Cholesteatoma Cholesteatoma University of Texas Medical University of Texas Medical Branch Branch Department of Otolaryngology Department of Otolaryngology Garrett Hauptman MD Garrett Hauptman MD Tomoko Makishima MD Tomoko Makishima MD January 25, 2006 January 25, 2006
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CholesteatomaCholesteatomaUniversity of Texas Medical University of Texas Medical
BranchBranch
Department of OtolaryngologyDepartment of Otolaryngology
Garrett Hauptman MDGarrett Hauptman MD
Tomoko Makishima MDTomoko Makishima MD
January 25, 2006January 25, 2006
OverviewOverview
DefinitionDefinition Classification and TheoriesClassification and Theories Anatomic ConsiderationsAnatomic Considerations Patient EvaluationPatient Evaluation ManagementManagement ComplicationsComplications
DefinitionDefinition
CholesteatomaCholesteatoma
Named by Johannes Mueller in 1838Named by Johannes Mueller in 1838 Erroneous belief that one of the primary Erroneous belief that one of the primary
components of the tumor was fatcomponents of the tumor was fat ““a pearly tumor of fat…among sheets of a pearly tumor of fat…among sheets of
polyhedral cells”polyhedral cells” More appropriate name has been More appropriate name has been
suggested to be keratoma to suggested to be keratoma to describe tumor compositiondescribe tumor composition
CholesteatomaCholesteatoma Expanding lesion of the temporal bone composed ofExpanding lesion of the temporal bone composed of
Cystic content: desquamated keratin centerCystic content: desquamated keratin center Matrix: keratinizing stratified squamous epitheliumMatrix: keratinizing stratified squamous epithelium Perimatrix: granulation tissue that secretes Perimatrix: granulation tissue that secretes
multiple proteolytic enzymes capable of bone multiple proteolytic enzymes capable of bone destructiondestruction
May develop anywhere within pneumatized May develop anywhere within pneumatized portions of the temporal boneportions of the temporal bone
Most frequent locations:Middle ear space
Mastoid
Classification Classification and Theoriesand Theories
Definition (Levenson, 1989)Definition (Levenson, 1989) White mass medial to normal tympanic White mass medial to normal tympanic
membranemembrane Normal pars flaccida and pars tensaNormal pars flaccida and pars tensa No prior history of otorrhea or No prior history of otorrhea or
perforationsperforations No prior otologic proceduresNo prior otologic procedures Prior bouts of otitis media were not Prior bouts of otitis media were not
grounds for exclusion as was the case in grounds for exclusion as was the case in original definition original definition
Congenital Congenital CholesteatomaCholesteatoma
Pathogenesis theoriesPathogenesis theories Failure of involution of ectodermal Failure of involution of ectodermal
epithelial thickening that is present epithelial thickening that is present during fetal development in proximity during fetal development in proximity to geniculate ganglion to geniculate ganglion
Metaplasia of the middle ear mucosaMetaplasia of the middle ear mucosa
Congenital Congenital CholesteatomaCholesteatoma
Anterosuperior Anterosuperior quadrantquadrant
> Posterosuperior quadrant
Congenital Congenital CholesteatomaCholesteatoma
Large congenital cholesteatomaLarge congenital cholesteatoma
ossicular erosion
cholesteatoma
Acquired CholesteatomasAcquired Cholesteatomas
Common factor: keratinizing Common factor: keratinizing squamous epithelium has grown squamous epithelium has grown beyond its normal limits beyond its normal limits
Ultimately form due to underlying Ultimately form due to underlying Eustachian tube dysfunction that causes Eustachian tube dysfunction that causes retraction of pars flaccidaretraction of pars flaccida Results in poor aeration of epitympanic space Results in poor aeration of epitympanic space
which draws pars flaccida medially on top of which draws pars flaccida medially on top of malleus neck, forming retraction pocketmalleus neck, forming retraction pocket
Normal migratory pattern of the tympanic Normal migratory pattern of the tympanic membrane epithelium altered by retraction membrane epithelium altered by retraction pocketpocket
Enhances potential accumulation of keratinEnhances potential accumulation of keratin
Secondary Acquired Secondary Acquired CholesteatomasCholesteatomas Implantation theoryImplantation theory
Squamous epithelium implanted in the middle ear as a Squamous epithelium implanted in the middle ear as a result of surgery, foreign body, blast injury, etc.result of surgery, foreign body, blast injury, etc.
