CM Wong's Curriculum Vitae - School of Life Sciences

CM Wong’s Curriculum Vitae

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CURRICULUM VITAE

Name: WONG Chi Ming (黃志明), Ph.D.

Sex: Male

Nationality: Chinese (Hong Kong)

Email Address: [email protected]

Research Interests

General fields: Acute myeloid leukemia, redox signaling, pulmonary arterial hypertension,

right heart hypertrophy and failure, asthma, cardiovascular Physiology and

Pharmacology, ion channels, endothelium and smooth muscle, hypertension,

sex hormones, redox proteomics, oxidative post-translational protein

modifications, diabetes mellitus, aging

Specific fields: 1. In vitro drug-screening for the possibility of personalizing treatment for

acute myeloid leukemia (AML) patients, mechanisms of drug resistant

2.Mechanisms of persistent organic pollutants for the increased

susceptibility of endothelial dysfunction and renal injury under diabetes

mellitus

3.Mechanisms of redox signaling by protein carbonylation and de-

carbonylation through ligand-receptor interactions in smooth muscle and

hearts

4.Apoptosis-based therapy by cancer chemotherapeutic agents to prevent

and/or reverse the development of pulmonary hypertension in animal

models (monocrotoline, hypoxia and SUGEN/hypoxia)

5.Inhibition of metal-catalyzed protein oxidation to prevent and/or reverse

the development of pulmonary hypertension

6. Mechanisms of right ventricular hypertrophy and failure

7.Roles of inflammatory cytokines for the development of asthma and

pulmonary hypertension

8.Roles of oxidative post-translational protein modifications (e.g. protein

carbonylation and glutathionylation and nitrosylation) in cardiovascular

physiology and pathophysiology by proteomics approach

9.Oxidant signaling by protein carbonylation for endothelial dysfunction in

diabetes mellitus

10.Vascular actions of estrogen and selective estrogen receptor modulators (e.g.

tamoxifen and raloxifene) to endothelial dysfunction

Expertise techniques

1. In vitro drug screening by PrestoBlue assay and flow cytometry for studying effect of

drugs on cancer cells (primary AML cells or cancer cell lines) viability

2. Use LC-MS/MS and RNA-Seq (next-generation sequencing) to study proteomic changes

and transcriptome alterations in cancer cells

3. Use NSG mice transplanted with MV4-11 or MOLM-13 cells (animal model of AML)

transduced with the luciferase reporter gene by tail vein injection to confirm the effects of

effective drug or combination of two drugs


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4. Use of MALDI imaging mass spectrometry to study the distribution of a large amount of

analytes at one time of tissue section.

5. Measurement of mitochondrial function by Seahorse Extracellular Flux Analyzer.

6. Functional studies of different sizes of blood vessels from different organs by organ bath

and myograph.

7. Cell culture of different cell types, for example endothelial cells and smooth muscle cells,

and organ culture of blood vessels for functional studies and Western blotting.

8. Electrophysiological studies of regulation of gating of the expressed ion channels, like

voltage-gated potassium channels, on Xenopus oocytes.

9. Ovariectomy and selective estrogen receptor modulator replacement therapy in rodents

10. Western blotting to study the changes of levels of protein expression by experimental

treatments.

11. 2-dimensional gel electrophoresis, interested protein spot isolation, trypsin digestion of

protein spots, and mass spectrometry (MALDI-TOF/TOF with PMF+ MS/MS analysis

and LC-MS/MS) analysis for identification of interested proteins and modification sites

analysis.

12. Studies of novel signal transduction roles of post-translational protein modifications, for

example protein carbonylation and glutathionation, initiated through ligand-receptor

interaction.

13. Haemodynamic studies of right and left ventricular by open-chest method of rodents and

direct Millar catheter insertion in order to investigate the effects of novel therapeutic

treatments on pulmonary arterial pressure.

14. Establishment of rodent animal models for pulmonary arterial hypertension by putting the

Sprague Dawley rats in hypoxia chamber for 2-weeks. Alternatively, rats can be

previously injected with SU5416 (VEGF receptor antagonist) and incubated in hypoxia

for 3 weeks and then normoxia for 5 or 8 weeks.

