1 Chemistry 3719 - Organic Chemistry I • Professor Dr. Peter Norris • Office 6014 Ward Beecher • Telephone (330) 941-1553 • Email [email protected]• Website http://www.as.ysu.edu/~pnorris/ public_html • Lab Coord. Dr. John Jackson • Office 5009 Ward Beecher • Telephone (330) 941-1551 Chemistry Computer Lab North end of Ward Beecher on the 5th floor 24 600 MHz Pentium machines (Gateway) 2 Hewlett Packard network laserjet printers 1 Student assistant All PC’s have MS Office, ChemDraw, ChemSketch, ACD NMR prediction software, Spartan molecular modeling package, Netscape Navigator and MS Internet Explorer Open 9-5 Mon through Fri (see lab door for schedule) www.adobe.com Free Adobe Acrobat Reader What is Organic Chemistry? The study of the compounds that contain carbon and the reactions of those materials (millions known) Why a whole year of Organic? Carbon can bond in multiple ways to form a huge number of different molecules, and these compounds form the basis of many different disciplines, e.g.: Biology (DNA, proteins, carbohydrates) Medicine and Pharmaceuticals (Aspirin, Taxol, AZT) Chemical Engineering (oil, plastics, fine chemicals) Timeline 1807 Berzelius introduces the term “Organic Chemistry” to describe the study of compounds isolated from nature. 1828 Wohler makes urea, the first natural organic compound to be synthesized in the laboratory. 1890 Fischer studies the chemistry of proteins, carbohydrates and the nucleic acids. 1950 Woodward and Eschenmoser complete the first total synthesis of Vitamin B12. 1990 Kishi, Nicolau, Smith, Schreiber, etc. complete total syntheses of compounds such as Brevetoxin B, Taxol, etc. 2001 Schreiber, Dervan, etc. developing “Chemical Biology,” “Chemical Genetics,” and “Chemical Proteomics” to study life processes.
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Chemistry 3719 - Organic Chemistry I
• Professor Dr. Peter Norris• Office 6014 Ward Beecher• Telephone (330) 941-1553• Email [email protected] • Website http://www.as.ysu.edu/~pnorris/
public_html• Lab Coord. Dr. John Jackson• Office 5009 Ward Beecher• Telephone (330) 941-1551
Chemistry Computer LabNorth end of Ward Beecher on the 5th floor
24 600 MHz Pentium machines (Gateway)
2 Hewlett Packard network laserjet printers
1 Student assistant
All PC’s have MS Office, ChemDraw, ChemSketch, ACD NMR prediction software, Spartan molecular modeling package, Netscape Navigator and MS Internet Explorer
Open 9-5 Mon through Fri (see lab door for schedule)
www.adobe.com
Free Adobe Acrobat Reader
What is Organic Chemistry?
The study of the compounds that contain carbon and the reactions of those materials (millions known)
Why a whole year of Organic?
Carbon can bond in multiple ways to form a huge number of different molecules, and these compounds form the basis of many different disciplines, e.g.:
Biology (DNA, proteins, carbohydrates)
Medicine and Pharmaceuticals (Aspirin, Taxol, AZT)
Chemical Engineering (oil, plastics, fine chemicals)
Timeline1807 Berzelius introduces the term “Organic Chemistry” to describe the
study of compounds isolated from nature.
1828 Wohler makes urea, the first natural organic compound to be
synthesized in the laboratory.
1890 Fischer studies the chemistry of proteins, carbohydrates and the
nucleic acids.
1950 Woodward and Eschenmoser complete the first total synthesis of
Vitamin B12.
1990 Kishi, Nicolau, Smith, Schreiber, etc. complete total syntheses of
compounds such as Brevetoxin B, Taxol, etc.
2001 Schreiber, Dervan, etc. developing “Chemical Biology,” “Chemical
Genetics,” and “Chemical Proteomics” to study life processes.
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Organic Synthesis
Taxol Synthesis - 1996 Nicolau and Holton total syntheses ~60 synthetic steps in each
Starting material (cheap) Products (expensive)H2N
O
NH2
UREA - 1828
Palytoxin
Brevetoxin B
Chemistry 3719 and 3720 (and labs)
Lectures
• Structure and nomenclature of compounds and groups
• Physical properties and analysis of materials
• Reactivity and transformations with reagents
• Importance of organic compounds in society
Labs
• Glassware and equipment used to prepare organics
• Instrumentation used to analyze compounds
• Writing detailed reports of lab preparations
Organic Chemistry at YSU
• B.S. and M.S. degrees in Chemistry
• State of the art instrumentation (>$1,000,000 worth)
• Active research programs (Norris and Jackson)
• Student involvement in 3719/20, 4850, 6990
• Students present at regional and national meetings
• Undergrad and graduate students publish in journals
• Companies come to recruit our students
• Students move on to top graduate programs (Penn,
Wisconsin, Ohio State, Purdue, Penn State, UNC, UC-
Irvine, Pitt.)
YSU Students in Organic Chemistry
• Scott Freeze – Penn, 4th year Ph.D. Organic Chemistry
• Rob Cicchillo – Penn State, 3rd year Ph.D. Biochemistry
• Jason McCartney – UC Irvine, 2nd year Ph.D. Organic
• Dan Berndt – UNC Chapel Hill, 2nd year Ph.D. Biochemistry
• Chris Ciolli – Wisconsin Madison, 4th year Ph.D. Organic
• Chris Gabriel – Ohio State, 3rd year Ph.D. Organic
• Andy Fluxe – Medicinal Chemist, Procter and Gamble