CHOICE BASED CREDIT SYSTEM STRUCTURE...324 CHOICE BASED CREDIT SYSTEM – STRUCTURE FOR THOSE WHO HAVE JOINED FROM THE ACADEMIC YEAR 2014–15 ONWARDS M.Sc CHEMISTRY Sem Subject Hrs.

324

CHOICE BASED CREDIT SYSTEM – STRUCTURE

FOR THOSE WHO HAVE JOINED FROM THE ACADEMIC YEAR 2014–15 ONWARDS

M.Sc CHEMISTRY

Sem Subject Hrs. Cr. Adl.

Cr.

Exam

(Hrs)

Marks

Allotted

Int. Ext.

I

01 Part – III

Core Organic Chemistry – I 4 4 3 25 75

02 Core Inorganic Chemistry – I 4 4 3 25 75

03 Core Physical Chemistry – I 4 4 3 25 75

04 Core

Lab

Organic Chemistry

Practical – I 5 – – – –

Core

Lab

Inorganic Chemistry


Core

Lab

Physical Chemistry


05 Elective

Major Analytical Chemistry 3 3 3 25 75

06 SLC In Plant Training

*Report;@Viva – 3 –

40

[*30:@10]

60

[*50:@1

0]

II

01 Part – III

Core Organic Chemistry – II 4 4 3 25 75

02 Core Inorganic Chemistry – II 5 4 3 25 75

03 Core

Lab

Organic Chemistry

Practical – I 5 4 6 40 60

04 Core

Lab

Inorganic Chemistry


05 Core

Lab

Physical Chemistry


06 NME Applied Chemistry 6 4 3 25 75

07 SLC

Computer Applications in

Chemistry

3 3 – 100

325

Sem Subject Hr

s. Cr.

Adl.

Cr.

Exam

(Hrs)

Marks

Allotted

Int. Ext.

III

01 Part – III

Core Organic Chemistry– III 4 4 3 25 75

02 Core Inorganic Chemistry – III 4 4 3 25 75

03 Core Physical Chemistry – II 4 4 3 25 75

04 Core

Lab

Organic Chemistry

Practical – II 5 – – – –

05 Core

Lab

Inorganic Chemistry


06 Core

Lab

Physical Chemistry


07 Elective

Major

Nano and Green

Chemistry 3 3 3 25 75

08 SLC Fundamentals of

Biochemistry – – 3 3 – 100

IV

01 Part – III

Core Organic Chemistry– IV 4 4 3 25 75

02 Core Inorganic Chemistry – IV 4 4 3 25 75

03 Core Physical Chemistry – III 4 4 3 25 75

04 Core

Lab

Organic Chemistry

Practical – II 5 5 6 40 60

05 Core

Lab

Inorganic Chemistry


06 Core

Lab

Physical Chemistry


07 Electives

Major Pharmaceutical Chemistry 3 3 3 25 75

08 Elective

Major

Project

*Report;@Viva 6 –

40

[*30:

@10]

60

[*50:@10]

09 SLC Cheminformatics 3 3 – 100

TOTAL 120 90 12

326

M.Sc CHEMISTRY: Those Who Have Joined From The

Academic Year 2014-15 Onwards Under CBCS System

Core Subject ORGANIC CHEMISTRY – I Code: 14224101

SEMESTER I

4 Hrs/Week Credits 4

Objectives:

To have a knowledge of Electron Displacement.

To know the details of Stereochemistry, Aromaticity detailed study

of Heterocycles and Carbohydrate.

UNIT – I: [12 Hrs]

Electron Displacement:

Inductive and Field Effects – Bond Distance – Bond Energies –

Delocalised Bonds – Cross Conjugation – Steric Inhibition of

Resonance – Hyper Conjugation –Effects of Structure on the

Dissociation Constants of Acids and Bases.

Quantitative Treatment of the Effect of Structure on Reactivity –

The Hammett Relationship – Significance of Reaction and Substituent

Constants – Application of the Hammett Equation in Reaction

Mechanism – Limitations, Modification and Deviations – Taft Equation.

UNIT – II: [12 Hrs]

Stereochemistry:

Symmetry Elements and Point Group Classification – Conditions

for Optical Activity – Optical Isomerism – Definitions – Newmann,

Sawhorse and Fisher Projection Formulae – Concept of Chirality – The

Cahn – Ingold – Prelog System of Nomenclature – Enantiotopic and

Diastereotopic Atoms, Groups and Faces – Molecules with more than

One Chiral Centre – Molecular Dissymmetry – Optical Activity of

Biphenyls, Allenes and Spirans – Optical Isomerism of Nitrogen and

Sulphur Compounds – Asymmetric Synthesis – Cram’s Rule – Prelog’s

Rule.

Geometrical Isomerism:

E – Z – Nomenclature – Determination of Configuration of

Geometrical Isomers Using Physical and Chemical Methods –

Stereoisomerism in Monocyclic Compounds (upto six – membered

ring).