15. Immunohistochemistry to study the changes of protein expression of proteins.

16. Detection of protein oxidation of samples from cultured cells or organs by OxyBlot

Protein Oxidation detection kit.

17. Detection of ROS generation from cultured cells by dichlorofluororescein diacetate

method.

18. Electrophoretic mobility shift assay to study the changes of binding interaction of proteins

and DNA.

19. Real-time polymerase chain reaction (PCR) to study the changes of mRNA levels of

target proteins.

20. Extraction of total RNA and reverse transcription of total RNA for PCR reaction.

21. Luciferase assay to study the transcriptional regulation of promoters of genes.

22. Microscopic analysis of stained slides (H&E staining) for change of wall-thickness of

small resistant pulmonary arteries and changes of myocyte sizes.

23. Apoptosis detection by TUNEL assay.

24. Protein overexpression by adenovirus-delivered DNA sequence in cell culture.

25. Protein knockdown by siRNA method in cell culture.

26. Indirect NO measurement by Griess reagents to measure nitrite and nitrate levels.

27. Cyclic GMP measurement by radioimmunoassay.

28. Serum and plasma collection from rodents.


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Education

1995 - 1998 Bachelor of Science in Biology

(Division I, Second Class Honours)

Department of Biology

Hong Kong University of Sciences and Technology, Hong Kong,

China

2000 - 2004 Doctor of Philosophy in Physiology

Department of Physiology

Chinese University of Hong Kong, Hong Kong, China

Prizes and Honours

2000 - 2004 Postgraduate Studentship, The Chinese University of Hong Kong

(CUHK)

May, 2004 CUHK Postgraduate Student Grants for Overseas Academic

Activities

May 19, 2008 Selected Oral Presentation, American Thoracic Society


October 19, 2009 Young Investigator Award, The Oxygen Club of Greater Washington

DC


Professional Affiliates

2000 - 2004 Member of Hong Kong Pharmacology Society

2004 - present Member of the Oxygen Club of Greater Washington DC

Invited Lectures

Title of Presentation: Protein carbonylation as a novel mechanism in redox signaling

Institution Name: Department of Pharmacology, Georgetown University

Date of Presentation: December 11, 2007

Title of Presentation: Protein carbonylation in cell signaling

Institution Name: Department of Pharmacology, Georgetown University

Date of Presentation: October 5, 2010


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Invited Editorial Board

2014-01-01 to 2017-12-31 Invited member of the World Journal of Cardiology Editorial

Board

Invited Reviewers

2007 – present Journal: Clinical and Experimental Pharmacology and Physiology

2009 – present Journal: Antioxidant and Redox Signaling

2012 – present Journal: Experimental Physiology

2013 – present Journal: PLoS One

2013 – present Journal: Journal of Cellular and Molecular Medicine

2013 – present Journal: Naunyn-Schmiedeberg’s Archives of Pharmacology

2014 – present Journal: PPAR research

2014 – present Journal: The Open Biochemistry Journal

Research Experiences

23/3/1999 – 31/7/2000 Research Assistant working on cloning of human large-conductance

calcium-activated potassium channels, ATP-sensitive potassium

channels and voltage-gated potassium channels


The Chinese University of Hong Kong, Hong Kong, China

2/8/2004 – 31/8/2004 Postdoctoral Fellow working on sex hormones- or selective estrogen

receptor modulators-induced vasorelaxation in rat aorta



6/9/2004 – 31/3/2011 Research Scholar working on redox signaling in pulmonary artery

smooth muscle cells, and mechanisms of right heart failure

Department of Pharmacology

Georgetown University Medical Center, Washington DC, USA

1/4/2011 – 6/9/2012 Research Assistant Professor working on redox signaling in

pulmonary artery smooth muscle cells, and mechanisms of right heart

failure

Department of Pharmacology and Physiology

Georgetown University Medical Center, Washington DC, USA

20/3/2013 – 19/8/2014 Research associate working on oxidant signaling for endothelial

dysfunction in diabetes mellitus, obesity and aging

School of Biomedical Sciences


2/11/2014 – 31/1/2017 Research Associate, Dr. CHUNG Chi-Kong Arthur laboratory,

working on the effect of persistent organic pollutants to the

susceptibility of endothelial dysfunction and renal injury,

Partner State Key Laboratory of Environmental and Biological

Analysis, Hong Kong Baptist University, Hong Kong

1/2/2017 – 31/7/2017 Postdoctoral fellow, Dr. LEUNG Yu-Hung Anskar laboratory,


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working on in vitro drug screening for curing acute myeloid leukemia

