Chiral Catalysis for Therapeutic Drugs I. Organisms sense the chirality of bioactive compounds A. Carvone enantiomers bind different chiral taste and odor sensors: 1) (S)-Carvone is a component of Dill and Caraway flavor 2) (R)-Carvone is a component of Spearmint flavor B. Limonene enantiomers bind different chiral taste and odor sensors: 1) (R)-Limonene is a component of Orange flavor 2) (S)-Limonene is a component of Lemon flavor
12
Embed
Chiral Catalysis for Therapeutic Drugs I.Organisms sense the chirality of bioactive compounds A.Carvone enantiomers bind different chiral taste and odor.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Chiral Catalysis for Therapeutic DrugsI. Organisms sense the chirality of bioactive compounds
A. Carvone enantiomers bind different chiral taste and odor sensors:
1) (S)-Carvone is a component of Dill and Caraway flavor
2) (R)-Carvone is a component of Spearmint flavor
B. Limonene enantiomers bind different chiral taste and odor sensors:
1) (R)-Limonene is a component of Orange flavor
2) (S)-Limonene is a component of Lemon flavor
C. Aspartame enantiomers bind different chiral taste and odor sensors:
1) One enantiomer of Aspartame is 160 times sweeter than sugar
2) The other enatiomer tastes bitter
II. Chiral DrugsA. Drugs are (or have been) frequently prepared as Racemic Mixtures
1) Usually, only one enantiomer is biologically active
2) The other was generally assumed to be completely inactive
B. Thalidomide is an example where the “silent” enantiomer was actually deadly