UNIT – III: [12 Hrs]

Aromaticity:

Aromatic Character in Benzene, Six – Membered Rings, Five,

Seven and Eight Membered Rings – Huckel’s Rule and Craig’s Rule –

Concept of Homoaromaticity and Antiaromaticity – Systems with 2, 4,

327

8 and 10π Electrons – Systems with more than 10π Electrons –

Alternant and Nonalternant Hydrocarbons. Chemistry of

Cyclopentadienyl Anion – Fulvene – Azulene –Sydnones. (12), (14),

(16), (18) – annulenes.

UNIT – IV: [12 Hrs]

Introduction to Reaction Mechanism:

Reactive Intermediates – Free Radicals – Carbenes – Carbanions

– Carbocations – Formation and Stability of Reactive Intermediates –

Kinetic and Thermodynamic Control of Chemical Reactions – Kinetic

and Non–Kinetic Methods of Determining Organic Reaction Mechanism

– Principle of Microscopic Reversibility – Hammond Postulate.

Aromatic Electrophilic Substitution – Orientation – Reactivity –

Mechanism of Nitration, Friedel – Craft’s Reaction – Ortho/Para Ratio

– Aromatic Nucleophilic Substitution Reactions – SNAr, SN1 and

Benzyne Mechanisms.

UNIT – V: [12 Hrs]

Heterocyclic Compounds:

Structure, Synthesis and Reactions of Oxazole, Thiazole,

Imidazole, Flavones and Isoflavones Anthocyanins. Quercetin –

Pyrimidines (Uracil) and Purines (chemistry of caffeine).

Carbohydrates:

Ring Structure of the Monosaccharides – Methods for

Determining the Size of Sugar Rings – Chemistry, Configuration and

Conformation of Sucrose, Lactose and Cellobiose.

TEXT BOOKS: 01. Finar I.L., Organic Chemistry, Vol. II, 5th Edition, ELBS,

England, 1975. 02. Morrison R.T., and Boyd R.N., Organic Chemistry, Prentice–

Hall, 6th Edition, New Delhi, 1995.

REFERENCES: UNIT – I:

01. Ferguson L.N., The Modern Structural Theory of Organic Chemistry, Prentice–Hall, 1969.

02. Gould E.S., Mechanism and Structure in Organic Chemistry,

Henry Holt and Co., New York, 1959. 03. Jerry March, Advanced Organic Chemistry, 4th Edition, Wilely,

New York, 1992. 04. Lowry T.H., and Richardson K.S., Mechanism and Theory in

Organic Chemistry, ELBS, New Delhi, 1995.

05. Pinc H., Hendrickson J.B., Cram D.J., and Hammond G.S., Organic Chemistry, 4th Edition, McGraw–Hill Kogakusha Ltd., Tokyo, 1980.

06. Shorter J., Correlation Analysis in Organic Chemistry, Clarendon Press, Oxford, 1973.

07. Sykes P., Guide Book to Mechanism in Organic Chemistry, Orient Longman, Cambridge, 1976.

328

UNIT – II: 01. Eliel E.L., Stereo Chemistry of Carbon Compounds, McGraw–

Hill, New York, 1962. 02. Kalsi P.S., Stereochemistry, Conformation and Mechanism, 2nd

Edition, Wiley Eastern Ltd., New Delhi, 1993. 03. Mislow K., Introduction to Stereochemistry, Benjamin, London,

1966.

04. Nasipuri D., Stereochemistry of Organic Compounds, Principles and Application, Wiley Eastern Ltd., 2nd Edition, New Delhi, 1994.

05. Potapov V.M., Stereochemistry, MIR Publishers, Moscow, 1979. UNIT – III:

01. Badger G.M., Aromatic Character and Aromaticity, Cambridge, London, 1969.

02. Garratt P.J., Aromaticity, McGraw–Hill, New Delhi, 1971.

03. March J., Advanced Organic Chemistry, Wiley, 4th Edition, New York, 1992.

UNIT – IV: 01. Finar I.L., Organic Chemistry, Vol. I and II, 5th Edition, ELBS,

London, 1975.

02. Harris J.M., and Wamser C.C., Fundamentals of Organic Reaction Mechanisms, John Wiley and Sons, Inc, New Delhi, 1976.

03. March J., Advanced Organic Chemistry, Wiley, 4th Edition, New York, 1992.

04. Sykes P., Guide Book to Mechanism in Organic Chemistry, Orient Longman, Cambridge, 1976.

UNIT – V:

01. Achesen R.M., Chemistry of Heterocyclic Compounds, Wiley Eastern, New Delhi, 1973.

02. Dyke S.F., Chemistry of Carbohydrates, Academic Press,

London, 1992. 03. Finar I.L., Vol. II, 5th Edition, ELBS, England, 1975.

04. Joule and Smith, Heterocyclic Chemistry, Van Nostrand Reinhold, New York, 1992.

Core Subject INORGANIC CHEMISTRY – I Code: 14224102

SEMESTER I


Objectives:

Advanced study of Quantum and bonding Characteristics.


Quantum Chemistry:

Planck’s Quantum Theory of Radiation, Photoelectric Effect,

Heisenberg’s Uncertainity Principle, Compton Effect, De–Broglie’s

Wave Equation. Postulates of Quantum Mechanics, Schrodinger Wave

Equation for Particle in one Dimensional box, Significance of Quantum

numbers – Pauli’s Exclusion Principle, LS Coupling Scheme, Term

Symbols.