(AML), mechanisms of drug resistant,

Department of Medicine, The University of Hong Kong, Hong Kong

GRANT RECORD

Ongoing awarded grant

As a Principal Investigator (PI)

Funding agents Fund Project title Amount

awarded

Grant

period

National Natural

and Science

Foundation of

China, China

General Program

21577115

Perfluorooctane sulfonate

(PFOS) induces oxidative

stress for increased

susceptibility of endothelial

dysfunction under diabetes

mellitus (DM)

¥770,600 2016-

2019

Applied grant on 2017 (03/2017): Health and Medical Research Fund (HMRF) grant

- As a Principal Investigator (PI) for HMRF grant application

- Project title: Development of an in vitro drug screening platform for mechanistic study and

therapeutic design for acute myeloid leukemia

-Amount requested: HK$ 944,424

-Grant period: 01/04/2018-31/03/2020

Publications

Research Papers or Books

1. Wong CM, Au CL, Tsang SY, Lau CW, Yao X, Cai Z, Chung AC (2017) Role of

inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in

rat aorta. British Journal of Pharmacology 174(8):718-733. Impact factor:5.491

2. Zungu-Edmondson M, Shults NV, Wong CM, Suzuki YJ (2016) Modulators of right

ventricular apoptosis and contractility in a rat model of pulmonary hypertension.

Cardiovascular Research 110(1):30-9. Impact factor:5.878

3. Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT,

Wong CM, Lan HY, Yao X, Raizada MK, Huang Y (2015) Upregulation of

angiotension (1-7)-mediated signaling preserves endothelial function through reducing

oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-92. Impact

factor:6.337 4. Ni X, Wong SL, Wong CM, Lau CW, Si X, Cai Y, Huang Y (2014)

Tetramethylpyrazine protects against hydrogen peroxide-provoked endothelial

dysfunction in isolated rat aortic rings: implications for antioxidant therapy of vascular

diseases. Evidence-based Complementary Alternative Medicine. 627181. Impact

factor:1.74


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5. Wong CM, Zhang Y, Huang Y (2014). Bone morphogenic protein-4-induced oxidant

signaling via protein carbonylation for endothelial dysfunction. Free Radical Biology

and Medicine 75:178-90. Impact factor:5.606

6. Ibrahim YF*, Wong CM*, Pavlickova L, , Liu L, Trasar L, Bansal G, and Suzuki YJ

(2014) Mecahnism of the susceptibility of remodeled pulmonary vessels to drug-induced

cell killing. Journal of the American Heart Association 3(1):e000520 (* denotes co-

first authorship) Impact factor: 4.863 7. Wong CM*, Marcocci L*, Das D, Wang X, Luo H, Zungu-Edmondson M, Suzuki YJ

(2013). Mechanism of protein decarbonylation. Free Radical Biology and Medicine

65C:1126-1133. (* denotes co-first authorship) Impact factor:5.606

8. Bansal G *, Das D *, Hsieh CY, Wang YH, Wong CM, Suzuki YJ (2013). IL-22

activates oxidant signaling in pulmonary artery smooth muscle cells. Cellular

Signalling 25(12):2727-2733. Impact factor:3.937

9. Wong CM, Preston IR, Hill NS and Suzuki YJ (2012) Iron chelation inhibits the

development of pulmonary vascular remodelling. Free Radical Biology and Medicine

53(9):1738-1747. Impact factor: 5.606

10. Wong CM, Bansal G, Pavlickova L, Marcocci L and Suzuki YJ (2013) Reactive

oxygen species and antioxidants in pulmonary hypertension. Antioxidants & Redox

Signaling 18(14):1789-1796. Impact factor:6.337

11. Wong CM, Bansal G, Marcocci L and Suzuki YJ (2012) Proposed role of primary

protein carbonylation in cell signaling. Redox Report 17(2):90-94. Impact factor:2.07

