Cocaine- and Extinction-Induced Neuroplasticity in AMPA Receptors Regulate Drug-Seeking Behavior DAVID W. SELF, PH.D. Associate Professor of Psychiatry and Neuroscience The Seay Center for Basic and Applied Research in Psychiatric Illness Southwestern Medical Center
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Cocaine- and Extinction-Induced Neuroplasticity in AMPA Receptors Regulate
Cocaine- and Extinction-Induced Neuroplasticity in AMPA Receptors Regulate Drug-Seeking Behavior . DAVID W. SELF, PH.D. Associate Professor of Psychiatry and Neuroscience The Seay Center for Basic and Applied Research in Psychiatric Illness Southwestern Medical Center. - PowerPoint PPT Presentation
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Cocaine- and Extinction-InducedNeuroplasticity in AMPA Receptors Regulate
Drug-Seeking Behavior
DAVID W. SELF, PH.D.Associate Professor of Psychiatry and Neuroscience
The Seay Center for Basic and AppliedResearch in Psychiatric IllnessSouthwestern Medical Center
Drug-Induced Neuroplasticity in the Mesolimbic Dopamine System
DAVTA
Propensity forCocaine-Seeking
Behavior?
From PfC and amygdala
AMPARsLTP
Glu
White et al., 1995Zhang et al., 1997Ungless et al., 2001Saal et al., 2003
NAc
From PfC, hippocampus,amygdala, and thalamus
Glu
AMPARsLTD
White et al., 1995Thomas et al., 2001
Herpes Simplex (HSV) Viral Vectorfor In Vivo GluR1 Over-Expression