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病理診断生涯教育プログラム Performance Improvement Program in Surgical Pathology
病理診断生涯教育プログラム Performance Improvement Program in Surgical Pathology
JPIP ◆ JPIP1
症例・演習問題
症例・演習問題
2019-11 6
2019-12 7
2019-13 8
2019-14 9
2019-15 10
2019-16 11
2019-17 12
2019-18 13
2019-19 14
2019-20 15
JPIP-B2 0 1 9
Ⓒ C A P 2 0 1 9
●6ページからの症例概要をご参照のうえ、ウェブサイトの「解答フォーム」から
ご解答ください。 [http://www.cgikk.com/pip/]
●各症例ごとに3問ずつの「演習問題」がありますので、こちらにもご解答ください。
※「解答フォーム」は一時保存ができないため、恐れ入りますが一度にすべての解答を
入力してください。
5
Case # 2019-11 症例 # 2019-11
Site: Right Breast
Clinical Summary
A 55-year-old woman with a history of lung carcinoma presents
with a 13.0 cm right breast mass. Grossly, the mass has a
spongy hemorrhagic appearance with illdefined borders.
Histologically the tumor is composed of epithelioid cells
admixed with hemorrhage. The tumor cells are positive for pan-
cytokeratin, EMA, CD31, and ERG.
Master List of Diagnoses
2832 Atypical vascular lesion
1703 Capillary hemangioma
1519 Epithelioid angiosarcoma
2533 Invasive carcinoma of no special type
(ductal; not otherwise specified)
1195 Metastatic lung adenocarcinoma
Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5
Excellent Satisfactory Unsatisfactory
Educational Questions
1. Which of the following is true regarding epithelioid
angiosarcoma (AS) tumor cells?
6137 They are positive for CD31 but always negative for
D2-40.
6138 They are positive for CD34 but negative for FLI1.
6139 They can be positive for cytokeratin and/or EMA.
6140 They can show cytoplasmic staining with FLI1.
6141 They show cytoplasmic staining with ERG.
2. Which is/are the most useful feature(s) to favor hemangioma
over angiosarcoma?
6142 Cytologic atypia of endothelial cells
6143 Presence of blood lakes and/or hemorrhage
6144 Presence of infiltrative growth pattern
6145 Presence of necrosis
6146 Small size, well circumscribed border and low mitotic
activity
3. Which of the following is a pattern characteristic of atypical
vascular lesion that will distinguish it from angiosarcoma?
6147 Negative for cMYC, high Ki-67 proliferative index
6148 Negative for cMYC, low Ki-67 proliferative index
6149 Positive for cMYC, high Ki-67 proliferative index
6150 Positive for cMYC, low Ki-67 proliferative index
6151 Positive for FLI1 and CD31
部位: 右乳腺
臨床概要
55歳女性。既往に肺癌がある。右乳腺に13.0cmの腫瘤を認め
る。肉眼的に、腫瘤は海綿状の出血性外観で、境界は不明瞭で
ある。組織学的に、その腫瘤は上皮様細胞から構成されてお
り、出血を混じている。腫瘍細胞は汎サイトケラチン、EMA、
CD31、およびERGに陽性である。
診断選択肢
(2832) 非定型血管病変
(1703) 毛細血管腫
(1519) 類上皮型血管肉腫
(2533) 非特殊型浸潤癌
(1195) 転移性肺腺癌
スライドの技術的品質
1 2 3 4 5
とても良い 良い 普通 やや不満 不満
演習問題
1~3のそれぞれの質問について答えなさい。
1. 類上皮型血管肉腫(AS)の腫瘍細胞に関して正しい記載は
以下のうちどれか
(6137) CD31に陽性だが、D2-40に常に陰性である
(6138) CD34に陽性だが、FLI1に陰性である
(6139) サイトケラチンおよび/または EMA に陽性であり得
る
(6140) FLI1で細胞質染色を示し得る
(6141) ERG で細胞質染色を示す
2. 血管肉腫より血管腫を支持する最も有用な特徴は以下のう
ちどれか
(6142) 内皮細胞の細胞異型
(6143) 血液湖および/または出血の存在
(6144) 浸潤性増殖パターンの存在
(6145) 壊死の存在
(6146) 小型病変であり、境界明瞭であり、核分裂像が少
ないこと
3. 血管肉腫との鑑別に有用な、非定型血管病変に特徴的なパ
ターンは次のうちどれか
(6147) cMYC 陰性、高い Ki-67標識率
(6148) cMYC 陰性、低い Ki-67標識率
(6149) cMYC 陽性、高い Ki-67標識率
(6150) cMYC 陽性、低い Ki-67標識率
(6151) FLI1および CD31に陽性
6
Case # 2019-12 症例 # 2019-12
Site: Right thigh
Clinical Summary
A 36-year-old man presents to his primary care physician with
complaints of an enlarging mass in his thigh. Physical exam
demonstrates a large, firm, fusiform mass in the deep anterior
thigh measuring approximately 10.0 x 7.0 x 6.0 cm. The patient
does not recall any trauma to the area, and the mass is not
painful to palpation. A needle biopsy and subsequent wide
resection of this mass is performed. Macroscopic examination
demonstrates a 10.0 cm mass with a gelatinous cut surface
without any grossly identified areas of necrosis.