12. Bansal G, Wong CM, Liu L and Suzuki YJ (2012) Oxidant signaling for interleukin-13

gene expression in lung smooth muscle cells. Free Radical Biology and Medicine

52(9):1552-1559. Impact factor: 5.606

13. Park AM, Nagase H, Liu L, Kumar SV, Szwergold N, Wong CM and Suzuki YJ. (2011)

Mechanism of anthracycline-mediated downregulation of GATA4 in the heart

Cardiovascular Research 90(1):97-104. Impact factor:5.878

14. Park AM§, Wong CM§, Jelinkova L, Liu L, Nagase H and Suzuki YJ. (2010) Pulmonary

hypertension-induced GATA4 activation in the right ventricle Hypertension 56(6):1145-

1151. (§ denotes co-first authorship) Impact factor:6.857

15. Wong CM, Marcocci L, Liu L and Suzuki YJ. (2010) Cell signaling by protein

carbonylation and decarbonylation. Antioxidants & Redox Signaling: Forum on Protein

Carbonylation. 12(3):393-404. Impact factor:6.337

16. Wong CM, Cleema AK, Zhang L and Suzuki YJ. (2010) Methods for studying redox

signaling by protein carbonylation. Methods in Redox Signaling. 12-18. (book chapter)

17. Liu L, Marcocci L, Wong CM, Park AM and Suzuki YJ. (2008) Serotonin-mediated

protein carbonylation in the right heart. Free Radical Biology and Medicine 45(6):847-

854. Impact factor: 5.606

18. Wong CM, Yung LM, Leung FP, Tsang SY, Au CL, Yao XQ, Chen ZY, Cheng CH,

Lau CW, Gollasch M and Huang Y. (2008) Raloxifene protects endothelial function

against oxidative stress. British Journal of Pharmacology 155(3):326-334. Impact

factor:5.491 19. Wong CM, Cleema AK, Zhang L, Suzuki YJ. (2008) Protein carbonylation as a novel

mechanism in redox signaling. Circulation Research 102:310-318 with commentary

102:273-274. Impact factor:13.965.

20. Wong CM*, Tsang SY, Yao XQ, Chan FL and Huang Y* (2008) Differential effects of

estrogen and progesterone on potassium channels expressed in Xenopus oocytes.

Steroids 73(3):272-279. (* denotes co-corresponding authors) Impact factor:2.282

21. Leung FP, Tsang SY, Wong CM, Yung LM, Chan YC, Leung HS, Yao XQ and Huang

Y (2007) Raloxifene, tamoxifen and vascular tone. Clinical and Experimental

Pharmacology and Physiology 34(8):809-813. Impact factor:2.01


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22. Suzuki YJ, Nagase H, Wong CM, Kumar SV, Jain V, Park AM and Day RM (2007)

Regulation of Bcl-xL expression in lung vascular smooth muscle. American Journal of

Respiratory Cell and Molecular Biology 36(6): 678-687. Impact factor:4.1

23. Wong CM, Yao XQ, Au CL, Tsang SY, Fung KP, Laher I, Vanhoutte PM and Huang Y

(2006) Chronic raloxifene therapy improves endothelial function in aortas from aged

ovariectomized female rats. Vascular Pharmacology 44(5):290-298. Impact

factor:3.718 24. Tsang SY, Yao XQ, Essen K, Wong CM, Chan FL, Gollasch M and Huang Y. (2004)

Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+

channels. Stroke 35: 1709-14. Impact factor:6.032

25. Tsang SY, Yao X, Chan FL, Wong CM, Chen ZY, Laher I and Huang Y. (2004) Estrogen

and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension

44(1): 78-82. Impact factor: 6.857

26. Lau CW, Chen ZY, Wong CM, Yao XQ, He DZ and Huang Y (2004) Attenuation of

endothelium-mediated relaxation by acetoside in rat aorta: role of endothelial [Ca2+]i and

nitric oxide-cyclic GMP pathway. Life Sciences 75(10): 1149-1157. Impact factor:2.936

27. Huang Y, Wong CM, Lau CW, Yao XQ, Tsang SY, Su YL and Chen, Z.Y. (2004)

Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids,

baicalin and baicalein, in rat aortic rings. Biochemical Pharmacology 67(4): 787-794.

