Challenges of the US Cascade of Care Melanie Thompson, MD AIDS Research Consortium of Atlanta Georgia Department of Public Health
Dec 15, 2015
Challenges of the US Cascade of Care
Melanie Thompson, MDAIDS Research Consortium of AtlantaGeorgia Department of Public Health
CHALLENGE #1: FINDING DATA TO BUILD A CASCADE
The “Gardner Cascade”
Gardner E, et al. CID 2011:52 (Mar 15)
CDC Treatment Cascade (July, 2012)
HIV Care Cascade in Georgia, 2010
0102030405060708090
100
80
51
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Diagnosed 1,970 with HIV diseaseEstimated 2,375 individuals with HIV disease (1,970 + 20%)Linked 1,026 (51%) to care within 3 months of HIV diagnosis
Courtesy J. Kelly, GA Department of Public Health
OOPS!
The “Gardner Cascade”
Gardner E, et al. CID 2011:52 (Mar 15)
75%
50% 80% 75% 80%
79%
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Sources of Data: HIV - Total and Diagnosed
• Total number of persons living with HIV in the US: CDC – Hall HI, Song R, Rhodes P, et al. Estimation of HIV incidence in the United
States. JAMA 2008; 300:520–9.
• Number of persons diagnosed with HIV in the US: CDC– Campsmith ML, Rhodes PH, Hall HI, Green TA. Undiagnosed HIV prevalence
among adults and adolescents in the United States at the end of 2006. J Acquir Immune Defic Syndr 2010; 53:619–24.
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Sources of Data: Linkage• St. Louis, Missouri (1997–2002): 73% in HIV care
within 1 year after HIV diagnosis (Perkins)
• New York City: 64% in care within 3 months of new HIV diagnosis (Torian)
• ARTAS: 60% receiving only passive referrals to care linked to HIV care within 6 months. (Gardner)
• “In summary, we conclude that 75% of individuals with newly diagnosed HIV infection successfully link to HIV care within 6–12 months after diagnosis”
Perkins D, et al. AIDS Care 2008; 20:318–26. Torian LV, et al. Arch Intern Med 2008; 168:1181–7.Gardner LI, et al. AIDS 2005; 19:423–31
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Sources of Data: Retention• Three population-based studies from the US:
45%–55% fail to receive HIV care during any year (Perkins, Ikard, Olatosi)
• Multiple cohort studies: 25%–44% of HIV-infected individuals are lost to follow-up (Hill, Arici, Coleman, Mocroft)
• “In summary, ~ 50% of known HIV-infected individuals are not engaged in regular HIV care.”
Hill T, et al. J Clin Epidemiol 2010; 11:432–8.Arici C, et al..HIV Clin Trials 2002; 3:52–7.Coleman S, et al.. AIDS Patient Care STDS 2007;21:691–701.Mocroft A, et al. HIV Med 2008; 9:261–9
Perkins D, et al. AIDS Care 2008; 20:318–26.Ikard K, et al. AIDS Educ Prev 2005; 17:26–38.Olatosi BA, et al. AIDS 2009; 23:725–30.
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Source of Data: Need for ART• In 2012, both DHHS and IAS-USA
recommended that all persons with HIV be offered ART regardless of CD4 cell count– Panel on Antiretroviral Guidelines for Adults, and Adolescents. Guidelines for the use
of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services, March 27, 2012: Available at: http:www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
– Thompson MA, et al. Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA 2012;308:387-402. doi:10.1001/jama.2012.7961.
• Therefore the number of persons “in need” of ART is the same as the number of persons living with HIV, whether diagnosed or undiagnosed o
Source of Data: ART• US (2003): 67% of HIV-infected persons in care were
eligible for ART (CD4 cell count <350 cells/µL);, 21% of these were not receiving therapy (Teshale)
• British Columbia: 89% of individuals in care required ART; 27% declined or failed to initiate therapy. (Lima)
• “We estimate that 80% of in-care HIV-infected individuals in the United States should be receiving ART but that 25% of these individuals are not receiving therapy.”
Teshale E, et al. abstract 12th CROI. Boston, MA, USA: 2005.Lima VD, et al. PLoS One 2010; 5:e10991. o
Source of Data: Viral Suppression• 2 studies: 78%–87% of individuals receiving
ART, including those receiving initial and subsequent regimens, had an undetectable viral load– Gill VS, Lima VD, Zhang W, et al. Improved virological outcomes in British Columbia concomitant
with decreasing incidence of HIV type 1 drug resistance detection. Clin Infect Dis 2010; 50:98–105.