Master List of Diagnoses
1283 Dedifferentiated liposarcoma
1058 Myxofibrosarcoma
1700 Myxoid liposarcoma
2440 Low-grade fibromyxoid sarcoma
1511 Pleomorphic liposarcoma
Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5
Excellent Satisfactory Unsatisfactory
Educational Questions
1. Which of the following is the most significant prognostic
indicator in myxoid liposarcoma?
6274 A mitotic index of greater than 5 mitoses per 10 high-
power fields.
6275 Identification of a CDKN2A mutation.
6276 p53 protein overexpression by immunohistochemistry.
6277 The presence of a round cell component (greater than 5%).
6278 The presence of coagulative necrosis.
2. Which of the following is the most useful aid in the diagnosis
of myxoid liposarcoma?
6279 An immunostain panel that includes CD34, desmin,
and SMA.
6280 Identification of t(12;16)(q13.p11) by molecular analysis.
6281 Immunostains for MDM2 and CDK4.
6282 The presence of MUC4 immunopositivity.
6283 The presence of ring or giant marker chromosomes.
3. Which of the following statements is true of myxoid
liposarcoma?
6284 Myxoid liposarcomas are often radiation-resistant.
6285 Myxoid liposarcomas often display a curvilinear rather
than a plexiform vascular pattern.
6286 Myxoid liposarcomas usually arise in the
retroperitoneum.
6287 Myxoid liposarcomas usually metastasize to sites
other than lung parenchyma.
6288 Targeted therapies do not exist for myxoid
liposarcoma.
部位: 右大腿
臨床概要
36歳男性。大腿に増大する腫瘤があり、かかりつけ医を受診
した。診察では、大腿前面深部に大型で硬い紡錘状の腫瘤があ
り、その大きさは約10.0 x 7.0 x 6.0 cm である。患者はその領
域へのいかなる外傷も思いあたらない。腫瘤の触診時に痛みは
ない。針生検に続き、腫瘤の広範切除が行われた。肉眼的に、
腫瘤は約10.0cm で、割面はゼラチン様であり、壊死は明らか
でない。
診断選択肢
(1283) 脱分化型脂肪肉腫
(1058) 粘液線維肉腫
(1700) 粘液型脂肪肉腫
(2440) 低悪性度線維粘液性肉腫
(1511) 多形型脂肪肉腫
スライドの技術的品質
1 2 3 4 5
とても良い 良い 普通 やや不満 不満
演習問題
1~3のそれぞれの質問について答えなさい。
1. 粘液型脂肪肉腫の最も重要な予後指標は次のうちどれか
(6274) 10高倍率視野あたり5個を超える核分裂像
(6275) CDKN2A 変異の同定
(6276) 免疫組織化学による p53蛋白の過剰発現
(6277) 円形細胞成分の存在(5%超)
(6278) 凝固壊死の存在
2. 粘液型脂肪肉腫の診断において最も有用なものは次のうち
どれか
(6279) CD34、デスミン、および SMA を含む免疫染色パネル
(6280) 分子学的解析による t(12;16)(q13.p11)の同定
(6281) MDM2および CDK4に対する免疫染色
(6282) 免疫染色で MUC4陽性
(6283) 環状または巨大マーカー染色体の存在
3. 粘液型脂肪肉腫について正しい記載は次のうちどれか
(6284) 粘液型脂肪肉腫はしばしば放射線抵抗性である
(6285) 粘液型脂肪肉腫は、叢状の血管パターンではな
く曲線状の血管パターンを示すことが多い
(6286) 粘液型脂肪肉腫は通常後腹膜に発生する
(6287) 粘液型脂肪肉腫は通常肺実質以外の部位に転移する
(6288) 粘液型脂肪肉腫に対する標的療法は存在しない
7
Case # 2019-13 症例 # 2019-13
Site: Peripancreatic lymph node
Clinical Summary A 58-year-old woman presents with diarrhea. Esophagogastroduodenoscopy reveals multiple ulcers throughout the upper gastrointestinal tract, which were refractory to prior proton pump inhibitor treatment. Computed tomography scan shows duodenal and peri-pancreatic masses and regional lymphadenopathy. Laboratory studies show markedly elevated gastrin level. A peripancreatic lymph node is excised. Master List of Diagnoses 2485 Hepatocellular carcinoma 2635 Metastatic papillary renal cell carcinoma 1539 Poorly differentiated neuroendocrine carcinoma
(small cell carcinoma) 2420 Solid pseudopapillary tumor of pancreas 1736 Well-differentiated neuroendocrine tumor Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5 Excellent Satisfactory Unsatisfactory Educational Questions 1. Which of the following is true in determining the proliferation
rate and, thus, the grade in a well-differentiated neuroendocrine tumor (WNET)?