329


Covalent Bonding:

Qualitative Treatment of VB and MO Theories – and Bonds –

Hybridization and Resonance – Applications of VB and MO Theories to

the Structures of Homonuclear and Heteronuclear Diatomic and

Linear Triatomic Molecules – Comparison of VB and MO Theory – The

Concept of Multicentre Bond as Applied to Electron Deficient

Molecules – VSEPR Theory.


Ionic Bonding:

Bond Order, Bond Energy, Bond Length, Bond Polarity – Partial

Ionic Character, Lattice Energy and Its Calculations by Born – Lande

and Born – Meyer Equations – Determinations by Born – Haber Cycle –

Kapustinski Equation – Covalent Character in Ionic Compounds.


Non– Aqueous Solvents:

Chemistry of Non – Aqueous Solvents – Classification of

Solvents – Properties of Ionizing Solvents – A General Study of Typical

Reactions in Liquid Ammonia, Sulphur Dioxide, Dinitrogen Tetroxide,

Anhydrous Hydrogen Fluoride, Sulphuric Acid and Acetic Acid –

Solution in Fused Salts.

HSAB Concept of Acids and Bases – Acid, Base Strength and

Hardness and Softness – Symbiosis – Theories of Hardness and

Softness.


Bio Inorganic Chemistry – I:

Metal Ions in Biological Systems – Essential and Trace Metals –

Na+/K+ Pump – Ionophores – Chlorophylls, Photosystem I, II – Heme

Proteins – Structure and Function of Haemoglobin, Myoglobin,

Haemocyanins, Heme Erythrin. Metalloenzymes of Vitamin B12 –

Hydrogenases.

TEXT BOOKS: 01. Huheey J.E., Keiter R.A., and Keiter R.L., Inorganic Chemistry,

Principles of Structure and Reactivity, 4th Edition, Addison – Wesley Publishing Company, New York, 1993.

02. Lee J.D., Concise Inroganic Chemistry, 5th Edition, ELBS,

Chapman and Hall, London, 1996. REFERENCES:

01. Bertini I., Gray and Others, Bioinorganic Chemistry – Viva Books Pvt., Ltd., 1998.

02. Cartmell E., and Fowles G.W.A., Valency and Molecular

Structure, ELBS, 4th Edition, England, 1979. 03. Chandra A.K., Introductory Quantum Chemistry, Tata McGraw–

Hill, New Delhi, 1990. 04. Cotton F.A., and Wilkinson G., Advanced Inorganic Chemistry,

4th Edition, John Wiley and Sons, New York, 1988.

330

05. Hay, R.W., Bio–Inorganic Chemistry, Ellis Horwood, New Delhi, 1984.

06. Sisler H.H., Chemistry in Non – Aqueous Solvents, Chapman and Hall, New York, 1961.

07. Wadington T.C., Non – Aqueous Solvents, Wiley, New York, 1953.

Core Subject PHYSICAL CHEMISTRY – I Code: 14224103

SEMESTER I


Objectives:

To have a knowledge of chemical thermodynamics and quantum

mechanics.

To know the details of kinetic theory of gases.


Kinetic Theory of Gases:

Distribution of Molecular Velocities, Derivation of Maxwell –

Boltzmann Distribution Law – Its Experimental Verification – Effect of

Temperature – Derivation of Root Mean Square Velocity, Average

Velocity and Most Probable Velocity from Maxwell – Boltzmann

Distribution Law – Mean Free Path – Molecular Collision – Molecular

Diameters – Transport Properties – Diffusion – Viscosity – Thermal

Conductivity Equipartition Principle of Energy - classical Theory of

Heat Capacity – Translational, Rotational and Vibrational Modes of

Molecules.


Chemical Thermodynamics:

Thermodynamics of Systems of Variable Composition – Partial

Molar Quantities, Partial Molar Volume – Experimental Determination;

Chemical Potential , Gibbs – Duhem Equation. Thermodynamic

Properties of Real Gases – Fugacity Concept; Determination of

Fugacity of Real Gases, Activity Concept for Condensed States, Choice

of Standard States, Experimental Methods to Determine Activity of

Non–Electrolytes. Thermodynamic Equation of State – Derivation and

their Application to Real Gases – Calculation of µJT, (dH/dP)T and

(dE/dV)T for real gases.

Third Law of Thermodynamics – Purpose, Formulation (planck,

lewis and randall) – Thermodynamic Properties at Absolute Zero –

Calculation of Absolute Entropies – Apparent Exception to the Third

Law.


Bio – Energetics:

Thermodynamics in Biology, Energy Flux, ATP, Transfer of

Potentials and Coupled Reactions, Irreversible Thermodynamics,

Biological Energy Conversions, High Energy Metabolites, General

331

Principles of Functional and Structural Organization of Bio Energetics,

Fundamental Reactions, Properties of ATP and Its Central Role in Bio

Energetics, Mechanisms and Energetics of Reactions of Metabolically

Bound H2 with O2.

