cbe.osu.edu · Web viewWilliam G. Lowrie Department of Chemical & Biomolecular Engineering 2015 FACULTY ACTIVITY REPORT _____ ARAVIND ASTHAGIRI Associate Professor, PhD Carnegie Mellon.

William G. Lowrie Department of Chemical & Biomolecular Engineering

2015 FACULTY ACTIVITY REPORT_____

ARAVIND ASTHAGIRI Associate Professor, PhD Carnegie Mellon. Computational catalysis, energy and sustainability.

Awards and Honors

Lumley Research Award, Ohio State College of Engineering (2015)

Refereed Papers

R. Rai, T. Li, Z. Liang, M. Kim, A. Asthagiri, and J.F. Weaver, “Growth and Termination of a Rutile IrO2(100) Layer on Ir(111),” Surf. Sci. (in press). Z. Huang, W. Luo, L. Ma, M. Yu, M. He, W. Chen, A. Asthagiri, and Y. Wu, “Electrocatalytic Hydrogen Evolution Activity of dimeric [Mo2S12]2- clusters: a molecular analog of MoS2 Edges,” Angew. Chemie, 54, 15181 (2015).W. Luo, X. Nie, M.J. Janik, and A. Asthagiri, “Facet dependence of CO2 reduction paths on Cu electrodes,” ACS Catalysis, 6, 219 (2016).S.A. Akhade, W. Luo, X. Nie, A. Asthagiri, and M.J. Janik, “Theoretical insight on reactivity trends in CO2 electroreduction across transition metals,” Cat. Sci. Tech. (in press DOI: 10.1039/C5CY01339A).J. Choi, L. Pan, V. Mehar, F. Zhang, A. Asthagiri, and J.F. Weaver, “Promotion of CO Oxidation on PdO(101) by adsorbed H2O,” Surf. Sci. (in press). F. Zhang, L. Pan, J. Choi, V. Mehar, J.T. Diulus, A. Asthagiri, and J.F. Weaver, “Propane sigma-complexes on PdO(101): Spectroscopic evidence for the selective coordination and activation of primary C-H bonds,” Angew. Chemie, 127, 14113 (2015). S. Yuk & A. Asthagiri, “A first-principles study of Pt thin films on SrTiO3(100): Support effects on CO adsorption,” J. Chem. Phys., 142, 124704 (2015).J. Choi, L. Pan, F. Zhang, J.T. Diulus, A. Asthagiri, and J.F. Weaver, “Molecular adsorption of NO on PdO(101),” Surf. Sci., 640, 150 (2015).J.F. Weaver, F. Zhang, L. Pan, T. Li, and A. Asthagiri, “Vacancy-mediated processes in the oxidation of CO on PdO(101),” Accounts of Chemical Research, 48, 1515 (2015). Grant Support

$600,000 (2015-2018). Aravind Asthagiri (Co-PI), Jason Weaver (PI); DOE-BES: Growth and Reactivity of Oxide Phases on Crystalline Pd and Pt surfaces.

$110,000 (2016-2018). Aravind Asthagiri (Co-PI), Jay Gupta (PI); ACS-PRF: Studies of CO2 Photoreduction on Cu2O at the Single Molecule Level.”

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$480,000 (2013-2016). Aravind Asthagiri (Co-PI), Umit Ozkan (PI); DOE-BES: Heteroatom-doped carbon materials as oxygen reduction electrocatalysts in acidic and alkaline media.”

BHAVIK R. BAKSHIProfessor, PhD MIT. Sustainability science and engineering, process systems engineering.

Awards and Honors

“Best Papers of 2015,” Environmental Science & Technology (ES&T), first runner-up.

Books and Book Chapters

R. J. Hanes and B. R. Bakshi. “Comprehensive life cycle accounting in sustainable process design.” Sustainability of Products, Processes and Supply Chains: Theory and Applications. Ed. by Fengqi You. Computer Aided Chemical Engineering. Elsevier, 2015.

S. Singh and B. R. Bakshi. “Carbon and Nitrogen Footprints of Chemical and Manufacturing Industry Sectors.” Sustainability in the Analysis, Synthesis and Design of Chemical Engineering Processes. Ed. by G. R. Mercado and H. Cabezas. Elsevier, 2015.

Refereed Papers

S. Bogra, B. R. Bakshi, and R. Mathur. “A Water Withdrawal Input-Output Model of the Indian Economy.” Environmental Science & Technology (2016, accepted).

S. S. Chopra, B. R. Bakshi, and V. Khanna. “Economic Dependence of US Industrial Sectors on Animal-mediated Pollination Service.” Environmental Science and Technology 49.24 (2015), pp. 14441–14451.

R. J. Hanes and B. R. Bakshi. “Process to Planet: A Multiscale Modeling Framework Toward Sustainable Engineering.” AIChE Journal 61.10 (2015), pp. 3332–3352.

R. J. Hanes and B. R. Bakshi. “Sustainable Process Design by the Process to Planet Framework.” AIChE Journal 61.10 (2015), pp. 3320–3331.

R. J. Hanes, N. B. Cruze, P. K. Goel, and B. R. Bakshi. “Allocation Games: Addressing the ill-posed nature of allocation in life cycle inventories.” Environmental Science and Technology, 49.13 (2015), pp. 7996–8003.

Berrin Kursun, Bhavik R. Bakshi, Manoj Mahata, and Jay F. Martin. “Life cycle and energy based design of energy systems in developing countries: Centralized and localized options.” Ecological Modelling 305 (2015), pp. 40–53.Prasad Mandade, Bhavik R. Bakshi, and G.D. Yadav. “Ethanol from Indian agro-industrial lignocellulosic biomass - a life cycle evaluation of energy, greenhouse gases, land and water.” The International Journal of Life Cycle Assessment 20.12 (2015), pp. 1649–1658.

Bhavik R. Bakshi, Guy Ziv, and Michael D. Lepech. “Techno-Ecological Synergy: A Framework for Sustainable Engineering.” Environmental Science & Technology 49.3 (2015), pp. 1752–1760.

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S. Singh and B. R. Bakshi. “Footprints of Carbon and Nitrogen: Revisiting the Paradigm and Exploring their Nexus for Decision Making.” Ecological Indicators 53 (2015), pp. 49–60. Matthew Winden, Nathan Cruze, Tim Haab, and Bhavik Bakshi. “Monetized value of the environmental, health and resource externalities of soy biodiesel.” Energy Policy 47 (2015), pp. 18–24.

Grant Support

$418,965 (2012-2016). Yebo Li, PI; co-PIs Bhavik R. Bakshi and Rudy Buchheit; US Department of Agriculture: Development and demonstration of a low VOC polyurethane coating system using bio polyols derived from crude glycerol.

$6,000,000 (2013-2017). Yebo Li, PI; co-PIs Bhavik R. Bakshi and several others; US Department of Agriculture, BRDI program: Bioenergy and Biofuels Production from Lignocellulosic Biomass via Anaerobic Digestion and Fisher-Tropsch Reaction.

$300,000 (2013-2016). Bakshi, Bhavik R., co-PI: Michael Lepech, Stanford University; National Science Foundation: Seeking Synergy Between Technological and Ecological Systems for Sustainable Engineering.

$46,645 (2014-2016). Bakshi, Bhavik R.; National Science Foundation: US-UK Planning Visit: Techno-Ecological Synergy for Sustainable Engineering.$410,000 (out of $12 million) (2015-2019.)

Bakshi, Bhavik R., PI: Anu Ramaswami, U. Minnesota; National Science Foundation: SRN: Integrated Urban Infrastructure Solutions for Environmentally Sustainable, Healthy and Livable Cities.

$99,994 (out of $12 million, 2015-2020). Bakshi, Bhavik R., PI: Charles Redman, Arizona State University; National Science Foundation: SRN: Urban Resilience to Extremes.

$179,085 (2016-2018). Bakshi, Bhavik R.; Ford Motor Company: Life Cycle Assessment of Carbon Fiber Composites for Auto Applications.

NICHOLAS BRUNELLIAssistant Professor, PhD California Institute of Technology. Heterogeneous and immobilized catalysis and catalytic materials; sustainability, energy, environment.

Refereed Papers

E.G. Borchetta, S. Negretti, K.M. Chepiga, N.A. Brunelli, Y. Labreche, Y. Feng, F. Rezaei, R.P. Lively, W.J. Koros, H.M.L. Davies,* and C.W. Jones.* "Composite Polymer/Oxide Hollow Fiber Contactors: Versatile and Scalable Flow Reactors for Heterogeneous Catalytic Reactions in Organic Synthesis." Angew. Chem. Int. Ed. 2015, 54 (22), 6470-6474.

L. Espinal, M.L. Green, D.A. Fischer, D.M. DeLongchamp, C. Jaye, J.C. Horn, M.A. Sakwa-Novak, W. Chaikittisilp, N.A. Brunelli, C.W. Jones. “Interrogating the Carbon and Oxygen K-edge NEXAFS of a CO2-dosed Hyperbranched Aminosilica.” J. Phys. Chem. Lett. 2015, 6 (1), 148-152.