Impact factor:4.581 28. Tsang SY, Yao XQ, Wong CW, Chan FL, Chen ZY and Huang Y (2004) Differential

regulation of potassium and calcium channel gene expression by chronic treatment with

estrogen and tamoxifen in rat aorta. European Journal of Pharmacology 483: 155-162.

Impact factor:2.896 29. Tsang SY, Wong CM, Yao XQ, Chan FL and Huang Y (2003) Estrogen and endothelial

nitric oxide. Current Topics in Pharmacology 7(2): 155-161. Impact factor:1.516

30. Tsang SY, Yao XQ Wong CM, Chen ZY and Huang Y. (2003) Role of Na+-Ca2+

exchanger in pinacidil-induced relaxation in rat mesenteric artery. British Journal of

Pharmacology 138(3): 453-460. Impact factor: 5.491

31. Tsang SY, Yao XQ, Chan HY, Wong CM, Chen ZY, Au CL and Huang Y. (2003)

Contribution of K+ channels to relaxation induced by 17ß-estradiol but not by

progesterone in rat mesenteric artery rings. Journal of Cardiovascular Pharmacology

41(1): 4-13. Impact factor:2.247

32. Tsang SY, Chan FL, Yao XQ, Wong CM and Huang Y (2003) Effect of progesterone in

the rat middle cerebral artery. Journal of Physiololgy 547. P:C15. Impact factor:4.739

33. Tsang SY, Yao XQ, Chan HY, Chen ZY, Wong CM and Huang Y. (2002) Effect of

17ß-estradiol exposure on vasorelaxation induced by K+ channel openers and Ca2+

channel blockers. Pharmacology 65(1): 26-31. Impact factor:1.442

Manuscripts revised, submitted or in preparation

1. Wong CM, Gong X, Yang C, Lau CW, Huang Y, Cai Z, Chung AC (2017)

Perfluorooctane sulfonate (PFOS) induces oxidative stress for increased susceptibility of

endothelial dysfunction under diabetes mellitus (DM). (In preparation and planning to

submit to Free Radical Biology and Medicine)

2. Wong CM, Yang C, Gong X, Cai Z, Chung AC (2017) Effect of perfluorooctane

sulfonate (PFOS) mediated oxidative stress for increased susceptibility of renal

dysfunction under diabetes mellitus (DM). (In preparation and planning to submit to Free

Radical Biology and Medicine)


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3. Wong CM, Leung AYH (2017) Mechanism and potential therapeutic role of

Homoharringtonine as an adjunct for AML carrying signalling aberration. (In preparation

and planning to submit to Oncotarget)

Conference Abstracts

1. CM Wong (2017) Cell signalling by protein carbonylation and decarbonylation.

NSFC/RGC Conference: Cardiovascular calcium signaling pathway: role in health and

disease, December 7-8, 2017, Page 32.

2. CM Wong, Z Cai, AC Chung (2016) Perfluorooctane sulfonate (PFOS) induces

oxidative stress for increased susceptibility of endothelial dysfunction under diabetes

mellitus (DM). The 18th Diabetes and Cardiovascular Risk Factors – East meets West

Symposium, 1-2 October 2016, Abstract #AB15.

3. X Gong, CM Wong, AC Chung (2016) Perfluorooctane sulfonate (PFOS)-induced

oxidative stress to enhance susceptibility of renal injury under diabetes mellitus (DM).

