers-on-
earth-two/
http://upload.wikimedia.org/wikipedia/commons/2/2e/Colchicine_structure.png
http://upload.wikimedia.org/wikipedia/commons/3/3b/Colchicine_3D.png
http://en.wikipedia.org/wiki/Colchicine http://upload.wikimedia.org/wikipedia/commons/f/
f0/Colchicinebiogenesis.svg http://www.inchem.org/documents/pims/pharm/
colchic.htm http://healthmad.com/health/the-deadliest-flowers-on-
earth-two/