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Cauda EquinaThe term cauda equina, Latin for horses tail, refers
to the terminal portion of the spinal cord and roots of the spinal
nerves beginning at the first lumbar nerve root.
Cauda equina syndrome (CES) is a compression of some or all of
these nerve roots, resulting in symptoms that include: Bowel and
bladder dysfunction, Saddle anesthesia, Varying degrees of loss of
lower extremity sensory and motor function.
Although a precise definition of CES has not been well
established, most authors believe that an element of bladder
dysfunction is required for the diagnosis.
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AnatomyThe caudal end of the spinal cord is the conus medullaris
and is attached to the coccyx by a thin non-neural filament, the
filum terminale.
The conus contains the cell bodies and dendrites of the exiting
L5 to S3 nerve roots.
The cauda equina is a collection of peripheral nerves (L1 to S5)
in a common dural sac within the lumbar spinal canal.
During development, the spinal cord appears to migrate
proximally because of the relatively greater growth of the
vertebral spinal column. As a result, the first nerve roots that
contribute to formation of the cauda equina, the L1 nerve roots,
actually exit the spinal cord at the T10 vertebral level.
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Bladder Anatomy
Neurophysiologically, lesions involving the cauda equina are
lower motor neuron lesions.
Therefore, patients with CES may demonstrate varying degrees of
lower extremity muscle weakness and sensory disturbance as well as
decreased or absent reflexes.
Neurogenic bladder dysfunction is an essential element of CES.
The detrusor urinae muscle and internal sphincter of the bladder
are smooth muscles. They are controlled by the parasympathetic
nervous system via the S 2-4 nerve roots and the sympathetic
nervous system via the hypogastric plexus (T11-L3).
The external sphincter of the bladder is a striated muscle that
is controlled by the pudendal nerve, which arises from the S2-4
Bladder dysfunction can be divided into two broad categories:
retention and incontinence.
CES causes a lower motor neuron lesion that interrupts the
nerves forming those reflex arcs. Consequently, patients lose both
sensory and motor innervation to the bladder.
The loss of contraction and sensation leads to urinary retention
and eventually to overflow incontinence.
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Aetiology AcuteTraumaInfectionHerniated nucleus polpususSubdural
/epidural haemorrhageVetebrae collapse due to metastatic
tumourIatrogenic ChronicExtrinsic tumourPrimary tumourSpinal
stenosisChronic central disc herniationAbscess , tuberculoma
- Central disc herniation
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NeoplasmCommon in primary tumour: Ependymomas and
neurofibromaMetastatic tumour (relatively rare to cause CES) eg:
only 0.7% of lung mets to spine have CESPrimary tumour of
sacrumMain symptoms is pain (resting pain or night pain)
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CLINICALMainly divided into 2 category:Cauda equina syndrome
with urinary retensionIncompplete cauda equina syndrome (reduce
urinary sensation, reduce desire to void, poor stream)Cauda equina
syndrome is used only when these include impairment of bladder,
bowel, or sexual function, and perianal or saddle numbness.
Patients with CES may present with a varying combination of
signs and symptomsLow back pain, (local or radicular pain) Groin
and perineal pain, radicular pain, Lower extremity weakness,
Hyporeflexia or areflexia,
Sensory deficits, Perineal hypoesthesia Saddle anesthesia,
Loss of bowel or bladder function.Loss of sexual function
Back pain: characteristically severeBilateral sciatica is
strongly associated with CES
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CLINICAL [cont.]BLADDERBladder dysfunction is a required
element.Early bladder dysfunction can be subtle and involve
difficulty initiating the urinary stream.Dysfunction may then
progress to urinary retention Eventually overflow incontinence, as
mentioned.
Before the development of CES, patients often will have
prodromal symptoms of low back pain and/or unilateral sciatica,
reflective of uncomplicated lumbar disk herniation or stenosis.
Back pain is present and characteristically severe, but it may
be resolving or even absent in patients with delayed presentation.
Bilateral sciatica is strongly associated with CES, but unilateral
lower extremity pain is a more frequent symptom at the time of
initial presentation.
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CLINICAL [cont]Saddle Anesthesia: Dense sensory loss involving
the perineum, buttocks is a relatively late sign of established CES
and may indicate poor potential for recovery of normal bladder
function.
2 distinct clinical presentations of CES: acute and
insidious.
