This is a collection of classifications of different groups of Pharmaceutical Drugs.
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►All anti-inflammatory drugs are divided into 2 groups: (a) Nonsteroid anti-inflammatory) drugs ; (b) Steroid anti-inflammatory drugs Nonsteroid anti-inflammatory drugs are classified according to chemical structure and anti-inflammatory activity.I group – preparations with strong anti-inflammatory activity A. Nonselective inhibitors of cyclooxygenase (COX) I. Acid derivatives 1) Derivatives of salicylic (ortho-oxybenzoic) acid Acetylsalicylic acid (Aspirin) Lysine acetylsalicylate Sodium salicilate Methyl salicylate 2) Pyrazolone derivatives Phenylbutazone 3) Derivatives of indole-acetic acid Indomethacin Sulindac Derivatives of phenylacetic acid Diclofenac Sodium (Voltaren) Derivatives of propionic acid Ibuprofen Ketoptofen Naproxen Derivatives of anthranylic acid Mefenamic acid Oxicam derivatives Piroxicam Tenoxicam Lornoxicam II. Non-acidic derivatives B. Preferential inhibitors of COX2 Meloxicam Nimesulide Nabumetone C. Selective inhibitors of COX2 Celecoxib Rofecoxib
II group – preparations with poor anti-inflammatory activity Pyrazolone derivative Metamizol Paraaminophenol derivatives Paracetamol (Acetaminophen) Preparations of other chemical structure- Ketorolac
► Antihistaminic drugs – blockers of H1-histaminic receptors: Drugs of the first generation (”old”): Diphenhydramine (Dimedrol) Promethazine (Diprazine, Pipolphen) Chloropyramine (Suprastin) Clemastine (Tavegyl) Phencarol Mebhydroline (Diazoline) Antihistamines of the second generation: Loratadine (Claritine, Clarotadin) Acrivastine (Semprex) Azelastine Cetirizine (Zyrtec) Ebastine (Kestine) Desloratadine (Aerius) Fexofenadine (Telfast) Inhibitors of mast cell and basophile degranulation: for internal use – Ketotifen for inhalation: Cromoglicic acid (Intal) Nedocromil (Tilade) combined drugs (cromoglicic acid +fenoterol = Ditec) for local use: Cromoglicic acid (Ifiral) Cromohexal Others drugs with antiallergic action: glucocorticoids antileukotriene drugs: - lipoxygenase blockers: zileuton - blockers of leukotriene receptors: zafirlukast, montelukast
►Classification of analgesics,I. Narcotic analgesicsII. Non-narcotic analgesics1. Narcotic analgesics containing alkaloids of opium. Among these are Morphine and Codeine.
1. Synthetic narcotic analgesics. Trimeperidine (Promedol) Fentanyl Piritramide Pentazocine Tramadol ButorphanolClassification of narcotic analgesics according to their action on different
types of opioid receptors.
A. Full agonists of opioid receptors. They stimulate all types of opioid receptors. Among these are Morphine, Trimeperidine, Fentanyl.
B. Partial agonists of opioid receptors. The drugs are also called agonists-antagonists because they stimulate some types of opioid receptors and block others. Among these are:
Pentazocine Butorphanol Nalbuphine Buprenorphine PiritramideC. Narcotic analgesics with a mixed mechanism of action. For
example,Tramadol.
2.Non-narcotic analgesics of different chemical groups.The main non-narcotic analgesics are nonsteroidal anti-inflammatory drugs (NSAID).
Nitrendipine, Nimodipine, Lacidipine5. Potassium channel opener - NicorandilII. Drugs increasing oxygen delivery to the myocardium:
They are less effective and so less popular and used rare.
1. Validol – the drug of reflex action, it is used for relief of angina pectoris symptoms
2. 2- adrenoceptor agonists: β Oxyphedrine3. Inhibitors of phosphodiesterase4. Coronary vasodilating drugs with adenosine mechanism of action. They increase adenosine concentration in the myocardium, dilate collateral vessels – Dipyridamole
III. Inhibitors of platelet aggregation - Aspirin (acetylsalicylic acid) in small doses – up to 100 mg in a day
They more influence on artery tone then on myocardium.
2) Benzothiazepine derivatives DiltiazemEqual influence both artery and myocardium.
3) Phenylalkylamine derivatives
VerapamilInfluence on myocardium is greater then on arteries. So it is used in
arrhythmia and coronary heart disease.
According to generation
Generation 1(short term action)
Nifedipine Nicardipine Diltiazem Verapamil
Generation 2(prolonged forms of preparations of generation I, retard-forms or new compounds with long time of action)
Isradipine Nimodipine
Generation III
Amlodipine • Lacidipine
Antihypotensive drugs.
Hypotension (low blood pressure) can be acute and chronic. Acute hypotension is observed in collapse, shock and faint. Chronic hypotension is characterized by permanent low arterial blood pressure. For the treatment of hypotension depending on its cause the following groups of preparations are used.
1. Vasoconstrictive agents:
a) Agonists of angiotensin II
Angiotensinamide (synthetic analogue of endogenous angiotensinamide).
It is manufactured in the form of powder in vials. It is dissolved ex tempore and administered intravenously. Angiotensinamide has short-time but vigourous action.
b) Adrenoceptor agonists (mainly - adrenoceptor agonists)α
4. General tonic (general stimulants) – they increase a tone of CNS.
Ginseng Aralia Devil's-club SchizandraTinctures from the plants are used in chronic hypotension conditions.