Basic Concepts of Non–Equilibrium Thermodynamics. Its

Application to Biological Systems – Transfer of Potential and Coupled

Reaction – Biological Energy Conversion in Catabolism and Anabolism.


The Birth of Quantum Mechanics:

De–Broglie’s Concept of Matter Waves, Experimental Verification

of Matter Waves, Compton Effect, Heisenberg’s Uncertainty Principle

and Complementarity, Postulates of Quantum Mechanics. Operators,

Linear Operators, Method of Getting the following Quantum

Mechanical Operators; Position, Momentum, Raising, Lowering and

Spin Angular Momentum.

Hermicity and Proving the Quantum Mechanical Operators are

Hermitian – Commutator Algebra – Evaluation of Commutators –

Vanishing and Non – Vanishing Commutators – Introducing, Dirac

Notation, Eigen Function, Eigen Value and Degeneracy. Expansion

Theorem. Orthogonality and Normalisation of Wave Functions.

Derivation of Schrodinger Wave Equation. Free Particle and Particle in

a Box Problem.


Phase Rule:

Gibbs Phase Rule – Its Thermodynamic Derivation, Study of Two

Component Systems – Solid – Liquid Equilibria, Simple Eutectic

System, Congruent and Incongruent Melting Systems – Magnesis and

Alumina System – Cu and Zn System – A Detailed Study of Iron –

Carbon System; Three Component Systems – Formation of One Pair,

Two Pairs and Three Pairs Partially Miscible Liquids – Systems

Composed of Two Solids and a Liquid : Crystallization of Pure

Component Only, Formation of Binary and Ternary Compounds,

Formation of Solid Solution and Partial Miscibility of Solid Phases.

TEXT BOOKS: 01. Atkins P.W., Physical Chemistry, 6th Edition, ELBS, Oxford

University Press, London, 1996.

02. Bajpai D.N., Advanced Physical Chemistry, S.Chand and Company Ltd., New Delhi, 1998.

03. Glasstone S., A Text Book of Physical Chemistry, 2nd Edition, Mcmillan India, 1974.

04. Maron S.H., and Lando J.B., Fundamentals of Physical

Chemistry, New Delhi, 1991. REFERENCES:

UNIT – I: 01. Barrow G.M., Physical Chemistry, McGraw–Hill, International

Student Edition, New Delhi, 1973.

02. Castellan C.W., Physical Chemistry, 3rd Edition, Narosa Publishing House, New Delhi, 1989.

332

UNIT – II: 01. Glasstone S., Thermodynamics for Chemists, Van Nostrand Co.,

Inc., New York, 2003 02. Rajaram J., and Kuriacose J.C., Thermodynamics, 3rd Edition,

Shoban Lal Nagin, Chand and Co., New Delhi, 1999. 03. Rastogi R.P., and Misra R.R., Introduction to Chemical

Thermodynamics, 4th Edition, Vikas Publishing Home Pvt. Ltd.,

New Delhi, 1984. UNIT – III:

01. Glasstone S., Thermodynamics Chemistry, Van Nostrand Co.,

Inc., New York, 2003. 02. Laidler K.J., Physical Chemistry with Biological Applications,

Benjamin–Cummings Publishing Co., Inc. New Delhi, 1980. 03. Lehninger A.L., Bioenergetics – The Molecular Basis of Biological

Energy Transformations, 2nd Edition, W.A.Benjamin Inc, Mento

Park, CA, 1971. 04. Marshall A.G., Biophysical Chemistry, John – Wiley and Sons,

New York, 1978. 05. Rajaram J., and Kuriacose J.C., Thermodynamics, 3rd Edition.

S.Chand and Co., New Delhi, 2006.

UNIT – IV: 01. Atkins P.W., Molecular Quantum Mechanics, 2nd Edition,

Oxford University Press, London, 1986.

02. Chandra A.K., Introductory Quantum Chemistry, 3rd Edition, Tata McGraw–Hill Publishing Company, New Delhi, 1988.

03. Hanna H.W., Quantum Mechanics in Chemistry, Benjamin/Cummings Publishing Co., London, 1983.

04. Levine I.N., Quantum Chemistry, Allyn and Bacon, Boston,

1983. UNIT – V:

01. Bajpai D.N., Advanced Physical Chemistry, S.Chand and

Company Ltd., New Delhi, 1998. 02. Findlay A., The Phase Rule and Its Applications, 4th Edition,

Campbell and Smith, New Delhi, 1984. 03. Maron S.H., and Lando J.B., Fundamentals of Physical

Chemistry, New Delhi, Macmillan, 1974.

Elective Major ANALYTICAL CHEMISTRY Code: 14224104

SEMESTER I

3 Hrs/Week Credits 3 Objectives:

An introduction to the basic theory and practice of quantitative

analysis.

UNIT – I: [8 Hrs]

Methods of Obtaining the Precipitate – Conditions – Choice of

Precipitants – Specific and Selective Precipitants – Sequestering Agents

– Theory of Precipitation. Co–Precipitation – Post Precipitation from

Homogeneous Solution.


Precision – Accuracy – Absolute and Relative Error –

Classification of Errors – confidence Limit – Student Q test – Rejection

of Experimental Data – Sources and Elimination of Errors.