Metaplasia theoryMetaplasia theory Desquamated epithelium is transformed to keratinized Desquamated epithelium is transformed to keratinized
stratified squamous epithelium secondary to chronic or stratified squamous epithelium secondary to chronic or recurrent otitis mediarecurrent otitis media
Epithelial invasion theory Epithelial invasion theory Squamous epithelium migrates along perforation edge Squamous epithelium migrates along perforation edge
medially along undersurface of tympanic membrane medially along undersurface of tympanic membrane destroying the columnar epitheliumdestroying the columnar epithelium
Papillary ingrowth theoryPapillary ingrowth theory Inflammatory reaction in Prussack’s space with an intact Inflammatory reaction in Prussack’s space with an intact
pars flaccida (likely secondary to poor ventilation) may pars flaccida (likely secondary to poor ventilation) may cause break in basal membrane allowing cord of epithelial cause break in basal membrane allowing cord of epithelial cells to start inward proliferationcells to start inward proliferation
AnatomyAnatomy
Middle Ear RegionsMiddle Ear Regions
Named based on position relative to Named based on position relative to superior and inferior aspect of superior and inferior aspect of external auditory canal (EAC)external auditory canal (EAC) Epitympanum: superior to superior limit Epitympanum: superior to superior limit
of EACof EAC Mesotympanum: bound superiorly by Mesotympanum: bound superiorly by
superior limit of EAC and inferiorly by superior limit of EAC and inferiorly by inferior limit of EACinferior limit of EAC
Hypotympanum: inferior to inferior limit Hypotympanum: inferior to inferior limit of EACof EAC
Middle Ear RegionsMiddle Ear Regions
EpitympanumEpitympanum
Lies above the level of the short Lies above the level of the short process of the malleusprocess of the malleus
Contents:Contents: Head of the malleusHead of the malleus Body of the incusBody of the incus Associated ligaments and mucosal foldsAssociated ligaments and mucosal folds
MesotympanumMesotympanum Contents: Contents:
StapesStapes Long process of the incusLong process of the incus Handle of the malleusHandle of the malleus Oval and round windowsOval and round windows
Eustachian tube exits from the anterior aspectEustachian tube exits from the anterior aspect Two recesses extend posteriorly that are often not Two recesses extend posteriorly that are often not
Lateral to facial nerveLateral to facial nerve Bounded by the fossa incudis superiorly Bounded by the fossa incudis superiorly Bounded by the chorda tympani nerve laterallyBounded by the chorda tympani nerve laterally
Sinus tympaniSinus tympani Lies between the facial nerve and the medial wall of the Lies between the facial nerve and the medial wall of the
mesotympanummesotympanum
HypotympanumHypotympanum
Lies inferior and medial to the floor Lies inferior and medial to the floor of the bony ear canalof the bony ear canal
Irregular bony groove that is seldom Irregular bony groove that is seldom involved by cholesteatoma involved by cholesteatoma
Anatomic ConsiderationsAnatomic Considerations
Annular ligament sends fibrous bands from Annular ligament sends fibrous bands from anterior and posterior tympanic spines that anterior and posterior tympanic spines that meet at neck of malleus and make up middle meet at neck of malleus and make up middle layer of pars tensalayer of pars tensa
Dehiscent area in the tympanic bone (Notch of Dehiscent area in the tympanic bone (Notch of Rivinus) lies above fibrous bandsRivinus) lies above fibrous bands
Dense fibers that form middle layer of pars Dense fibers that form middle layer of pars tensa do not extend to pars flaccidatensa do not extend to pars flaccida Lack of structural support predisposes Shrapnell’s Lack of structural support predisposes Shrapnell’s
membrane to retract when negative middle ear membrane to retract when negative middle ear pressure is present secondary to Eustachian tube pressure is present secondary to Eustachian tube dysfunction dysfunction
Anatomic ConsiderationsAnatomic Considerations
Cholesteatomas of Cholesteatomas of epitympanum start epitympanum start in Prussack’s in Prussack’s space between space between pars flaccida and pars flaccida and neck of malleus neck of malleus with upper with upper boundary being boundary being the lateral mallear the lateral mallear fold fold
Cholesteatoma SpreadCholesteatoma Spread
Predictable in that they are Predictable in that they are channeled along characteristic channeled along characteristic pathways by:pathways by: LigamentsLigaments FoldsFolds Ossicles Ossicles
Common Sites of Common Sites of Cholesteatoma OriginCholesteatoma Origin
Posterior Posterior epitympanumepitympanum
Posterior Posterior mesotympanummesotympanum
Anterior Anterior epitympanumepitympanum
Cholesteatoma SpreadCholesteatoma Spread