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E.G. Moschetta, N.A. Brunelli, C.W. Jones. “Reaction-dependent heteroatom modification of acid-base catalytic cooperativity in aminosilica materials.” Appl. Catal. A 2015, 504 (5), 429-439.

Grant Support

$110,000 (2016-2018). Brunelli, PI.; ACS-PRF-DNI: Designing Uniform Paired Copper Catalytic Sites for Conversion of Methane to Methanol (PRF# 55946-DNI5).

$40,000 (2015). Brunelli, PI.; OSU-MRI Exploratory Materials Research Grant: Investigating Crystallization Mechanisms of Microporous Materials Using Ion Mobility-Mass Spectrometry (IM-MS).

JEFFREY CHALMERSProfessor, PhD Cornell. Biochemical engineering, bioengineering, biomedical engineering.


Jeffrey J. Chalmers, Maryam B. Lustberg, Clayton Deighan, Kyoung-Joo Jenny Park, Yongqi Wu, Peter Amaya, “Depletion of normal cells for CTC enrichment,” Circulating Tumor Cells: Isolation and Analysis. John Wiley & Sons, 2015.

Zborowski, M., Chalmers, J.J., “Magnetophoresis: Fundamentals and Applications,” Wiley Encyclopedia of Electrical and Electronics Engineering. John Wiley & Sons, 2015.

Refereed PapersGallardo-Rodrigguez, J.J., Lopez-Rosles, L., Sanchez-Miron, A., Garcia-Camacho, F., Molina-Grima, E., Chalmers, J.J. New insights into shear-sensitivity in dinoflagellate microalgae. Bioresource Technology. 699-705. 2016.

Chalmers, J.J., “Mixing, aeration and cell damage, 30+ years later: what we learned, how did it affect the cell culture industry and what would we like to know more about,” Current Opinions in Chemical Engineering, Vol 10:94-102. (2015)

Joao Paulo Oliveira-Costa, Alex Fiorini de Carvalho2, Giorgia Gobbi da Silveira1, Peter Amaya3, Yongqi Wu, Kyoung-Joo Jenny Park, Mabel Pinilla Gigliola, Maryam Lustberg, Marcilei Eliza Cavicchioli Buim, Elisa Napolitano Ferreira, Luiz Paulo Kowalski, Jeffrey J. Chalmers, Fernando Augusto Soares, Dirce Maria Carraro, Alfredo Ribeiro-Silva, “Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells,” OncoTarget. 28;6(25)20902-20. (2015).

Barrow, M, Taylor, A ,Nieves, DJ, Bogart, LK,, Mandal, P.,Collins, CM , Moore, LR, Chalmers, JJ, Levy, R Williams, SR, Murray, P, Rosseinsky, MJ, Adams, DJ, “Tailoring the surface charge of dextran-based polymer coated SPIONs for modulated stem cell uptake and MRI contrast,” Biomaterials Science. 3(4):608-616. (2015).

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Buck, A., Moore, L.R., Lane, C.D., Kumar, A., Stroff, C., White, N., Xue, w., Chalmers, J.J., Zborowski, M., “Magnetic separation of algae genetically modified for increased intracellular iron uptake,” Journal of Magnetism and Magnetic Material. 380:201-204. (2015). 17.

Mathsyaraja, H., Thies, K., Taffany, D.A., Deighan, C., Liu, T., Pecot, T., Yu, L., Fernandez, S.A., Shapiro, C., Otero, J., Timmers, C., Lustberg, M.B., Chalmers, J.J., Leone, G., Ostrowski, M.C. CSF1 Induces Oncogenic microRNAs in Macrophages to Drive Metastatic Tumor Growth. Oncogene 34(28):3651-3661. (2015).

Patents

Chalmers JJ, Melnik K, Lara-Velasco, OR, Tong X, Zborowski M, Moore LR, Farag S. Biological Cell Separator and Disposable Kit. US Patent 9,176,111; 2015.

Grant Support

$10,000 (Phase 1: 2015-2016). Genentech: Multi-color immunohistochemistry staining of Genentech cells.

$50,000 (2015.) Millipore Merck, RF 60046284: Microcarrier cell shear collaboration.

$20,000 (2014-2016). PI. National Cancer Institute–R21CA17864: Role of tumor-associated endothelial cells in chaperoning tumor cells.

$60,000 (2014-2019). Co-Investigator; National Institutes of Health: Targeted delivery of miroRNA-loaded microvesicles for cancer therapy.

$359,779 (2012-2015). PI: Jessica Winter, co-PIs: Barbara Wyslouzil, Jeffrey Chalmers, Gang Ruan; National Science Foundation: Micellular Electrospray Synthesis of Magnetic Quantum Dots.

$716,118 (2011-2016). Zborowski, PI, Chalmers subcontract; National Institutes of Health: Magnetic Cell Sorting and Analysis.

STUART COOPERUniversity Scholar Professor, CBE Chairman Emeritus, PhD Princeton University. Polymer science and engineering, properties of polyurethanes and ionomers, blood-materials interactions, tissue engineering.

Awards and Honors

Voted president-elect of Sigma Xi, one of the largest scientific societies in the world. Will serve as President Elect in 2016, President in 2017 and Past President in 2018.


Edited Advances in Polyurethane Biomaterials with Jianjun Guan (MSE), Woodhead Publishing an imprint of Elsevier, 22 chapters 660 pages, 2015.

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LIANG-SHIH FANDistinguished University Professor, C. J. Easton Professor, PhD West Virginia University. Fluidization, particle technology, environmental control technology, multiphase flow and reaction engineering.

Awards and Honors

The 67th Institute Lecture of AIChE at its Annual Meeting in Utah, November 15-20, 2015.

Plenary/Keynote Lecturer of the following National or International Conferences:

Gordon Conference, Carbon Capture, Utilization and Storage, Stonehill College, MA, May 31 – June 5, 2015.

5th UK-China and 13th UK Particle Technology Forum, Leeks, U.K. July 12-15, 2015.

8th US/China Chemical Engineering Conference, Keynote Lecture, October 13, 2015.

Japan Science and Technology Agency Symposium on “Co-Generation,” Tokyo, Japan January 29, 2016.

Distinguished Scholar Lecture, Arizona State University, School for Engineering of Matter, Transport and Energy, April 3, 2015.


"Chemical Looping Combustion and Gasification," with Elena Chung, Sam Bayham, Mandar Kathe, Andrew Tong, and Liang Zeng, in Handbook of Clean Energy Systems, edited by Jinyue Yan, Volume 3, pp. 1409-1430, Wiley, (2015).

Refereed Papers

Deshpande, N., N. Phalak, S. Sundaresan, L.-S. Fan, “Carbon dioxide (CO2) capture from coal-fired power plants using calcium looping,” Chemical Engineering Education, vol.49, No. 2, Spring 105-110 (2015).

Mirzababaei, J., L.-S. Fan, S. S. Chuang, “Solid oxide fuel cells fueled with reduced Fe/Ti oxide,” Journal of Materials Chemistry A, 3(5), 2242-2250 (2015).

Fan, L.-S., L. Zeng, S. Luo, “Chemical‐looping technology platform,” AIChE Journal, 61(1), 2-22 (2015).

Deshpande, N., A. Majumder, L. Qin, L.-S. Fan, “High-pressure redox behavior of iron-oxide-based oxygen carriers for syngas generation from methane,” Energy & Fuels, 29(3), 1469-1478 (2015).

Zhou, Q., L.-S. Fan, “Direct numerical simulation of low-Reynolds-number flow past arrays of rotating spheres,” Journal of Fluid Mechanics, 765, 396-423 (2015).

Wang, D., L.-S. Fan, “L-valve behavior in circulating fluidized beds at high temperatures for group D particles,” Industrial & Engineering Chemistry Research, 54(16), 4468-4473 (2015).

Fan, L.-S., “The next chapter,” Powder Technology, 269, A1-A2 (2015).

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Zeng, L., A. Tong, M. Kathe, S. Bayham, L.-S. Fan, “Iron oxide looping for natural gas conversion in a countercurrent moving bed reactor,” Applied Energy, 157, 338-347 (2015).

Bayham, S., O. McGiveron, A. Tong, E. Chung, M. Kathe, D. Wang, Z. Liang, L.-S. Fan, “Parametric and dynamic studies of an iron-based 25-kWth coal direct chemical looping unit using sub-bituminous coal,” Applied Energy, 145, 354-363 (2015).

Wang, A., Q. Marashdeh, L.-S. Fan, “ECVT imaging and model analysis of the liquid distribution inside a horizontally installed passive cyclonic gas–liquid separator,” Chemical Engineering Science, 141, 231-239 (2016).

Bayham, S. C., A. Tong, M. Kathe, L.-S. Fan, “Chemical looping technology for energy and chemical production,” Wiley Interdisciplinary Reviews: Energy and Environment, 2015, doi: 10.1002/wene.173 Kathe, M., A. Empfield, J. Na, E. Blair, L.-S. Fan, “Hydrogen production from natural gas using an iron-based chemical looping technology: thermodynamic simulations and process system analysis,” Applied Energy, Applied Energy, 165 (1), 2016, 183-201, 2015, doi:10.1016/j.apenergy.2015.11.047.