6163 If mitotic activity and Ki-67 are discordant for grade determination, the lowest grade should be used.
6164 Ki-67 index of 20% or greater classifies a WNET as grade 2.
6165 Mitotic activity and Ki-67 are evaluated in 10 high-power fields.
6166 Mitotic activity and Ki-67 are evaluated in hot-spot areas.
6167 Regardless of mitotic activity and Ki-67 index, if metastases are present, the tumor is considered grade 3 neuroendocrine carcinoma.
2. Which of the following immunohistochemical patterns would
support pancreatic solid pseudopapillary tumor, differentiating it from WNET?
6173 Amyloid deposition in a WNET is associated with von Hippel-Lindau syndrome.
6174 Determination of cell types present in a WNET may be elucidated from morphologic findings specific for a given cell type in combination with clinical syndrome present.
6175 H. pylori gastritis and long-term use of proton pump inhibitors are associated with WNETs of the pancreas.
6176 MEN1-associated tumors typically are associated with multiple metastases and an aggressive clinical course.
6177 Zollinger-Ellison syndrome-associated WNETs are frequently metastatic.
(6175) H. pylori 胃炎およびプロトンポンプ阻害薬の長期使用は、膵臓の WNET に関連する
(6176) MEN1関連腫瘍は通常、多発転移と進行性の臨床経過に関連する
(6177) Zollinger-Ellison症候群に関連したWNETはしばしば転移性である
8
Case # 2019-14 症例 # 2019-14
Site: Spleen Clinical Summary A 68-year-old man with a 3-week history of shortness of breath and abdominal discomfort presents to the emergency department. Ultrasound reveals a massively enlarged spleen—the edge is approximately 12.0 cm below the costal margin. No lymphadenopathy is seen. Concurrently performed CBC shows lymphocytosis. Peripheral blood smear examination by an image analyzer flags abnormal lymphocytes with cytoplasmic projections. A manual differential shows that these lymphocytes form 36% of the white blood cells and that the cytoplasmic projections are polar and not circumferential. Given the abdominal discomfort and risk for rupture, an emergency abdominal splenectomy is performed. The spleen weighs 1220 grams and measures 22.0 x 12.0 x 5.0 cm with a dark purple and red capsule with signs of clotted blood and surface rupture. Sections reveal a central area of hemorrhage and several small nodules. Fresh tissue is submitted for flow cytometry, cytogenetics and molecular studies, and histologic examination. Flow cytometry shows that 30% of lymphocytes are kappa restricted B-lymphocytes that are negative for CD5, CD11c, CD103, and CD10. Karyotype revealed a deletion in the long arm of chromosome 7 (del 7q). BRAF V600E mutation analysis is negative. Master List of Diagnoses 2268 Classic Hodgkin lymphoma 1630 Hairy cell leukemia 2408 Hepatosplenic T-cell lymphoma 1809 Lymphoplasmacytic lymphoma 2730 Splenic diffuse red pulp small B-cell lymphoma 1990 Splenic marginal zone lymphoma Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5 Excellent Satisfactory Unsatisfactory Educational Questions 1. Which of the following is true regarding splenic marginal zone
lymphoma (SMZL)? 6178 Almost all cases are of plasma cell origin. 6179 Almost all cases of SMZL are Epstein-Barr virus
driven. 6180 Most cases are seen in adolescents. 6181 Prognosis is very bleak. 6182 SMZL lymphocytes are negative for CD5, CD10, and
CD103. 2. Which of the following is correct regarding SMZL?