The 18th Diabetes and Cardiovascular Risk Factors – East meets West Symposium, 1-2

October 2016. (Oral presentations of Young Investigator Awards)

4. C Yang, CM Wong, Z Cai, AC Chung (2016) Persistent organic pollutants induce pre-

adipocytes differentiation and increase oxidative stress in 3T3-L1 cells. The 18th

Diabetes and Cardiovascular Risk Factors – East meets West Symposium, 1-2 October

2016, Abstract #AB17.

5. CM Wong and YJ Suzuki (2012) Proteasome Inhibitors Reverse Pulmonary Vascular

Remodeling. American Journal Respiratory and Critical Care Medicine

6. YF Ibrahim, CM Wong and YJ Suzuki (2012) Promotion of autophagy signals by a

cancer chemotherapeutic agent as a protective mechanism against pulmonary

hypertension. American Journal Respiratory and Critical Care Medicine

7. YJ Suzuki, CM Wong and AM Park (2011) Right heart-specific mechanism for GATA4

activation. FASEB J.

8. CM Wong and YJ Suzuki (2011) Carbonylation-decarbonylation and carbonylation-

degradation pathways in the mechanism of oxidant signaling. FASEB J. A157

9. CM Wong, L Marcocci and YJ Suzuki (2010) Regulation of Rho signaling by protein

carbonylation and decarbonylation. American Journal Respiratory and Critical Care

Medicine 10. CM Wong and YJ Suzuki (2010) Metal chelators inhibit pulmonary artery smooth

muscle cell growth and vascular thickening. American Journal Respiratory and

Critical Care Medicine 11. CM Wong*, L Marcocci and YJ Suzuki (2009) Regulation of Rho signaling by protein

carbonylation and decarbonylation. Oxygen Club of Greater Washington 2009 Annual

Symposium Abstract#006. (*denotes a recipient of young investigator award)

12. CM Wong and YJ Suzuki (2009) Metal chelators inhibit pulmonary artery smooth

muscle cell growth and vascular thickening. Oxygen Club of Greater Washington 2009

Annual Symposium Abstract#005.

13. CM Wong and YJ Suzuki (2009) Protein carbonylation signaling in pulmonary

hypertension. American Journal Respiratory and Critical Care Medicine 179: A174.

14. AM Park, C Liu, CM Wong and YJ Suzuki (2009) Pulmonary hypertension activates

GATA-4 in the right heart: role of CBF/NF-Y in the regulation of GATA-4 gene

transcription. American Journal Respiratory and Critical Care Medicine 179: A4140.

15. CM Wong and YJ Suzuki (2008) Endothelin-1 regulates annexin A1 through reactive

oxygen-mediated carbonylation in pulmonary artery smooth muscle cells. American

Journal Respiratory and Critical Care Medicine 177: A288.


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16. CM Wong and YJ Suzuki (2007) Serotonin promotes redox signalling via protein

carbonylation in pulmonary artery smooth muscle. American Journal Respiratory

Critical Care Medicine 175: A41 (PP305).

17. CM Wong and YJ Suzuki (2007) Endothein-1 promotes redox signalling via protein

carbonylation in pulmonary artery smooth muscle. American Journal Respiratory

Critical Care Medicine 175: A41 (PP304).

18. CM Wong and YJ Suzuki (2006) Chronic hypoxia increases protein carbonylation in rat

pulmonary artery. Oxidative post-translational modifications of proteins in

cardiovascular disease.

19. CM Wong and YJ Suzuki (2006) Endothein-1 promotes redox signalling via protein

carbonylation in pulmonary artery smooth muscle. Evolution of Pulmonary

Hypertension: Emerging Disease and Novel Therapeutics Abstract#78.

20. YJ Suzuki, SV Kumar, CM Wong and AM Park (2006) Regulation of apoptosis in lung

vascular smooth muscle. Evolution of Pulmonary Hypertension: Emerging Disease

and Novel Therapeutics Abstract#76.

21. CM Wong and YJ Suzuki (2006) Chronic hypoxia increases protein carbonylation in rat

pulmonary artery. American Journal Respiratory Critical Care Medicine A173 (D46).

22. CM Wong and YJ Suzuki (2006) Protein carbonyl formation by endothelin-1 in vascular

smooth muscle cells. American Journal Respiratory Critical Care Medicine A855

(PP702).