333


Infrared Spectroscopy (IR):

Introduction, Instrumentation, Sampling Technique, Selection

Rules, Types of Bonds, Absorption of Common Functional groups.

Factors Affecting Frequencies, Application.

Polarography:

Introduction, Instrumentation, Role of Supporting Electrolyte,

Determination of Half–Wave Potential and their Applications.


Chromatography:

Principles – Classification of Chromatography – TLC, Paper

Chromatography – Column Chromatography – Ion Exchange, Gas

Chromatography and HPLC.

UNIT – V: [9 Hrs]

Elements of Spectroscopy:

Fourier Transform Spectroscopy – Fundamental Laws of

Photometry – Spectrophotometric Accuracy – Photometric Precision –

Quantitative Methodology – Difference Spectroscopy and Derivative

Spectroscopy.

TEXT BOOKS: 01. Gurdeep R. Chatwal, Sham K. Anand, Instrumental Methods of

Chemical Analysis, 4th Edition, Veds, Himalaya, New Delhi, 2003.

02. Skoog, West and Holler, Analytical Chemistry – An introduction,

7th Edition, Saunders College Publishers, New York, 1999. REFERENCES:

01. John A. Dean, Chemical Separation Methods, 5th Edition, Van Nostrand Reinhold Company, New York, 1969.

02. Willard H.H., Merristt L.L., Dean J.A., and Settle F.A.,

Instrumental Methods of Analysis, 5th Edition, CBS Publishers of Distribution, New Delhi, 1986.

Self–Learning Course IN PLANT TRAINING Code: 14804122

[Common for all PG Course except MBA and M.Com (CA)]

SEMESTER I

Addl. Credits 3

Objectives of Training:

To apply creative skills

To develop critical thinking skills

Working model for the solution of a real time problem

To improve practical working skills

To develop life long learning skills

Short term in plant industrial training of 15 days.

Students must select their own industrial unit of their choice for

training.

334

The training includes process, product and viva–voce or class

room presentation.

Process must include working file.

Working file includes draft copies of work, a working log, work

schedule and resources used.

Product includes actual design and development of training.

Components required in the viva–voce or class room

presentation.

Information about the topic

Personal relevance

Presentation skills

Power point presentation (must)

Findings

Conclusions

Evaluation:

Total Internal External

Project 80 30 50

Viva 20 10 10

Total 100 40 60

Core Subject ORGANIC CHEMISTRY – II Code: 14224201

SEMESTER II

4 Hrs/Week

Credits 4 Objectives:

To study the detailed aspects of conformational analysis, analytical

techniques like to know about 1H NMR and 13CNMR, various oxidation

and reduction reactions in detail and their reagents, detailed study of

chemistry of alkaloids.

UNIT – 1: [12 Hrs]

Conformational Analysis:

Configuration and Conformation – Conformations of Ethane

and n – Butane – Conformational Analysis – Stereoelectronic and

Steric factors – Conformation of Simple Acyclic Compounds –

Conformation of Monosubstituted and Disubstituted Cyclohexanes –

Correlation of the Conformation of Acyclic and Cyclic Systems with

their Physical and Chemical Properties – Conformational Free Energy

Difference – Determination of Conformational Free Energy difference –

Quantitative Treatment of Mobile System – Eliel – Ro Equation –

Conformations and Reactivity of cyclohexanones.


Spectroscopy:

UV Spectroscopy – Principle – Absorption Spectra of Conjugated

Dienes, – Unsaturated Carbonyl Compounds – Woodward Rules –

Calculating of max.

335

IR Spectroscopy – Molecular Vibrations – Vibrational Frequency

– Factors Influencing Group Frequencies – Quantitative Studies.

Mass Spectroscopy – Principle – Type of Ions – Base Peak –

Parent Ion, Metastable Ion and Isotopic Ions – Fragmentation –

General Rules – Pattern of Fragmentation for Various classes of

Compounds – Mc Lafferety Rearrangement – Retro Diels – Alder

Reaction.


NMR Spectroscopy:

1H – NMR Origin of NMR Spectra – Chemical Shift. Spin – Spin

Coupling – Coupling Constant – First Order and Second Order Spin –

Spin Splitting – Influence of Stereochemical Factors on Chemical Shift

of Protons – Simplification of Complex Spectra – Spin Decoupling –

Double Resonance – Shift Reagents, CIDNP.

13C – NMR Spectroscopy – Basic Principle of FT Technique –

Relaxation Time – Assignment of the Signals – Off – Resonance

Decoupling – Additivity Relationship – 2D NMR.

Structural Problems based on all the above Techniques.

UNIT –IV: [12 Hrs]

Oxidation and Reduction – Reagents in Organic Synthesis:

a) Oxidation: Mechanism, Applications and Stereo Chemical

Aspects of the Oxidations using Chromic Acid, Selenium

Dioxide, Osmium Tetroxide, N – Bromo Succinimide, Oppenauer

Oxidation.

b) Reduction: Catalytic Reduction (homogeneous and

heterogeneous) – Reductions using LiA1H4, DIBAL and Sodium

Borohydride – Birch Reduction – Meerwein Pondorf Verley

Reduction – Hydroboration.

c) Reagents in Organic Synthesis: Lithium Dimethyl Cuprate,

Lithium Diisopropylamide (LDA), Dicyclohexyl Carbodiimide, 1,3

– Dithiane (umpolung), Woodward and Prevost Hydroxylation,

DDQ, Phase Transfer Catalyst (quaternary ammonium salt,

crown ethers).