5. If hypotension is due to loss of blood then preparations increasing volume of blood circulation - plasma-substituting solutions, colloid solutions, crystalloid solutions (salt solutions).
Classification of antiarrhythmic drugs, their groups and preparations.
I. Drugs blocking ion channels of cardiac hystiocytes (conducting system of heart and contractile myocardium)
1. Drugs blocking sodium channels (membrane stabilizers; group IA)
Subgroup IA (quinidine and quinidine like drugs):
Quinidine sulfate Disopyramide
Procainamide Ajmaline
Subgroup IB:
Lidocain Phenytoin
Subgroup IC:
Flecainide Propafenone Ethmosine Ethacizine
2. Drugs blocking L-type of calcium channels (group IV)
Verapamil Diltiazem
3. Drugs blocking potassium channels (drugs increasing repolarization duration and action potential; group III)
Amiodaron (Cordaron) Ornid Sotalol
II. Drugs mainly influencing on receptors of heart efferent innervation
Drugs weakening adrenergic influences:
- adrenergic blockersβ
Anaprilin and etc.
Drugs increasing adrenergic influences:
- adrenergic agonistsβ
Isoprenaline
sympathomimetics
Ephedrine
Drugs weakening cholinergic influences:
muscarinic receptor blocker
Atropine sulfate
III. Different drugs having antiarrhythmic activity
Potassium and magnesium drugs Cardiac glycosides Adenosine
Antiarrhythmic drugs are also classified into following groups:
A. Drugs used in tachyarrhythmia and extrasystoles Drugs blocking sodium channels Drugs blocking calcium channels Drugs blocking potassium channels - adrenergic blockersβ Cardiac glycosides (digitalis drugs) Adenosine Potassium and magnesium drugs B. Drugs used in bradyarrhythmia and conduction abnormality Muscarinic receptor blocker - adrenergic agonistsβ
4. Drugs of the 4th generation: Moxifloxacin Clinafloxacin Gatifloxacin Trovafloxacin (3F)
1. Classification of antituberculous drugs (groups and medicines).According to their chemical structure antituberculous drugs can be divided into:
I. Antituberculous antibiotics: Rifampicin Rifabutin Capreomycin Cycloserine Streptomycin Kanamycin AmikacinII. Hydrazides of isonicotinic acid: Isoniazid Metazide Opiniazide FtivazideIII. Derivatives of para-aminosalicylic acid: Para-aminosalicylic acidIV. Synthetic drugs with other chemical structure: Pyrazinamide Ethionamide Ethambutol ThiacetazoneV. Fluoroquinolones: Lomefloxacin Ciprofloxacin
OfloxacinVI Macrolides :
Clarithromycin Azithromycin
According to their clinical utility antituberculous drugs can be divided into:
I. Drugs of first line: These drugs have high antitubercular efficacy as well as low toxicity; are used routinely
Streptomycin Rifampicin Isoniazid Ethambutol PyrazinamideII. Drugs of second line: These drugs have either low antitubercular efficacy or high toxicity or both; are used in special circumstances only.
According to localization of amoebas, antiamoebic drugs can be divided into:
A. Antiamoebic drugs (amoebicides) used for the treatment of intestinal and extraintestinal amoebiasis.
Metronidazole Tinidazole Ornidazole
B. Amoebicides (with direct action) which are effective against amoebas localized within lumen of the large intestine.
Chiniofon Iodoquinol
C. Amoebicides (with indirect action) which are effective against amoebas localized within lumen of the large intestine and in intestinal wall.
TetracyclinesD. Tissue amoebicides acting on amoebas localized in intestinal wall and in the liver.
Emetine Dehydroemetine
E. Tissue amoebicides effective against amoebas localized in the liver.
Chloroquine
Classification of antihelmintic drugs:
Antihelmintic drugs can be classified into:I. Drugs used for the treatment of intestinal helminthiasises.1. Drugs used for the treatment of intestinal nematodosises
Actinomycins: Dactinomycin Anthracyclines: Rubomycin, Doxorubicin, Carminomycin Phleomycins: Bleomycin Drugs with other chemical structure: Olivomycin, Mitomycin,
RufocromomycinIV. Vegetable antineoplastic drugs:
Vinca alkaloids: Vincristine, Vinblastine Taxanes (alkaloids of Western yew tree): Paclitaxel, Docetaxel Epipodophyllotoxin: Etoposide, Tenyposide Alkaloids of showy autumn crocus: Colchamine, Colchicine
Derivatives of purine alkaloids (caffeine, theobromine) increase cerebral blood flow. From this drug group Pentoxyphylline (Agapurin, Trental) is used now for stroke treatment. It takes moderate vasodilating action, decreases platelet aggregation, increases erythrocyte membrane elasticity and improves microcirculation. The vasodilating effect is due to the adenosine receptor block. Besides the drug inhibits phosphodiesterase and increases the cyclic adenosine monophosphate contents in platelets. Pentoxyphylline is also used in peripheral circulation disorders, diabetic angiopathy, eye blood flow disorders. Adverse effects include dyspepsia, dizziness, redness.
Classification of drugs influencing tone and contractions of myometrium
A. AGENTS INCREASING STRENGTH AND FREQUENCY OF RHYTHMIC CONTRACTION OF UTERUS (DELIVERY STIMULATING)