Posterior epitympanic cholesteatoma Posterior epitympanic cholesteatoma passing through superior incudal space passing through superior incudal space and aditus ad antrumand aditus ad antrum
Cholesteatoma SpreadCholesteatoma Spread
Posterior mesotympanic cholesteatoma Posterior mesotympanic cholesteatoma invading the sinus tympani and facial invading the sinus tympani and facial recessrecess
Cholesteatoma SpreadCholesteatoma Spread
Anterior epitympanic cholesteatoma with Anterior epitympanic cholesteatoma with extension to geniculate ganglionextension to geniculate ganglion
Detailed otologic history Detailed otologic history Hearing lossHearing loss OtorrheaOtorrhea OtalgiaOtalgia Nasal obstructionNasal obstruction TinnitusTinnitus VertigoVertigo
Previous history of middle ear diseasePrevious history of middle ear disease Chronic otitis media Chronic otitis media Tympanic membrane perforationTympanic membrane perforation Prior surgeryPrior surgery
Patient EvaluationPatient Evaluation Head and neck examinationHead and neck examination Otologic examination Otologic examination
Otomicroscopy is essential in evaluating the Otomicroscopy is essential in evaluating the extent of diseaseextent of disease
Clean ear thoroughly of otorrhea and debris Clean ear thoroughly of otorrhea and debris with cotton-tipped applicators or suctionwith cotton-tipped applicators or suction
Culture wet, infected ears and treat with topical Culture wet, infected ears and treat with topical and/or oral antibioticsand/or oral antibiotics
Pneumatic otoscopy should be performed in Pneumatic otoscopy should be performed in every patient with cholesteatomaevery patient with cholesteatoma
Positive fistula (pneumatic otoscopy will result in Positive fistula (pneumatic otoscopy will result in nystagmus and vertigo) response suggests erosion of nystagmus and vertigo) response suggests erosion of the semicircular canals or cochleathe semicircular canals or cochlea
Patient EvaluationPatient Evaluation
Hearing evaluation to assess for conductive Hearing evaluation to assess for conductive hearing losshearing loss Pure tone audiometry with air and bone Pure tone audiometry with air and bone
conductionconduction Speech reception thresholdsSpeech reception thresholds Word recognition Word recognition
512Hz tuning fork exam512Hz tuning fork exam Always correlate with audiometry resultsAlways correlate with audiometry results
TympanometryTympanometry May suggest decreased compliance or TM May suggest decreased compliance or TM
perforationperforation
Patient EvaluationPatient Evaluation
Degree of conductive loss will vary Degree of conductive loss will vary considerably depending on the extent of considerably depending on the extent of diseasedisease Moderate conductive deficit in excess of 40 Moderate conductive deficit in excess of 40
dB indicates ossicular discontinuitydB indicates ossicular discontinuity Usually from erosion of the long process of the Usually from erosion of the long process of the
incus or capitulum of the stapesincus or capitulum of the stapes Mild conductive deafness may be present Mild conductive deafness may be present
with extensive disease if cholesteatoma sac with extensive disease if cholesteatoma sac transmits sound directly to stapes or transmits sound directly to stapes or footplate footplate
Patient EvaluationPatient Evaluation
Preoperative imaging with computed Preoperative imaging with computed tomographies (CTs) of temporal tomographies (CTs) of temporal bones (2mm -section without bones (2mm -section without contrast in axial and coronal planes) contrast in axial and coronal planes) Allows for evaluation of anatomyAllows for evaluation of anatomy May reveal evidence of the extent of the May reveal evidence of the extent of the
disease disease Screen for asymptomatic complicationsScreen for asymptomatic complications
Patient EvaluationPatient Evaluation
CT is not essential for preoperative CT is not essential for preoperative evaluationevaluation
Should be obtained for:Should be obtained for: Revision cases due to altered landmarks from Revision cases due to altered landmarks from
previous surgeryprevious surgery Chronic suppurative otitis mediaChronic suppurative otitis media Suspected congenital abnormalitiesSuspected congenital abnormalities Cases of cholesteatoma in which sensorineural Cases of cholesteatoma in which sensorineural
hearing loss, vestibular symptoms, or other hearing loss, vestibular symptoms, or other complication evidence exists complication evidence exists
Patient EvaluationPatient Evaluation Preoperative counseling is an absolute Preoperative counseling is an absolute
necessity prior to surgerynecessity prior to surgery Primary objective of surgery is a safe dry Primary objective of surgery is a safe dry
ear which is accomplished by:ear which is accomplished by: Treating all supervening complicationsTreating all supervening complications Removing diseased bone, mucosa, Removing diseased bone, mucosa,