6183 BRAF V600E mutation is seen in both SMZL and hairy cell leukemia.
6184 Del 7q is seen in about 30% of SMZL cases, but no specific driver genes are known.
6185 MYD88 mutation is seen in the vast majority of SMZL cases.
6186 NOTCH2 has been identified as the driver mutation in a majority of SMZL cases.
6187 TP53 mutation is associated with all SMZL cases and is useful diagnostically.
3. Which of the following is characteristic for the histologic
appearance of SMZL? 6188 Diffuse large areas of atypical small to medium-sized
A 71-year-old man presents with a superficial 7.0 cm mass of
the left lower leg. He first noticed it 8 months ago. The tumor is
surgically excised. Gross examination shows a vaguely
circumscribed mass with a fleshy cut surface and areas of
myxoid change and necrosis. By immunohistochemistry, the
tumor is negative for pancytokeratin, S100, desmin, and CD34.
Master List of Diagnoses
2240 Low-grade fibromyxoid sarcoma
1058 Myxofibrosarcoma
1700 Myxoid liposarcoma
3023 Myxoinflammatory fibroblastic sarcoma
1521 Pleomorphic rhabdomyosarcoma
Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5
Excellent Satisfactory Unsatisfactory
Educational Questions
1. Which of the following is true about myxofibrosarcoma?
6193 It most commonly arises in the retroperitoneum.
6194 It often metastasizes to other soft tissue sites.
6195 Local recurrence is common.
6196 Most patients are adolescent.
6197 Only high-grade lesions show curvilinear vasculature.
2. Which of the following translocations is diagnostic for
myxoinflammatory fibroblastic sarcoma?
6198 t(1;10)
6199 t(7;16)
6200 t(11;16)
6201 t(12;16)
6202 t(12;22)
3. Which of the following sarcomas can be diagnosed via a
specific immunohistochemical marker?
6203 Low-grade fibromyxoid sarcoma
6204 Myxofibrosarcoma
6205 Myxoid liposarcoma
6206 Myxoinflammatory fibroblastic sarcoma
6207 Undifferentiated pleomorphic sarcoma
部位: 軟部組織
臨床概要
71歳男性。左下腿に7.0cm の表在性腫瘤を認める。8ヶ月前、
患者はその腫瘤にはじめて気づいた。腫瘤の外科的切除が施行
された。肉眼的に、腫瘤は境界不明瞭で、割面は粘液腫様変性
と壊死を所々に伴って肉様である。免疫組織化学では、腫瘍は
汎サイトケラチン、S100、デスミン、および CD34 に陰性であ
る。
診断選択肢
(2240) 低悪性度線維粘液性肉腫
(1058) 粘液線維肉腫
(1700) 粘液型脂肪肉腫
(3023) 粘液炎症性線維芽細胞性肉腫
(1521) 多形型横紋筋肉腫
スライドの技術的品質
1 2 3 4 5
とても良い 良い 普通 やや不満 不満
演習問題
1~3のそれぞれの質問について答えなさい。
1. 粘液線維肉腫について正しい記載は、次のうちどれか
(6193) 後腹膜に最も多く発生する
(6194) 他の軟部組織に転移することがよくある
(6195) 局所再発することが多い
(6196) ほとんどの患者は青年期である
(6197) 曲線状の血管を示すのは高悪性度病変のみである
2. 粘液炎症性線維芽細胞性肉腫の診断に有用な転座は次のう
ちどれか
(6198) t(1;10)
(6199) t(7;16)
(6200) t(11;16)
(6201) t(12;16)
(6202) t(12;22)
3. 特定の免疫組織化学的マーカーによって診断できるのは、
次の肉腫のうちどれか
(6203) 低悪性度線維粘液性肉腫
(6204) 粘液線維肉腫
(6205) 粘液型脂肪肉腫
(6206) 粘液炎症性線維芽細胞性肉腫
(6207) 未分化多形肉腫
10
Case # 2019-16 症例 # 2019-16 Site: Liver Clinical Summary A 63-year-old woman presents with abdominal pain and swelling of several weeks’ duration. Her past history includes a prior cesarean section 30 years earlier and is otherwise unremarkable. Abdominal examination demonstrates a tender, firm, right upper quadrant mass that measures between 9.0-10.0 cm and appears to originate from the liver. Other findings include mild ascites and enlarged liver, but a normal-sized spleen. Subsequent radiologic imaging reveals an 11.3 cm centrally placed heterogenous mass in the liver, appearing to extend retroperitoneally with impediment to