CPTA Annual Conference September 20, 2013 Sharon L. Dunn, PT, PhD, OCS 1 Cellular Response to Mechanical Force Sharon L. Dunn, PT, PhD, OCS Associate Professor, LSUHSC A Clinician’s Approach to Basic Science • Application of practice to science • Quest for relevance • So much to do……. – so little time Genome Mapping and PT • Genetic Profiling – Susceptibility to disease – Specificity of management • Genetic Engineering – Gene therapy – Regenerative medicine • Influence of our interventions on genetic regulation – “Mechanotransduction” www.cottonexpressions.com Mechanotransduction: “Our” Basic Science? Transduction Transcription & Translation Mechanoreceptors we know Joint Receptors and Muscle Spindle Mechanoreceptors we know Hair Cells – Inner Ear Oghalai lab - Stanford Gellespie & Muller Cell, 2009
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Cellular Response to Mechanical Force · 2018. 4. 2. · Transduction Transcription & Translation Mechanoreceptors we know Joint Receptors and Muscle Spindle Mechanoreceptors we know
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CPTA Annual Conference September 20, 2013
Sharon L. Dunn, PT, PhD, OCS 1
Cellular Response to Mechanical Force
Sharon L. Dunn, PT, PhD, OCS
Associate Professor, LSUHSC
A Clinician’s Approach to Basic Science
• Application of practice to science
• Quest for relevance
• So much to do…….
– so little time
Genome Mapping and PT
• Genetic Profiling – Susceptibility to disease
– Specificity of management
• Genetic Engineering – Gene therapy
– Regenerative medicine
• Influence of our interventions on genetic regulation – “Mechanotransduction”
www.cottonexpressions.com
Mechanotransduction: “Our” Basic Science?
Transduction Transcription & Translation
Mechanoreceptors we know Joint Receptors and Muscle Spindle
Zollner, et al, J Mechanical Behavior of Biomedical Materials, 2013
Fibroblast Transduction
A mouse embryonic fibroblast plated on collagen, stained for actin (green), paxillin (magenta) and p130CAS (cyan) and captured on a spinning disk microscope. This image, highlighting stress fibers and cell-matrix adhesions, was captured by Alvin Guo of the Sawada lab
A mouse embryonic fibroblast stained for the actin cytoskeleton (red) and nucleus (blue) and captured on a spinning disk microscope. This image of stress fibers was captured by Alvin Guo of the Sawada lab