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感染症学雑誌 第67巻 第12号
播種性非定型抗酸菌症を合併 したAIDSの2例 1227
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Jun HAYASHI & Seizaburo KASHIWAGIThe Department of General Medicine, Kyusyu University Hospital
Two cases of Acquired Immune Deficiency Syndrome (AIDS) with disseminated non-tuberculousmycobacterial infection are reported. Both patients had hemophilia and were infected with HumanImmunodeficiency Virus type 1 (HIV) by antihemophilic factor infusion. In case 1, a 44-year-old male,Mycobacterium marinum, which ordinarily causes cutaneous infection, was isolated from sputumbefore death and from the lung, spleen, bone marrow, liver and lymph node at autopsy. This is the firstreport of disseminated M. marinum infection with AIDS. In case 2, a 25-year-old male, Mycobacteriumavium complex, which is the most common strain in non-tuberculous mycobacterial infection among
patients with HIV, was isolated from the lung by TBLB and at autopsy from the lung, liver, spleen,bone marrow, lymph node, stomach, small intestine and testis. He also had a giant intraabdominallymphadenopathy, associated with the M. avium complex infiltration. In conclusion, non-tuberculousmycobacteria can be easily disseminated in patients with AIDS because of dysfunction of cellularimmunity, even when their primary lesions are not severe.