Chapter 10: Meiosis and Sexual Reproduction (Outline) Reduction in Chromosome Number Homologous Pairs Genetic Recombination Crossing-Over Independent Assortment Fertilization Phases of Meiosis Meiosis I Meiosis II Meiosis Compared to Mitosis Human Life Cycle
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Chapter 10: Meiosis and Sexual Reproduction (Outline) Reduction in Chromosome Number Homologous Pairs Genetic Recombination Crossing-Over Independent.
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Chapter 10: Meiosis and Sexual Reproduction (Outline) Reduction in Chromosome Number
Special type of cell division Used only for sexual reproduction Halves the chromosome number prior to
fertilization Parents diploid (2n) Meiosis produces haploid gametes (1n) Gametes fuse in fertilization to form diploid zygote Becomes the next diploid generation
If gametes were not haploid the number of chromosomes would double itself in each generation
Homologous Pairs ofChromosomes
In diploid body cells, chromosomes occur in pairs
Diploid cells have two of each type
Human cells have 46 chromosomes in 23 homologous pairs
Homologous Chromosomes Paired chromosomes in somatic cells
Similar in size, shape and position of their centromeres
Carry information about the same genetic traits (not always the same information)
When stained, they show similar banding patterns
Homologous Chromosomes
Homologous Pairs ofChromosomes
Homologous chromosomes have genes controlling the same trait at the same position Each gene occurs in duplicate, why?
The variants that exist for a gene are called alleles
An individual may have: Identical alleles for a specific gene on both homologs
(homozygous for the trait), or
A maternal allele that differs from the corresponding paternal allele (heterozygous for the trait)
Sexual reproduction produces genetic variety Asexual reproduction is advantageous when
environment is stable However, if environment changes, genetic
variability introduced by sexual reproduction may be advantageous
Phases of Meiosis I
Prophase I
Each chromosome is internally duplicated (consists of two identical sister chromatids)
Homologous chromosomes (maternal homologue and paternal homologue) align side by side (synapsis)
Synapsis results in association of four chromatids (a tetrad)
Paired homologous chromosomes exchange genetic material (crossing-over)
Phases of Meiosis I
Metaphase I
Homologous pairs (bivalents) or tetrads arranged onto the metaphase plate independently
The centrioles are at opposite poles of the cell
Spindle fibers from one pole of the cell attach to one duplicated chromosome of each pair (seen as sister chromatids)
Phases of Meiosis I
Anaphase I
Synapsis breaks up
Homologous chromosomes separate from one another and move towards opposite poles
Each pole randomly receives a maternal or paternal chromosome from each homologous pair
Each is still an internally duplicate chromosome with two chromatids
Phases of Meiosis I
Telophase I Daughter cells have one internally duplicate
chromosome from each homologous pair
One (internally duplicate) chromosome of each type (1n, haploid)
Nuclear envelope may reorganize, and cytokinesis may take place
Interkinesis Similar to mitotic interphase but shorter
No replication of DNA, why?
Meiosis I
Phases of Meiosis II:Similar to Mitosis
Prophase II – Chromosomes condense Metaphase II – chromosomes align at
metaphase plate Anaphase II
Centromere dissolves Sister chromatids separate and move to opposite
poles (daughter chromosome) Telophase II and Cytokinesis II
Four haploid cells All genetically unique
Meiosis II
Overview of Meiosis I & II
Contrasting Mitosis and Meiosis
Several fundamental differences between the two processes include: Meiosis requires two nuclear divisions, but mitosis
requires one nuclear division
Meiosis produces four daughter cells, but mitosis results in two daughter cells following cytokinesis
In meiosis, daughter cells are haploid, whereas mitosis preserves chromosome number
In meiosis, daughter cells are genetically different from parent and each other, but mitosis results in daughter cells that are genetically identical to parent and to each other
Meiosis vs. Mitosis Occurrence
Meiosis occurs only at certain times in the life cycle of sexually reproducing organisms
In humans, meiosis occurs in reproductive organs and produces gametes
Mitosis is more common since it occurs in all tissues during growth & repair
Process Meiosis I compared to Mitosis
Meiosis II compared to Mitosis
Meiosis I Compared to Mitosis
Meiosis II Compared to Mitosis
Life Cycle Basics:Plants Life cycle – reproductive events that occur from one
generation to the next similar generation Haploid multicellular gametophyte alternate with
diploid multicellular sporophyte Mosses are haploid most of their
life cycle In fungi and most algae, only the
zygote is diploid In plants, algae and fungi,
gametes are produced by haploid individuals
Life Cycle Basics:Animals In animals, somatic cells are diploid and
multiply by mitosis – the only haploid cells produced are gametes
Gametes develop when germ line cells undergo meiosis
Gametogenesis is the formation of gametes Spermatogenesis (male gametogenesis) forms
four haploid sperm cells for each cell that enters meiosis
Oogenesis (female gametogenesis) forms one egg cell (ovum) for every cell that enters meiosis, plus polar bodies
The Human Life Cycle
A sperm and egg fuse at fertilization
Results in a zygote Undergoes mitosis
Results in multicellular embryo As a result of mitosis, each
somatic cell in body Has same number of
chromosomes as zygote Has genetic makeup
determined when zygote was formed
Oogenesis in Humans
Ovaries contain oogonia that produce primary oocytes during fetal development
Primary oocyte continue to develop at onset of puberty and divide through meiosis I into two cells
One of these cells (secondary oocyte) receive most of the cytoplasm; the other polar body may divide or disintegrate
Secondary oocyte begins meiosis II but stops at metaphase II
Then leaves the ovary and enters the oviduct If sperm enters, meiosis II continues & another polar
body forms
Spermatogenesis in Humans
Spermatogenesis takes place within the testes
Stem cells within the testes (spermatogonia) become primary spermatocytes; undergo spermatogenesis