Cellular Basis of Learning and Memory BIPN 148 Spring 2006 April 3-June 9, 2006 This course will examine the cellular and molecular mechanisms that underlie.

Cellular Basis of Learning and MemoryBIPN 148

Spring 2006April 3-June 9, 2006

This course will examine the cellular and molecular mechanisms that underlie learning and memory. Topics covered will include the role of the hippocampus in learning and memory, neurotransmitter systems and receptors involved in learning and memory, and biochemical mechanisms of synaptic plasticity. Emphasis will be placed on discussing experiments from the primary literature. A solid background in cell and molecular biology is expected.

Prerequisites: BILD 1; BILD 2; BIBC 100/102; BIPN140 highly recommended.

Times: MWF at 4:00Location: CSB 001Web Site: http://www.biology.ucsd.edu/classes/bipn148.SP06/

Recommended Text Ghosh and Scanziani Lecture NotesLecture notes are available for purchase through University Readers at http://www.universityreaders.com/students

Grading: Weekly Quizzes: 30%Group paper and presentation: 30%Final Exam: 40%Grading is on a curve.

Discussion Sessions/TA office hours (optional): Pacific Hall 1115Wednesdays at 5:00Fridays at 3:00

Contact Information

Professors: Anirvan Ghosh, Pacific Hall 1123, [email protected], 822 4142.Massimo Scanziani, CMG 2nd Floor, [email protected], 822 3839

TEACHING ASSISTANTS: Will Barkis ([email protected]) and Mark Chen ([email protected])

HUMAN MEMORY

DECLARATIVE(EXPLICIT)

NONDECLARATIVE(IMPLICIT)

FACTS EVENTS

PROCEDURAL (SKILLS AND

HABITS)

PRIMING SIMPLE CLASSICAL

CONDITIONING

NONASSOCIATIVELEARNING

EMOTIONAL RESPONSES

SKELETAL MUSCULATURE

MEDIAL TEMPORAL

LOBE

STRIATUM NEOCORTEX AMYGDALA CEREBELLUM REFLEXPATHWAYS

Subdivisions of Human Memory

Milner B, Squire LR, Kandel ER: "Cognitive neuroscience and the study of memory". Neuron 1998, 20:445-468.

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Ivan Pavlov

Classical Conditioning(an example of implicit memory)

Implicit Memory: Pavlovian Associative Conditioning

Conditioned Stimulus

UnconditionedStimulus

Conditioned Stimulus

UnconditionedResponse

ConditionedResponse

TRAINING

CONTEXTUAL TEST CUED TEST

•Animal is placed in novel context•Hears a tone•Receives foot shock

•Animal is returned to same context•Test for freezing behavior

•Animal is placed in modified context•Hears a tone•Test for freezing behavior

Implicit Memory: Fear Conditioning

0.0

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1.0

LiCl NaClgr

ams

blue

berr

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Implicit memory: Conditioned Taste Aversion

DAY 1

DAY 2

1st Exposure to Food Item

2nd Exposure to Food Item

Injection of LiCl or NaCl

Grams Ingested on 2nd Exposure(LiCl treated group compared to NaCl treated

control)

A B

Implicit Memory: Neophobia

DAY 1

DAY 2

1st Exposure to Food Item

A

Grams Ingested(1st exposure compared to second exposure)

B

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1st intake 2nd intakegr

ams

blue

berr

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2nd Exposure to Food Item

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Hermann Ebbinghaus(Distinction between short-term

and long term memory)

Ebbinghaus Test

ZOGMIFXELRICDAJNEQSORYANQIJGEB

Memorize this set of words

Wait for 1 minute

(keep the words in mind!)

Write down the words in sequence

Did anyone get all 10 right?

Sensory Information

Working Memory/Short term Memory(Minutes)

Long Term Memory(Hours/Days/Years)

By testing subjects after various delays Ebbinghaus developed the concept of short-term and long term memory

Working Memory Requires Frontal Lobe Function

Declarative Memory Required the Hippocampus