Center for Tobacco Reference Products Update on 1R6F Production and Proficiency Testing Program September 20, 2015 Naples, FL Funding for this presentation was made possible, in part, by the Food and Drug Administration through grant RFA-FD-14-001. The views expressed in written materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the United States Government. 2015_TSRC59_Chambers.pdf TSRC2015(69) - Document not peer-reviewed
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Center for Tobacco Reference Products Update on 1R6F Production
and Proficiency Testing ProgramSeptember 20, 2015
Naples, FL
Funding for this presentation was made possible, in part, by the Food and Drug Administration through grant RFA-FD-14-001. The views expressed in written materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the United States Government.
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Center for Tobacco Reference Products Goals
• Develop and Provide Certified Tobacco Reference Products
• Establish Proficiency Testing Program• Enhance CTRP Tobacco Research Capability
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• 50 million cigarettes
• 8 production days (23 shifts)
• Contract analysis for HPHCs and physical parameters
• CTRP certificate of analysis• Without the certificate, the material
however costly its production, is valueless (ISO Guide 31)
Status of 1R6F Production/Certification
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University of Kentucky Center for Tobacco Reference Products
Certified Reference Material Certificate of Analysis
Description of CRM Blended Cigarette, unflavored, 84 mm length Lot/Batch Number 1R6F Major starting materials Flue-cured 34%, Burley, 24%, Oriental 12%, Reconstituted 20%, Expanded Flue-cured 7%, and Expanded
Burley 3%. Humectants added to total blend at 8-9% (Isosweet 6.3%, glycerin, 1.7%, propylene glycol 1%) Matrix Tobacco blend
Interpretation of Data
1. Certified values listed below reflect analysis results submitted by ISO 17025-accreditted laboratories using a combination of methods and instrumentation that emulate actual; methods and instrumentation techniques currently utilized in the analysis of given parameters in the analytical community
2. The “Uncertainty” is a combined uncertainty of the CRM as dictated by ISO Guide 35 (2006) using a coverage factor, k = 2.
1R6F Reference Cigarette Certified Values and Uncertainties
International System for Standardization (ISO) Smoking Regime Parameter Certified Value Uncertainty Unit Number of
accepted sets of results, p
Total Particulate Matter (TPM) Tar CO Nicotine Puff counts
1R6F Reference Cigarette Certified Values and Uncertainties
Health Canada Intense (HCI) Smoking Regime Parameter Certified Value Uncertainty Unit Number of
accepted sets of results, p
Total Particulate Matter (TPM) Tar CO Nicotine Puff counts