The acute presentation was characterized by the sudden onset of
severe low back pain, sciatica, urinary retention requiring
catheterization, motor weakness of the lower extremities, and
perineal anesthesia.
The insidious presentation was characterized by recurrent
episodes of low back pain occurring over periods of a few weeks to
years, followed by the gradual onset of sciatica, sensorimotor
loss, and bowel and bladder dysfunction. This latter presentation
often occurs in the setting of long-standing spinal stenosis.
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SIGNSSensation to pinprick in the perianal region (S2-S5
dermatomes), perineum, and posterior thigh is performed. These
patients typically have preserved sensation to pressure and light
touch, so if discrimination is not made between pinprick and light
touch sensation, then the diagnosis of CES may be missed.
A rectal examination is performed on all patients with potential
CES to assess the tone and voluntary contracture of the external
anal sphincter. Decreased rectal tone is often an early finding in
a patient with CES.
Both the anal wink test and a bulbocavernosus reflex should be
evaluated. The bulbocavernosus reflex is a segmental polysynaptic
reflex with crossover in the sacral spinal cord (S2-4). The reflex
is performed by applying pressure to the glans penis or clitoris
and/or traction on the Foley catheter.
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Bulbocavernous reflex
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Cornus medullarisCauda equinapainB/L, symetrical, perineal
areaSevere, asymmetryRadicular painUnusualUsual Sensory
deficitSaddle, B/LSaddle, asymmetryMuscle lossSymmetrical, mild
weakness, fasciculationAsymmetrical, atrophy, flaccid paralysis, no
fasciculationImpotence commonLess commonSphincter dysfunction bowel
and bladderPresented earlyPresented lateSeverity symptomsUsually
not severeUsually severe
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Cornus medullarisCauda equinaVetebrae Level
L1-L2L2-sacrumReflexAreflexia(if epiconus involve, patella reflex
abscent, bulbacarvenosus reflex spared)Areflexia, bulbacarvenosus
reflex abscent
OutcomeLess favourableMore favourable
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Clinical diagnosis of cauda equina syndrome even by resident
neurosurgeons has a 43% false positive rate, so accurate
confirmatory imaging is important. Magnetic resonance imaging (MRI)
is the imaging modality of choice.Urgent MRI is recommended for all
patients who have new-onset urinary symptoms with associated back
pain or sciatica.MRI with gadolinium contrast of the lumbosacral
area is the diagnostic test of choice to define pathology in the
areas of the conus medullaris and cauda equina
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Fig 2 Left: MRI scan showing compression of the cauda equina
(arrow) due to a large posterior disc herniation at L4/5. Right:
MRI scan showing a large disc herniation at L5/S1 (arrow) bulging
posteriorly and compressing the cauda equina syndrome
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Fig 3Top: Axial cross sectional MRI view at the level of L5/S1
of a patient with cauda equina syndrome showing a large irregular
disc herniation (arrow) occupying most of the vertebral canal.
Bottom: By contrast, a cross sectional MRI view at L5/S1 in a
patient without cauda equina syndrome showing an unobstructed
vertebral canal (arrows from top down: body of S1 vertebra;
vertebral canal containing cauda equina with no compression; spine
of S1)
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EMG: shows evidence of denervation. Can also help in monitoring
recovery.CXR: TRO malignancy or TBDuplex ultrasound to rule out
vascular compromiseNCS: to rule out distal peripheral nerve
lesionSomatosensory evoked potential: TRO multple sclerosisLP: to
rule out inflammatory dsESR: inflammatory ds
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Measurement of a patients post void residual volume provides an
accurate assessment of urinary retention.
Urodynamic studies should be performed in all patients both
preoperatively and postoperatively, such a comprehensive
preoperative evaluation is often not feasible, may delay treatment,
and is not widely practiced.
The postoperative spine patient presents a unique clinical
scenario to the practitioner. Increasing back pain followed by
unilateral or bilateral leg pain may be potential signs of
developing CES.
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TreatmentConsensus exists that the most appropriate treatment of
CES Recommended procedures range from simple microdiskectomy to a
wide laminectomy, diskectomy, and open inspection of the nerve
roots within the dural sac.
Timing of SurgeryThe optimal timing of surgery following
diagnosis of CES remains a topic of great controversy.
Traditional practice has been to proceed with surgical
decompression in a timely fashion, preferably within 24 hours.