Grant Support

$300,000 (2012-2015). Liang-Shih Fan, Co-PI; National Science Foundation: Microfluidics for Cell Entrapment.

$300,000 (2012-2015). Liang-Shih Fan, PI; National Science Foundation: Biomass Tar Interaction with Metal Oxide Oxygen Carriers.

$66,666 (2013-2015). Liang-Shih Fan, Co-PI; US Department of Energy: Novel Low-Cost Environmentally-Friendly Synthetic Approaches toward Core-Shell Structured Micro-Particles or Fossil Energy Applications.

$500,000 (2013-2015). Liang-Shih Fan, PI; US Department of Energy: Coal-Direct Chemical Looping (CDCL) - Phase II Study.

$100,000 (2013-2015). Liang-Shih Fan, PI; Ohio Coal Development Office: Coal Agglomeration Study in the CDCL Process.

$3,328,314 (2014-2016). Liang-Shih Fan, PI; National Energy Technology Laboratory (NETL)/Ohio Development Services Agency: Pilot Scale Operation and testing of Syngas chemical looping for Hydrogen production.

$3,208,225 (2014-2016). Liang-Shih Fan, PI; National Energy Technology Laboratory (NETL)/Ohio Development Services Agency: Commercialization of an atmospheric iron-based coal direct chemical looping process for power production, Phase II.

$32,743 (2013-2015). Liang-Shih Fan, PI; Howard University: Novel Low-Cost Environmentally-Friendly Synthetic Approaches toward Core-Shell Structured Micro-Particles for Fossil Energy Applications.

$200,000 (2014-2015). Liang-Shih Fan, PI; Ohio University/Ohio Development Services Agency: Study of Physical and chemical interaction between coal and oxygen carrier particles in the OSU Coal-direct chemical looping process.

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$200,000 (2016-2017). Liang-Shih Fan, PI; Ohio Development Service Agency: Study of Physical and Chemical Interactions between Coal and Oxygen Carrier Particles in the OSU Coal-Direct Chemical Looping Process II.

$200,000 (2016-2017). Liang-Shih Fan, PI; Ohio Development Service Agency: Techno-economic Analysis of the Carbonation-Calcination Reaction (CCR) Process for CO2 Capture from Coal Combustion Power Plants.

$2,700,000 (2015-2017). Liang-Shih Fan, PI; National Energy Technology Laboratory/ Ohio Development Service Agency: Chemical Looping Coal Gasification Sub-Pilot Unit Demonstration and Economic Assessment for IGCC Applications.

MARTIN FEINBERGMorrow Professor (now Professor Emeritus), PhD Princeton University. Complex reaction engineering, chemical reaction network theory.


Feinberg, Martin, “Chemical Reactions” in The Princeton Companion to Applied Mathematics, eds. H. Higham et al., Princeton University Press, Princeton, NJ, 2015.

Refereed Papers

Daniel Knight, Guy Shinar, and Martin Feinberg, “Sharper graph-theoretical conditions for the stabilization of complex chemical reaction networks,” Mathematical Biosciences, 262, 10-27 (2015).

Software

Haixia Ji, Daniel Knight, Philip Ellison and Martin Feinberg, The Chemical Reaction Network Toolbox, Version 2.3, (2015), available at http://www.crnt.osu.edu/CRNTWin

Grant Support

$340,718 (2010-2015). Martin Feinberg; National Science Foundation, Emerging Frontiers: Design Principles of Biochemical Reaction Networks.

LISA HALLHC Slip Slider Professorship and Assistant Professor, PhD University of Illinois at Urbana-Champaign. Polymer physics, theory and simulation, statistical thermodynamics.

Awards and Honors

NSF Faculty Early Career Development (CAREER) Award, 2015.

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Refereed Papers

Prasant Vijayaraghavan, Jonathan R. Brown, and Lisa M. Hall, “Modeling the Effect of Polymer Composition on Ionic Aggregation in Poly(propylene glycol)-Based Ionenes,” Macromolecular Chemistry and Physics, accepted Jan. 2016.Youngmi Seo, Jonathan R. Brown, and Lisa M. Hall, “Effect of Tapering on Morphology and Interfacial Behavior of Diblock Copolymers from Molecular Dynamics Simulations,” Macromolecules, 48, 4974−4982, 2015.Grant Support

$475,000 (2015). NSF CAREER Award.

$137, 258 (out of $299,816, 2015-2018). PI: Vishnu Sundaresan, OSU; co-PI: Hall; National Science Foundation CMMI: Thermoelectric Extrusion of Smart Structural Composites with Molecular Precision (1463103).

$342,000 (OSU portion, 2015-2018). PI: Thomas Epps (U of Delaware), PI: Lisa Hall; Department of Energy, Materials Chemistry: Designing Efficient Nanostructured Polymer Electrolytes Using Tapered Block Polymers – Joint Experiment and Theory Effort in Controlled Interface Design (DE-SC0014209).

W.S. WINSTON HODistinguished Professor of Engineering, PhD University of Illinois at Urbana. Molecularly based membrane separations, fuel-cell fuel processing and membranes, transport phenomena in membranes, separations with chemical reaction, reverse osmosis.

Awards and Honors

Distinguished Alumnus Award, the 70th Anniversary of the Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan, 2015.

Chemcon Distinguished Speaker Award – Prof. G. S. Laddha Medal, Indian Institute of Chemical Engineers, 2015.

Honorary Professor, Tianjin University, Tianjin, China, 2015-now.

Invited Keynote Lecturer, “New Scale-up Membranes for CO2 Capture and Separation,” 8th China-US Conference of Chemical Engineering, Shanghai, China, October 12-16, 2015.

Invited Keynote Lecturer, “New Fouling-Resistant High-Flux Membranes for Seawater Desalination,” 8th China-US Conference of Chemical Engineering, Shanghai, China, October 12-16, 2015.

Invited Keynote Lecturer, “New Scale-up Membranes for CO2 Capture and Separation,” Inaugural Indo-US Symposium on Carbon Capture, Sequestration, Utilization and Other Frontiers, CHEMCON 2015 (Annual Meeting of the Indian Institute of Chemical Engineers), Guwahati, Assam, India, December 27 – 30, 2015.

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Invited Plenary Lecturer, “Recent Developments on Membranes for CO2 Separation and Water Purification,” 26th Annual Meeting of NAMS (North American Membrane Society) to be held in Bellevue, Washington, May 21-25, 2016; see http://www.membranes.org/2016/index.html.


V. K. Vakharia and W. S. W. Ho, “Separation and Purification of Hydrogen Using CO2-Selective Facilitated Transport Membranes,” in “Hydrogen Production from Renewable Resources,” Zhen Fang, Richard L. Smith, Jr., and Xinhua Qi, eds., Springer Book Series -Biofuels and Biorefineries, Springer, Dordrecht, Germany, Chap. 12, pp. 315-338 (2015).

He Bai and W. S. W. Ho, “Proton-Exchange Membranes for Fuel Cells,” in “Encyclopedia of Membranes,” Enrico Drioli and Lidietta Giorno, eds., Springer-Verlag Berlin Heidelberg, Germany, doi:10.1007/978-3-642-40872-4_1309-3 (2016).

Refereed Papers

H. Dong, L. Zhao, L. Zhang, H. L. Chen, C. J. Gao, and W. S. W. Ho, “High-Flux Reverse Osmosis Membranes Incorporated with NaY Zeolite Nanoparticles for Brackish Water Desalination,” J. Membr. Sci., doi:10.1016/j.memsci.2014.11.054, 476, 373-383 (2015).

Z. Tong, V. K. Vakharia, M. Gasda, and W. S. W. Ho, “Water Vapor and CO2 Transport through Amine-Containing Facilitated Transport Membranes,” React. Funct. Polym., doi:10.1016/j.reactfunctpolym.2014.09.010, 86, 111-116 (2015).

B. Wang, C. Sun, Y. Li, L. Zhao, W. S. W. Ho, P. K. Dutta, “Rapid Synthesis of Faujasite/Polyethersulfone Composite Membrane and Application for CO2/N2 Separation,” Microporous Mesoporous Mater., 208, 72-82 (2015).

W. Salim and W. S. W. Ho, “Recent Developments on Nanostructured Polymer-Based Membranes,” Curr. Opinion Chem. Eng., doi.org/10.1016/j.coche.2015.03.003, 8, 76-82 (2015).

V. K. Vakharia, K. Ramasubramanian, and W. S. W. Ho, “An Experimental and Modeling Study of CO2-Selective Membranes for IGCC Syngas Purification,” J. Membr. Sci., doi:10.1016/j.memsci.2015.04.007, 488, 56-66 (2015).

K. Ramasubramanian; M. A. Severance; P. K. Dutta, and W. S. W. Ho, “Fabrication of Zeolite/Polymer Multilayer Composite Membranes for CO2 Capture: Deposition of Zeolite Particles on Polymer Supports,” J. Colloid Interf. Sci., doi:10.1016/j.jcis.2015.04.014, 452, 203-214 (2015).

L. Ansaloni, Y. Zhao, B. T. Jung, K. Ramasubramanian, M. Giacinti Baschetti, W. S. W. Ho, “Facilitated Transport Membranes Containing Amino-Functionalized Multi-Walled Carbon Nanotubes for High-Pressure CO2 Separations,” J. Membr. Sci., doi: 10.1016/j.memsci.2015.03.097, 490, 18-28 (2015).