– Das M, Chu PL, Santos GM, et al. Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco.PLoS One 2010; 5:e11068.
• “ ~ 80% of treated individuals have an undetectable viral load (defined as < 50 copies/mL).”
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CDC Cascade, 2011
MMWR, December 2, 2011;60(47);1618-23.
CDC Cascade Data Sources
• Linkage to care – Marks G, et al. Entry and retention in medical care among HIV diagnosed persons:
a meta-analysis. AIDS 2010:24:2665-78– Torian, et al. (see previous)
• Retention in care– Hall IH, et al. Retention in care of HIV-infected adults in 13 US areas. National HIV
Prevention Conference. Atlanta. August 14-17, 2011. – Tripathi A, et al. The impact of retention in early HIV medical care on viro-immunological
parameters and survival: a statewide study. AIDS Res Hum Retroviruses 2011;27;751-8.
• Antiretroviral prescription: Medical Monitoring Project
• Viral suppression: Medical Monitoring Project
June 5, 2012 www.annals.org
RECOMMENDATIONS:ENTRY INTO/RETENTION IN CARE
Systematic monitoring of successful entry into HIV care is recommended for all individuals diagnosed with HIV (IIA)
Systematic monitoring of retention in HIV care is recommended for all patients (IIA)
Brief, strengths-based case management for individuals with a new HIV diagnosis is recommended (IIB)
Intensive outreach for individuals not engaged in medical care within 6 months of a new HIV diagnosis may be considered (IIIC)
Use of peer or paraprofessional patient navigators may be considered (IIIC)
www.iapac.org
CHALLENGE #2: STANDARDIZE THE METRICS
IOM Metrics
http://www.iom.edu/Reports/2012/Monitoring-HIV-Care-in-the-United-States.aspx
7 Core HHS Indicator MeasuresMeasure Numerator Denominator
HIV Positivity # HIV positive tests in 12-month period # HIV tests conducted in 12-mo
Late HIV Diagnosis # persons with a dx of Stage 3 HIV (AIDS) within 3 mo of dx of HIV infection in 12-mos
# persons with an HIV diagnosis in the 12-mos
Linkage to HIV Medical Care
# who attended a routine HIV medical care visit within 3 months of HIV dx
# who attended a routine HIV medical care visit within 3 mo of HIV dx
Retention in HIV Medical Care
# with an HIV dx and at least 1 HIV medical care visit in each 6 mo period of the 24 mo measurement period, with a minimum of 60 days between the 1st medical visit in the prior 6 mo period and the last medical visit in the subsequent 6 mo period
# with an HIV diagnosis with at least 1 HIV medical care visit in the first 6 mo of the 24 mo ‐measurement period
Antiretroviral Therapy (ART)
# with an HIV dx who are prescribed ART in 12 months
# with an HIV diagnosis with ≥ 1 HIV medical care visit in 12 mo
Viral Load Suppression
# with HIV diagnosis with a viral load <200 copies/mL at last test in the 12–month period
# with HIV diagnosis who had at least one HIV medical care visit in the 12-months
Housing Status # with HIV diagnosis who were homeless or unstably housed in the 12-month period
# with HIV diagnosis receiving HIV services in the last 12 months
CHALLENGE #3: CASCADES DIFFER BY CONTEXT
CDC Treatment Cascade (July, 2012)
CDC Treatment Cascade: Race
CDC Treatment Cascade: Age
CDC Treatment Cascade: Risk
CHALLENGE #4: IMPLEMENTATION BARRIERS
Impact of Social Determinants of Health on the Care Cascade
• Every step is affected by– Stigma and discrimination – Racism, homophobia– Poverty – Risk of criminalization– High incarceration rates and difficulty with transition– Housing instability– Employment instability– Co-existing conditions: substance use, mental health
disorders
Increasing Diagnosis: Challenges• Testing must be free and accessible• Stigma deters testing
– Fear of loss of job, loss of insurance or increased premiums, – Pre-existing conditions – ACA will address– Rejection by family and friends, effect on children– Domestic violence
• Mixed messages: high impact (targeted) testing vs “know your status”; funding streams dictate testing availability
• Home HIV testing: not inexpensive; how to track numbers and linkage?
