Kate M. Wassum, Ingrid C. Cely, Dr. Sean B. Ostlund, Dr. Nigel T. Maidment, Dr. Bernard W. Balleine Charles Drew University of Medicine and Science 4 th Annual Drug Abuse Research Symposium September 26 th 2008 Endogenous Opioid Regulation of Goal- Directed and Habitual Behavior
15
Embed
Charles Drew University of Medicine and Science 4 th Annual Drug Abuse Research Symposium
Endogenous Opioid Regulation of Goal-Directed and Habitual Behavior. Kate M. Wassum , Ingrid C. Cely, Dr. Sean B. Ostlund, Dr. Nigel T. Maidment, Dr. Bernard W. Balleine. Charles Drew University of Medicine and Science 4 th Annual Drug Abuse Research Symposium September 26 th 2008. - PowerPoint PPT Presentation
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Kate M. Wassum, Ingrid C. Cely, Dr. Sean B. Ostlund, Dr. Nigel T. Maidment, Dr. Bernard W. Balleine
Charles Drew University of Medicine and Science4th Annual Drug Abuse Research SymposiumSeptember 26th 2008
Endogenous Opioid Regulation of Goal-Directed and Habitual Behavior
NAc NAs
DMS DLS
PFC
VTA
VP
CeN
MDT
Incentive Value
Opioid Receptors
How and Where are Opioid Receptors Involved in Goal-Directed Behavior?
How are opioid receptors in the basolateral amygdala, ventral pallidum and nucleus accumbens shell involved in affective and incentive value aspects of reward-related behavior?
BLA
Parsing Reward during Goal-Directed Instrumental Behavior
0
20
40
60
80
100
120
Hungry Sated
Motivational State
Ext
inct
ion
Res
po
nse
R
ate
Reduction in responding without ever experiencing the incentive value change.
• Reward PalatabilityAffective component of reward consumption. ‘Liking’Reflected in taste reactivity or licking frequency.
• Incentive ValueThe relative significance of a specific reward outcome that is used to drive reward seeking. ‘How much a rat thinks the outcome of his actions is worth’
• General Motivational ArousalThe animal’s general drive towards all rewards.
Parsing Reward: Heterogeneous Seeking-Taking Chain with Lickometer
SeekingResponse rate changes only after incentive learning Incentive Value
TakingResponse rate changes before consumptionGeneral Motivational Arousal
• Intact endogenous opioid system is necessary for normal goal-directed learning– Endogenous opioids in the VP and NAs important for expression of
palatability, but not reward seeking– Endogenous opioids in the BLA important for the encoding, but not
the retrieval of incentive value, independent from palatability
• Blockade of opioid receptors during learning results in inability of actions to be modulated by negative changes in outcome value
• Potential mechanism by which drugs of abuse may, by compromising the endogenous opioid system, render drug seeking actions inflexible to the value of their outcome
Acknowledgements • Dr. Nigel Maidment • Dr. Bernard Balleine
• Dr. Sean Ostlund• Dr. Robert Brown• Dr. Neil Winterbauer
• ***Ingrid Cely*** • Matt Maga• Hoa Lam• Larry Ackerson