the inferior vena cava (IVC) and the left and middle hepatic outflow veins. The patient undergoes an extended left hepatectomy en bloc with a portion of the IVC. The resected liver weighs 1118 grams and demonstrates a large, 12.6 x 11.5 x 5.5 cm grey-white, variegated and poorly circumscribed mass. There are foci of necrosis, cystic change and alternating firm and soft solid areas within the tumor. The tumor is largely intrahepatic but attached to the wall of the IVC, partially occluding the hepatic veins. Immunohistochemically, the tumor cells are positive for vimentin, alpha smooth muscle actin (SMA), and h-caldesmon; weak focal staining for S100 and CD34 is also noted, but desmin, ERG-1, CD117/c-KIT, DOG-1, EMA, CK18, and cytokeratin AE1/3 are negative. Master List of Diagnoses 2056 Angiosarcoma 1944 Epithelioid hemangioendothelioma 1901 Gastrointestinal stromal tumor 2389 Leiomyosarcoma 1674 Metastatic melanoma 2009 Monophasic synovial sarcoma 1648 Sarcomatoid hepatocellular carcinoma 1649 Solitary fibrous tumor 1070 Undifferentiated embryonal sarcoma Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5 Excellent Satisfactory Unsatisfactory Educational Questions 1. Which of the following is correct regarding primary hepatic
leiomyosarcoma (hLMS)? 6208 Any expression of S100 essentially rules out LMS. 6209 It can arise from the ligamentum teres. 6210 It is a common hepatic sarcoma in children. 6211 Its radiologic features are indistinguishable from
hepatocellular carcinoma. 6212 Positive ERG-1 is helpful in confirming LMS.
2. Which staining pattern is most consistent with undifferentiated
embryonal sarcoma? 6213 Negative alpha-1 antitrypsin but PASD-positive
cytoplasmic globules 6214 Negative keratin in oval, spindled, and/or anaplastic
tumor cells 6215 Positive CD34, keratin, and alpha-1 antitrypsin 6216 Positive keratin and PAS positive but PASD negative
cytoplasmic globules. 6217 Positive keratin with dot-like pattern and alpha-1
antitrypsin. 3. Which of the following is the most likely diagnosis for an
epithelioid liver tumor expressing DOG-1 and CD34 but negative for ERG-1 and keratin?
Site: Lung Clinical Summary The patient is a 63-year-old female, former smoker, who presents with cough and a 12-pound weight loss. Computed tomography scan shows a 3.5 cm mass-like consolidation in the right lower lobe with internal air bronchograms and adjacent foci of ground glass opacities. There is no evidence of mediastinal lymphadenopathy. Following a diagnostic biopsy, the patient undergoes a video-assisted right lower lobectomy and a mediastinal lymph node dissection. Gross examination reveals a 3.0 cm, firm, grey-white, well demarcated parenchymal mass, without gross visceral pleura invasion. Master List of Diagnoses 1364 Ciliated muconodular papillary tumor of the lung 1817 Colloid adenocarcinoma 2787 Invasive mucinous adenocarcinoma 1931 Metastatic adenocarcinoma 1819 Mucinous adenocarcinoma in situ 1715 Mucinous cystadenoma 1953 Mucous gland adenoma Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5 Excellent Satisfactory Unsatisfactory Educational Questions 1. Which of the following characteristics would favor the
diagnosis of a colloid carcinoma over an invasive mucinous adenocarcinoma (IMAC)?