W. S. W. Ho and K. Li, “Recent Progress in Separation Science and Technology,” Curr. Opinion Chem. Eng., doi:10.1016/j.coche.2015.03.004, 8, vii-x (2015).

B. Wang, W. S. W. Ho, J. D. Figueroa, and P. K. Dutta, “Bendable Zeolite Membranes: Synthesis and Improved Gas Separation Performance,” Langmuir, 208:72-82 (2015).

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Y. Chen, B. Wang, L. Zhao, P. Dutta, and W. S. W. Ho, “New Pebax®/Zeolite Y Composite Membranes for CO2 Capture from Flue Gas,” J. Membr. Sci., doi:10.1016/j.memsci.2015.08.045, 495, 415-423 (2015).

Y. Chen, L. Zhao, B. Wang, P. Dutta, and W. S. W. Ho, “Amine-containing Polymer/Zeolite Y Composite Membranes for CO2/N2 Separation,” J. Membr. Sci., doi:10.1016/j.memsci.2015.09.036, 497, 21-28 (2016). L. Zhao, Y. Chen, B. Wang, C. Sun, S. Chakraborty, K. Ramasubramanian, P. K. Dutta, and W. S. W. Ho, “Multilayer Polymer/Zeolite Y Composite Membrane Structure for CO2 Capture from Flue Gas,” J. Membr. Sci., doi:10.1016/j.memsci.2015.10.006, 498, 1-13 (2016).

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Patents

W. S. W. Ho, H. Verweij, K. Shqua, and K. Ramasubramanian, “Systems, Compositions, and Methods for Fluid Purification,” US Patent 9,216,390 (December 22, 2015).

M. Gasda, A. Ballantine, C. Karuppaiah, and W. S. W. Ho, “Carbon Dioxide Separator, Fuel Cell System Including Same, and Method of Operating Fuel Cell System,” US Provisional Patent Application No. 62/111,875 (filed February 4, 2015).

Grant Support

$3,000,000 (2011-2015). W.S. Winston Ho, PI, Dutta, Prabir K., Co-PI; Department of Energy, National Energy Technology Laboratory (NETL): Novel Inorganic/Polymer Composite Membranes for CO2 Capture. OSURF Project No. 60032950.

$500,000 (2013-2015). W.S. Winston Ho, PI, Dutta, Prabir K., Co-PI; Ohio Development Services Agency (ODSA): Novel Inorganic/Polymer Composite Membranes for CO2 Capture. OSURF Project No. 60040322.

$218,031 (2014-2017). W.S. Winston Ho, PI; Bloom Energy Corporation: Carbon Dioxide Removal for Solid Oxide Fuel Cell Systems. OSURF Project No. 60037842.

$577,216 (2015-2017). W.S. Winston Ho, PI; Bloom Energy Corporation: Carbon Dioxide Removal for Solid Oxide Fuel Cell Systems – Phase IV-1 (& 2): Quaternary Ammonium Hydroxide and Fluoride Membranes. OSURF Project No. 60047812.

$1,248,278 (2016-2018). W.S. Winston Ho, PI; Department of Energy, National Energy Technology Laboratory (NETL): Novel CO2-Selective Membranes for CO2 Capture from <1% CO2 Sources.

$1,000,000 (2016-2018). W.S. Winston Ho, PI; Ohio Development Services Agency (ODSA): Novel Prototype Membrane for CO2 Capture.

$80,000 (out of $240,000, 2016-2018). Junhang Dong, PI, Peter Smirniotis, Co-PI, both at the University of Cincinnati, W.S. Winston Ho, Co-PI; Ohio Development Services Agency (ODSA): Integrating H2 Permselective WGS Membrane Reactor with CO2 Membrane Separator for Efficient Pre-Combustion Carbon Capture.

ISAMU KUSAKA Associate Professor, PhD California Institute of Technology. Statistical mechanics, thermodynamics, transport phenomena at mesoscale.

Books and Book ChaptersIsamu Kusaka, S t a t i s t i c a l M e c h a n i c s for E n g i n ee r s , Springer International Publishing Switzerland, 2015.(2015). ISBN 978-3-319-13809-1, ISBN 978-3-319-15018-5 (eBook), DOI 10.1007/978-3-319-13809-1.

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L. JAMES LEE Professor and Kurtz Chair holder, University of Minnesota. Polymer and composite engineering, micro-nanotechnology, BioMEMS/NEMS.

Refereed Papers

L. Chang, M. Howdyshell , W-C Liao, C-L Chiang, D. Gallego-Perez, Z. Yang, J.C. Byrd, N. Muthusamy, W. Lu, L.J. Lee and R. Sooryakumar, “Magnetic Tweezers-based 3D Micro-channel Electroporation for Efficient Cell Manipulation and High-Throughput Gene Transfection,” Small, 11(15), 1818-1828 (2015).

X. Wang, H. He, Y. Lu, W. Ren, K-Y Teng, C-L Chiang, Z. Yang, B. Yu, S. Hsu, S.T. Jacob, K. Ghoshal and L.J Lee, “Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog,” Biochimica et Biophysica Acta, 1853, 244-253 (2015).

X. Zhao, Y. Wu D. Gallego-Perez, K.J. Kwak, C. Gupta, X. Ouyang and L.J. Lee, “Non-Endocytic Uptake of Multi-walled Carbon Nanotube Exhibits High Toxicity to Human Bronchial Epithelial Cells,” Analytical Chemistry, 87, 3208-3215 (2015).

Y. Wu, J. Ma, P Woods, N. Chesarino, L.J. Lee, S.P. Nana-Sinkam and I.C. Davis, DVM, “Selective Targeting of Alveolar Type II Respiratory Epithelial Cells by Anti-surfactant Protein-C Antibody-conjugated Lipoplexes,” J. Controlled Release, 203, 140-149 (2015).

A. Pulliero, Y. Wu, D. Fenoglio, A. Parodi, M. Romani, C.P. Soares, G. Filaci, L.J. Lee, P. Nana-Sinkam and I. Zzotti, “Nanoparticles Increase the Efficacy of Cancer Chemopreventive Agents in Cells Exposed to Cigarette Smoke Condensate,” Carciogenesis, 36(3), 368-377 (2015).

J. Khalife, H. Radomska, R. Santhanam, X. Huang, P. Neviani, J. Saultz, H. Wang, Y-Z Wu, H. Alachkar, M. Anghelina, A. Dorrance, J. Curfman, C. Bloomfield, B. Medeiros, D. Perrotti, L.J. Lee, R.J. Lee, M. Caligiuri, F. Pichiorri, C. Croce, R. Garzon, M. Guzman, J. Mendler and G. Marcucci, "Pharmacological Targeting of miR-155 via the NEDD8-Activating Enzyme Inhibitor MLN4924 (Pevonedistat) in Acute Myeloid Leukemia,” Leukemia, 29(10), 1981-1992 (2015).

P.E. Boukany, S.Q. Wang, S. Ravindranath and L.J. Lee, “ Shear Banding in Entangled Polymers in the Micron Scale Gap: a Confocal-Rheoscopic Study,” Soft Matter., 11(41), 8058-8068 (2015).

L. Chang, P. Bertani, D., Gallego-Perez, Z, Yang, F. Chen, C.L. Chiang, V. Malkoc, T. Kuang, K. Gao, L.J. Lee and W. Lu, “3D Nanochannel Electroporation for High-throughput Cell Transfection with High Uniformity and Dosage Control,” Nanoscale, 8(1), 243-252 (2015).

X. Wang, H. He, Y. Lu, W. Ren, K.Y. Teng, C.L. Chiang, Z. Yang, B. Yu, S. Hsu, S.T. Jacob, K. Ghoshaland L.J. Lee, “Indole-3-carbinol Inhibits Tumorigenicity of Hepatocellular Carcinoma Cells via Suppression of MicroRNA-21 and Upregulation of Phosphatase and Tensin Homolog,” Biochim Biophys Acta., 1853(1), 244-253 (2015).

H. Li, S. Xu, Q. Shan, Yung, J. pang, M. Zhang, S. Liu, R. Muthusamy, K. Chan, JC. Byrd, L.J. Lee, G. Marcucci and R.J. Lee, "CD33-targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia,” Molecular Pharmaceutics, 12(6), 2010-2018 (2015).

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P. Bertani, W. Lu, L. Chang, D. Gallego-Perez and L.J. Lee, “Bosch Etching for the Creation of a 3D Nano-Electroporation System for High Throughput Gene Delivery,” Journal of Vacuum Science and Technology, B 33, 06F903 (2015).

Z. Yang, L. Chang, C-L Chiang and L.J. Lee, “Micro-/Nanochannel Electroproation for Active Gene Delivery: from Bench to Bedside,” Current Pharmaceutical Design, 21(42), 6081-6088 (2015).

L. Chang, D. Gallego-Perez, X. Zhao, Z. Yang, C-L Chang, V. Malkoc, J. Shi, C.K. Sen, L. Odonnell, J. Yu, W. Lu and L.J. Lee, “Dielectrophoresis-assisted 3D Nanoelectroporation for Non-viral Cell Transfection in Adoptive Immunotherapy,” Lab-on-a-Chip, 15, 3147 - 3153 (2015).