Alkaloids:

Classification – General Properties – General Methods of

Structure Elucidation of Alkaloids – Structure, Synthesis and

Stereochemistry of the following Alkaloids - Quinine, Morphine,

Lysergic Acid – Biosynthesis of Alkaloids.

Novel Ring systems:

Nomenclature of Bicyclic and Tricyclic Systems – Chemistry of

Adamentane, Diamantane (congressane), Catenanes, rotoXanes and

Fullerenes.

336

TEXT BOOKS: 01. Finar I.L., Organic Chemistry, Vol. 11, 5th Edition, ELBS,

England, 1975. 02. Morrison R.T., and Boyd R.N., Organic Chemistry, Prentice–

Hall, 6th Edition, New Delhi, 1995. REFERENCES: UNIT – I:

01. Eliel E.L., Stereochemistry of Carbon Compounds McGraw–Hill, New Delhi, 1962.

02. Eliel E.L., Stereochemistry of Carbon Compounds, Wiley

Eastern, New York, 1991. 03. Kalsi P.S., Stereochemistry, Conformation and Mechanism,

Wiley Eastern Ltd., 2nd Edition, New Delhi, 1993. 04. Mislow K., Introduction to Stereochemistry, Benjamin, London,

1966.

05. Nasipuri D., Stereochemistry of Organic Compounds, Principles and Application, Wiley Eastern Ltd., 2nd Edition, New Delhi,

1994. UNIT – II and III:

01. Dyer J.R., Application of Absorption Spectroscopy, 2nd Edition,

Prentice–Hall, Hampshire, 1965. 02. Howe I., Williams D.H. and Bowen R.D., Mass Spectrometry,

Principles and Applications McGraw Hill, 2nd Edition, New

Delhi, 1981. 03. Kemp, Organic Spectroscopy, ELBS, 3rd Edition, Hampshire,

UK, 1987. 04. Silverstein B.M., Bassler G.C., and Morrill T.C., Spectrometric

Identification of Organic Compounds. Wiley, 5th Editionn.,

New York, 1963. UNIT – IV:

01. Carruthers W., Some Modern Methods of Organic Synthesis,

Cambridge University Press, 2nd Edition., London, 1982. 02. House H.O., Modern Synthetic Reactions, Benjamin W.A., Inc.

California, 2nd Edition, California, 1972. 03. Norman R.O.C., Organic Synthesis, 3rd Edition, London, 1993. 04. Pinc S.H., Hendrickson J.B., Cram D.J., and Hammond G.S,

Organic Chemistry, McGraw–Hill Kogakusha Ltd., Tokyo 4th Edition, 1980.

UNIT – V: 01. Bentley, The Alkaloids, Interscience Publishers, 1957. 02. Finar I.L., Organic Chemistry, Vol. 11, ELBS. England, 1975.

03. Pelletier, Chemistry of Alkaloids, New York.

Core Subject INORGANIC CHEMISTRY – II Code: 14224202

SEMESTER II


Advanced Learning of Solid State, Bioinorganic Chemistry and

Coordination Theories.


Solid State Chemistry - I:

Crystal System – X–ray Diffractions – Bragg’s Equation – Bragg’s

Method – Rotation Crystal Method and Powder Methods of X–ray

337

Diffraction, Indexing Powder Pattern – Structure of Typical compounds

such as Calcite, Cesium Chloride, Zinc Blende, Wurtzite, Rutile,

Fluorite, Antifluorite, Perovskite, Covalent Crystals such as Diamond

and Graphite.


Solid State Chemistry - II:

Crystal Defects – Point, Line and Plane Defects – Color Centres –

Non– Stoichiometry – Electronic Structure of Solids – Free Electron

and Band Theories – Types of Solids – Electrical Conductivity and

Super Conductivity – High Temperature Super Conductors – Types of

Semi Conductors – Thermo Electric Power and Hall Effect – PN

Junction – Transistors – Optical Properties – Photovoltaic Effect –

Semiconductors in Solar Energy Conversion.


Bio–Inorganic Chemistry – II:

Structure and Function of Metallo Proteins in Electron Transfer

Processes – Cytochromes – Iron – Sulphur Proteins – Copper Proteins –

Biological Nitrogen Fixation – in – Vivo and in – Vitro – Model System –

Metal – Nucleic Acid Interactions – Metals in Medicines – Metal

Deficiency Diseases – Metals used for Diagnosis and Chemotherapy –

Toxic Effect of Metals.


Coordination Compounds:

Theories of Bonding – VB, CFT and MO Theories – Splitting of d

– Orbitals in Oh, Td, sq Planar and TBP Geometries – CFSE

Calculation in Terms of Dq – Factors Affecting Crystal Field Splitting –

Spectrochemical Series – Magnetic Properties of Transition Metal

Complexes.