granulation polyps, and cholesteatomagranulation polyps, and cholesteatoma Preserving as much normal anatomy as Preserving as much normal anatomy as
possiblepossible Improvement of hearing is a secondary Improvement of hearing is a secondary
goalgoal
Patient EvaluationPatient Evaluation
Possible adverse outcomes must be Possible adverse outcomes must be discusseddiscussed Facial paralysisFacial paralysis VertigoVertigo Further hearing lossFurther hearing loss TinnitusTinnitus
Patient should understand that long-Patient should understand that long-term follow-up will be necessary and term follow-up will be necessary and that they may need additional surgeries that they may need additional surgeries
Cholesteatoma Cholesteatoma ManagementManagement
Preventative Preventative ManagementManagement
Tympanostomy tube for early retraction Tympanostomy tube for early retraction pocketspockets
Surgical exploration for retraction Surgical exploration for retraction persistencepersistence
Cholesteatoma Cholesteatoma ManagementManagement
Treated surgically with primary goal Treated surgically with primary goal of total eradication of cholesteatoma of total eradication of cholesteatoma to obtain a safe and dry earto obtain a safe and dry ear
Patients with unacceptable risk of Patients with unacceptable risk of anesthesia need local careanesthesia need local care
Prior to the advent of the tympanoplasty, Prior to the advent of the tympanoplasty, all cholesteatoma surgery was performed all cholesteatoma surgery was performed using CWD approachusing CWD approach
Procedure involves:Procedure involves: Taking down posterior canal wall to level of Taking down posterior canal wall to level of
vertical facial nerve vertical facial nerve Exteriorizing the mastoid into external Exteriorizing the mastoid into external
auditory canalauditory canal Epitympanum is obliterated with removal Epitympanum is obliterated with removal
of scutum, head of malleus and incusof scutum, head of malleus and incus
Canal-Wall-DownCanal-Wall-Down
Classic CWD operation is the modified radical Classic CWD operation is the modified radical mastoidectomy in which middle ear space is mastoidectomy in which middle ear space is preservedpreserved
Radical mastoidectomy is CWD operation in Radical mastoidectomy is CWD operation in which:which: Middle ear space is eliminatedMiddle ear space is eliminated Eustachian tube is plugged Eustachian tube is plugged
Meatoplasty should be large enough to allow Meatoplasty should be large enough to allow good aeration of mastoid cavity and permit good aeration of mastoid cavity and permit easy visualization to facilitate postoperative easy visualization to facilitate postoperative care and self cleaning care and self cleaning
Canal-Wall-DownCanal-Wall-Down
Indications for CWD approach:Indications for CWD approach: Cholesteatoma in an only hearing earCholesteatoma in an only hearing ear Significant erosion of the posterior bony canal Significant erosion of the posterior bony canal
wallwall History of vertigo suggesting a labyrinthine History of vertigo suggesting a labyrinthine
fistulafistula Recurrent cholesteatoma after canal-wall-up Recurrent cholesteatoma after canal-wall-up
surgerysurgery Poor eustachian tube functionPoor eustachian tube function Sclerotic mastoid with limited access to Sclerotic mastoid with limited access to
epitympanumepitympanum
Canal-Wall-DownCanal-Wall-Down
Advantages:Advantages: Residual disease is easily detectedResidual disease is easily detected Recurrent disease is rareRecurrent disease is rare Facial recess is exteriorizedFacial recess is exteriorized
Disadvantages:Disadvantages: Open cavity created Open cavity created
Takes longer to healTakes longer to heal Mastoid bowl maintenance can be a lifelong Mastoid bowl maintenance can be a lifelong
problemproblem Shallow middle ear space makes OCR difficultShallow middle ear space makes OCR difficult Dry ear precautions are essential Dry ear precautions are essential
Canal-Wall-DownCanal-Wall-Down
Canal-Wall-DownCanal-Wall-Down
Canal-Wall-DownCanal-Wall-Down
Canal-Wall-DownCanal-Wall-Down
Canal-Wall-DownCanal-Wall-Down
Canal-Wall-UpCanal-Wall-Up CWU procedure developed to avoid problems CWU procedure developed to avoid problems
and maintenance necessary with CWD and maintenance necessary with CWD proceduresprocedures
CWU consists of preservation of posterior bony CWU consists of preservation of posterior bony external auditory canal wall during simple external auditory canal wall during simple mastoidectomy with or without a posterior mastoidectomy with or without a posterior tympanotomytympanotomy
Staged procedure often necessary with a Staged procedure often necessary with a scheduled second look operation at 6 to 18 scheduled second look operation at 6 to 18 months for:months for: Removal of residual cholesteatomaRemoval of residual cholesteatoma Ossicular chain reconstruction if necessaryOssicular chain reconstruction if necessary
