Centre for Organometallic Chemistry Dr. R. Ramesh Professor and Coordinator Genesis Organometallic chemistry lies at the interface between classical organic and inorganic chemistry which provides a common platform for both organic and inorganic chemists to work under a single roof. This field has provided a series of important conceptual insights and surprising structures. The sustained interest in the area is due to the application of organometallic compounds in selective organic synthesis, particularly in the development of industrially important, high-performance, homogeneous catalysts and the enormous potential of organometallics as precursors in the production of new advanced materials such as sensors, switches and other types of solids with important, nonlinear optical properties. Further, bio- organometallic chemistry is an emerging field of research and, in particular, the use of organotransition metal complexes as potential anticancer agents appears to be promising. About the centre In appreciation of the contributions made by the research group under the leadership of Prof. R. Ramesh, Bharathidasan University has approved the proposal for the creation of a Centre and thereby the ‘Centre for Organometallic Chemistry’(COMC)was established in the year 2016.The Centre has been supported by various national funding agencies like UGC, CSIR, DST-SERB. Further, Indo-French Center for Promotion of Advanced Research (IFCPAR), New Delhi has sanctioned an amount of Rs.1.90 crores under the scheme of collaborative research project, with Dr. David Semeril and Dr. Domnique Matt, Laboratory of Molecular Inorganic Chemistry and Catalysis, University of Strasbourg, France. This project offers exchange visits for both Principal Investigators and research scholars for three years. At present the centre has instruments facilities such as GC-MS, GC, Electrochemical analyser, Schlenk line set- up, Rotavapours and some more will be acquired. Mission COMC encourages the development of novel and innovative ideas and solutions in the field of organometallic chemistry and to generate new materials for various applications. Vision Our Centre (COMC) is dedicated to Promote the development of innovative research programs Perform high-quality research in the field of organometallic chemistry
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Centre for Organometallic Chemistry
Dr. R. Ramesh
Professor and Coordinator
Genesis
Organometallic chemistry lies at the interface between classical organic and inorganic
chemistry which provides a common platform for both organic and inorganic chemists to work
under a single roof. This field has provided a series of important conceptual insights and
surprising structures. The sustained interest in the area is due to the application of
organometallic compounds in selective organic synthesis, particularly in the development of
industrially important, high-performance, homogeneous catalysts and the enormous potential
of organometallics as precursors in the production of new advanced materials such as sensors,
switches and other types of solids with important, nonlinear optical properties. Further, bio-
organometallic chemistry is an emerging field of research and, in particular, the use of
organotransition metal complexes as potential anticancer agents appears to be promising.
About the centre
In appreciation of the contributions made by the research group under the leadership of
Prof. R. Ramesh, Bharathidasan University has approved the proposal for the creation of a
Centre and thereby the ‘Centre for Organometallic Chemistry’(COMC)was established in the
year 2016.The Centre has been supported by various national funding agencies like UGC, CSIR,
DST-SERB. Further, Indo-French Center for Promotion of Advanced Research (IFCPAR), New
Delhi has sanctioned an amount of Rs.1.90 crores under the scheme of collaborative research
project, with Dr. David Semeril and Dr. Domnique Matt, Laboratory of Molecular Inorganic
Chemistry and Catalysis, University of Strasbourg, France. This project offers exchange visits for
both Principal Investigators and research scholars for three years. At present the centre has
instruments facilities such as GC-MS, GC, Electrochemical analyser, Schlenk line set- up,
Rotavapours and some more will be acquired.
Mission
COMC encourages the development of novel and innovative ideas and solutions in the
field of organometallic chemistry and to generate new materials for various applications.
Vision
Our Centre (COMC) is dedicated to
Promote the development of innovative research programs
Perform high-quality research in the field of organometallic chemistry
Sensitize a diverse population of students towards this area of research
Develop the strategic partnerships with chemical industry, pharmaceuticals, research
laboratories spread over the country
Extending the Centre’s facilities for campus and external users
Produce knowledgeable graduates for careers in academia, industry and Government sectors
Encourage participation of young students in seminars/ workshops/conferences
Objectives
The main objectives of the Centre involve,
Design and synthesize of new platinum group metals based organometallic compounds
Generation of active and recyclable catalysts for organic transformations
Organic synthesis via organometallic compounds
Development of potential metallo drugs
New materials such as sensors, switches, nanomaterials for diverse applications.