23. YJ Suzuki, H Nagase, S Vinod Kumar, CM Wong, AM Park and RM DAY (2006)

Regulation of Bcl-xL expression in pulmonary artery smooth muscle. American

Journal Respiratory Critical Care Medicine A278 (oral presentation).

24. CM Wong and YJ Suzuki (2005) Protein carbonyl formation by endothelin-1 in

vascular smooth muscle cells. 18th Annual conference of the oxygen club of greater

Washington, D.C., USA, Abstract#20

25. CM Wong, XQ Yao, CL Au, KP Fung, FL Chan and Y Huang (2004) Raloxifene

improves endothelial function of aortas in ovariectomized female rats. FASEB J.

18(4):A638.

26. CM Wong, XQ Yao, CL Au, ZY Chen, PM Vanhoutte, Y Huang (2003) Raloxifene

Improves Endothelial Function Impaired by Free Radicals. Physiology Symposium –

2003, Hong Kong. Abstract#24

27. SY Tsang, XQ Yao, FL Chan, CM Wong, ZY Chen, I Laher, Y Huang (2003) Estrogen

and Tamoxifen Modulation of Cerebrovascular Tone in Ovareictomized Rats.

Physiology Symposium – 2003, Hong Kong, Abstract#25

28. Y Huang, CM Wong, SY Tsang, XQ Yao (2003) Selective estrogen receptor

modulators and vascular reactivity. International Symposium on Vascular Physiology,

Tainan 11-14 Nov 2003. Abstract: S6

29. SY Tsang, FL Chan, XQ Yao, CM Wong, Y Huang (2003) Effect of progesterone in the

rat middle cerebral artery. J. Physiol. 547. P: C15.

30. SY Tsang, XQ Yao, CM Wong, Y Huang (2002) Interaction between nitric oxide and

endothelium-derived hyperpolarizing factor. Taiwan-Hong Kong Physiology

Symposium 2002, Abstract# P-5.

31. CM Wong, XQ Yao, SY Tsang, Y Huang (2002) Inducible nitric oxide mediates

raloxifene-induced relaxation in the rat aorta. Taiwan-Hong Kong Physiology

Symposium 2002, Abstract# P-11.

32. SY Tsang, CW Lau, XQ Yao, FL Chan, K Essin, CM Wong, M Gollasch, Y Huang

(2002) Mechanisms that mediate raloxifene-induced cerebral vascular relaxation. J. HK

Coll. Cardiol. 10(4):232 (CPP3).


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33. CM Wong, ZY Chen, XQ Yao, FL Chan, SY Tsang, Y Huang (2002) Raloxifene

inhibits free radical-induced endothelium dysfunction in the rat aorta. J. HK Coll.

Cardiol. 10(4):238 (PP28).

34. SY Tsang, FL Chan, XQ Yao, CM Wong, Y Huang (2002) Cerebrovascular action of

progesterone in the rats. J. HK Coll. Cardiol. 10(4):239 (PP30).

35. HY Chan, XQ Yao, GW He, SY Tsang, CM Wong, Y Huang (2002) Short-term

incubation with physiological level of estrogen impairs ß1-adrenoceptor-mediated but

enhances ß2-adrenoceptor mediated coronary relaxation. J. Cardiac Surgery

36. SY Tsang, XQ Yao, CM Wong and Y Huang (2002) Multiplicity in the vascular

response to pinacidil in rat mesenteric artery. J. Cardiac Surgery

37. CM Wong, XQ Yao, SY Tsang, Y Huang (2002) Different effects of estrogen and

progesterone on K+ currents expressed in Xenopus oocytes. J. Cardiac Surgery

38. SY Tsang, XQ Yao, FL Chan, CM Wong, Y Huang (2002) Altered vascular reactivity

of the cerebral arteries in ovariectomized rats. J. Cardiac Surgery

39. HY Chan, XQ Yao, GW He, SY Tsang, CM Wong, Y Huang (2001) Synergistic

interaction between ß-agonists and 17ß-estradiol in blood vessels. J HK Coll Cardiol

9(Suppl.):120 (PP11).

