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Chemical aspects of the cell The cell from a chemical point of view
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Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

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Page 1: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Chemical aspects of the cell

The cell from a chemical point of view

Page 2: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

2

Main chemicals elements of the cells

Atoms in red correspond to 99% of the total number of atoms present in the

human body and about 96% of our total weight.

Page 3: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Constituição celular

Figure 2.7 Alberts - Chapter 2 3

Page 4: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Some energies important for cells

Figure 2.2 & 2.6 Alberts - Chapter 2 4

Page 5: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

5

Cell structures

Figure 1.8

Karp – Chapter 1

Page 6: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

6

Page 7: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Fatty acids

7 Figure 1.3 - Karp – Chapter 1

Page 8: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Levels of cellular and molecular organization

8

Electron micrograph of the epithelial layer of cells

Figure 1.3 - Karp – Chapter 1

Page 9: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

9

Levels of cellular and molecular organization

Actin protein

subunits that make

up each

microfilament

Apical microvilli

Page 10: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Levels of cellular and molecular organization

10

Individual mitochondrion

Inner membrane of a mitochondrion including the

stalked particles (upper arrow) where ATP is

produced

Molecular models of the ATP-synthesizing

machinery

Page 11: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Structures of an eukariotic cell

11 Figure 1.10 - Karp – Chapter 1

Page 12: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Protein–protein interactions of hub proteins

Figure 2.42

Karp-Chapter 2 12

(a) The enzyme RNA polymerase II, which synthesizes messenger RNAs in the

cell, binds a multitude of other proteins simultaneously using multiple interfaces.

(b) The enzyme Cdc28, which phosphorylates other proteins as it regulates the

cell division cycle of budding yeast. Cdc28 binds a number of different proteins

(Cln1-Cln3).

Page 13: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Three polysaccharides with identical sugar monomers

Figure 2.17 – Karp

Chapter 2 13

Glycogen (a), starch

(b), and cellulose (c)

are each composed

entirely of glucose

subunits

Page 14: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Nucleic acid

Figure 2.26-Alberts

Chapter 2 14

Page 15: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Nucleosome

15 Figure 5.22 - Alberts - Essential... Chapter 5

Page 16: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Relative sizes of cells and cell components

Figure 1.19 - Karp – Chapter 1 16

Page 17: Chemical aspects of the cell - nequimed.iqsc.usp.brnequimed.iqsc.usp.br/files/2017/03/introduction.pdf · Levels of cellular and molecular organization 8 Electron micrograph of the

Biochemical process at the cell

Alberts-Chapter 2 17