Retrospective Clinical Research Report Cerebrospinal fluid changes and clinical features of aseptic meningitis in patients with Kawasaki disease Fan Hu 1,2,3 , Xiaoqing Shi 1,2,3 , Yang Fan 1,2,3 , Hanmin Liu 1,2,3 and Kaiyu Zhou 1,2,3 Abstract Objective: To assess the distinguishing features of aseptic meningitis (AM) in patients with Kawasaki disease (KD) compared with bacterial meningitis (BM) patients. Methods: Thirty-eight patients with KD and 126 patients with BM were retrospectively inves- tigated. The following clinical manifestations and laboratory parameters were compared between the two groups: duration of fever before lumbar puncture, conjunctival injection, oral cavity changes, rash, cervical lymphadenopathy and extremity changes, vomiting, front fontanel bulging, neck stiffness, leukocyte number, hemoglobin level, platelet number, C-reactive protein level, cerebrospinal fluid (CSF) content, liver enzyme level, and urinalysis. Results: Vomiting and neck stiffness were more prevalent in patients with BM. KD patients with AM showed elevated blood leukocyte numbers and C-reactive protein levels in the early febrile stage. CSF glucose was significantly lower in patients with BM compared with KD patients with AM. Receiver operating characteristic curve analysis showed that the optimal cutoff value of CSF glucose for discrimination of BM and AM/KD was 2.945 mmol/L, with a sensitivity of 84.2% and a specificity of 71.4%. Conclusions: Detailed investigations of clinical manifestation and laboratory parameters are necessary to distinguish AM and BM in patients with KD. Decreased CSF glucose is a potential indicator of BM. 1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China 2 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China 3 Key Laboratory of Obstetrics, Gynecology and Pediatric Diseases of Sichuan Province, Chengdu, Sichuan, China Corresponding author: Hanmin Liu, Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu 610041, China. Email: [email protected] Journal of International Medical Research 49(2) 1–8 ! The Author(s) 2021 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/0300060520980213 journals.sagepub.com/home/imr Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Related Documents