Synthesis
Centre for Organometallic Chemistry is mainly focusing on the synthesis of platinum
group of organometallic complexes containing various multidendate ligands.These compounds
have attracted much attention in organic synthesis, catalysis, materials and biology. In light of
this, we have been actively working in the synthesis of Ru, Rh, Pd, Pt and Ni based complexes of
carbonyls, tripodals, pincers, NHC, resorcin[4]arene, Schiff bases including TSC, hydrazones.
Further, severalsub areas in this field were identified to advance environmentally friendly and
sustainable processes and the research work is in progress.
Ru-Pincer complex
complexes
Pd-(Bis) TSC
complex
Metal mediated organic synthesis
Transition metals especially platinum
group metals open up new opportunities for
organic synthesis. In search for unconventional
and efficient approach towards metal mediated
organic synthesis, our research group is actively
involved in the development of flexible, efficient
and environmental benign catalytic protocols
for the synthesis of organic compounds,
intermediates and pharmaceutically important
targets. Our research group is engaged in the
development of several new Ru catalysts for
greener synthesis of amides and imines and Pd
catalysts for C-C, (Suzuki-Miyaura, Heck), C-N
(Buchwald-Hartwig), C-O, coupling reactions
and various other reactions. Organic
compounds were synthesized in excellent yield
with low loading catalysts with high TON/TOF.
Further, our goal is to develop new class of
organometallic catalysts, which are expected to
find widespread applications in the synthesis of
organic materials and bioactive compounds.
Catalytic organic transformations
Organometallic catalysts are able to efficiently
promote different organic transformations. In this
class, ketones and imines to alcohols/amines
(transfer hydrogenation), alcohols to carbonyl
compounds (oxidation), aldehydes to amides and
olefin to aldehydes (oxidation) are powerful method
for the synthesis of fine chemicals for both
laboratory and industrial applications. In particular,
ruthenium and rhodium catalyst containing pincer,
Schiff base, thioamide, hydrazone and
thiosemicarbazone ligands have proven to be
effective catalysts for above organic
transformations. Recently, we have developed
ruthenium(II), ruthenium(III) and rhodium(III)
catalysts for many organictransformations.
Investigations are going on to improve catalytic
activity with high product yield in open atmosphere,
without usadditives. Notably, these protocol works
well with ultra- low loading of catalysts with high
turnover numbers in short time towards different
substrates.
Pd- hydrazone
complex
Ru-hydrazone
complex
Rh-Pincer complex
Cyclometallated Ru- TSC
complex
Bio-organometallic chemistry
Bioorganometallic chemistry is an
emerging area in chemical biology due to varied
biological applications of organometallic
compounds.Our current research goal is to design
and study novel cytotoxic organometallic
complexes for targeted therapeutic and diagnostic
applications. We are engaged in the synthesis and
development of specifically targeted cytotoxic
metal complexes such as Cu, Ru, Ni for various
therapeutic and diagnostic applications. Their
detailed binding interaction studies with biological
targets (nucleic acid, proteins etc.) and fate in
biological medium were also investigated. Recently
we have reported several ruthenium(II) arene
complexes with excellent cytotoxicity than
cisplatin against many human cancer cell lines and
Postdoctoral Research: University of Fribourg, Switzerland & Kookmin University, South Korea Current Position: Assistant Professor Govt Arts College Dharmapuri, Tamil Nadu, India.
Dr. R. N. Prabhu-2012 Postdoctoral Research: University of Hyderabad
Current Position: Assistant Professor Bishop Heber College,
Tiruchirappalli Tamil Nadu, India.
Dr. K. Naresh Kumar-2006 Postdoctoral Research: University
of Zurich, Switzerland Current Position:
Research Manager Indian Oil Corporation Limited New Delhi, India.
Dr. E. Sindhuja-2015 Current Position: Assistant professor Sri Paramakalyani College Alwarkurichi, Tirunelveli
Tamil Nadu, India.
Dr. S. Kannan-2008 Postdoctoral Research: Kookmin University, South Korea
Current Position: Research Manager Indian Oil Corporation Limited
New Delhi, India.
Dr. A. K. Devi-2015 Current Position: Assistant professor Vivekanandha College for Women, Namakkal Tamil Nadu, India
Dr. M. Ulaganatha Raja-2011 Postdoctoral Research: University
of Neuchatel, Switzerland Current Position:
Assistant Professor SVN College, Nagamalai
Madurai, Tamil Nadu, India.
Dr. M. Subarkhan-2017 Current Position:
Zhejiang University, PR China Postdoctoral Researcher
Dr. N. Raja-2012 Postdoctoral Research: University of Neuchatel, Switzerland
Current Position: Assistant Professor Anna University constituent College, Ariyalur, Tamil Nadu, India.