Reaction Mechanism of Co–ordination Compounds:

Substitution Reaction of Octahedral Complexes – Labile – Inert

Complexes – Mechanism of Acid Hydrolysis – Base Hydrolysis and

Anation Reaction. Substitution Reactions of Square Planar Complexes

– Factors Affecting Reactivity of Square Planar Complexes – The Trans

Effect and Its Applications. Electron Transfer Reactions –

Complimentary and Non – Complimentary Reactions – Outer Sphere

and Inner Sphere Electron Transfer Mechanism.

TEXT BOOKS: 01. Azaroff L., Introduction to Solids, Tata McGraw–Hill, New Delhi,

1977.

02. Huheey J.E., Keiter E.A., and Keiter R.L, Inorganic Chemistry: Principles, 4th Edition, Addison–Wesley Publishing Company,

New York, 1993.

338

REFERENCES: 01. Azaroff L., Elements of X–ray Crystallography, Tata McGraw–

Hill, New Delhi. 02. Bertini I., and Gray, Bio–Inorganic Chemistry, Viva Books Pvt.

Ltd., New Delhi, 1998. 03. Cotton F.A., and Wilkinson G., Advanced Inorganic Chemistry,

4th Edition, John Wiley and Sons, New York, 1988.

04. Hay R.W., Bio–Inorganic Chemistry, Ellis, Horwood, 1984. 05. Purcell K.F., and Kotz J.C., Inorganic Chemistry, W.B. Saunders

Company, London, 1997.

06. Shriver D.F., and Atkins P.W., Inorganic Chemistry, 2nd Edition, Oxford Press, London, 1999.

Core Lab ORGANIC CHEMISTRY PRACTICAL – I Code: 14224203

SEMESTER I & II

5 Hrs/Week


To acquire skill in organic qualitative analysis and preparation.

01. Organic Preparation – I:

About Eight Single Stage Preparation of Organic

Compounds.

02. Organic Qualitative Analysis:

Separation and Analysis of Two Component Mixtures.

REFERENCES:

01. Brain S. Furnin, Antony J. Hanneford, Peterw G. Smith and

Austin R. Tatchell, Pearson Education, 2005.

02. Vogel’s, Text Book of Practical Organic Chemistry.

Core Lab INORGANIC CHEMISTRY PRACTICAL – I Code: 14224204

SEMESTER I & II


Objectives:

To acquire skill in semi micro inorganic qualitative analysis and

titration by metal ion indicator.

01. Semi – Micro Qualitative Analysis:

Analysis of Mixtures Containing Two Familiar and Two

Less Familiar Cations from the following:

Hg, W, Pb, Tl, Se, Te, Mo, Cu, Cd, As, Sb, Ce, Th,

Zr, Ti, V, Cr, Mn, U, Ni, Co, Zn, Ca, Ba, Sr, Li,

Mn. (Insoluble and interfering and ion may be

avoided)

02. Estimation of Metal Ions by EDTA. (minimum three metals )

339

REFERENCE:

01. Dr. V.V. Ramanujam, Inorganic Semimicro Qualitative Analysis,

The National Publishing Company, 1999.

02. Vogel’s, Text Book of Macro and Semimicro Qualitative Inorganic

Analysis, Longman Group Limited, London and New York, 1982.

Core Lab PHYSICAL CHEMISTRY PRACTICAL – I Code: 14224205

SEMESTER I & II

5 Hrs/Week


To apply the theory knowledge to laboratory work

To acquire manipulatory skills in handling apparatus and

instruments.

01. Inversion of Cane Sugar and Ratio of Acid Strengths.

02. Solution Enthalpy by Thermometric Methods.

a) Oxalic acid in Water

b) Ammonium Oxalate in Water

c) Potassium Nitrate in Water

d) Benzoic Acid in Benzene/Water

e) Naphthalene in Toluene

03. Determination of Activity Co–efficient by Solubility Method.

04. Conductometric Titrations:

a) Acid–Base Titrations.

i. HCl – NaOH – HCl (unknown)

ii. CH3COOH – NaOH – HCl (unknown)

iii. HCl – NaOH – a mixture of HCl and CH3COOH / HCl

and NH4Cl.

b) Displacement Titrations

i. NH4Cl – NaOH – NH4Cl (unknown)

ii. CH3COONa – NaOH – CH3COONa (unknown)

iii. Estimation of CH3COOH and CH3COONa in a buffer.

c) Precipitation Titrations

i. K2SO4 – BaCl2 – K2SO4 (unknown)

ii. Pb(NO3)2 – Na2CO3 – Pb(NO3)2 (unknown)

05. Distribution of Benzoic Acid between Water and Benzene

06. Distribution of Iodine between Water and Carbon Tetra Chloride

07. Adsorption of Oxalic acid / CH3COOH on Charcoal.

REFERENCE:

01. James AM., and Prichand FB., Practical Physical Chemistry,

3rd Edition, Longman Group Limited, London, 1982.

Non–Major Elective APPLIED CHEMISTRY Code: 14464222

SEMESTER II


To study the basic concepts of Polymers and Fuels. To know the details

of Chemotherapy and Paints.

