CogSci Projects for Spring 2005.

UH

CogSci Projects for Spring 2005.

Inter- and Intra-Individual Gating Differences.

Ben H.JansenDepartment of Electrical and Computer Engineering, and Center for Neuro-

Engineering and Cognitive Science, University of Houston, [email protected]

Supported by NIH/NIMH R01 MH58784, NSF/REU and UH-GEAR

Collaborators: Nashaat N Boutros, MD, Dept. Psychiatry, Yale U;

Lingli Hu, Bharat Bonala, Karthik Sundaresan, Prashant Kota, Hitesh Doshi,

Vijay Grandhi, Gopal Agarwal, Ruben Jacob, Anant Hegde, Darshan Iyer,

Violet Garoosi

Sensory Gating

Gating: ability to suppress irrelevant stimuli

Double Stimulus Paradigm:– Two identical tone

bursts 0.5 s apart– S1 response larger than

S2-6

-4

-2

0

2

4

6

8

-100 -50 0 50 100 150 200 250 300

S1S2

V

ms

P50

N100

P200

stim

Gating Deficits in Schizophrenia?

S1

-6

-4

-2

0

2

4

6

8

-100 -50 0 50 100 150 200 250 300

NCSZ

S2

-6

-4

-2

0

2

4

6

8

-100 -50 0 50 100 150 200 250 300

NCSZ

ms ms

V V

Paradigms and Data Set• 16 normal subjects, 17 schizophrenia patients.• Max. 4 sessions/subject• Cz-linked ears, Artifacts removed • Paradigms:

0.5s8.0s

S2 S2S2S1 S1 S1

8.0s

… S6S1 S5 … S6S1 S5

• Double Clicks:• A: identical• B, C: non-identical

• Trains:• F, G: S1=…=S5=S6

/

S1 and S2 Grand Average Amplitudes:Paradigms

ABCFG

V

S1 S2 S1 S2 S1 S2

P50

N100

P200

NC SZ

Gating in Normal ControlsS1 S2

B

C

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

50 100 200 300 400 500

-5

0

5

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

5

A

F

G

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

50 100 200 300 400 500

-5

0

5

0 100 200 300 400 500-5

0

5

65 48 56

83 60 56

63 47 48

90 56 58

75 55 58

P50 N100 P200

71 51 53

83 56 58

64 591 62

57 74 69

127 82 90

80 72 73

102 99 87

Gating in SchizophreniaS1 S2

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

5

B

C

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

5

A0 100 200 300 400 500

-5

0

5

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

5

F

G

0 100 200 300 400 500-5

0

5

0 100 200 300 400 500-5

0

5

P50 N100 P200

831 72 73

91 85 80

1Red means greater than NC

AUDITORY P300

Bharat Bonala, Prashant Kota, Karthik Sunderasan, Nashaat N Boutros, and Ben H Jansen

Differences between normal and schizophrenia subjects.Brain-Machine Interface.

P300 and the Odd-Ball Paradigm

2 sec

FF F F F FR R R F

F Frequent/Non-Target stimulus

R Rare/Target stimulus P300: response to a relevant, infrequently occurring stimulus.

Normal Controls have larger P300 than Schizophrenia Patients

Using the BMI

A B C D E F

G H I J K L

M N O P Q R

S T U V W X

Y Z 1 2 3 4

5 6 7 8 9 --

A

G

M

S

Y

5

B

H

N

T

Z

6

C

I

O

U

1

7

D

J

P

V

2

8

E

K

Q

W

3

9

F

L

R

X

4

--

A B C D E F

G H I J K L

M N O P Q R

S T U V W X

Y Z 1 2 3 4

5 6 7 8 9 --

Spelling Machine

Donchin et al, IEEE-T-BME, 2000

HUNGRY

THIRSTY

LIGHT ON

LIGHT OFF

HUNGRY

THIRSTY

LIGHT ON

LIGHT OFF