Procedure should be adapted to extent of Procedure should be adapted to extent of disease as well as skill of otologistdisease as well as skill of otologist
Canal-Wall-UpCanal-Wall-Up
CWU may be indicated in patients CWU may be indicated in patients with large pneumatized mastoid and with large pneumatized mastoid and well aerated middle ear spacewell aerated middle ear space Suggests good eustachian tube functionSuggests good eustachian tube function
CWU procedures are contraindicated CWU procedures are contraindicated in:in: Only hearing earOnly hearing ear Patients with labyrinthine fistulaPatients with labyrinthine fistula Long-standing ear diseaseLong-standing ear disease Poor eustachian tube functionPoor eustachian tube function
Canal-Wall-UpCanal-Wall-Up Advantages:Advantages:
Rapid healing timeRapid healing time Easier long-term careEasier long-term care Hearing aids easier to fitHearing aids easier to fit No water precautionsNo water precautions
Disadvantages:Disadvantages: Technically more difficultTechnically more difficult Staged operation often necessaryStaged operation often necessary Recurrent disease possibleRecurrent disease possible Residual disease harder to detectResidual disease harder to detect
Indicated for limited cholesteatoma Indicated for limited cholesteatoma involving middle ear, ossicular involving middle ear, ossicular chain, and epitympanumchain, and epitympanum
If extent of the cholesteatoma is If extent of the cholesteatoma is unknown approach can be combined unknown approach can be combined with CWU mastoidectomy or with CWU mastoidectomy or extended to CWD procedureextended to CWD procedure
Procedure involves:Procedure involves: Elevation of tympanomeatal flap via Elevation of tympanomeatal flap via
endaural incision with removal of scutum endaural incision with removal of scutum to limits of the cholesteatomato limits of the cholesteatoma
Aditus obliteration with muscle, fascia, Aditus obliteration with muscle, fascia, cartilage or bone prior to reconstruction of cartilage or bone prior to reconstruction of the middle ear spacethe middle ear space
Reconstruction of lateral attic wall with Reconstruction of lateral attic wall with bone or cartilage is optionalbone or cartilage is optional
May lead to retraction disease and possible May lead to retraction disease and possible recurrence in patients with poor eustachian recurrence in patients with poor eustachian tube function tube function
Useful for attic and mastoid cholesteatoma that Useful for attic and mastoid cholesteatoma that does not involve middle ear space and lateral to does not involve middle ear space and lateral to ossiclesossicles
Like modern modified radical mastoidectomy with Like modern modified radical mastoidectomy with exception that middle ear space is not entered exception that middle ear space is not entered
Mastoid should be poorly developed for creation Mastoid should be poorly developed for creation of a small cavityof a small cavity
Eustachian tube function should be adequate with Eustachian tube function should be adequate with intact pars tensa and aerated middle ear space.intact pars tensa and aerated middle ear space.
Rarely used todayRarely used today
Canal Wall StatusCanal Wall Status
In 2002 Shohet et. al. reports In 2002 Shohet et. al. reports recidivism rates with CWU as high as recidivism rates with CWU as high as Adults = 36%Adults = 36% Children = 67%Children = 67%
Approximately 30% of cases for Approximately 30% of cases for cholesteatoma will be CWDcholesteatoma will be CWD House Ear Institute 1982House Ear Institute 1982 St. Joseph’s Hospital in Phoenix, AZ 2003St. Joseph’s Hospital in Phoenix, AZ 2003
Canal Wall StatusCanal Wall Status
Syms et. al. examined surgical Syms et. al. examined surgical approach to manage cholesteatoma- approach to manage cholesteatoma- retrospective review of 486 cases in retrospective review of 486 cases in 20032003 68.5% CWU: 31.5% CWD68.5% CWU: 31.5% CWD CWU had “second look operation”CWU had “second look operation”
Residual cholesteatoma found in 26.9% Residual cholesteatoma found in 26.9% second proceduressecond procedures
Residual cholesteatoma found in 2.7% third Residual cholesteatoma found in 2.7% third proceduresprocedures
Canal Wall StatusCanal Wall Status
Kos et. al. examined long-term Kos et. al. examined long-term implications of CWD- retrospective implications of CWD- retrospective review in 2004review in 2004 259 cases with follow-up range of 1 to 259 cases with follow-up range of 1 to
24 years (mean = 7 years)24 years (mean = 7 years) Recurrent cholesteatoma in 6.1%Recurrent cholesteatoma in 6.1% TM perforation in 7.3%TM perforation in 7.3% Dry, self-cleaning ears in 95%Dry, self-cleaning ears in 95% Otorrhea in 5%Otorrhea in 5%
Improved in 30.7%Improved in 30.7% Unchanged in 41.3%Unchanged in 41.3% Decreased in 28%Decreased in 28%