Adequate Pain managementAnticoagulant
Intermittent self catheterization Manual evacuation of
rectum
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CASE 1This 34-year-old woman had been healthy, apart from a
10-year history of chronic low back pain. She presented at the
Emergency Room with worsening of the low back pain over the last 10
days, but because, in particular, on the previous day, she had
developed a new, severe pain in the perineal and sacral area. A few
hours later, she noted numbness in the perineum and increased
urinary frequency. She felt that she was not emptying her bladder
completely. She also had some increased frequency of bowel
movements and defecation was painful. She denied any weakness in
the legs.
On examination, she was in pain. The abnormalities were
restricted to the lower limbs. Straight leg raising was markedly
limited bilaterally. Cross SLR test was positive. Power was normal
in the legs. The right ankle reflex was absent. Sensory examination
showed marked diminution of light touch and pin prick in the
perineal and perianal areas. A rectal examination showed reduced
rectal tone.
A diagnosis of a central lumbosacral disk herniation was made
and a CT scan was performed. This showed a large posterior disk
herniation at L4-L5 (Figures 1 and 4). She underwent surgical
diskectomy within hours. The following day, her back pain was
considerably better and sensation in the perineum and bowel
function gradually returned to normal. Bladder function was normal
from the first postoperative day.
Comment: This history is characteristic of an acute central disk
herniation causing cauda equina compression. Urgent imaging for
confirmation of the diagnosis and urgent surgery are required in
order to optimize the patients chances of a good recovery of
bladder and bowel function.
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CASE 2This 73-year-old man had suffered from diabetes mellitus
which had been controlled by oral hypoglycemic agents for the last
18 years. He was referred for evaluation with a history of pain in
the anal, sacral, right gluteal area, and the posterior aspect of
the upper right thigh over the last 3 years. The pain was
consistently brought on by lying down and relieved by standing. He
had to sleep in a reclining chair. He denied any motor or sensory
symptoms in his legs. However, for 3 years, he had had erectile
dysfunction, would have to get up three times at night to urinate,
and had developed constipation that required regular laxatives. A
urological evaluation showed no prostatic hypertrophy, and a
thorough gastroenterological evaluation revealed no explanation for
the constipation.Neurological examination was completely normal
except in the lower limbs. Here the power was normal, but the ankle
reflexes were absent, which could have been due to diabetic
neuropathy or to bilateral S1 radicular involvement. A careful
sensory examination with light touch and pin prick showed no
abnormalities anywhere in the legs, and, in particular, this was
normal in the sacral dermatomes. Rectal tone was normal.
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A myelogram and CT-myelogram scans were performed and these
showed an intradural lobulated mass opposite the lower border of
the L5 vertebra causing complete obstruction of the sub-arachnoid
space. Surgical exploration revealed that the tumor, although
largely intradural, did have some extension through the dura and,
indeed, through the posterior lamina of the sacrum and into the
muscles overlying the sacrum. The tumor was resected almost
entirely, which involved removing a few filaments of sacral spinal
nerve roots. The pathology of this tumor was greatly debated, the
consensus being an atypical schwannoma.
Postoperatively, the patient had urinary retention requiring
catheterization. This improved, but from then on, he had to
self-catheterize twice a day. The partial constipation and erectile
dysfunction continued unchanged. Six years later, the patient had
the recurrence of pain, less ability to micturate, requiring
increased bladder self-catheterizations, and a marked worsening of
the constipation requiring increased laxatives, suppositories, and
enemas. Re-examination showed signs of a mild peripheral neuropathy
in the feet, presumably due to his diabetes. However, there was a
clear reduction in sensation in the perianal area and there was a
reduction in anal tone. Further radiological studies showed a large
soft-tissue mass producing destruction of the majority of the
sacrum and spreading to the soft tissues both anteriorly and
posteriorly to the sacrum. A biopsy was performed and again the
pathology was debated, but the consensus was that this represented
a malignant schwannoma. The patient had radiotherapy and there was
some reduction in the bulk of the tumor as seen on CT scanning. The
pain disappeared, but the bladder and bowel dysfunction remained
unchanged. The patient died 8 years later of unrelated causes.
Comment: The pattern of pain in this patient, particularly pain
that is worsened by lying and relieved by standing, is
characteristic of cauda equina mass lesions. Although the patients
erectile, bladder and bowel symptoms at the time of presentation
could have been attributed to his long-standing diabetes mellitus,
in the context of this type of pain, it was thought to be due to
involvement of the cauda equina
Symptoms depends on extend of hernia, size of canal, number of
nerve root*