Clinical Implication of Clinical Implication of Multimodal Neuroimaging Multimodal Neuroimaging Jungsu S. Oh, Ph.D. Assistant Professor BK21 Division of Human Life Science Seoul National University On behalf of Jun Soo Kwon, M.D., Ph.D. (Clinical Neuroscience and Computational Neuroscience Unit) Professor at BCS, Seoul National University WCU
Clinical Implication of Multimodal Neuroimaging. Jungsu S. Oh, Ph.D. Assistant Professor BK21 Division of Human Life Science Seoul National University. On behalf of Jun Soo Kwon, M.D., Ph.D. (Clinical Neuroscience and Computational Neuroscience Unit) - PowerPoint PPT Presentation
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Clinical Implication of Clinical Implication of Multimodal NeuroimagingMultimodal Neuroimaging
Jungsu S. Oh, Ph.D. Assistant Professor
BK21 Division of Human Life ScienceSeoul National University
On behalf of Jun Soo Kwon, M.D., Ph.D.(Clinical Neuroscience and Computational Neuroscience Unit)
Professor at BCS, Seoul National University WCU
BackgroundBackground
• Interests in brain function and connectivity have much grown up in recent decades.
• Synergic effects of Multi-modal/Multi-technique Imaging, which is useful– not only for assessing chronic patients– but also for detecting subtle changes in
• Ultra-high-risk (UHR) pathological subjects• Neuro-plasticity groups
Example of “High-risk” groupExample of “High-risk” groupin the course of schizophreniain the course of schizophrenia
Healthy↑
↓Severity of Symptoms
Basic Structures of BrainBasic Structures of Brain
– High-End: Stochastic Tractography and High High-End: Stochastic Tractography and High Angular Resolution Diffusion Imaging (DSI, QBI)Angular Resolution Diffusion Imaging (DSI, QBI)
Quantitative DTI analysis using Brodmann ROI-Quantitative DTI analysis using Brodmann ROI-based parcellation and tract parameterization based parcellation and tract parameterization
(Oh et al., Human Brain Mapping, in press)(Oh et al., Human Brain Mapping, in press)
Shape-based parameterization
(Oh et al., NeuroImage, 2007)(Oh et al., NeuroImage, 2007)
(Oh et al., Unpublished data)
Application in Drug-naïve
OCD patients
Application in UHR Schizophrenia
patients??
((Oh et al., in preparation)Oh et al., in preparation)
Functional imaging-based estimation Functional imaging-based estimation of functional activation and of functional activation and
connectivityconnectivity
(Oh et al., Annual Meeting of (Oh et al., Annual Meeting of Biol Psychiatry 2008)Biol Psychiatry 2008)
Deficits of early stage of auditory processing in UHRN1m and MMNm dipole moments may represent a vulnerability marker in evaluating the risk of transition to psychotic stage in UHR group.
Decreased desynchronization of alpha rhythm in UHR
Deficits of top-down inhibitory control
N1m MMNm
((Koh et al., Koh et al., Unpublished dataUnpublished data))
Resting-state fMRIResting-state fMRI
(Shin et al., Biol Psychiatry, in press)(Shin et al., Biol Psychiatry, in press)
Synergic Effects of Synergic Effects of Multi-modal/Multi-technique Multi-modal/Multi-technique