Sensorineural hearing loss greater than Sensorineural hearing loss greater than 60dB in 2 patients60dB in 2 patients
Facial paralysis in 1 patientFacial paralysis in 1 patient Vertigo in 4 patientsVertigo in 4 patients
Novel TechniquesNovel Techniques
In 2005 Gantz et. al. reported 130 In 2005 Gantz et. al. reported 130 cases of canal wall reconstruction cases of canal wall reconstruction tympanomastoidectomy with mastoid tympanomastoidectomy with mastoid obliterationobliteration No evidence of recurrence = 98.5%No evidence of recurrence = 98.5% Recurrence treated with CWD (1.5%)Recurrence treated with CWD (1.5%) Second look ossiculoplasty in 78%Second look ossiculoplasty in 78% Post-operative wound infection was Post-operative wound infection was
14.3% for first 42 patients14.3% for first 42 patients Decreased rate to 4.5% in last 88 patients Decreased rate to 4.5% in last 88 patients
with 2 days of post-operative IV antibioticswith 2 days of post-operative IV antibiotics
Complete cortical mastoidectomy with opening Complete cortical mastoidectomy with opening of facial recess and removal of incus and malleus of facial recess and removal of incus and malleus headhead
Microsagittal saw used to cut posterior canal Microsagittal saw used to cut posterior canal wallwall
Cholesteatoma removedCholesteatoma removed Posterior canal wall bone replacedPosterior canal wall bone replaced
Cortical bone chips used to block attic and mastoid Cortical bone chips used to block attic and mastoid from tympanumfrom tympanum
Bone pate’ holds bone chips in placeBone pate’ holds bone chips in place
Novel TechniquesNovel Techniques
Novel TechniquesNovel Techniques
In 2005, Godinho et. al. reported 42 In 2005, Godinho et. al. reported 42 cases of Canal Wall Window (CWW) cases of Canal Wall Window (CWW) performed for pediatric cholesteatomaperformed for pediatric cholesteatoma CWW compared to CWU and CWDCWW compared to CWU and CWD
CWW converted to CWD in 14%CWW converted to CWD in 14% Dry ear resultsDry ear results
CWW = 94%, CWD = 92%, CWU = 90%CWW = 94%, CWD = 92%, CWU = 90% Recidivation rate at 1 yearRecidivation rate at 1 year
to CWU, rather than increased air-bone gap to CWU, rather than increased air-bone gap seen with CWDseen with CWD
Novel TechniquesNovel Techniques
CWW effective for posterior superior CWW effective for posterior superior cholesteatomacholesteatoma Increases visibilityIncreases visibility Conduit for instrument manipulationConduit for instrument manipulation
CWW techniqueCWW technique CWU mastoidectomy performedCWU mastoidectomy performed Lateral epitympanotomyLateral epitympanotomy Slit drilled from lateral cortex to medial Slit drilled from lateral cortex to medial
aspect of canal wall at annulusaspect of canal wall at annulus
Novel TechniquesNovel Techniques
Novel TechniquesNovel Techniques
CWW reconstructionCWW reconstruction Tragal cartilage placed in defect after Tragal cartilage placed in defect after
scoring proximal perichondrium and scoring proximal perichondrium and cartilagecartilage
Cortical bone graft may be used as an Cortical bone graft may be used as an alternativealternative
Novel TechniquesNovel Techniques
ComplicationsComplications
Cholesteatoma SequelaeCholesteatoma Sequelae InfectionInfection OtorrheaOtorrhea Bone destructionBone destruction Hearing lossHearing loss Facial nerve paresis or paralysisFacial nerve paresis or paralysis Labyrinthine fistulaLabyrinthine fistula Intracranial complications Intracranial complications
Complications are caused by expansion and infection
(30%)(30%) Erosion of lenticular process and/or stapes Erosion of lenticular process and/or stapes
superstructure may produce 50dB conductive hearing superstructure may produce 50dB conductive hearing loss loss
Hearing loss varies despite disease extent (natural Hearing loss varies despite disease extent (natural myringostapediopexy, transmission of sound through myringostapediopexy, transmission of sound through cholesteatoma sac)cholesteatoma sac)
Sensorineural hearing loss: involvement of Sensorineural hearing loss: involvement of labyrinthlabyrinth
Following surgery, 30% have further impairment Following surgery, 30% have further impairment due to:due to: Extent of disease present Extent of disease present Complications in healing processComplications in healing process
Labyrinthine FistulaLabyrinthine Fistula
Incidence: as high as 10% Incidence: as high as 10% Symptom: Sensorineural hearing loss and/or Symptom: Sensorineural hearing loss and/or
vertigo induced by noise or pressure changevertigo induced by noise or pressure change Common site: horizontal semicircular canal, Common site: horizontal semicircular canal,
basal turn of cochleabasal turn of cochlea Diagnosis: Fine cut temporal bone CT Diagnosis: Fine cut temporal bone CT
mastoidectomy with management of matrix mastoidectomy with management of matrix overlying fistulaoverlying fistula
Facial ParalysisFacial Paralysis May develop:May develop:
