Microbiology Student Outline – Chemotherapy and Antibiotics Chemotherapy and Antibiotics Reading: Chapter 20 1. Introduction A. Selective Toxicity 2. Chemotherapy A. Definitions: i. Chemotherapeutic Agents ii. Antibiotics iii. Spectrum of Microbial Activity a. Narrow-spectrum Antibiotics • Penicillin G b. Broad-spectrum Antibiotics • Superinfection * Elimination of competition: Candida albicans * also, Resistance to Drugs iv. Bactericidal Page 1
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Chemotherapy and Antibiotics€¦ · Web viewChemotherapy and Antibiotics. Reading: Chapter 20. 1. Introduction. A. Selective Toxicity . 2. Chemotherapy. A. Definitions: i. Chemotherapeutic
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Microbiology Student Outline – Chemotherapy and Antibiotics
Chemotherapy and Antibiotics
Reading: Chapter 20
1. Introduction
A. Selective Toxicity
2. Chemotherapy
A. Definitions:
i. Chemotherapeutic Agents
ii. Antibiotics
iii. Spectrum of Microbial Activity
a. Narrow-spectrum Antibiotics
• Penicillin G
b. Broad-spectrum Antibiotics
• Superinfection
* Elimination of competition: Candida albicans
* also, Resistance to Drugs
iv. Bactericidal
v. Bacteriostatic
Page 1
Microbiology Student Outline – Chemotherapy and Antibiotics
B. Characteristics of a good chemothereputic agent
i. Selective Toxicity
ii. non-allergenic
iii. disease should not become readily resistant to the drug
iv. host should not destroy, neutralize, or excrete the drug
v. the drug must be able to reach the infection site.
3. Overview of Chemotheraputic Modes of Action (Pull out downloadable handout)
4. Inhibition of Cell Wall Synthesis
A. Penicillin (pp. 559 - 562)
• Antibiotics
• History & Alexander Fleming
i. Structure
ii. Mechanism
• Peptidoglycan
* N-acetylgucosamine
* N-acetylmuramic acid
• Transpeptidase
Page 2
Microbiology Student Outline – Chemotherapy and Antibiotics