Chromosome Geography Lecture

Chromosome Geography LectureChromosome Geography Lecture

The Chromosome as a Polymer BlobThe Chromosome as a Polymer Blob

b=2P

Chromosome Geography @ CaltechChromosome Geography @ Caltech

Sturtevant and Morgan Benzer

Chromosome Geography: Genomic vs. Chromosome Geography: Genomic vs.

physical positionphysical position

Cremer and CremerLucy Shapiro

Fluorescence In-Situ Hybridization Fluorescence In-Situ Hybridization

(FISH)(FISH)

http://www.microscopyu.com/articles/fluorescence/insitu/brennerinsitu.html

Schemes for Mapping Chromosome Schemes for Mapping Chromosome

GeographyGeography

Gitai et al, 2005

Yokota et al, 1995

Quantifying the GeographyQuantifying the Geography

Gasser, Science 2002

Quantifying the GeographyQuantifying the Geography

Heun, Gasser, Science 2001 Bystricky, Gasser, PNAS 2004

Quantifying the GeographyQuantifying the Geography

Sachs et al.

The Immune SystemThe Immune System

The Immune SystemThe Immune System

Kees Murre, UCSD

oriCI

oriCII

xy

Pro

babili

ty

Pro

babili

ty

x

y

Replication origins are confined!(Theriot et al.)

Chromosome Geography in VibrioChromosome Geography in Vibrio

Models for Chromosome SegregationModels for Chromosome Segregation

Gitai et al, 2005