L. Rogers, M. Robbins, D. Dakhlallah, Z. Yang, L.J. Lee, M. Mikhail, G. Nuovo, G. Pryhuber, C. Marsh and T. Tipple, “MicroRNA-17~92 Cluster Expression is Attenuated in Bronchopulmonary Dysplasia,” Ann Am Thorac. Soc., 12(10), 1506-1513 (2015).

X. Zhao, X. Huang, X. Wang, Y. Wu, A.K. Eisfeld, S. Schwind, P.E. Boukany, D. Gallego-Perez, G.I. Marcucci and L.J. Lee, “Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia,” Advanced Science, 2, 1500111 (2015).Y. Wu, D. Gallego-Perez and L.J. Lee, “Microwell Aarray-mediated Delivery of Lipoplexes Containing NucleicAacids for Enhanced Therapeutic Efficacy,” Methods Mol. Biol., 1218, 131-142 (2015).

R. Mani, C-L Chiang, F.W. Frissora, R. Yan, X. Mo, S. Baskar, C. Rader, R. Klisovic, M.A. Phelps, C-S Chen, R.J. Lee, J.C. Byrd, R. Baiocchi, L.J. Lee and R. Muthusamy, “ROR1 Targeted Delivery of OSU-2S, a Non-immunosuppressive FTY720 Derivative Exerts Potent Cytotoxicity in Mantle Cell Lymphoma In-vitro and In-vivo” Experimental Hematology, 43(9), 770-774 (2015).

D. Fu, T. Kuang, F. Chen, L.J. Lee, X. Peng, “Fabrication of High Strength PA6/PP Blends with Pressure-induced Flow Processing,” Materials Chemistry and Physics, 164, 1-5 (2015).

D. Li, Y-C Yen, D. Fu, A. Benatar and L.J. Lee, “Ultrasound-Assisted-Pressure-Induced-Flow Leading to Superior Polymer/Carbon Nanotube Composites and Foams,” Polymer, 80, 237-244 (2015).

X. Ouyang, S-H Ko, J. Castro and L.J. Lee, "A Kinetics Study of Diacrylic- Styrene Crosslinking Copolymerization,” Journal of Polymer Research, 22(148), 1-6 (2015).

X. Ouyang, Wenyi Huang, Eusebio Cabrera, Jose Castro, and L.J. Lee, “Graphene-Graphene Oxide-Graphene Hybrid Nanopapers with Superior Mechanical, Gas Barrier and Electrical Properties,” AIP Advances, 5, 017135 (2015).

J. Zhou, P. He, J. Yu, L.G. Shen, L.J. Lee and A. Yi, "Investigation on the Friction Coefficient between Graphene-coated Silicon and Glass Using Barrel Compression Test,” Journal of Vacuum Science and Technology B, 33, 031213 (2015).

Z. Zhao, W-C Liao, N. Bhagavatula, L.J. Lee and J.M. Castro, “Permeability Measurements and Flow Simulation for Polyaniline (PANI) Carbon Nanafiber Modified Nanopaper on Glass Fiber Preform,” Polymer Composites, Doi: 10.1002/pc.23197.

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L. Chang, J. Hu, F. Chen, Z. Chen, J. Sha, Z. Yang, Y. Li and L.J. Lee, “Nanoscale Bio-Platforms for Living Cell Interrogation: Current Status and Future Perspectives,” Nanoscale, DOI: 10.1039/C5NR06694H (2016).D. Fu, T. Kuang, Y-C Yen, D. Li, A. Benatar, X.F. Peng and L.J. Lee, “PS/MWCNT Composite and Its Foam Assisted by Ultrasound Vibration,” J. Cellular Plastics, in press.

K. Gao, X. Huang, X. Wang, P.E. Boukany, G. Marcucci and L.J. Lee, “Analysis of Mcl-1 Induced Apoptosis in Wild Type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanoelectroporation and Single Cell qRT-PCR,” Molecular Therapy, in press.

S-H Kim, R. Ezhilarasan, R. Chhipa, J. Wang, E. Phillips, A. Sparks, D. Taylor, D. Gallego-Perez, E.P. Sulman, V. Goidts, L.J. Lee, D. Guttridge, B. DasGupta, K. Bhat, J. Walker and I. Nakano, “Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-kB-dependent Manner,” Cancer Cell, in press.

D. Gallego-Perez, J.J. Otero, C. Czeisler, J. Ma, C. Ortiz, P. Gygli, F.P. Catacutan, H.N. Gokozan, A. Cowgill, T. Sherwood, S. Ghatak, V. Malkoc, X. Zhao, W-C Liao, S. Gnyawali, X. Wang, A.F. Adler, K. Leong, B. Wulff, T.A. Wilgus, C. Askwith, S. Khanna, C. Rink, C.K. Sen, L.J. Lee, “Deterministic Transfection Drives Efficient Nonviral Reprogramming and Uncovers Reprogramming Barriers,” Nanomedicine, in press.

Patents

L.J. Lee, J. Yu and Y-C Yen, “Graphene-like Nanosheet Structure Network on a Substrate and the Method for Forming the Same,” US Patent 20150023860A1 on December 10 (2015).

L.J. Lee, K.J. Kwak, B. Yu and Y. Wu, “An Immune Tethered Lipoplex Nanoparticle Biochip, Its Fabrication and Biodetection Applications,” Chinese Patent CN103197066B on November 23 (2015).

Grant Support

$12,900,000 (2009-2015). L.J. Lee, PI; NSF: Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Medical Devices.

$422,875 (2013-2016). L.J. Lee, PI; NIH: Precise Transfection of Safe Cell Reprogramming by Nanoelectroporation.

$367,901 (2013-2015). L.J. Lee, PI; NIH: Tethered Cationic Lipoplex Nanoparticle Array for Early Lung Cancer Detection.

$422,875 (2014-2016). L.J. Lee, PI; NIH: Tethered Cationic Lipoplex Nanoparticle Array for Assay for HCC Detection and Surveillance.

$2,200,000 (2015-2017). L.J. Lee, PI; Ohio Third Frontier Program: Carbon Nanomaterials and Composites Platform.

$35,000 (2015-2016). L.J. Lee, PI; Owens Corning: Annual Membership Fees for Green Thermal Insulation Foams.

$30,000 (2015-2016). L.J. Lee, PI; LCY Group: Advanced PP Foams.

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UMIT S. OZKAN College of Engineering Distinguished Professor, PhD Iowa State University. Catalysis, electro-catalysis and catalytic materials. Application of catalysis in the areas of energy conversion and emission control.

Refereed Papers

Mamtani, K. and Ozkan, U.S., “Heteroatom-doped Carbon nanostructures as Oxygen Reduction Reaction Catalysts in Acidic Media: An Overview.” Catalysis Letters, Silver Anniversary Special Issue 145, 436-450 (2015).

Zhao, Z., Lakshminarayanan, N., Swartz, S.L., Arkenberg, G.B., Felix, L.G., Slimane, R. B., Choi, C.W., Ozkan, U.S., “Characterization of olivine-supported nickel silicate catalyst for tar removal from biomass gasification,” Applied Catalysis A, 489, 42-50 (2015).

Soykal, I.I., Matter, P.H., Thrun, L., Long, R., Swartz, S., Ozkan, U.S., “Amperometric NOx Sensor Based on Oxygen Reduction,” IEEE Sensors. (2015) DOI: 10.1109/JSEN.2015.2498544

Choi, H., Fuller, A., Davis, J., Co, A., Ozkan, U.S., “Effect of Ce doping on the performance and stability of strontium cobalt ferrite perovskites as SOFC anode catalysts,” Topics in Catalysis. 58:359–374 (2015).

Soykal, I.I., Sohn, H., Bayram, B., Gawade, P. Snyder, M.P.Stephen E. Levine, Oz, H. and Ozkan, U.S.“Effect of Microgravity on Synthesis of Nano Ceria,” Catalysts 5(3), 1306-1320 (2015).

Sinha-Majumdar, S., Alexander, A-M., Celik, G., Gawade, P., Ozkan, U.S., “Incorporation of binder during sol-gel preparation of Pd-based sulfated zirconia for reduction of nitrogen oxides under lean-burn conditions,” I&ECR, Accepted.

Johnson, G.B., Hjalmarsson, P., Norrman, K., Ozkan, U.S., Hagen, A., “Biogas catalytic reforming studies on nickel based solid oxide fuel cell anodes” Fuel Cells, Accepted.

Mamtani, K., Singh, D., Millet, J-M., Ozkan, U.S., “Evolution of FeNC catalysts through synthesis stages.” ACS Catalysis, Accepted.

Patents

U.S. Ozkan, “Phosphorus-Doped Carbon-Containing Catalyst for Proton Exchange Membranes and Method for Making Same.” US Patent 9,136,542, September 2015.

Ozkan, Umit S., von Deak, Dieter, Biddinger, Elizabeth J., “Phosphourous-Doped Carbon-Containing Catalyst for Proton Exchange Membranes and Method for Making Same.” US Patent 9,136,542, September 2015.

