PATHO LAB 2 CELL GROWTH & DIFFERENTIATION FRACTIONAL CURETTAGE SPECIMEN 70 yr old presenting with vaginal bleeding HYPERPLASIAyNote that this specimen is the endometrium butsince belongs to a pt who underwent curettage.yNote the pt's age (70) - too old to have vaginalbleeding; should be menopaused where there should be decreased glands in the endometrium indicates a PATHOLOGIC cellular adaptationySeeglands (arrows): Increased - Of different sizes ( some are dilated) yCAUSES: a. excessesof hormones or growth factors b. viral infections (papillomaviruses) - skin warts yDoc mentioned that in hyperplasia in the endometrium, the glands increase in numberbutthe stroma (arrowheads) don'tso there is some crowding of the glandsySimple Hyperplasia: yComplex Hyperplasia: yAtypia: precursor to carcinoma of theendometrium HYPERPLASIA, PROSTATE From a 70y/o male presenting with dysuria yHyperplasia is common to organs with glandsyProstrate (remember normal anatomy) - urethra passes through it - contributes to ejaculation - Normal weight: 10-20gms yThere may be an increased number ofglands & stroma in the prostrateyBenign Prostatic Hypertrophy - I t is a fibromuscular organ; yProstati c Hyperplasia, Nodular (Pathologic)- Grossly, it appears nodular - Glands and stroma proliferateyDysuria - begins at 50 y/o above- Weight can increase to 30-40gms- Increase tissue volumeyTRANSITIONAL ZONE- zone most commonly affected by hyperplasia yPERIPHERAL ZONE- zone most commonly affected by prostaticadenocarcinoma
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