Jul 12, 2015
The circadian clock plays a role not just
in sleep wake cycles but also in the
regulation of metabolic systems.
circadian misalignment
Circadian misalignment has been linked
to a number of negative health
problems.
Individuals who work night shifts suffer
severe circadian misalignment
Impaired glucose tolerance and
circadian misalignment
Animal experiments
Circadian misalignment impaired energy metabolism
Type 2 diabetes (T2D) & bed times
Evening types & breakfast skipping
Social Jetlag
BMI & social jetlag
AIMS:
To investigate if chronotype is
independently associated with
Glycaemic control in T2D
Examine the relationship between daily
calorific intake and Glycaemic control
194 Adults TD2
Height, Weight, medications & HbA1c levels
PSQI, MSF, Berlin questionnaire &CES-D
Midsleep time weekdays
Midsleep time freedays
= Social Jetlag
Table 2: Chronotype and Glycaemic Control
HbA1c levels tended to be higher in
those with social jetlag >30mins though
was not significant
There was a small positive correlation
between dinner calorie intake and
HbA1c levels (r = 0.26, p= <.0001)
There was a medium positive correlation
between chronotype and Glycaemic
control (r = 0.34, p<.0001)
Multiple regression was carried out – controlling for
gender, race, BMI, insulin use, diabetic
complications & perceived sleep debt.
Results indicated that chronotype was
independently associated with Glycaemic control
(B = .025, p=000.1)
For each hour delay in MSF there was a 2.5%
increase in HbA1c levels
Both MSF and calorific intake at dinnertime were
significantly associated with HbA1c levels.
Chronotype is associated with Glycaemic control in T2D
This association is independent of sleep debt, perceived sleep debt and poor sleep quality
Results also indicated that later chronotypeswere found to be both significantly younger and report more depressive symptoms