Grant Support

$450,000 (2012-2016). Umit Ozkan, PI, Anne Co, co-PI; National Science Foundation: Controlling olefin selectivity in electrocatalytically-assisted alkane dehydrogenation.

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$480,000 (2013-2016). PI: Umit Ozkan, co-PI: Aravind Asthagiri; USDOE Basic Energy Sciences: Heteroatom-doped carbon materials as oxygen reduction electro-catalysts in acidic and alkaline media.

$100,000 (2014-2015). Umit Ozkan, PI; Ohio Coal Development Office: Electrocatalytic separation of oxygen from air.

$152,862 (2014-2015). Umit Ozkan, PI; HONDA: Catalytic Reforming of VOCs Generated During Paint Operations.

$362,520 (2014-2017). Umit Ozkan, PI; GOALI: Swellable superhydrophobic organosilica materials as a novel catalyst support for water purification systems, (OSURF #60044132).

$160,000 (2014-2016). Umit Ozkan, PI; Ohio Coal Research Consortium: Catalytic Treatment of Water Contaminated During Coal Processing.

$160,000 (2015-2017). Umit Ozkan, PI; Ohio Coal Research Consortium: Production of functionalized carbon nano structures from coal gas.

$165,000 (2016). Umit Ozkan, PI; HONDA: Catalytic reforming of VOCs generated during paint operations.

ANDRE PALMERProfessor and Chair, PhD Johns Hopkins. Bioengineering and biomaterials for transfusion medicine.

Awards and Honors

Fellow of the American Institute for Medical and Biological Engineering (AIMBE)

Refereed Papers

C. J. Roche, A. Talwar, A. F. Palmer, P. Cabrales, G. Gerfen and J. M. Friedman, “Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties,” Journal of Biological Chemistry 290: 99-117 (2015)

M. S Kwon, S. K. Woo, S. H. Yoon, A. F. Palmer, U. Banerjee, D. B. Kurland, S. Iqbal, S. Ivanova, V. Gerzanich, J. M. Simard, “Methemoglobin is an endogenous toll-like receptor 4 ligand – relevance to subarachnoid hemorrhage,” International Journal of Molecular Sciences 16: 5028-46 (2015).

R. Xue, C. Ge, K. Richardson, A. Palmer, M. Viapiano, J. Lannutti, “Microscale sensing of oxygen via encapsulated porphyrin nanofibers: effect of indicator and polymer ‘core’ permeability” ACS Applied Materials & Interfaces 7: 8606-14 (2015).

K. Agarwal, M. Saji, S. Lazaroff, A. F. Palmer, M. D. Ringel, M. Paulaitis, “Analysis of exosome release as a cellular response to MAPK pathway inhibition,” 31: 5440-8 Langmuir (2015).

J. Fontes, U. Banerjee, M. C. Iazbik, M. L. Marín, C. G. Couto and A. F. Palmer, “The effect of ascorbic acid on storage of greyhound erythrocytes,” 76: 789-800 American Journal of Veterinary Research (2015).

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D. Espes, J. Lau, M. Quach, U. Banerjee, A. F. Palmer and P. O. Carlsson, “Co-transplantation of polymerized hemoglobin reduces beta cell hypoxia and improves beta cell function in intramuscular islet grafts,” 99: 2077–2082 Transplantation (2015).

C. A. Schaer, J. W. Deuel, D. Schildknecht, L. Mahmoudi, I. Garcia-Rubio, C. Owczarek, F. Vallelian, S. Schauer, R. Kissner, U. Banerjee, A. F. Palmer, D. R. Spahn, D. C. Irwin, P. W. Buehler, and D. J. Schaer, “Haptoglobin preserves vascular nitric oxide signaling during hemolysis,” accepted American Journal of Respiratory and Critical Care Medicine (2015).

Grant Support

$399,000 (2014-2016). (PI: Palmer, A.F., co-PI: Cabrales, P.); National Institutes of Health: Attenuating the oxidative and myocardial toxicity of polymerized hemoglobins, Grant: R56HL123015.

JAMES RATHMANProfessor, PhD University of Oklahoma. Molecular informatics, computational modeling for safety/risk assessment, analysis of large chemical and biological datasets.

Refereed Papers

Yang, C.; Tarkhov, A.; Marusczyk, J.; Bienfait, B.; Gasteiger, J.; Kleinoeder, T.; Magdziarz, T.; Sacher, O.; Schwab, C.; Schwoebel, J.; Terfloth, L.; Arvidson, K.; Richard, A.; Worth, A.; Rathman, “A New Publicly Available Chemical Query Language, CSRML, to support Chemotype Representations for Application to Data Mining and Modeling,” J. Journal of Chemical Information and Modeling, 2015, 55 (3), pp 510–528.

DAVID TOMASKOProfessor, PhD University of Illinois Urbana-Champaign. Molecular thermodynamics, supercritical fluid processing, polymer processing, engineering education.


Tomasko, D.L. and Munj, H., “Polymer Nanocomposites and Nanocomposite Foams in Compressed CO2” in Supercritical Fluid Nanotechnology: Advances and Applications in Composites and Hybrid Nanomaterials, C. Doming and P. Subra-Paternault, Eds., Pan Stanford Publishing Pte Ltd., Singapore, 2015.

Refereed Papers

Patankar, S., Gautam, S., Rother, G., Podlesnyak, A., Ehlers, G., Liu, T., Sheets, J., Cole, D., Tomasko, D., “Role of Confinement on Adsorption and Dynamics of Ethane and an Ethane-CO2 Mixture in Mesoporous CPG Silica,” J. Phys. Chem. C., 2016, 120 (9), 4843–4853.

Gautam, S., Liu, T., Patankar, S., Tomasko, D., Cole, D., “Location dependent orientational structure and dynamics of ethane in ZSM5,” Chem. Phys. Lett., 2016, 648, 130-136.

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Tomasko, D.L., Ridgway, J.S., Waller, R.J., Olesik, S.V., “Association of bridge program outcomes with STEM retention of targeted demographic groups,” J. College Science Teaching, 45.4. (Mar/Apr 2016): 90-99.

Geiger, B., Nelson, M.T., Munj, H.R., Tomasko, D.L., Lannutti, J.J., “Dual Drug Release from CO2-Infused Nanofibers via Hydrophobic and Hydrophilic Interactions,” J. Appl. Polym. Sci., 2015, 132, 42571.Grant Support

$614,775 (2013-2016). Tomasko, David (PI), co-PI: Howard Greene; National Science Foundation, DUE-1259709, Project 60042813: Human Connect: Scholarships in science, technology, engineering and math.

$646,067 (2011-2016). Tomasko, David (Co-PI), PI: D. Cole (Earth Sciences), Co PI: A. Striolo (Univ. of Oklahoma); DOE Basic Energy Sciences, Project 60031581 Collaborative research: Nanopore confinement of C-H-O mixed volatile fluids relevant to subsurface energy systems.

JESSICA O. WINTERProfessor, PhD University of Texas at Austin. Bionanotechnology, cancer, drug delivery.

Awards and Honors

40 Under 40, Columbus Business First


G. Nabar, M. Souva, K.H. Lee, S. De, J. Lutkenhaus, B. Wyslouzil, J.O. Winter (Anticipated 2016). “Chapter 3: Scalable Nanomanufacturing of Nanocomposites Using Spray-Based Approaches,” Thomas Mensah, Ben Wang, Virginia Davis, Jessica Winter, Eds., Frontiers of Nanotechnology: Manufacturing Processes, Wiley, forthcoming.

Refereed Papers

J. Grodecki, S. Rao, A. Short, J. Otero, J. Lannutti, A. Sarkar, J. Winter (2015). "Glioma-Astrocyte Interactions on White Matter Tract-Mimetic Aligned Electrospun Nanofibers," Biotechnology Progress, 31(5):1406-1415. [DOI: 10.1002/btpr.2123]

A.R. Short, A. Deshmukh, D. Koralla, B. Stocker, B. Wissel, M. Calhoun, D. Dean, J.O. Winter, Hydrogels that allow and facilitate bone repair, remodeling, and regeneration (2015). Journal of Materials Chemistry B, 3: 7818-7830. [DOI: 10.1039/C5TB01043H]

Grant Support $420,000 (out of $17.9M, 2014-2020). PI: Chris Hammel; National Science Foundation, DMR-1420451: Materials Research Science and Engineering Center, Center for Emergent Materials.

$1,174,126 (2013-2017). PI: Jessica Winter, co-PIs: Barbara Wyslouzil, Carol Lynn Alpert (Museum of Science, Boston), Lisa Hall; National Science Foundation CMMI-1344567, SNM: Continuous, Large-Scale Nanocomposite Production Via Micellular Electrospray.

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$330,000 (2012-2015). PI: Jessica Winter, co-PIs: Barbara Wyslouzil, Jeffrey Chalmers, Gang Ruan; National Science Foundation, DMR-1206745: Micellular Electrospray Synthesis of Magnetic Quantum Dots.

$100,000 (2013-2015). PI: Metin Gurcan, co-PIs: Jessica Winter, Jose Otero, Brad Elder, Vinay Pudivalli; Pelotonia Cancer Research, OSU: Defining molecular events for targeted therapy of glioblastoma using digital image analysis.