Acutely secondary to infection Acutely secondary to infection Slowly from chronic expansion of cholesteatomaSlowly from chronic expansion of cholesteatoma
Temporal bone CT: localize the nerve Temporal bone CT: localize the nerve involvementinvolvement
Most common site: geniculate ganglion due to Most common site: geniculate ganglion due to disease in the anterior epitympanumdisease in the anterior epitympanum
Management: Needs immediate surgeryManagement: Needs immediate surgery Removal of cholesteatoma and infected material with Removal of cholesteatoma and infected material with
decompression of the nerve (mastoidectomy, middle decompression of the nerve (mastoidectomy, middle fossa approach)fossa approach)
Administration of intravenous antibiotics and high-Administration of intravenous antibiotics and high-dose steroidsdose steroids
Iatrogenic injury to the nerve during surgery should Iatrogenic injury to the nerve during surgery should be immediately repaired with decompression of nerve be immediately repaired with decompression of nerve proximal and distal to site of injuryproximal and distal to site of injury
Management:Management: Presence of mental status changes with Presence of mental status changes with
nuchal rigidity or cranial neuropathies nuchal rigidity or cranial neuropathies warrant neurosurgical consultation with warrant neurosurgical consultation with urgent interventionurgent intervention
Epidural abscess, subdural empyema, Epidural abscess, subdural empyema, meningitis and cerebral abscesses meningitis and cerebral abscesses should be treated immediately prior to should be treated immediately prior to definitive otologic management of ear definitive otologic management of ear diseasedisease
ConclusionsConclusions Pathogenesis of cholesteatoma remains uncertainPathogenesis of cholesteatoma remains uncertain Essential to possess basic knowledge of the Essential to possess basic knowledge of the
important anatomic and functional characteristics important anatomic and functional characteristics of the middle ear for successful management of of the middle ear for successful management of cholesteatomascholesteatomas
Careful and thorough evaluations are the key to Careful and thorough evaluations are the key to early diagnosis and treatment early diagnosis and treatment
Treatment is surgical with primary goal to Treatment is surgical with primary goal to eradicate disease and provide a safe and dry eareradicate disease and provide a safe and dry ear
Surgical approaches must be customized to each Surgical approaches must be customized to each patient depending on extent of diseasepatient depending on extent of disease
Surgeon must be aware of serious and potentially Surgeon must be aware of serious and potentially life-threatening complications of cholesteatomaslife-threatening complications of cholesteatomas
BibliographyBibliography Portions of this paper and presentation were taken directly form the June 18, 2003 Portions of this paper and presentation were taken directly form the June 18, 2003
Grand Rounds presentation by Michael Underbrink and Arun Gadre entitled Grand Rounds presentation by Michael Underbrink and Arun Gadre entitled Cholesteatoma.Cholesteatoma.
Bailey BJ. Head and Neck Surgery – Otolaryngology 3rd Edition. 2001: 1787-1797.Bailey BJ. Head and Neck Surgery – Otolaryngology 3rd Edition. 2001: 1787-1797. Godinho RA, Kamil SH, Lubianca JN, Keogh IJ, Eavey RD. Pediatric cholesteatoma: Godinho RA, Kamil SH, Lubianca JN, Keogh IJ, Eavey RD. Pediatric cholesteatoma:
canal wall window alternative to canal wall down mastoidectomy. Otology and canal wall window alternative to canal wall down mastoidectomy. Otology and Neurotology. 2005. 26:466-471.Neurotology. 2005. 26:466-471.
Gantz BJ, Wilkinson EP, Hansen MR. Canal wall reconstruction Gantz BJ, Wilkinson EP, Hansen MR. Canal wall reconstruction tympanomastoidectomy with mastoid obliteration. The Laryngoscope. 2005. 115: tympanomastoidectomy with mastoid obliteration. The Laryngoscope. 2005. 115: 1734-1740.1734-1740.
Syms MJ, Luxford WM. Management of cholesteatoma: status of the canal wall. Syms MJ, Luxford WM. Management of cholesteatoma: status of the canal wall. The Laryngoscope. 2003. 113: 443-448.The Laryngoscope. 2003. 113: 443-448.
Kos MI, Castrillon R, Montandon P, Guyot JP. Anatomic and functional long-term Kos MI, Castrillon R, Montandon P, Guyot JP. Anatomic and functional long-term results of canal wall-down mastoidectomy. Annals of Otology, Rhinology and results of canal wall-down mastoidectomy. Annals of Otology, Rhinology and Laryngology. 2004. 113: 872-876.Laryngology. 2004. 113: 872-876.
Karmarkar S, Bhatia S, Saleh E, et al. Cholesteatoma surgery: the individualized Karmarkar S, Bhatia S, Saleh E, et al. Cholesteatoma surgery: the individualized technique. Annals of Otology, Rhinology and Laryngology. 1995. 104: 591–595.technique. Annals of Otology, Rhinology and Laryngology. 1995. 104: 591–595.
