Central Ischemic Response Severe drop in Brain MAP > increase in flow to brain & brain MAP, shunt blood away from other organs (vasoconstriction via sympathetic) HOWEVER, long term O2 deprivation shuts down brainstem…lose the integrator Causes systemic vasodilatation and further drop in MAP…… DEATH! Lose systemic sympathetic Results in severe vasodilation HR and contractility DROP Reduced Cardiac Output MAP = CO x R
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Central Ischemic Response Severe drop in Brain MAP > increase in flow to brain & brain MAP, shunt blood away from other organs (vasoconstriction via sympathetic)
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Central Ischemic ResponseSevere drop in Brain MAP > increase in flow to brain & brain MAP,
shunt blood away from other organs (vasoconstriction via sympathetic)
HOWEVER, long term O2 deprivation shuts down brainstem…lose the integrator
Causes systemic vasodilatation and further drop in MAP…… DEATH!
Lose systemic sympatheticResults in severe vasodilation