40. CM Wong, XQ Yao, SY Tsang, Y Huang (2001). Effect of steroid hormones on KCa

and KV channels expressed in Xenopus oocytes. Physiology Symposium 2001. Abstract#

O7

41. ZY Chen, CM Wong, CW Lau, ZD He, XQ Yao, Y Huang (2001) Vasorelaxant,

antiproliferative and antioxidant activities of L. purpurascens and phenylethanoid

glycosides. J HK Coll Cardiol 9(Suppl.):114 (CPP4)

42. CM Wong, XQ Yao, SY Tsang, Y Huang (2001) Differential effects of 17ß-estradiol

and progesterone on KCa and KV channels expressed in Xenopus oocytes. . J HK Coll

Cardiol 9(Suppl.):126 (PP28)

43. CM Wong, XQ Yao, SY Tsang, Y Huang (2000) Effects of Steroid Hormones on

Potassium Channels. Taiwan-Hong Kong Physiology Symposium 2000, Abstract # P-15

44. Y Huang, J-P Bourreau, K Chong, CW Lau, CM Wong, XQ Yao (2001) Modulation of

nifedipine-induced relaxation by internal Ca2+ store depletion in rat arteries. J. Hong Kong

College Cardiol. 9:Abstract OP2.

Conferences Attended

1. Taiwan-Hong Kong Annual Physiology Symposium 2000 – Kaosiung, Taiwan. (Poster

Presentation)

2. Annual Physiology Symposium 2001 – Hong Kong, China. (Oral Presentation)

3. Hong Kong Pharmacology Society – Hong Kong, China. (Oral Presentation)

4. 1st International Symposium on Cardiovascular Science – Hong Kong, China. (Poster

Presentation)

5. 5th Annual Scientific Meeting of Cardiovascular Science and Medicine – Hong Kong,

China. (Poster Presentation)



7. Taiwan-Hong Kong Annual Physiology Symposium 2002 – Kaosiung, Taiwan. (Poster

Presentation)



9. Experimental Biology 2004, Washington, DC, USA, April 17-21, 2004 (Poster

presentation).


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10. 18th Annual conference of the oxygen club of greater Washington, DC, USA, July 29,

2005 (Poster presentation).

11. American thoracic society international conference 2006. San Diego, CA, USA. May 19-

24, 2006 (Poster presentation).

12. Oxidative post-translational modifications of proteins in cardiovascular disease – Boston,

USA, Oct 3-6, 2006 (Poster presentation).

13. 19th Annual conference of the oxygen club of greater Washington, DC, USA, Oct 12-13,

2006 (Poster presentation).

14. Evolution of pulmonary hypertension: emerging diseases and novel therapeutics. National

Institutes of Health, Bethesda, Maryland, USA. Dec 7-8, 2006 (Poster presentation).

15. American thoracic society international conference 2007. San Francisco, CA, USA. May

18-23, 2007 (Poster presentation).

16. American thoracic society international conference 2008. Toronto, Canada. May 16-21,

2008 (Oral presentation).


20, 2009 (Oral presentation).

18. Oxygen Club of Greater Washington 2009 Annual Symposium, USA, Oct 20, 2009 (Oral

and Poster presentations, a recipient of young investigator award).



20. Experimental Biology 2011, Washington, DC, USA, April 9-13, 2011 (Poster

presentation).

21. American thoracic society international conference 2011. Denver, USA. May 15-20, 2011

(Oral presentation).

22. American thoracic society international conference 2012. San Francisco, USA. May 19-


23. The 18th Diabetes and Cardiovascular Risk Factors – East meets West Symposium, Hong

Kong Convention and Exhibition Centre, Hong Kong, October 1-2, 2016 (Poster

presentation).

24. NSFC/RGC Conference: Cardiovascular calcium signaling pathway: role in health and

disease, Charles K. Kao Auditorium, Hong Kong Science Park, Hong Kong, December 7-

8, 2017 (Invited oral presentation)

Services

Teaching Assistant, Department of Physiology, CUHK 1999-2004

CM Wong's Curriculum Vitae - School of Life Sciences

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