• Fourth generation Ag-Ab testing will bring about increased need for surveillance and services for acute infection
Linkage and Retention: Challenges• Barriers include Ryan White eligibility requirements
for indigent populations– Identity, income, residency, HIV status
• Transportation, child care• Clinics only open when patients are at work; taking off
work costs money, risks job• Co-morbidities require seeing different doctors• Frequent doctor visits = disclosure• Co-pays• Other life priorities, lack of education about why care
is important• Depression, substance use disorders
ART and Viral Suppression: Challenges
• Fear of toxicity• Cost: high co-pays, high deductables,
Medicare donut hole• Meds = disclosure• Drugs for co-morbidities• Potential drug interactions• Lack of education about benefits
CHALLENGE #5: HOW WILL THE ACA AFFECT THE CARE CASCADE?
What is Affordable Care?• “Affordable” premiums are not the whole story• High deductable plans are unaffordable for
many• High co-pays are often unaffordable and may
lead to inconsistent drug access• SU/MH benefits often minimal, if present• Transportation not covered• Case management not covered
When Insurance Isn’t Enough
• It is October• Denise is a 38 yo black woman with a new HIV
diagnosis with CD4 count of 675 cells/µL• She works in a restaurant and has insurance– Her insurance has a $2000 deductable
• She began EFV/TDF/FTC because of ease of use but could not tolerate EFV
• She changed to ATV/RTV + TDF/FTC but could not tolerate ritonavir
• She then started RAL + TDF/FTC
Lessons Learned: PCIP
• Most existing Ryan White clinics not prepared or structured to file for and receive insurance payments: patients on PCIP must seek other care providers
• Copays and deductables now paid by state RW funds may not be covered for ACA plans
• Traditional health insurance often does not provide wrap-around services: what will RW cover? Patients dependent upon these services
a few thoughts…
Recommendations• Base cascades on real data: build systems to collect• Need to coordinate with databases outside of public
health: Medicare/Medicaid, Vital Statistics, pharmacy databases
• Need standard definition of each indicator (harmonize IOM, HHS, HRSA, CDC)
• Need resources and guidance to assist local jurisdictions in creating their own care cascades– Use cascade to monitor specific targeted populations over
time: race/ethnicity, age, risk, gender– Use local outcomes to build cascades of geographic areas:
states, local jurisdictions, clinics, zip codes, census tracts– Use cascade to educate and advocate
FUTURE RESEARCH RECOMMENDATIONS :ENTRY INTO/RETENTION IN CARE
Operational research to optimize / standardize measurement Comparative evaluation of monitoring strategies in conjunction
with intervention studies Comparison of retention measures with one another Comparative evaluation of case management in community
settings Comparative evaluation and cost effectiveness for best practices
for implementation of case management interventions Comparative evaluation of other intervention approaches: peer
support, patient navigation, health literacy, life skills Prospective evaluation of pay for performance interventions
www.iapac.org
Recommendations
• We must fund wrap-around services, transportation, case management, patient navigation: RW safety net for insured patients
• We must have an ARV safety net – Coverage for deductables and ARV co-pays for
persons with private insurance who meet criteria• We must have a safety net for undocumented
persons who will not be accepted in Medicaid expansion programs
Back Up Slides
IOM Standards
• Proportion of people newly diagnosed with HIV with a CD4+ cell count >200 cells/mm3 and without a clinical diagnosis of AIDS
• Proportion of people newly diagnosed with HIV who are linked to clinical care for HIV within 3 months of diagnosis
• Proportion of people with diagnosed HIV infection who are in continuous care (two or more visits for routine HIV medical care in the preceding 12 months at least 3 months apart)
• Proportion of people with diagnosed HIV infection who received two or more CD4 tests in the preceding 12 months
• Proportion of people with diagnosed HIV infection who received two or more viral load tests in the preceding 12 months
• Proportion of people with diagnosed HIV infection in continuous care for 12 or more months and with a CD4+ cell count ≥350 cells/mm3
• Proportion of people with diagnosed HIV infection and a measured CD4+ cell count <500 cells/mm3 who are not on ART
• Proportion of people with diagnosed HIV infection who have been on ART for 12 or more months and have a viral load below the level of detection
• All-cause mortality rate among people diagnosed with HIV infection
Supportive services
• Proportion of people with diagnosed HIV infection and mental health disorder who are referred for mental health services and receive these services within 60 days
• Proportion of people with diagnosed HIV infection and substance use disorder who are referred for substance abuse services and receive these services within 60 days
• Proportion of people with diagnosed HIV infection who were homeless or temporarily or unstably housed at least once in the preceding 12 months
• Proportion of people with diagnosed HIV infection who experienced food or nutrition insecurity at least once in the preceding 12 months
• Proportion of people with diagnosed HIV infection who had an unmet need for transportation services to facilitate access to medical care and related services at least once in the preceding 12 months