Christina Leslie, Lonnie Welch, Chairs Gustavo Stolovitzky, Chair Andrea Califano, Chair Steven Leard, Chris Williams Manolis Kellis, Chair Alex Pico,

Christina Leslie, Lonnie Welch, Chairs

Gustavo Stolovitzky, Chair

DREAM CHALLENGES

PROGRAM COMMITTEEAndrea Califano, Chair

SYSTEMS BIOLOGY

MEETING LOGISTICSSteven Leard, Chris WilliamsManolis Kellis, Chair

REGULATORY GENOMICS

Alex Pico, Barry Demchak, Trey Ideker

CYTOSCAPE WORKSHOPS

13 Keynote Speakers

63 Oral communications

152 Posters

4 Workshops (2 Cytoscape + 2 DREAM)

DREAM: 368 challenge submissions

RECOMB/ISCB CONFERENCE ON REGULATORY AND SYSTEMS

GENOMICS WITH DREAM CHALLENGES & CYTOSCAPE

UPDATES ON DREAM DURING 2014

A Dialogue on Reverse Engineering Assessment and Methods

8.5 + 9

GOING FRACTIONALGreat demand from colleagues wishing to share their data challenges led us to organize winter (n+0.5) and spring challenges (n+1)

WORKING WITH THE COMMUNITYDREAM was a component of several grants funded in 2014

U54 NIH LINCS Program: • Harvard Medical School: Pharmaco Response Signatures and Disease

Mechanism• OHSU: Extrinsic Perturbations of Cell Physiology and Associated

Regulatory Networks

U54 DCIC:• ISMMS: Data Coordination and Integration Center for LINCS-BD2K

Canada NSERC• Cancer Genome Collaboratory (the Somatic Mutation Challenges)

R21:• Univ of Notre Dame: Transcript networks and crowdsourcing to predict

drug combinations in malaria parasites

And we are also involved in several other submitted grants

WORKING WITH THE COMMUNITY

• We organized the first DREAM Hackathon for the AML Challenge at Rice University

• Organized over 15 Webinars

• Two community phases following the competitive phase

DREAM 8.5 and 9 exceeded previous participation

All the data is/will be available in Synapse

www.synapse.org

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DREAM 8.5 & 9 BY THE NUMBERS

Challenges DREAM 8.5 + 9

Registered Users

Leader board

Forum Entries

Unique Submissions

Unique Teams

SMC 360 1094 120 173 50

RA 369 4914 52 32 21

AD 520 1972 80 43 24

AML 231 583 184 72 42

GEP 300 2896 233 48 22

Total 1780 11459 669 368 159

DREAM CHALLENGES AND SAGE BIONETWORKS

Our association has led to a very productive year

Feb 2013

Come to the Workshop Tuesday at 6:45PM (pizza & drinks on us)

Synapse: collaborative platform for DREAM Challenges and much more

SYNAPSE IS ENHANCING ITS CHALLENGE HOSTING CAPABILITYIES

http://dreamchallenges.org/

Announcing New DREAM Website

2014 DREAM PUBLICATIONSNCI - DREAM Drug Sensitivity Prediction Challenge (Jun 2014)

NCI - DREAM Drug Synergy Prediction Challenge (Dec 2014)

2014 DREAM PUBLICATIONSDREAM 7 - ALS Progression Prediction Challenge (Nov 2014)

DREAM6+7: Net Inf & Param Estimation Challenge (Feb 2014)

2014 DREAM PUBLICATIONS

DREAM 9.5 AND 9 COMING UP

We are organizing several Challenges that we will discuss later today (more info in dreamchallenges.org)

DREAM 9.5 (this winter) ICGC-TCGA DREAM SMC Challenges: RNA and

heterogeneity DREAM Olfaction prediction Challenge Prostate Cancer Challenge

DREAM10 (work in progress, next spring) ALS Stratification Challenge (Indiegogo campaign) Drug Synergy Prediction Challenge Digital Mammography Challenge

Thanks: Conference Sponsors and Journals

Challenge Organizers

Too many thanks to express…

The 159 teams that participated

and

Thea Norman!

HOUSE KEEPING ANNOUNCEMENTS

• There is a crew making a short video on DREAM. Let us know if you don’t want to appear in it.

• There is a board for posting information, jobs, etc. Take a look (I am looking for a post-doc).

• There will be a workshop at 6:00PM today, and another at 6:45PM tomorrow. Please write your name in the sheets that are going around to know how many pizzas and beer to order!

DREAM FRIDAY MORNING SESSION