(2015-2016). PI: Jessica Winter, co-PI: George Bachand, Sandia National Labs, Permits labor and tool use at Sandia; Department of Energy, C2015A0078, Center for Integrated Nanotechnologies: Microtubule shuttles for Nanotransport and Delivery.

DAVID W. WOODAssociate Professor, PhD Rensselaer Polytechnic Institute. Biotechnology, bioseparations, biosensors, protein engineering.


Stimple, S. D. and Wood, D. W., “Chapter 12: Process Development,” in Biosimilars of Monoclonal Antibodies, (eds. Cheng Liu and K. John Morrow). John Wiley & Sons, Inc., Hoboken, NJ, USA, (In press for 2016).

Shi, C., Han, T-C. and Wood, D. W., “Purification of Microbially Expressed Recombinant Proteins via a Dual ELP Split Intein System,” in Methods in Molecular Biology: Split Inteins: Methods and Protocols, (ed. Henning Mootz). Humana Press, Totowa, NJ, USA, (In press for 2016).

Refereed Papers

Cronin, M., Coolbaugh, M. J., Nellis, D., Zhu, J., Wood, D. W., Nussinov, R. & Ma, B., “Dynamics differentiate between active and inactive inteins,” European Journal of Medicinal Chemistry, 91, 51-62 (2015).

Patents

Nellis, D., Wood, D. W., Zhu, J. & Ma, B., “Reversible Regulation Of Intein Activity Through Engineered New Zinc Binding Domain,” PCT/US13/53195, Application filed August 1, 2013.

Grant Support

$10,815 (2013-2015). David Wood, PI, small research grant; Sanofi Pasteur (Sanofi-Aventis Group): Evaluation of a self-cleaving tag purification system with three Sanofi Pasteur proteins. The goal of this project is to demonstrate our self-cleaving tag technology with initially three (now five) test proteins provided by Sanofi Pasteur. Success will lead to licensing discussions, which are ongoing.

$240,239 (2013-2016). David Wood, PI; National Science Foundation, Chemical and Biological Separations (CBET): A self-cleaving tag protein purification platform for biopharmaceutical research and manufacturing. This project seeks to develop an enhanced self-cleaving tag technology for use in the biopharmaceutical industry, and specifically for proteins expressed in mammalian cell culture.

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$1,069,472 (out of $16,000,000, 2013-2017). Govind Rao (UMBC), PI; subcontract: DARPA BioMod Program: This project seeks to develop a laptop-sized device that can produce any biopharmaceutical on demand within 16 hours. The proposal was prepared by a group of investigators and Wood is developing first-capture methods for the newly synthesized proteins using self-cleaving affinity tag technology. $400,000 (2012-2015). Wood, co-PI with Richard Lease; National Science Foundation CBET: Riboswitch-sRNA for dual transcript control by a ligand. This project seeks to develop novel feedback methods for controlling gene expression through post-transcriptional regulation of gene transcripts. The methods will be applied to the development of new strains of bacteria for the production of bio-butanol.

BARBARA WYSLOUZILProfessor, PhD Caltech. Aerosol science, nucleation, nanoparticle growth and structure, biomedical applications of aerosols.

Refereed Papers

L.S. Hadlocona, L.Y. Zhao, G. Bohrer, W. Kenny, S.R. Garrity, J. Wang, B. Wyslouzil & J. Upadhyaya, Modeling of particulate matter dispersion from a poultry facility using AERMOD, Journal of the Air & Waste Management Association, 65 206-217, (2015) http://dx.doi.org/10.1080/10962247.2014.986306

Kelley Mullick, Ashutosh Bhabhe, Alexandra Manka, Judith Wölk, Reinhard Strey and Barbara E. Wyslouzil, Isothermal nucleation rates of n-propanol, n-butanol, and n-pentanol in supersonic nozzles: critical cluster sizes and the role of coagulation, J. Phys. Chem. B, 119, 9009-9019 (2015) http://dx.doi.org/10.1021/jp508335p

L.S. Hadlocona, L.Y. Zhao, B.E. Wyslouzil, H.P. Zhu. Semi-mechanistic modelling of ammonia absorption in an acid spray wet scrubber based on mass balance, Biosystems Engineering, 136, 14-24 (2015)http://dx.doi.org/10.1016/j.biosystemseng.2015.05.002

Shinobu Tanimura, Yensil Park, Andrew Amaya, Viraj Modak, and Barbara E. Wyslouzil, Following heterogeneous nucleation of CO2 on H2O ice nanoparticles with microsecond resolution, RSC Advances, 5,105537-105550 (2015), http://dx.doi.org/10.1039/C5RA19782A

Anthony D. Duong, Michael A. Collier, Eric M. Bachelder, Barbara E. Wyslouzil, Kristy M. Ainslie, One Step Encapsulation of Small Molecule Drugs in Liposomes via Electrospray-Remote Loading, Molecular Pharmaceutics, 13, 92 - 99 (2016) http://dx.doi.org/10.1021/acs.molpharmaceut.5b00528

Matthew D. Gallovic, Douglas G. Montjoy, Michael A. Collier, Clement Do, Barbara E. Wyslouzil, Eric M. Bachelder, Kristy M. Ainslie, Chemically Modified Inulin Microparticles Serving Dual Function as a Protein Antigen Delivery Vehicle and Immunostimulatory Adjuvant, Biomaterials Science, published online 11 Jan 2016, http://dx.doi.org/10.1039/C5BM00451A

Yoojeong Kim, Glyn Wellum, Kerrianne Mello, Kenneth E. Strawhecker, Richard Thoms, Arjan Giaya, and Barbara E. Wyslouzil, Effects of Relative Humidity and Particle and Surface Properties on Particle Resuspension Rates, Aerosol Science and Technology (In Press).

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Grant Support $213,000 (2010-15). Barbara Wyslouzil, PI; National Science Foundation GOALI Collaborative Research: Fundamental Studies of water hydrocarbon condensation.

$478,000 (2012-16). Barbara Wyslouzil, PI; National Science Foundation: Nanodroplets to nanoparticles: Integretated studies of freezing.

$359,000 (2012-15). Jessica Winter, PI; Barbara Wyslouzil, Jeffrey Chalmers co-PIs; National Science Foundation: Micellular Electrospray Synthesis of Magnetic Quantum Dots.

$1,174,000 (2012-16). Jessica Winter, PI; Barbara Wyslouzil, Lisa Hall, C. Alpert, co-PIs; National Science Foundation: SNM: Continuous, large-scale nanocomposite production via micellular electrospray.

$475,000 (2015-18). Barbara Wyslouzil, PI; National Science Foundation: Integrated studies of nanodroplet freezing.

$355,000 (2015-18). Barbara Wyslouzil, PI; National Science Foundation: Heterogeneous nucleation on nanoparticles.

S. T. YANGProfessor, PhD Purdue University. Bioprocess, biochemical, metabolic and tissue engineering; biofuels and bio-based chemicals; high throughput screening for drug discovery and bioprocess optimization; stem cell engineering.


J. Wang, M. Lin, M. Xu, and S.T. Yang. Anaerobic fermentation for production of carboxylic acids as bulk chemicals from renewable biomass, in R. Hatti-Kaul (ed.), Adv. Biochem. Eng./Biotechnol., Anaerobes in Biotechnology, (2016) DOI: 10.1007/10_2015_5009

Referred Papers

Z Wang, Y Jin, S-T Yang, High cell density propionic acid fermentation with an acid tolerant strain of Propionibacterium acidipropionici, Biotechnol Bioeng, 112: 502–511 (2015),

K Zhang and ST Yang, Effects of pH on fumaric acid adsorption onto IRA900 ion exchange resin, Sep. Sci. Technol., 50:1, 56-63 (2015).

A Zhang, J Sun, Z Wang, S-T Yang, H Zhou, Effects of carbon dioxide on cell growth and propionic acid production from glycerol and glucose by Propionibacterium acidipropionici, Bioresour. Technol., 175: 374–381 (2015).

Z Wang, E Ammar, A Zhang, L Wang, M Lin, S-T Yang, Metabolic engineering of Propionibacterium freudenreichii subsp. shermanii for enhanced propionic acid fermentation: Effects of overexpressing propionyl-CoA: succinate CoA transferase, Metab Eng, 27: 46–56 (2015).

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L Zhang, X Li, Q Yong, ST Yang, J Ouyang, S Yu, Simultaneous saccharification and fermentation of xylo-oligosaccharides manufacturing waste residue for L-lactic acid production by Rhizopus oryzae, Biochem Eng J, l 94: 92–99 (2015).

C Ma, K Kojima, N Xu, J Mobley, L Zhou, S-T Yang, X Liu, Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum, J Biotechnol., 193: 108–119 (2015).

K Zhang, S-T Yang, In situ recovery of fumaric acid by intermittent adsorption with IRA-900 ion exchange resin for enhanced fumaric acid production by Rhizopus oryzae, Biochem Eng J, 96: 38–45 (2015).

T Yang, Z Rao, X Zhang, M Xu, Z Xu, S-T Yang, Economic conversion of spirit-based distillers' grain to 2,3-butanediol by Bacillus amyloliquefaciens, Process Biochem., 50: 20–23 (2015).