UNIT – I: Chemotherapy: [18 Hrs]

01. Sulpha Drugs – Sulphadiazine, Prontosil, Prontosil–s.

340

02. Antibiotics: Definition, Penicillin – Tetracycline (auromycin and

terramycin) – Streptomycin and Chloromyceitin – Structure and

Uses.

03. Antipyretics: Salicyclic Acid Derivatives, Indolyl Derivatives and

p–Aminophenol Derivatives (medicinal uses and structure only).


Polymers:

Introduction – Nomenclature of Polymers – Polymerization

Processes – Some Important Plastics – Elastomers – Fibres –

Fabrication of Polymers – Foamed Plastics.


Soaps and Detergents:

Oils, Fats, Soaps and Detergents – Manufacture of Soap – Cold

Process – Detergents – Surface Active Agents – General Properties.


Paints and Lacquers:

Paint – Principles – Pigments – Solvents – Paint Additives –

Ingredients in Paints – Manufacture – Lacquers and Varnishes.


Fuels:

Introduction – Classification of Fuels – Petrochemicals –

Utilization of Fuels – Nuclear Fuels – Solar Power – Explosives,

Propellants and Rocket Fuels.

REFERENCES:

01. Ashutosh Kar, Medicinal Chemistry, New Age International Publishers, New Delhi, 2007.

02. Kuriacose J.C., and Rajaram J., Chemistry in Engineering and

Technology, Vol. II, Tata McGraw–Hill, New Delhi, 1998. 03. Dr. M.R. Balasubramanian, Dr. S. Krishnamoorthy and Dr. V.

Murugesan, Engineering Chemistry, Allied Publishers Limited,

Chennai, 1999. 04. Turner G.P.A., Introduction to Paint Chemistry and Principles

of Paint Technology, 3rd Edition, Chapman and Hall Ltd, London, 1988.

05. Jain P.C., and Monica Jain, Engineering Chemistry, Dhanpat

Rai and Sons, Delhi, 1995.

Self-Learning Course COMPUTER APPLICATIONS IN CHEMISTRY SEMESTER II Code: 14804222

Addl. Credits 3 Objectives:

To have a knowledge of Chemistry and basic Programming.

UNIT – I:

Introduction to Computers:

History and Development of Computers, Mainframe, Micro’s and

Super Computer Systems – CPU and Other Peripheral Devices –

341

Evolution of Programming Languages – Machine Language, Assembly

Language and Higher Level Language.

UNIT – II:

Principle of ‘Basic’ Programming:

Constants, Variables – Expressions – Hierarchy of Operations –

Arithmetic Statements – I/O State – Statements – Branching –

Conditional Branching – Loops – Library Functions. Subscripted

Variables and Subroutines – DIM Statements – Array – One

Dimensional and Two Dimensional Matrix, Manipulations – DEF

Function.

UNIT – III:

Chemistry and Basic Programming:

Introduction – Calculation of Molecular Weight of Organic

Compounds – Mean Activity Coefficient of An Electrolyte –

Determination of RMS, Average, Most Probable Velocity of Gases –

Calculation of Ionic Strength of a Mixture of Two Electrolytes .

UNIT – IV:

C Programming:

Introduction – Variables – Constants – Operations – Functions –

Arrays and Pointers – Structures and Unions – Files in C Language –

Writing a C Program using the Various Features of C Language.

UNIT – V:

Application of C Language in Chemistry:

Solving Simple Problems such as – Determination of Electro

Negativity of an Atom from Bond Energy Data using Pauling’s Relation

– Determination of Normality, Molarity and Molality of Solutions –

Determination of Concentration of Complexes using Beer – Lambert’s

Law – Ionic Strength of a given Solution.

REFERENCES:

01. Raman K.V., Computers in Chemistry, Tata McGraw–Hill Publishing Company Limited, New Delhi, 2003.

02. Peter and Norttron, Introduction to Computers, Tata McGraw–Hill Publishing Company Limited, New Delhi, 2007.

03. Balagurusamy E., Programming in ANSI C, Tata McGraw–Hill

Publishing Company Limited, New Delhi, 2008.

342

M.Sc CHEMISTRY : Those who have joined from the

academic year 2014-15 onwards under CBCS System

EVALUATION PATTERN

Internal : 25 Marks

External : 75 Marks

INTERNAL:

Test -15 (average of the better two of the three tests conducted)

Assignment - 5

Seminar - 5

Question Paper Pattern:

INTERNAL EXTERNAL

Part – A : 5/5*1 = 5

Part – B : 5/8*2 = 10

Part – C : 2/3*7.5 = 15

*30

Part – A : 5/8*2 = 10

Part – B : 5/7*7 = 35

Part – C : 3/5*10 = 30

75

* Internal test mark 30 will be converted to 15.

CHOICE BASED CREDIT SYSTEM STRUCTURE...324 CHOICE BASED CREDIT SYSTEM – STRUCTURE FOR THOSE WHO HAVE JOINED FROM THE ACADEMIC YEAR 2014–15 ONWARDS M.Sc CHEMISTRY Sem Subject Hrs.

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