Dr. R. Raj Kumar-2017 Current Position: Postdoctoral Researcher Xian Jiatong University PR China
Dr. D. Pandiarajan-2012 Postdoctoral Research: University of Zurich, Switzerland
Current Position: Assistant Professor Jain University Bengaluru, India.
Dr. S. Muthumari-2019 Current Position: Postdoctoral Researcher IIT-Bombay, Mumbai.
9 A new series of Ru(II) and Pd(II) aroylhydrazone complexes: Synthesis, structure, catalytic applications to transfer hydrogenation and carbon-carbon coupling reactions
PI 40.0 2013- 2016 SERB
10 Influences of the resorcin [4] arene on the catalytic outcomes
PI 189.64 2013- 2016 Indo-French
11 Development of new organoruthenium catalyst for direct synthesis of amide and amines/imines from dehydrogenation of alcohols
PI 32.0 2017-2020 SERB
International Research Collaborations
1. Phong University of Science and Technology, South Korea. 2. University of Strasbourg, France. 3. Institute of High Energy Physics, China. 4. University of Zurich, Swiss. 5. University of Silesia, Poland.
National Research Collaborations
1. Indian Institute of Chemical Biology (CSIR), Kolkata. 2. Indian Institute of Science (IISc), Bangaluru. 3. University of Hyderabad, Hyderabad. 4. Bharathiar University, Coimbatore. 5. Cochin University of Science and Technology (CUSAT), Kochi. 6. Indian Institute of Technology (IIT), New Delhi. Selected Publications
1. Direct Synthesis of 2,4,5-Trisubstituted Imidazoles from Primary Alcohols by Diruthenium(II) Catalysts under Aerobic Conditions S. Saranya and R. Ramesh*, Org. Biomol. Chem., 17 (2019) 1402. (IF: 3.564)
2. The Tandem C-H/N-H Activation of N-methyl Arylamide Catalysed by Dinuclear Pd(II)
Benzhydrazone complex: A Concise Access to Phenanthrodinone. T. S. Manikandan, R. Ramesh*, D. Semeril, Organometallics, 38 (2019) 319. (IF: 4.051)
3. Synthesis and Structures of Arene Ruthenium(II)-NHC complexes: Efficient catalytic α-
alkylation of ketones via hydrogen auto transfer reaction. G. Balamurugan, S. Balaji, R.Ramesh* and N. Bhuvanesh, Appl. Organomet. Chem., 33 (2019) 4696. (IF: 3.581)
4. Chiral calixarene and resorcinarene derivatives: Conical cavities substituted at their
upper rim by two phosphito units and their uses as ligands in Rh- catalysed hydroformylation. N. Natarajan, M. Pierrevekin, D. Semeril, C. Bauder, D. Matt and R. Ramesh, Catalysis Commun., 118 (2019) 70. (IF: 3.463)
5. Synthesis and structure of arene ruthenium(II) complexes: one pot catalytic approach to
synthesis of bioactive quinolines under mild condition. S. Muthumari, S. Saranya and R. Ramesh*, Appl. Organomet. Chem., 32 (2018) 4582. (IF: 3.581)
6. Synthesis and structure of arene ruthenium(II) benzhydrazone complexes:
Antiproliferative activity, apoptosis induction and cell cycle analysis R. Raj Kumar, R. Ramesh* and G. Malecki, J. Organomet. Chem., 862 (2018) 95. (IF: 1.946)
7. Synthesis and structure of Ru(II) complexes of thiosemicarbazones: Highly selective
catalysts for oxidation of olefins to aldehydes. S. Muthumari and R. Ramesh*, ChemistrySelect 3 (2018) 3036. (IF: 1.505)
8. Direct aerobic strategy for selective synthesis of imines via alcohols and
aminespromoted by ruthenium(II) (η6-cymene) complexes T. S. Manikandan, S. Naveen, N. Loknath and R. Ramesh*, ChemistrySelect, 3 (2018) 1561. (IF: 1.505)
9. Synthesis, antiproliferative activity and apoptosis promoting effects of arene Ru(II)
complexes with N, O chelating ligands N. Mohan, M.M. Khan and R. Ramesh*, J. Organomet. Chem., 859 (2018) 124. (IF: 1.946)
10. Synthesis and structure of new binuclear ruthenium(II) arene benzyl