M Xu, J Zhao, L Yu, I-C Tang, C Xue, S-T Yang, Engineering Clostridium acetobutylicum with a histidine kinase knockout for enhanced n-butanol tolerance and production, Appl. Microbiol. Biotechnol., 99:1011–1022 (2015).

R Laguna, SJ Young, C-C Chen, N Ruiz, S-T Yang, F R Tabita, Development of a plasmid addicted system that is independent of co-inducers, antibiotics and specific carbon source additions for bioproduct (1-butanol) synthesis in Escherichia coli, Metab. Eng. Comm., 2: 6–12 (2015).

K Zhang, C Yu, S-T Yang, Effects of soybean meal hydrolysate as the nitrogen source on seed culture morphology and fumaric acid production by Rhizopus oryzae, Process Biochem., 50: 173-179 (2015).

Wang, M Lin, L Wang, EM Ammar, S-T Yang, Metabolic engineering of Propionibacterium freudenreichii subsp. shermanii for enhanced propionic acid fermentation: Effects of overexpressing three biotin-dependent carboxylases, Process Biochem, 50: 194-204 (2015).

L Wang, J Miao, Z Wang, L Wang, Q Qing, S-T Yang, Biocatalytic synthesis of ethyl (R)-2- hydroxy-4-phenylbutyrate with a newly isolated Rhodotorula mucilaginosa CCZU-G5 in an aqueous/organic biphasic system, Bioresourc. Bioprocessing, 2: 6 (2015) DOI 10.1186/s40643-015-0037-9

Y Du, W Jiang, M Yu, I-C Tang, S-T Yang, Metabolic process engineering of Clostridium tyrobutyricum Δack-adhE2 for enhanced n-butanol production from glucose: Effects of methyl viologen on NADH availability, flux distribution and fermentation kinetics, Biotechnol Bioeng, 112: 705–715 (2015). DOI: 10.1002/bit.25489

M Shao, Z Rao, X Zhang, M Xu, T Yang, H Li, Z Xu, ST Yang, Bioconversion of cholesterol to 4-cholesten-3-one by recombinant Bacillus subtilis expressing choM gene encoding cholesterol oxidase from Mycobacterium neoaurum JC-12, J Chem Technol Biotechnol, 90: 1811–1820 (2015). DOI: 10.1002/jctb.4491

L Yu, J Zhao, M Xu, J Dong, S Varghese, M Yu, I-C Tang, S-T Yang, Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from glucose: Effects of CoA transferase, Appl. Microbiol. Biotechnol., 99(11):4917-4930 (2015). Doi: 10.1007/s00253-015-6566-5

H. Fu, S.T. Yang, Z. Xiu, Phase separation in a salting-out extraction system of ethanol- ammonium sulfate, Sep. Purifi. Technol., 148: 32-37 (2015).

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L Yu, M Xu, IC Tang, ST Yang, Metabolic engineering of Clostridium tyrobutyricum for n- butanol production from maltose and soluble starch by overexpressing α-glucosidases, Appl. Microbiol. Biotechnol., 99(14):6155-65 (2015). DOI 10.1007/s00253-015-6680-4

L Yu, M Xu, IC Tang, ST Yang, Metabolic engineering of Clostridium tyrobutyricum for n- butanol production through co-utilization of glucose and xylose, Biotechnol. Bioeng., 112: 2134-2141 (2015). doi: 10.1002/bit.25613

J Guo, Z Rao, T Yang, Z Man, M Xu, X Zhang, ST Yang, Cloning and identification of a novel tyrosinase and its overexpression in Streptomyces kathirae SC-1 for enhancing melanin production, FEMS Microbiol Lett, 362(8):fnv041 (2015). DOI: 10.1093/femsle/fnv041

T Yang; Z Rao; X Zhang; M Xu; Z Xu; ST Yang, Enhanced 2,3-butanediol production from biodiesel-derived glycerol by engineering of cofactor regeneration and manipulating carbon flux in Bacillus amyloliquefaciens, Microbial Cell Factories, 14(1): 122 (2015).

T Yang, Z Rao, G Hu, X Zhang, M Liu, Y Dai, M Xu, Z Xu, ST Yang, Metabolic engineering ofBacillus subtilis for redistributing the carbon flux to 2,3-butanediol by manipulating NADH levels, Biotechnol Biofuels, 8(1): 129 (2015).

X Yang, M Xu, ST Yang, Metabolic and process engineering of Clostridium cellulovorans for biofuel production from cellulose, Metab Eng., 32: 39–48 (2015).

J Guo, Z Rao, T Yang, Z Man, M Xu, X Zhang, S-T Yang, Enhancement of the thermostability of Streptomyces kathirae SC-1 tyrosinase by rational design and empirical mutation, Enzyme Microb. Technol., 77:54-60 (2015).

T Yang, Z Rao, BG Kimani, M Xu, X Zhang, ST Yang, Two-step preparation of gama- aminobutyric acid from cassava powder using Corynebacterium glutamicum and Lactobacillus plantarum, J Industrial Microbiol., 42(8):1157-65 (2015).

X Zhao, X Zhang, Z Rao, T Bao, X Li, M Xu, T Yang, ST Yang, Identification and characterization of a novel 2,3-butanediol dehydrogenase/acetoin reductase from Corynebacterium crenatum SYPA5-5, Lett. Appl. Microbiol., 61: 573-579 (2015).

AF El-Baz, AI El-Batal, FM Abomosalam, AA Tayel, YM Shetaia, ST Yang, Extracellular biosynthesis of anti-Candida silver nanoparticles using Monascus purpureus, J Basic Microbiol. 55: 1-10 (2015).

P Songserm, S Thitiprasert, V Tolieng, J Piluk, S Tanasupawat, S Assabumrungrat, S-T Yang, A Karnchanatat, N Thongchul, Regulating pyruvate carboxylase in the living culture of Aspergillus terreus NRRL 1960 by L-aspartate for enhanced itaconic acid production, Appl Biochem Biotechnol., 177(3):595-609 (2015).

C Xue, F Liu, M Xu, J Zhao, L Chen, J Ren, S-T Yang, F-W Bai, A novel in situ gas stripping- pervaporation process integrated with acetone-butanol-ethanol fermentation for hyper n-butanol production, Biotechnol. Bioeng., 113(1):120-129 (2016).

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S Long, Z Rao, X Zhang, K Chen, M Xu, T Yang, ST Yang, Amino acid residues adjacent to the catalytic cavity of tetramer L-asparaginase II contributed significantly to its catalytic efficiency and thermostability, Enzyme Microbial Technol, 82: 15-22 (2016).

C Ma, J Ou, N Xu, J Fierst, ST Yang, X Liu, Rebalancing redox to improve biobutanol production by Clostridium tyrobutyricum, Bioengineering, 3, 2 (2016).

L Zhang, X Li, Q Yong, ST Yang, J Ouyang, S Yu, Impacts of lignocellulose-derived inhibitors on L-lactic acid fermentation by Rhizopus oryzae, Bioresourc Technol., 203: 173-180 (2016).

X Yang, M Xu, ST Yang, Restriction-modification system analysis and development of in vivo methylation for the transformation of Clostridium cellulovorans, Appl. Microbiol. Biotechnol., 100, 2289-2299 (2016).

M Shao, X Zhang, Z Rao, M Xu, T Yang, HLi, Z Xu, ST Yang, A mutant form of 3-ketosteroid-Δ1-dehydrogenase gives altered androst-1,4-diene-3,17-dione/androst-4-ene-3,17- dione molar ratios in steroid biotransformations by Mycobacterium neoaurum ST-095, Ind. Microbiol. Biotechnol., in press (2016). DOI 10.1007/s10295-016-1743-9

Patents

S.T. Yang and Mingrui Yu, “Metabolic engineering of Clostridium tyrobutyricum for butanol Production,” US 2013/0323809A1, Notice of allowance dated October 28, 2015.

Grant Support

$1.22M (2015-2017). S.T. Yang; Department of Energy EERE – BTI: Engineering clostridia for n-butanol production from lignocellulosic biomass and CO2.

JACQUES ZAKIN Helen C. Kurtz Professor Emeritus, D.Eng. Sci., New York University. Surfactant drag reduction, heat transfer enhancement, rheology.

Refereed Paper

"Comparison of the effects of methyl- and chloro-substituted salicylate counterions on drag reduction and rheological behavior and micellar formation of a cationic surfactant,” by Z. Lin, Y. Zheng, Y. Talmon, A. Maxson and J. L. Zakin, Rheologica Acta, 55(2), 117-123 January 2016) DOI 10.1007/s00397-015-0904-5 (December 2015).

Grants

$20,000 (2014-2015). Dreyfus Fund Senior Mentoring Award.

$2,470 (2015). Ohio State Emeritus Academy Small Research Grant Award Equipment Grant.

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cbe.osu.edu · Web viewWilliam G. Lowrie Department of Chemical & Biomolecular Engineering 2015 FACULTY ACTIVITY REPORT _____ ARAVIND ASTHAGIRI Associate Professor, PhD Carnegie Mellon.

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