Roden D, Honrubia V, Wiet R. Outcome of residual cholesteatoma and hearing in Roden D, Honrubia V, Wiet R. Outcome of residual cholesteatoma and hearing in mastoid surgery. Journal of Otolaryngology. 1996. 25: 178–181.mastoid surgery. Journal of Otolaryngology. 1996. 25: 178–181.
Chang C, Chen M. Canal-wall-down tympanoplasty with mastoidectomy for Chang C, Chen M. Canal-wall-down tympanoplasty with mastoidectomy for advances cholesteatoma. Journal of Otolaryngology. 2000. 29: 270–273.advances cholesteatoma. Journal of Otolaryngology. 2000. 29: 270–273.
Shohet JA, de Jong AL. The management of pediatric cholesteatoma. Shohet JA, de Jong AL. The management of pediatric cholesteatoma. Otolaryngology Clinics of North America. 2002. 35:841–851.Otolaryngology Clinics of North America. 2002. 35:841–851.
McElveen JT Jr, Chung AT. Reversible canal wall down mastoidectomy for acquired McElveen JT Jr, Chung AT. Reversible canal wall down mastoidectomy for acquired cholesteatomas: preliminary results. The Laryngoscope. 2003. 113:1027–1033.cholesteatomas: preliminary results. The Laryngoscope. 2003. 113:1027–1033.
What To DoWhat To Do Treatment should be tailored to caseTreatment should be tailored to case Absolute CWD indicationsAbsolute CWD indications
Cholesteatoma in an only hearing earCholesteatoma in an only hearing ear Significant erosion of the posterior bony canal wallSignificant erosion of the posterior bony canal wall History of vertigo suggesting a labyrinthine fistulaHistory of vertigo suggesting a labyrinthine fistula Recurrent cholesteatoma after canal-wall-up Recurrent cholesteatoma after canal-wall-up
surgerysurgery Poor eustachian tube functionPoor eustachian tube function Sclerotic mastoid with limited access to Sclerotic mastoid with limited access to
epitympanumepitympanum No harm in starting CWU and converting to No harm in starting CWU and converting to
CWD as necessaryCWD as necessary Know your surgical limitationsKnow your surgical limitations
QuizQuiz
QuizQuiz
1. What space lies 1. What space lies between the pars between the pars flaccida and #13?flaccida and #13? A. Prussak’s spaceA. Prussak’s space B. Anterior pouch B. Anterior pouch
of Von of Von TroeltschTroeltsch
C. Posterior pouch C. Posterior pouch of of Von Von TroeltschTroeltsch
D. The final frontierD. The final frontier
QuizQuiz
2. The primary component of 2. The primary component of cholesteatoma is fat, as discovered cholesteatoma is fat, as discovered by Johannes Mueller in 1838.by Johannes Mueller in 1838. A. TrueA. True B. FalseB. False
QuizQuiz
3. What 2 major groups are 3. What 2 major groups are cholesteatomas classified into (pick cholesteatomas classified into (pick 2 letters)?2 letters)? A. AcquiredA. Acquired B. InfectedB. Infected C. ExpansiveC. Expansive D. CongenitalD. Congenital
QuizQuiz
4. Possible adverse outcomes of 4. Possible adverse outcomes of surgical treatment of cholesteatomas surgical treatment of cholesteatomas areare A. Facial paralysisA. Facial paralysis B. VertigoB. Vertigo C. Further hearing lossC. Further hearing loss D. TinnitusD. Tinnitus E. All of the aboveE. All of the above
QuizQuiz
5. CT Scans must be obtained prior 5. CT Scans must be obtained prior to any surgery for cholesteatomato any surgery for cholesteatoma A. TrueA. True B. FalseB. False C. It depends on who your faculty isC. It depends on who your faculty is
QuizQuiz
6. CWU procedures are 6. CWU procedures are contraindicated incontraindicated in A. Only hearing earsA. Only hearing ears B. Patients with a labyrinthine fistulaB. Patients with a labyrinthine fistula C. Long-standing ear diseaseC. Long-standing ear disease D. Poor eustachian tube functionD. Poor eustachian tube function E. All of the aboveE. All of the above
QuizQuiz
7. Surgical treatment of 7. Surgical treatment of cholesteatoma has a primary goal of cholesteatoma has a primary goal of hearing restorationhearing restoration A. TrueA. True B. FalseB. False
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8. Surgical approaches must be 8. Surgical approaches must be customized to each patient customized to each patient depending on extent of diseasedepending on extent of disease A. TrueA. True B. FalseB. False
Quiz BonusQuiz Bonus
What is this a What is this a picture of?picture of? A. Cat eyeA. Cat eye B. Snake skinB. Snake skin C. Tympanic C. Tympanic
membrane stained membrane stained with osmium to with osmium to show keratin show keratin patchespatches