6223 Absence of TTF-1 staining and staining for cytokeratin 20 6224 Presence of cytologically bland, mucin producing
tumor cells 6225 Presence of gelatinous, mucoid consistency on gross
examination 6226 Presence of hemorrhage and necrosis 6227 Presence of pools of mucin that destroys alveolar
architecture and incomplete rimming of alveoli by tumor cells
2. Which of the following immunoprofiles is most characteristic
Site: Ovary Clinical Summary A 51-year-old woman presents with abdominal discomfort. On clinical examination, ascites is noted. Imaging studies reveal bilateral ovarian masses and the patient subsequently undergoes exploratory laparoscopic surgery. Intraoperatively, miliary omental nodules are also noted. Total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and bilateral pelvic and para-aortic lymph node dissection is performed. Gross examination reveals multiple yellow-tan nodules, ranging from 0.2-1.5 cm, studding the surfaces of both ovaries and the omentum. Immunohistochemistry shows the tumor cells are positive for calretinin, WT1, and PAX8, while negative for Ber-EP4 and MOC-31. Master List of Diagnoses 2422 Adenomatoid tumor 2331 Low-grade serous carcinoma 1005 Malignant mesothelioma 2377 Serous borderline tumor 5555 Well-differentiated papillary mesothelioma Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5 Excellent Satisfactory Unsatisfactory Educational Question 1. Which of the following is true of well-differentiated papillary
mesothelioma (WDPM)? 6238 Standard management for WDPM includes adjuvant
chemotherapy 6239 WDPM is typically associated with a history of
asbestos exposure. 6240 WDPM is typically MOC31-positive and CK5/6-
negative. 6241 WDPM is usually an incidental finding, predominately
affecting women. 6242 WDPMs tend to form large peritoneal plaques.
2. The presence of which of the following favors a diagnosis of
Site: Lymph node Clinical Summary A 47-year-old man is found to have a white blood cell count of 15,000/microliter and an absolute lymphocyte count of 10,000/microliter. Physical examination reveals axillary lymphadenopathy, and an enlarged lymph node is excised. Flow cytometry is performed on the axillary lymph node and reveals a CD5+ CD200+ kappa restricted B-cell population. Immunohistochemistry demonstrates aggregates of small cells that are positive for CD20, CD23, and LEF1, but negative for SOX11 and BCL1. There are also scattered large atypical cells, which are negative for CD30 and positive for CD45rb. Master List of Diagnoses 2268 Classic Hodgkin lymphoma 2334 Mantle cell lymphoma 5568 Marginal zone lymphoma 2411 Small lymphocytic lymphoma/chronic lymphocytic leukemia 2844 T-cell/histiocyte-rich large B-cell lymphoma Slide Quality: Evaluate the slide for technical quality
1 2 3 4 5 Excellent Satisfactory Unsatisfactory Educational Questions 1. Which entity has the following immunohistochemical profile:
positive for SOX11, positive for BCL1, and usually negative for CD200? 6253 Classical Hodgkin lymphoma (CHL) 6254 Mantle cell lymphoma (MCL) 6255 Marginal zone lymphoma (MZL) 6256 Small lymphocytic lymphoma/chronic lymphocytic
leukemia (SLL/CLL) 6257 T-cell/histiocyte-rich large B-cell lymphoma (TCHRBCL)
2. Which of the following is usually characterized by proliferation centers and LEF1 positivity and can contain scattered Reed-Sternberg-like cells? 6253 CHL 6254 MCL 6255 MZL 6256 SLL/CLL 6257 TCHRBCL
3. Which of the following statements is true?
6258 Acute inflammatory cells such as neutrophils and plasma cells are characteristic of TCHRBCL.
6259 Dim microscope light assists in visualization of proliferation centers in SLL/CLL.
6260 In SLL/CLL, abnormalities of chromosome 13q are an unfavorable prognostic marker.
6261 The phenotype of the large cells in TCHRBCL is CD30(+), PAX5(+), EBER ISH(+), and CD45rb(-).
6262 The typical translocation for SLL/CLL is t(11;14)(q13;q32).