bis(benzoylhydrazone) complexes: Investigation on antiproliferative activity and apoptosis induction M. Subarkhan, S. Saranya, and R. Ramesh*, Inorg. Chem. Front., 5 (2018) 585. (IF: 5.106)
11. Cavitand chemistry: nickel half-sandwich complexes with imidazolylidene ligands
bearing one or two resorcinarenyl substituents N. Natarajan, T. Chavagnan, D. Sémeril*, E. Brenner, D. Matt, R. Ramesh, and L. Toupet, Eur. J. Inorg. Chem., (2018) 890. (IF: 2.507)
12. Cyclometalated Ru(II)-NHC complexes as effective catalysts for transfer hydrogenation:
Influence of wintip group on catalytic outcomes G. Balamurugan, R. Ramesh* and G. Małecki., ChemistrySelect, 2 (2017) 10603. (IF: 1.505)
13. One-pot catalytic approach for the selective aerobic synthesis of imines from alcohols
and amines using efficient arene diruthenium(II) catalysts under mild condition S. Saranya, R. Ramesh* and G. Małecki., Eur. J. Org. Chem., (2017) 6726. (IF: 2.882)
14. Versatile coordination ability of thioamide ligand in Ru(II) complexes: synthesis,
computational studies, in vitro anticancer activity and apoptosis induction R. Raj Kumar, R. Ramesh* and G. Malecki, New. J. Chem., 41 (2017) 9130. (IF: 3.201)
15. Transfer hydrogenation of ketones catalyzed by half-sandwich (η6-p-cymene)
ruthenium(II) complexes incorporating benzoylhydrazone ligands N. Mohan, S. Muthumari and R. Ramesh*, Appl. Organomet. Chem., 31(2017) 3648. (IF: 3.581)
16. Synthesis and structural characterization of Pd(II) thiosemicarbazonato complex:
catalytic evaluation in synthesis of diaryl ketones from aryl aldehydes and arylboronic acids
R. N. Prabhu and R. Ramesh*, Tetrahedron Lett., 58 (2017) 405. (IF: 2.125) 17. Ru(II) carbazole thiosemicarbazone complexes with four membered chelate ring:
Synthesis, molecular structures and evaluation of biological activities R. Raj Kumar, R. Ramesh* and G. Malecki, J. Photochem.Photobiol B: Biol. 165 (2016) 310. (IF: 3.165)
18. Steric control on the coordination behaviour of carbazole thiosemicarbazones towards
[RuH(Cl)(CO)(AsPh3)3]: A combined experimental and theoretical study R. Raj Kumar, R. Ramesh and G. Malecki, New. J. Chem., 40 (2016) 10084. (IF: 3.201)
19. Synthesis and molecular structure of arene ruthenium(II) benzhydrazone complexes: Impact of substitution at chelating ligand and arene moiety on antiproliferative activity
M. Mohamed Subarkhan, R. Ramesh, Y. Liu, New J. Chem., 40 (2016) 9813. (IF: 3.201) 20. Synthesis and characterization of cycloruthenated benzhydrazone complexes: Catalytic
applications to selective oxidative cleavage of olefins to aldehyde. T.S. Manikandan, R. Ramesh, D. Semeril, RSC Adv., 6 (2016) 97107. (IF: 2.936)
21. Square-planar Ni(II) thiosemicarbazonato complex as an easily accessible and
convenient catalyst for Sonogashira cross-coupling reaction R. N. Prabhu and R. Ramesh*, Tetrahedron Lett., 57 (2016) 4893. (IF: 2.125)
22. Ruthenium(II) Arene Complexes Containing Benzhydrazones: Synthesis, structure and
Antiproliferative Activity M. Mohamed Subarkhan and R. Ramesh*, Inorg. Chem. Front., 3(2016) 1245. (IF: 5.106)
23. Synthesis and catalytic evaluation of ruthenium(II) benzhydrazone complex in transfer
hydrogenation of ketones T. S. Manikandan, S. Saranya, R. Ramesh*, Tetrahedron Lett., 57 (2016) 3764. (IF: 2.125)
24. Highly efficient palladium(II) hydrazone based catalysts for the Suzuki coupling reaction
in aqueous medium S. Muthumari and R. Ramesh*, RSC Adv., 6 (2016) 52101. (IF: 2.936)
25. Antiproliferative activity of cationic and neutral thiosemicarbazone copper(II)
complexes M. Mohamed Subarkhan, R. N. Prabhu, R. Raj Kumar and R. Ramesh*, RSC Adv., 6 (2016), 25082. (IF: 2.936)